Antioxidant activity of Curculigo orchioides: An overview.
Journal name: World Journal of Pharmaceutical Research
Original article title: Antioxidant activity of curculigo orchioides using different methods - an oerview
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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Shalima N.K., Biju C. R., Byju K., Arunlal V. B., G. Babu and Akhilesh K.
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World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Antioxidant activity of curculigo orchioides using different methods - an oerview
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20165-6233
Copyright (license): WJPR: All rights reserved
Summary of article contents:
Introduction
The production of free radicals is an intrinsic part of normal cellular metabolism, but excessive uncontrolled generation can lead to serious health issues such as cancer, atherosclerosis, and aging. Antioxidants play a pivotal role in mitigating the effects of these free radicals by inhibiting or delaying the oxidation of susceptible substrates. This paper investigates the antioxidant activity of the rhizomes of Curculigo orchioides, a plant from the Amaryllidaceae family, known for its medicinal properties.
Antioxidant Mechanisms of Curculigo orchioides
The study highlights the concept of antioxidant activity, particularly focusing on the methanolic extract of Curculigo orchioides (MEC). Through experimentation on carbon tetrachloride (CCl4)-intoxicated rats, the extract was shown to effectively combat oxidative stress indicated by the reduction of lipid peroxidation markers and restoration of antioxidant enzyme activities. Key parameters like thiobarbituric acid reactive substances (TBARS) and glutathione levels were measured, revealing that the MEC significantly mitigated liver damage over a period of 90 days at a dose of 70 mg/kg body weight.
In Vitro Antioxidant Assays
The study employed various in vitro assays to evaluate the antioxidant potential of Curculigo orchioides. The DPPH scavenging assay demonstrated the extract's ability to neutralize free radicals effectively, with a concentration-dependent response. Additionally, reducing power assays and hydrogen peroxide scavenging activity further confirmed the extract's potency relative to the standard reference compounds. The results consistently indicated significant antioxidant activity across all testing methods, showcasing the diverse mechanisms through which the extract operates.
Phenolic Compounds and Their Antioxidant Role
Phenolic compounds present in Curculigo orchioides have been identified as key contributors to its antioxidant capabilities. The analysis indicates that these compounds, particularly different flavonoid derivatives, exhibit robust free radical scavenging properties. The study emphasizes that lower EC50 values, which indicate higher antioxidant activity, correlate directly with the concentration of these active constituents. This aspect highlights the importance of these natural compounds in promoting health through their antioxidant functions.
Conclusion
In conclusion, Curculigo orchioides presents a promising source of natural antioxidants, demonstrating significant activity in both in vivo and in vitro studies. The findings underscore the rhizomes’ potential for use in medicinal applications, food, cosmetics, and pharmaceuticals, particularly in the prevention and treatment of conditions associated with oxidative stress. The plant can be considered a low-cost, potent herbal medicine, warranting further clinical trials to explore its benefits in human health and disease management.
FAQ section (important questions/answers):
What is the main focus of the study on Curculigo orchioides?
The study evaluates the antioxidant activity of Curculigo orchioides rhizomes using various methods to understand its potential medicinal benefits.
What are the known benefits of antioxidants in the body?
Antioxidants help delay or inhibit oxidation, protecting against diseases like cancer, atherosclerosis, cirrhosis, and mitigating aging effects.
What active compounds are found in Curculigo orchioides?
Curculigo orchioides contains flavones, glycosides, steroids, saponins, and triterpenoids, contributing to its medicinal properties.
How was the antioxidant activity of Curculigo orchioides measured?
Antioxidant activity was measured using methods like DPPH assay, reducing power, and hydrogen peroxide scavenging activity.
What results support the antioxidant activity of Curculigo orchioides?
The study showed significant scavenging activity against free radicals and improvements in liver biochemical parameters in treated models.
What potential applications does Curculigo orchioides have?
Curculigo orchioides may be used in food, cosmetics, and pharmaceuticals, especially for treating diseases associated with oxidative stress.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antioxidant activity of Curculigo orchioides: An overview.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In this context, 'activity' refers to the ability of a substance, such as extracts from plants, to produce a specific effect, particularly antioxidant activity. This effect is crucial because antioxidants play a role in neutralizing free radicals, which can cause oxidative stress and contribute to various diseases. Therefore, assessing the activity of such substances is essential for understanding their potential health benefits.
2) Shalima (Salima):
'Shalima' refers to one of the authors of the study, which investigates the antioxidant activity of Curculigo orchioides. This name indicates the contribution of the author to the research and highlights the collaboration among researchers in the field of pharmaceutical studies, particularly in evaluating natural substances for medicinal purposes.
3) Water:
'Water' is often a key solvent in scientific studies, including this one. It is essential for extracting active compounds from plants and conducting various assays. Additionally, hydration plays a critical role in many physiological processes in living organisms, emphasizing the importance of water in both extraction and biological activity.
4) Medicine:
'Medicine' delineates the field concerned with diagnosing, treating, and preventing diseases. The study's focus on Curculigo orchioides showcases its potential applications in herbal medicine, highlighting the importance of integrating traditional knowledge with modern scientific research to develop effective therapies using plant-derived substances.
5) Substance:
'Substance' refers to any material with a defined composition, often pertaining to chemicals or compounds studied in pharmaceutical and biochemical contexts. In the article, substances like methanolic extracts of Curculigo orchioides are examined for their antioxidant properties, underlining the relevance of specific substances in health and disease management.
6) Disease:
'Disease' signifies a pathological condition affecting the body, often caused by various factors, including genetic, environmental, and lifestyle influences. Understanding how substances like those derived from Curculigo orchioides can combat diseases associated with oxidative stress, such as cancer and atherosclerosis, frames the article's investigation within a health-centered context.
7) Study (Studying):
'Study' refers to the systematic investigation aimed at understanding specific phenomena, in this case, the antioxidant activity of Curculigo orchioides. This investigation enriches scientific literature by providing evidence that may support the therapeutic use of plant-based extracts, emphasizing the role of empirical research in validating traditional medicine.
8) India:
'India' signifies the geographical and cultural context of the study. It is home to diverse flora, including Curculigo orchioides, traditionally used in various medicinal systems. The country's rich biodiversity and traditional knowledge base boost interest in exploring its plant species for potential health benefits, such as antioxidant activities.
9) Kerala:
'Kerala', a state in India, serves as the specific location of the research institute involved in this study. It highlights regional biodiversity and traditional healing practices, showcasing how local plants contribute to medicinal purposes. Kerala's rich heritage in Ayurvedic medicine further emphasizes the relevance of studying its native flora.
10) Devaki:
'Devaki' is part of the institutional name associated with the research, specifically the Devaki Amma Memorial College of Pharmacy. This reference underscores the contributions of educational institutions and their researchers to the field of pharmaceutical science, promoting the study of various medicinal plants for health-related innovations.
11) Family:
'Family' in a botanical context refers to the classification grouping of plants. In this study, Curculigo orchioides belongs to the Amaryllidaceae family, categorizing it among related plants with similar characteristics. Understanding family classification aids in recognizing potential medicinal properties based on phylogenetic relationships.
12) Cancer:
'Cancer' is a critical pathological condition characterized by uncontrolled cell growth. The study's examination of Curculigo orchioides's antioxidant activity is particularly relevant, as antioxidants can help mitigate oxidative stress linked to cancer progression. This association highlights the search for natural remedies in cancer prevention and treatment.
13) Gold (Golden):
'Golden' is commonly used to describe Curculigo orchioides, also known as Golden eye grass. This descriptor not only refers to the common name but also may evoke the plant's historical significance and perceived value in traditional practices, underscoring the cultural importance attached to medicinal plants.
14) Amma:
'Amma' in the context of the institute's name signifies maternal respect and tradition within Indian culture. It denotes a connection to values of nurturing knowledge, especially in the realm of medicine and healing, reflecting the importance of familial support in education and healthcare.
15) Drug:
'Drug' encompasses any substance used for treatment, prevention, or diagnosis of diseases. The study's focus on the antioxidant properties of extracts from Curculigo orchioides establishes its potential as a natural drug, reinforcing the relevance of herbal remedies in the pharmaceutical field.
16) Antibiotic (Antibacterial):
'Antibacterial' pertains to the ability of a substance to inhibit the growth of bacteria. In the study, the references to the plant's multiple uses, which may include antibacterial properties, showcase the expanding research into multifunctional plant extracts for potential therapeutic applications.
17) Alleviation:
'Alleviation' refers to the reduction of severity or intensity of a condition or suffering. The study aims to showcase how antioxidants from Curculigo orchioides can contribute to alleviating oxidative stress-related diseases, thereby framing the research within a context of improving health and wellbeing.
18) Discussion:
'Discussion' segment in scientific writing analyzes the implications of the findings. In this context, it serves to relate the study results of antioxidant activity back to existing literature, proposing how these findings can influence future research and applications in medicine, nutrition, and health.
19) Agnivesha (Agnivesa, Agni-vesha):
'Agnivesha' references an ancient Indian physician and text, indicating the historical roots of plant-based medicine. By invoking this traditional knowledge, the study supports the validity of using indigenous plants for modern therapeutic investigations, aligning ancestral wisdom with contemporary scientific approaches.
20) Observing:
'Observing' reflects the practice of careful analysis and measurement in scientific studies. This term signifies the methodical approach taken in evaluating the antioxidant activities of Curculigo orchioides, illustrating the importance of diligence in research for reliable conclusions and applications.
21) Himalaya (Hima-alaya):
'Himalaya' denotes the geographical region contributing to the natural habitat of Curculigo orchioides. Highlighting the Himalayas emphasizes the ecological significance and diverse flora of the region, showcasing a rich source of plants with potential health benefits and an area of interest for pharmacognostic studies.
22) Sanskrit:
'Sanskrit' represents the ancient language of India associated with historical texts on medicine and healing practices. References to Sanskrit highlight the cultural heritage and classical knowledge underlying traditional Indian medicines, reinforcing the importance of scholarly work in bridging ancient and modern health practices.
23) Samhita:
'Samhita' refers to a compilation of ancient texts that are foundational in the practice of Ayurveda, detailing medicinal knowledge. Mentioning this term connects the modern study with timeless traditions of healing and signifies an awareness of established methods in the evaluation of herbal medicines.
24) Hindi (Himdi):
'Hindi' signifies the linguistic context within which traditional uses of plants are documented and shared among communities in India. Recognizing Hindi highlights the cultural relevance of regional languages in promoting and preserving indigenous knowledge, including remedies derived from local flora.
25) Field:
'Field' encompasses the area of study or practice. In this context, referencing the field of pharmaceutical science indicates the intermingling of traditional healing practices with contemporary research aimed at discovering new therapeutic agents from natural products, such as the extracts analyzed in the study.
26) Babu:
'Babu' is likely a reference to an author or contributor to the study, reinforcing the collaborative nature of scientific investigation. It underscores the importance of multiple researchers from various backgrounds working together to explore the properties of plant extracts and contribute to scientific knowledge.
27) Food:
'Food' signifies the fundamental source of nutrition but is also increasingly recognized for its potential health benefits. The study's linking of Curculigo orchioides as a source of antioxidants underscores the growing trend of exploring how traditional foods and herbal products can contribute to health and disease prevention.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antioxidant activity of Curculigo orchioides: An overview.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Herbal medicine, Clinical trial, Antioxidant activity, Oxidative stress, Indigenous system of medicine, Lipid peroxidation, DPPH assay, Reducing power, Methanolic extract, Active constituent, Alkaline phosphatase, Phosphomolybdenum assay, Hydrogen peroxide scavenging activity, Traditional medicinal system, Free Radical, Saponin, Alanine Aminotransferase, Aspartate Aminotransferase, Superoxide radical scavenging activity, Curculigo orchioides, Phenolic compound, EC50 values, Gamma glutamyltranspeptidase.