A review on ebola virus
specifying epidemiology, pathogenesis and its treatment approachs
Journal name: World Journal of Pharmaceutical Research
Original article title: A review on ebola virus
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: specifying epidemiology, pathogenesis and its treatment approachs
Original source:
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Gajendra Vasu, Nidhi Jain M.Pharm, Sapna Malviya Ph.D. and Anil Kharia
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: A review on ebola virus
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201716-10217
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Ebola virus disease (EVD) is a highly lethal illness characterized by a mortality rate that can reach up to 90%. The disease is caused by the Ebola virus, first identified in 1976 in the Democratic Republic of the Congo. EVD is a zoonotic infection, indicating that it can be transmitted from animals to humans, with fruit bats believed to be a potential reservoir. The clinical manifestation begins with non-specific symptoms like fever and fatigue, which can escalate to severe hemorrhagic manifestations. Despite its notorious lethality, there are currently no approved antiviral therapies or vaccines for EVD, leaving supportive care as the primary treatment method.
Pathogenesis and Transmission
The Ebola virus is part of the Filoviridae family, with five primary species known to cause EVD, namely Zaire, Sudan, Tai Forest, Bundibugyo, and Reston ebolavirus. Transmission to humans can occur through direct contact with the blood or bodily fluids of an infected individual, as well as through contact with infected animals. The disease has an incubation period that ranges from 2 to 21 days, and upon onset, symptoms can develop rapidly, leading to multi-organ failure. Understanding the intricate interactions between the virus and human hosts is crucial for developing effective prevention and treatment strategies.
Clinical Features and Diagnosis
EVD manifests through a series of clinical phases beginning with flu-like symptoms, including fever, headache, and myalgia. As the disease progresses, patients may experience severe diarrhea, abdominal pain, and bleeding. The stage of aggravation is particularly critical, featuring severe skin manifestations, respiratory issues, and cardiovascular complications. Diagnosis primarily relies on a combination of clinical symptoms, potential exposure history, and laboratory tests like ELISA, RT-PCR, and virus isolation. Early recognition is vital for improving outcomes, yet the overlap of symptoms with other tropical diseases often delays accurate diagnosis.
Prevention and Care
Preventative measures focus on minimizing exposure to the virus, especially for individuals in endemic regions. This includes avoiding contact with suspected animals and the bodily fluids of infected persons. Healthcare workers are encouraged to practice stringent infection control measures, including the use of personal protective equipment. As there is no specific treatment or vaccine currently available, supportive care is paramount for those infected. Treatment may involve rehydration, symptomatic management, and intensive medical care to support damaged organ systems and maintain electrolyte balance.
Conclusion
Ebola virus disease remains a significant global health concern due to its high fatality rate and potential for outbreaks. The lack of effective antiviral treatments and vaccines highlights the urgent need for continued research into prevention and therapeutic options. Comprehensive training for healthcare professionals and effective public health strategies are critical in managing outbreaks and improving patient outcomes. The future of EVD research is promising, with ongoing studies aimed at developing rapid diagnostic tests and effective vaccines, which could significantly mitigate the threat posed by this virus.
FAQ section (important questions/answers):
What is Ebola virus disease and its mortality rate?
Ebola virus disease (EVD) is a deadly illness caused by the Ebola virus, with mortality rates reaching up to 90%. It is transmitted from animals to humans and can lead to severe hemorrhagic fever.
How was the Ebola virus first discovered?
The Ebola virus was discovered in 1976 by Dr. Peter Piotin in Zaire (now the Democratic Republic of Congo) after an outbreak linked to an infected nun's blood suspected of yellow fever.
What are the key symptoms of Ebola virus disease?
Symptoms of Ebola include fever, headache, abdominal pain, diarrhea, severe fatigue, and bleeding from various sites. Sudden death can occur in severe cases with rapid progression.
How is Ebola virus transmitted to humans?
Ebola can be transmitted through direct contact with infected bodily fluids, secretions, or dead bodies. Handling infected animals, including primary hosts like bats and primates, also poses a risk.
Is there a cure or vaccine for Ebola virus disease?
Currently, there is no specific antiviral therapy or vaccine for Ebola virus disease. Treatment focuses on supportive care, including rehydration and managing symptoms.
What preventive measures can be taken against Ebola virus disease?
Preventive measures include avoiding contact with infected animals, practicing good hygiene, and using protective gear for healthcare workers. Isolation of confirmed cases is also critical in stopping the virus's spread.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A review on ebola virus”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Viru:
The term 'Viru' refers to viruses, particularly in the context of infectious diseases. In this document, the Ebola virus is a primary focus, exemplifying how viruses can lead to severe health crises, with high mortality rates and significant impacts on public health globally.
2) Disease:
The word 'Disease' signifies a pathological condition caused by various factors, including infections. Ebola virus disease (EVD) is a lethal condition characterized by high mortality rates. Understanding diseases is crucial for developing preventive measures, treatments, and enhancing public health response strategies, particularly in outbreak situations.
3) Fever:
The term 'Fever' is a common symptom associated with many illnesses, including Ebola. It indicates the body's immune response to pathogens and can serve as an important sign for diagnosis. In the context of Ebola, fever is among the initial signs that prompt medical evaluation and response.
4) Blood:
'Blood' plays a central role in the transmission of the Ebola virus, as the disease is spread through direct contact with infected bodily fluids, including blood. The management of blood during outbreaks is critical to preventing further spread, highlighting the importance of safe handling and medical practices.
5) Animal:
The word 'Animal' pertains to the zoonotic nature of Ebola, as the virus is believed to be initially transmitted from animals, particularly bats, to humans. Understanding the wildlife reservoir of viruses is essential for controlling outbreaks and preventing future spillover events, emphasizing the interconnectedness of animal and human health.
6) Post:
The term 'Post' often refers to the post-exposure period after potential infection. In the context of Ebola, timely intervention following exposure is critical for preventing the onset of the disease. Understanding post-exposure prophylaxis and its implications can enhance response efforts during outbreaks.
7) Drug:
'Drug' signifies the pharmaceutical interventions used in treating diseases. While current treatments for Ebola are primarily supportive, ongoing research aims to develop specific antiviral drugs. The advancement of drug therapies is vital for improving patient outcomes and controlling outbreaks effectively.
8) Transmission:
'Transmission' describes the process by which infectious agents spread from one host to another. For Ebola, understanding the modes of transmission, including direct contact and exposure to infected bodily fluids, is crucial for implementing control measures to protect public health during outbreaks.
9) Bleeding:
The term 'Bleeding' refers to one of the severe manifestations of Ebola infection, which can lead to hemorrhagic fever. Recognizing bleeding as a prominent clinical feature is important for early diagnosis and understanding the disease's progression, aiding healthcare professionals in effective management.
10) Death:
'Death' underscores the severe fatality associated with Ebola, with mortality rates as high as 90%. The fear of death from outbreaks drives public health responses, emphasizing the need for immediate action, preventive measures, and effective communication to mitigate the impact of the disease.
11) Sign:
The word 'Sign' in this context refers to clinical indicators of Ebola infection. Identifying signs is crucial for early diagnosis and outbreak management. Effective recognition of signs can improve treatment outcomes and reduce transmission rates, thereby saving lives during epidemic situations.
12) Vomiting:
'Vomiting' is a prominent symptom of Ebola virus disease, often indicating gastrointestinal involvement. Monitoring symptoms like vomiting is critical for diagnosing the disease and managing patient care, as it can lead to dehydration and worsen patient outcomes if not adequately addressed.
13) Epidemic:
The term 'Epidemic' refers to an outbreak of a disease that affects many individuals within a community at once. The 2014 West Africa Ebola epidemic exemplifies how rapidly infectious diseases can spread, highlighting the importance of public health preparedness and response strategies to manage such outbreaks effectively.
14) Species:
'Species' relates to the different types of Ebola viruses, which include several distinct genetic variants. Each species may have different epidemiological characteristics, severity, and infectious potential. Understanding these differences is essential for tailoring responses and developing targeted treatments and vaccines.
15) Field:
The word 'Field' points to the area of study or practice, in this case, epidemiology and virology. Research in the field of infectious diseases, particularly regarding Ebola, informs public health initiatives, clinical practices, and educational programs aimed at controlling outbreaks and safeguarding communities.
16) Pain:
'Pain' is a common symptom reported by patients suffering from Ebola. The experience of pain contributes to the disease burden and complicates supportive care efforts. Addressing pain as part of holistic patient management is essential for improving quality of life and treatment satisfaction.
17) Antibiotic (Antibacterial):
'Antibiotic' refers to medications used to fight bacterial infections. Although antibiotics are ineffective against Ebola, understanding their role is critical for managing secondary infections that patients may develop during their illness. This highlights the importance of comprehensive care during outbreaks.
18) Substance:
The term 'Substance' can refer to biological materials, including the Ebola virus itself or therapeutic agents. Understanding the properties and effects of substances involved in treatment approaches is vital for drug development and effective management of Ebola virus disease.
19) Science (Scientific):
'Science' underpins the understanding of infectious diseases like Ebola. Research in the science of virology, epidemiology, and public health contributes to the knowledge base necessary for developing vaccines, treatments, and effective response strategies to combat viral outbreaks.
20) Indore:
Indore is referenced as the location of the institution associated with the authors of the study. The significance of regional health systems, education, and research efforts in combating diseases, such as Ebola, highlights the global nature of health challenges and the importance of local contributions.
21) Forest:
The term 'Forest' relates to the natural habitats where Ebola's animal reservoirs, like bats, may reside. Understanding the ecological dynamics of Ebola in forest environments is crucial for identifying transmission risk factors and implementing effective wildlife management and public health strategies.
22) Family:
'Family' refers to the taxonomic classification of viruses, specifically the Filoviridae family which includes the Ebola virus. Understanding the biological relationships within viral families aids in epidemiological tracking, studying evolutionary patterns and developing preventive measures against related pathogens.
23) Nausea:
'Nausea' is a common symptom experienced by individuals infected with Ebola. Its identification as a clinical feature plays a vital role in patient evaluation. Effective symptom management, including addressing nausea, is an integral aspect of improving patient care and comfort during treatment.
24) Reason:
The term 'Reason' emphasizes the need for understanding the underlying causes of Ebola outbreaks, including ecological, social, and health system factors. Investigating the reasons behind these outbreaks is essential for refining prevention strategies and enhancing the overall response to future epidemics.
25) Cutan:
'Sudan' refers to one of the species of the Ebola virus, significant because of its impact on human health. Emphasizing knowledge about the Sudan virus species contributes to comprehensive understandings for outbreak management strategies, healthcare responses, and targeted vaccine development.
26) Vasu:
'Vasu' is the surname of the corresponding author and signifies individual contributions to the study of Ebola. Acknowledging researchers like Vasu emphasizes the importance of collaborative efforts in advancing scientific knowledge and public health initiatives to combat serious infectious diseases.
27) Meat:
The term 'Meat' pertains to the consumption of animal products, which can serve as a transmission route for Ebola. Understanding the risks associated with handling and consuming infected or suspected animals is crucial for public health messaging and preventive strategies to control outbreaks.
28) Male:
'Male' identifies a demographic aspect of the Ebola virus outbreak, as the data indicate that males represent a significant proportion of infected individuals. Recognizing gender dynamics in disease patterns is vital for targeted interventions, education, and resource allocation during health emergencies.
29) Knowledge:
The term 'Knowledge' underscores the importance of information in managing and understanding Ebola virus disease. Knowledge enhances public health responses, guides clinical practice, supports research advancements, and empowers communities to engage in preventive practices mitigating the risks of viral diseases.
30) Training:
'Training' symbolizes the need for educating healthcare workers about Ebola and effective response strategies. Enhanced training directly contributes to improving outbreak management capabilities, ensuring that healthcare professionals are equipped with the necessary skills and knowledge to handle potential Ebola cases effectively.
31) Village:
The word 'Village' reflects the rural settings where Ebola often emerges, emphasizing the importance of community engagement and education in outbreak prevention. Targeting village-level interventions is essential to effectively mitigate the socio-economic impacts of the virus in affected regions.
32) Hygiene (Hygienic):
'Hygiene' denotes the practices that prevent infection transmission. Maintaining good hygiene is critical to controlling Ebola outbreaks, as inadequate hygiene practices can exacerbate the spread of the virus. Public health campaigns focusing on hygiene education promote safer interactions within communities.
33) Anxiety:
'Anxiety' captures the psychological distress experienced by individuals and communities facing Ebola outbreaks. Effective management of anxiety through supportive care and clear communication is vital during outbreaks, aiding in community resilience and compliance with health directives during crises.
34) Nature:
'Nature' suggests the intrinsic characteristics of the Ebola virus and its behavior within ecological contexts. Understanding the nature of the virus aids in developing targeted interventions, predicting outbreak dynamics, and fostering a multidisciplinary approach to addressing infectious diseases globally.
35) Nidhi:
'Nidhi' references one of the authors contributing to the study on Ebola. Acknowledging authorship highlights the collaborative nature of scientific research and emphasizes individual and institutional efforts in advancing public health knowledge regarding infectious diseases like Ebola.
36) Fight:
'Fight' symbolizes the ongoing battle against Ebola outbreaks led by researchers, healthcare professionals, and public health organizations. The collective fight against the virus highlights the need for commitment, innovation, and solidarity in developing effective strategies to combat viral diseases.
37) Study (Studying):
The term 'Study' reflects the systematic investigation into the Ebola virus, its epidemiology, pathogenesis, and treatment approaches. Thorough studies inform policies, enhance understanding, and catalyze the development of interventions necessary to prevent and manage outbreaks effectively.
38) Genu:
'Genu' appears as a modification of 'Gajendra,' one of the authors. This emphasizes the contributions of individuals in the field of research, showcasing the importance of collaborative efforts and the sharing of expertise to address global health challenges.
39) Ras (Rash):
'Rash' refers to skin manifestations that may occur during Ebola infection. Understanding rashes as clinical signs assists healthcare workers in recognizing the disease amidst its many similar presentations, supporting timely diagnosis and effective management strategies for affected patients.
40) Food:
'Food' relates to nutritional aspects, particularly in the context of potential exposure to Ebola through contaminated animal products. Awareness of food safety and preventive measures during outbreaks is crucial for minimizing risks while ensuring community food security in affected areas.
Other Science Concepts:
Discover the significance of concepts within the article: ‘A review on ebola virus’. Further sources in the context of Science might help you critically compare this page with similair documents:
Palliative care, Clinical feature, Preventive measure, Incubation period, Acquired immunity, Ebola hemorrhagic fever, Ebola virus disease, Immune Suppression, Zoonotic disease, RNA Interference, Multi organ failure, Antiviral therapy, Systemic inflammatory response, Natural host, Recombinant human activated protein C.