Phytochemical study and wound healing of Dalbergia sissoo extracts.
Journal name: World Journal of Pharmaceutical Research
Original article title: Phytochemical investigation and evaluation of wound healing potential of crude leave extracts of dalbergia sissoo (roxb.), in wistar rats
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Sangram K. Panda, Ram P. Padhy, Gayatri D. Rout Ray and Subhashree. Padhy
World Journal of Pharmaceutical Research:
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Full text available for: Phytochemical investigation and evaluation of wound healing potential of crude leave extracts of dalbergia sissoo (roxb.), in wistar rats
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The research article investigates the phytochemical composition and wound healing potential of crude leaf extracts of Dalbergia sissoo (Roxb.) in Wistar rats. Traditional medicine in tribal areas, including Odisha, India, often involves the use of various plant drugs for treating skin disorders such as wounds. Despite the prevalence of such practices, there are few reports detailing the wound healing activities of specific plants, which prompted the authors to explore Dalbergia sissoo. The study aims to fill this gap by evaluating the efficacy of different extracts obtained from the leaves of this plant.
Wound Healing Activity of Ethanol Extract
One of the significant findings of the study is the notable wound healing activity exhibited by the ethanolic extract of Dalbergia sissoo leaves. In the excision wound model, rats treated with this extract showed an impressive increase in wound contraction, achieving an 86.23% closure compared to a mere 61.26% in the control group. In addition, the period for eschar fall was significantly shorter, indicating rapid healing. This suggests that the ethanolic extract may play a crucial role in enhancing the natural healing process of wounds.
Role of Phytochemicals in Healing
The study also carried out a detailed phytochemical analysis of the leaf extracts, identifying the presence of various bioactive constituents such as alkaloids, flavonoids, terpenoids, saponins, phenols, steroids, and tannins. Each of these compounds has been associated with potential medicinal properties, including antimicrobial and anti-inflammatory effects. The presence of these phytochemicals may contribute to the observed wound healing efficacy of Dalbergia sissoo, indicating that a combination of these constituents could have synergistic effects, enhancing the plant's overall therapeutic benefits.
Incision Wound Model Outcomes
Beyond the excision model, the researchers also evaluated the effects of various extracts on incision wounds. In this model, the ethanol extract once again demonstrated a significant increase in tensile strength when compared to the control group, affirming its potent wound healing capabilities. The results showed clear superiority of the ethanol extract over other solvent extracts, such as those obtained from n-butanol, ethyl acetate, and petroleum ether, thus further validating its efficacy as a therapeutic agent in wound management.
Conclusion
In conclusion, the study provides compelling evidence of the wound healing properties of Dalbergia sissoo, especially from its ethanolic leaf extract. The results support its traditional use in folk medicine for wound care and suggest that the observed effects may be partially due to the rich array of phytochemicals identified in the extracts. However, the authors emphasize the necessity for further research to isolate and characterize specific compounds, as well as to conduct more extensive testing to fully understand the mechanisms behind the wound healing potential of this medicinal plant.
FAQ section (important questions/answers):
What was the main objective of the study on Dalbergia sissoo?
The study aimed to investigate the phytochemicals and wound healing potential of crude leave extracts of Dalbergia sissoo in albino rats using incision and excision wound models.
Which extract of Dalbergia sissoo showed the most significant wound healing?
The ethanolic extract exhibited the most significant wound healing properties compared to other extracts, showing increased wound contraction and breaking strength in both excision and incision models.
How were the crude extracts of Dalbergia sissoo prepared?
Crude extracts were prepared using successive Soxhlet extraction with solvents like ethanol, ethyl acetate, n-butanol, and petroleum ether from the powdered leaves of Dalbergia sissoo.
What types of phytochemicals were found in the extracts?
The phytochemical analysis revealed the presence of alkaloids, flavonoids, terpenoids, saponins, phenols, steroids, and tannins in the different solvent extracts.
What method was used to assess wound healing activity in rats?
Excision and incision wound models were used to evaluate wound healing activity, with specific observations on wound closure percentage and breaking strength across treated and control groups.
What conclusion was drawn regarding Dalbergia sissoo's wound healing effect?
The study concluded that both local and systemic administration of the ethanolic extract of Dalbergia sissoo leaves significantly promoted wound healing, supporting its traditional medicinal use.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Phytochemical study and wound healing of Dalbergia sissoo extracts.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Sissoo:
Sissoo refers to Dalbergia sissoo, a species of tree in the Fabaceae family, known for its medicinal properties. It has traditionally been used in folk medicine for wound healing and treating various ailments, especially among tribal communities in regions like Odisha, India. Its significance in the study lies in its potential therapeutic effects.
2) Animal:
In the context of this study, 'animal' refers to the Wistar strain of albino rats used for testing the wound healing potential of Dalbergia sissoo leaf extracts. The use of animal models is essential in pharmacological research to evaluate the efficacy and safety of herbal treatments before considering human applications.
3) Dalbergia sissoo:
Dalbergia sissoo is a tropical tree widely recognized for its economic and medicinal value. The study focuses on its leaf extracts to explore their wound healing properties. The tree’s traditional uses in folk medicine highlight its importance in ethnopharmacology and validate the need for scientific investigation of its extract's effects.
4) Incision:
In the research, 'incision' refers to a specific wound model where parallel cuts are made through the skin to assess the healing efficacy of the extracts. This method is essential for determining the tensile strength of the skin post-wound closure, contributing valuable data to the study of wound healing.
5) Jeypore:
Jeypore is a town in the Koraput district of Odisha, India, where the research was conducted. The area's rich biodiversity supports the collection of various medicinal plants, including Dalbergia sissoo. Jeypore's unique ecological features contribute to the study's focus on local ethnomedicinal practices.
6) Study (Studying):
The study aims to investigate the phytochemical composition and wound healing potential of Dalbergia sissoo leaf extracts. It provides a systematic approach to verifying traditional claims about the efficacy of the plant in wound care, contributing to the broader field of herbal medicine and pharmacognosy.
7) Panda (Pamda):
Panda refers to Sangram K. Panda, the lead author of the research. His contributions include setting up the study and overseeing the experimental procedures. Authors like Panda play a crucial role in guiding research and ensuring its alignment with scientific methodologies and ethical standards.
8) Phytochemical:
Phytochemicals are bioactive compounds derived from plants, which can have health benefits. The study involves the analysis of various phytochemicals in Dalbergia sissoo extracts to establish their potential therapeutic effects. Identifying these compounds aids in understanding their roles in promoting wound healing.
9) India:
India is highlighted as the geographic focus of the study, where Dalbergia sissoo is commonly used in traditional medicine. The rich diversity of flora in India provides ample opportunities for researching medicinal plants and their applications in healthcare, particularly in rural and tribal communities.
10) Activity:
Activity refers to the therapeutic effects demonstrated by Dalbergia sissoo extracts in promoting wound healing. The study assesses the extracts' biological activity by measuring parameters like wound contraction and healing time, showcasing the plant's potential as a natural remedy for skin injuries.
11) Medicine:
Medicine encompasses the traditional and modern practices used to treat diseases. The study aligns with the growing recognition of traditional medicine as a valuable and cost-effective approach to healthcare, especially in developing countries, by exploring the medicinal properties of Dalbergia sissoo.
12) Table:
Table refers to organized data presented within the study's context, summarizing findings related to phytochemical composition and wound healing effectiveness. Tables are crucial for facilitating the comparison of results, allowing for a clearer understanding of the experiments conducted and their outcomes.
13) Disease:
Disease refers to health disorders that the studied remedies, such as those derived from Dalbergia sissoo, aim to address. Traditional uses of the plant include treating various ailments; therefore, understanding its medicinal properties can lead to effective natural treatments for diverse health conditions.
14) Powder:
Powder refers to the processed leaves of Dalbergia sissoo, which were ground into a coarse form for extraction. The preparation of plant powders is significant in herbal medicine, as it facilitates the extraction of active compounds used in therapeutic applications, such as wound healing.
15) Water:
Water is a crucial solvent used in the extraction process carried out within the study. Its role in the extraction process emphasizes the importance of solvents in isolating phytochemicals from plant material, impacting the efficacy and availability of herbal remedies in medicine.
16) Post:
Post refers to the time after a specific action, such as wounding or treatment application. In this study, 'post' is used to describe the period following surgical procedures during which measurements were taken to assess healing progress, vital for evaluating the effectiveness of treatments.
17) Container:
Container refers to the airtight storage used for keeping crude extracts of Dalbergia sissoo. It is fundamental to preserve the integrity of the extracts and prevent degradation, ensuring reliable results in the assessment of their wound healing properties.
18) Flavonoid:
Flavonoids are a group of phytochemicals that have been identified in the leaf extracts of Dalbergia sissoo. Their presence suggests potential anti-inflammatory and antioxidant activities, contributing to the plant's wound healing properties, thus highlighting the importance of phytochemical screening in herbal research.
19) Species:
Species refers to the classification of organisms that share common characteristics; in this context, Dalbergia sissoo is the species being researched. Understanding the specific characteristics and properties of this species can illuminate the potential uses of its extracts in herbal medicine.
20) Natan:
Nathan refers to Dr. M. S. Swami Nathan, associated with the Biju Patnaik Medicinal Plants Garden and Research Centre, where the plant material was authenticated. His role in validating the plant ensures that the study is based on correctly identified species, emphasizing the importance of proper botanical identification in research.
21) Svamin (Swami, Svami, Swamin):
Swami refers to Dr. M. S. Swami Nathan, who contributes to identifying and validating the plant species used in the study. The expertise of botanical scholars is crucial in ensuring that the correct plant materials are utilized, thus enhancing the credibility and accuracy of research findings.
22) Drug:
Drug refers to a substance used for medical treatment. The study explores the potential of Dalbergia sissoo extracts as herbal drugs for wound healing, demonstrating the shift towards natural remedies in modern medicine and underscoring the relevance of traditional knowledge in healthcare.
23) Discussion:
Discussion is part of the research document where results are interpreted and examined in the context of existing knowledge. It explores the implications of findings regarding the wound healing properties of Dalbergia sissoo, particularly its phytochemicals, thus contributing to the scientific dialogue about herbal medicine.
24) Developing:
Developing refers to developing countries, where traditional medicine is often a primary source of healthcare. The study sheds light on the importance of plants like Dalbergia sissoo in providing accessible, cost-effective medicinal resources in regions with limited access to synthetic medications.
25) Suffering:
Suffering pertains to individuals afflicted by health conditions that could benefit from natural remedies. Recognizing the folk medicinal uses of Dalbergia sissoo showcases its potential to alleviate suffering in communities where access to modern healthcare may be limited.
26) Relative:
Relative in the biological context refers to organisms that are connected through common ancestry. In this study, understanding the relatives within the Fabaceae family can shed light on the shared properties of related species and their potential medicinal uses.
27) Gayatri:
Gayatri refers to one of the authors, Gayatri D. Rout Ray, contributing to the research. The involvement of multiple researchers fosters collaboration, ensures thorough investigations, and combines expertise across different areas of study relevant to herbal medicine and pharmacology.
28) Cuttack:
Cuttack is a city in Odisha, India, associated with the Dadhichi College of Pharmacy, where the ethical committee approved the animal research. The city plays a role in the academic and scientific environment, supporting research initiatives aimed at enhancing healthcare through traditional remedies.
29) Family:
Family refers to the taxonomic classification of organisms; in this context, Dalbergia sissoo belongs to the Fabaceae or legume family. Recognizing the family helps in understanding its biological characteristics and potential medicinal properties shared with other members of the family.
30) Nausea:
Nausea refers to a common ailment that potentially can be alleviated through traditional remedies like those derived from Dalbergia sissoo. The study acknowledges various traditional uses of the plant, expanding its relevance in treating gastrointestinal disturbances alongside its wound healing capabilities.
31) Vidya:
Vidya refers to the name of the college associated with the ethical committee conducting the animal studies. Educational institutions like Vidya Vihar College contribute significantly to the foundation and ethics of research, establishing standards for scientific investigations focused on health and medicine.
32) House:
House refers to the animal house where the Wistar rats were kept during the study. Maintaining a controlled environment is necessary for achieving reliable experimental results. The setting ensures that the research adheres to ethical treatment guidelines for laboratory animals.
33) Oriya:
Oriya refers to the local language and culture of Odisha, where traditional practices involving Dalbergia sissoo are common. Understanding regional significance adds a layer of cultural context to the medicinal uses of plants, emphasizing the integration of traditional knowledge in scientific research.
34) Blood:
Blood includes reference to health aspects that might be treated with Dalbergia sissoo extracts, as traditional use claims suggest benefits for blood diseases. Acknowledging such uses underscores the potential applications of the plant in broader health contexts, warranting further research.
35) Food:
Food refers to the standard pellets provided to the Wistar rats in the study. Nutrition is crucial for maintaining the health and well-being of experimental animals, influencing the outcomes of scientific studies aiming to evaluate medicinal effects.
36) Cage:
Cage pertains to the individual housing for rats during the study, which ensures that the animals are kept separately to prevent stress and allow for proper monitoring of their healing process. Proper animal care is essential in research to achieve accurate results.
37) Rich (Rch):
Rich describes the biodiversity present in the Koraput district, which supports various medicinal plants, including Dalbergia sissoo. The area's wealth of flora provides opportunities for research into traditional remedies, promoting the exploration of local plant species for their therapeutic potentials.
38) Line:
Line may refer to a lineage of scientific inquiry or evolution of knowledge regarding the medicinal uses of plants over time. Understanding this 'line' facilitates contextualizing current research within the continuum of ethnobotanical practices and traditional knowledge.
39) Shishu (Sisu, Sishu):
Sisu is an alternate name for Dalbergia sissoo, commonly used among locals. Understanding the local nomenclature offers insights into the cultural significance of the plant and its traditional applications in healing and medicine as known among indigenous communities.
40) Pur:
Poor refers to the limited access that many populations in developing regions have to modern healthcare or effective medications. Highlighting this context emphasizes the potential of traditional medicinal plants like Dalbergia sissoo in providing accessible healthcare solutions to improve health outcomes.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Phytochemical study and wound healing of Dalbergia sissoo extracts.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Medicinal plant, Traditional medicine, Statistical analysis, Control group, Aseptic condition, Clinical Practice, Phytochemical Investigation, Wound contraction, Ethanolic extract, Institutional Animal Ethical committee, Excision wound model, Solvent extraction, Wound healing potential, Tensile strength, Incision wound model, Crude leaf extract, Phytoconstituent.