Antidepressant effects of methanol extract of Commelina benghalensis.
Journal name: World Journal of Pharmaceutical Research
Original article title: Antidepressant activity of methanol extract of commelina benghalensis linn. whole plant.
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Nishan Chakrabarty, Tanvir Ahmad Chowdhury, Mohammed Shoibe, Mohammad Shah Hafez Kabir, Md. Nazmul Hasan, Md. Hosne Mobarak Chowdhury, Md. Rakibul Hasan, Fahima Zaheed, Muhammad Abdulla Al Noman, Md. AbdullahAl Masum
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Antidepressant activity of methanol extract of commelina benghalensis linn. whole plant.
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20167-6629
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
Introduction
The study conducted by Chakrabarty et al. investigates the antidepressant activity of the methanol extract of Commelina benghalensis, a plant used in traditional medicine. Given the global prevalence of depression and its severe impact on human health, the researchers aimed to explore the potential therapeutic effects of this perennial herb native to tropical regions. This research is relevant because existing antidepressant therapies often have delayed onset and multiple side effects, highlighting the need for alternative treatments.
Antidepressant Activity of Commelina benghalensis
The antidepressant properties of the methanol extract of C. benghalensis were evaluated using two widely recognized animal models: the forced swimming test (FST) and the tail suspension test (TST). In these tests, the duration of immobility in mice reflects depressive behavior. Results indicated that both 200 mg/kg and 400 mg/kg doses of the extract significantly reduced the duration of immobility compared to the control group. These findings suggest that the extract possesses substantial antidepressant effects, evidenced by a notable decrease in the time spent immobile.
Phytochemical Composition of the Plant
The phytochemical composition of Commelina benghalensis is significant to understanding its medicinal properties. The plant contains various bioactive compounds, including alkaloids, flavonoids, and terpenoids, which are known for their diverse therapeutic effects. Previous studies have indicated that these compounds may contribute to the plant's antioxidant and anti-inflammatory properties, which could further support its role in alleviating depressive symptoms. The presence of phytochemicals strengthens the rationale for further investigation into their specific mechanisms within the context of depressive disorders.
Methodology of the Study
The experiment was performed on Swiss albino mice, maintained under controlled laboratory conditions. The C. benghalensis leaves were extracted with methanol and the efficacy measured through the FST and TST frameworks. Each group of mice received either a control treatment, a standard antidepressant (Imipramine), or varying doses of the plant extract. The immobility duration was accurately recorded under standardized conditions, ensuring reliable results that affirm the extract's potential as an antidepressant agent based on statistical analysis.
Conclusion
The research underscores the promising antidepressant activity of the methanol extract of Commelina benghalensis compared to conventional treatments. The significant reduction in immobility times in various tests points to its potential as an alternative treatment modality for depression. Given these findings, further investigations are warranted to isolate the active constituents and elucidate the specific mechanisms underlying their antidepressant effects, thereby contributing to the development of newer therapeutic agents for this pervasive mental health disorder.
FAQ section (important questions/answers):
What was the objective of the study on Commelina benghalensis?
The study aimed to investigate the antidepressant activity of the methanol extract of Commelina benghalensis using forced swimming and tail suspension tests in mice.
How were the methanol extract doses administered in the research?
The methanol extract doses of 200 mg/kg and 400 mg/kg body weight were administered orally to the mice for testing their antidepressant effects.
What tests were used to evaluate antidepressant activity in mice?
The antidepressant activity was evaluated using the Forced Swimming Test (FST) and the Tail Suspension Test (TST), measuring the duration of immobility in mice treated with the extract.
What were the findings of the study regarding immobility times?
The study found that both doses of the methanol extract significantly reduced immobility times in the FST and TST, indicating potential antidepressant effects compared to the control group.
What did the authors suggest for future research on Commelina benghalensis?
The authors suggested further investigation to isolate the active constituents responsible for the antidepressant activity and to understand the underlying mechanism of action.
What prior knowledge underpins the research on antidepressants?
The research is based on the understanding that antidepressants generally enhance the levels of neurotransmitters in the brain, addressing deficiencies linked to mood disorders like depression.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antidepressant effects of methanol extract of Commelina benghalensis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Animal:
In the context of this study, 'animal' refers to Swiss albino mice used as test subjects for assessing the antidepressant activity of the methanol extract of Commelina benghalensis. Mice are commonly chosen for behavioral studies due to their genetic similarity to humans and their well-characterized behavior in experimental models.
2) Activity:
'Activity' in this research denotes the measurable effects of the methanol extract on the behavior of the test animals, specifically its antidepressant effects as demonstrated through the forced swimming test and tail suspension test. Such activities provide insight into the efficacy of the extract against induced depressive states.
3) Chittagong:
'Chittagong' is the location in Bangladesh where the Commelina benghalensis plant was collected and where the study was conducted. This geographical context is important as it connects the research to local practices and the herbal usage of the plant, reinforcing its significance in traditional medicine.
4) Water:
In this study, 'water' refers to the medium used in the forced swimming test. The test requires rodents to swim in a specific height of water, where their movement is quantified to assess depressive-like behavior. Thus, water is crucial for simulating the conditions to evaluate antidepressant activity.
5) Drug:
'Drug' specifically relates to the methanol extract of Commelina benghalensis and its comparison with the standard antidepressant imipramine. This term also encompasses the broader category of substances with potential therapeutic effects emphasized in pharmacological studies, highlighting the extract’s role in addressing mood disorders.
6) Table:
'Table' indicates the structured presentation of data within the research, summarizing results related to immobility times during tests. It helps in visually comparing the effects of different treatments on the test subjects, making complex information accessible and facilitating data analysis for readers.
7) Study (Studying):
'Study' refers to the systematic investigation conducted to evaluate the antidepressant effects of Commelina benghalensis. It encompasses the methodology, results, and insights derived from the research, emphasizing rigorous scientific inquiry aimed at understanding the therapeutic potential of the plant extract.
8) Depression:
'Depression' is the central theme of this research, identified as a serious mood disorder affecting millions. The study investigates how the methanol extract can modulate depressive symptoms in mice, aiming to contribute to the larger discourse on alternative treatment options for mental health conditions.
9) Inflammation:
'Inflammation' relates to one of the many health benefits associated with Commelina benghalensis, indicating the plant's traditional use in treating various inflammatory conditions. Although not the primary focus of this study, it underscores the potential multifaceted therapeutic applications of the plant within herbal medicine.
10) Leprosy:
'Leprosy' mentions one of the traditional medicinal uses of Commelina benghalensis. This relevance showcases the plant’s historical context in folk medicine practices, linking its biological investigation to culturally significant uses, further encouraging evaluation for potential efficacy based on traditional knowledge.
11) Kabir:
'Kabir' identifies Mohammad Shah Hafez Kabir, a corresponding author of the study. His involvement signals academic contribution and emphasizes the collaborative effort in researching the antidepressant properties of the examined plant, highlighting the importance of diverse expertise in scientific studies.
12) Sah:
'Shah' as part of the name Mohammad Shah Hafez Kabir, suggests a cultural or regional identity, aligning with the authorship of the research. This brings a local perspective to the study, revealing the contribution of Bangladeshi researchers in global scientific discussions.
13) Mud:
'Mood' pertains to the emotional state that the study aims to address through evaluating antidepressant activity. The research investigates how the methanol extract of Commelina benghalensis influences behavioral indicators of mood, essential for understanding its potential psychological benefits.
14) Phytochemical:
'Phytochemical' refers to the bioactive compounds within Commelina benghalensis that may be responsible for its antidepressant effects. This term is foundational in pharmacognosy, linking plant chemistry to potential therapeutic applications and motivating further studies to isolate and identify effective constituents.
15) Reliability:
'Reliability' in the context of this study reflects the consistency and accuracy of the experimental methods used, particularly in validating the antidepressant tests performed. Establishing reliability is crucial for ensuring that the findings can be trusted and replicated in future research.
16) Discussion:
'Discussion' constitutes a significant section of the article, where the authors interpret their findings, contextualize them within existing literature, and propose implications for future research. This critical analysis allows for broader insights into the study’s relevance in the field of psychiatric treatment.
17) Snake-bite:
'Snake-bite' highlights another traditional use of Commelina benghalensis, indicating its folkloric medicinal importance. While secondary to the current study's objectives, it emphasizes the plant’s broader relevance in various health issues, promoting a deeper understanding of its pharmacological significance.
18) Psychosis:
'Psychosis' refers to a severe mental disorder that might be alleviated by the consumption of Commelina benghalensis, linking it back to its historical medicinal claims. This reference suggests potential multilayered therapeutic uses, encouraging further exploration into the plant's effects on mental health disorders.
19) Flavonoid:
'Flavonoid' signifies a class of compounds that may be present in Commelina benghalensis, associated with various health benefits, including antioxidant and anti-inflammatory effects. The investigation of flavonoids is important for understanding the plant's chemical profile and its potential contribution to therapeutic outcomes.
20) Medicine:
'Medicine' in this study reflects the broader context of health care where herbal remedies like Commelina benghalensis play a crucial role. The research delves into the pharmacological aspects of the plant, advocating for its potential use as a complementary treatment for mental health issues.
21) Epilepsy:
'Epilepsy' represents yet another ailment for which Commelina benghalensis is traditionally used, emphasizing the plant's diverse applications in treating health conditions. This underscores the necessity for scientific validation of such claims in modern medicine, providing a holistic view of the plant's utility.
22) Science (Scientific):
'Science' embodies the systematic study undertaken in this research to explore the antidepressant properties of the plant. It encapsulates the methodology, analysis, and the objective nature of the investigative process aimed at understanding and verifying traditional medicine claims.
23) Family:
'Family' relates to the botanical classification of Commelina benghalensis under the Commelinaceae family. This classification is essential in understanding the plant’s ecological relationships and characteristics, contributing to a broader understanding of the genus and its potential phytotherapeutic benefits.
24) Powder:
'Powder' pertains to the form in which the leaves of Commelina benghalensis were processed for extraction in the study. Proper preparation is crucial as it influences the efficiency of the extraction process and the subsequent efficacy of the resulting methanol extract.
25) Indian:
'Indian' reflects the geographical and cultural significance of Commelina benghalensis, emphasizing its traditional usage in Indian medicine. Understanding this context is pertinent in evaluating the plant's herbal applications and the historical practices informing modern scientific investigations.
26) Botany:
'Botany' is the scientific study of plants, a field directly connected to the research on Commelina benghalensis. Recognizing its botanical background fosters an appreciation of the plant’s classification and the significance of plant-based studies in pharmacology and ethnomedicine.
27) Glass:
'Glass' refers to the material used in constructing the experimental chambers for the forced swimming test. The choice of glass signifies a practical consideration for research conditions, providing a clean and visible medium to observe and measure the behavior of the test subjects.
28) Fever:
'Fever' is another condition historically treated with Commelina benghalensis, linking it to its anti-inflammatory properties. This reference connects traditional uses with modern pharmacological inquiry, reinforcing the plant's wide-ranging applications in natural medicine.
29) Genu:
'Genu' highlights the importance of the genus classification in botanical terms, referring to Commelina, which includes various species with shared characteristics. Understanding the genus is essential for studying and comparing the medicinal properties of different plants within the same family.
30) Food:
'Food' relates to the consumption of Commelina benghalensis, either as an edible vegetable or animal fodder in certain cultures. This aspect extends the understanding of the plant beyond medicinal usage, portraying its nutritional implications alongside its therapeutic potential.
31) Hind:
'Hind' signifies the location of the mice in the forced swimming test. ‘Hind’ refers to their hind limbs, which they cannot use to support themselves in water, facilitating the assessment of immobility—an essential behavioral measure indicating depression.
32) Cage:
'Cage' refers to the housing of the mice before testing. This term highlights the importance of proper animal welfare and environmental conditions, ensuring the animals are acclimatized to reduce stress factors that could affect the results of the behavioral tests.
33) Wall:
'Wall' refers to the physical boundary of the swimming chamber during the forced swimming test. Understanding the spatial dimensions is vital, as the design of the chamber influences the mice's behavior and the overall assessment of their immobility and stress responses.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antidepressant effects of methanol extract of Commelina benghalensis.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Medicinal properties, Research findings, Statistical analysis, Significant difference, Depression symptoms, World Health Organization, P Value, Antidepressant activity, Forced swimming test, Immobility time, Tail suspension test, Methanol extract, Controlled experiment, Neurotransmitter levels, Comparable results, Bioactive component, Antidepressant drug.