Standardization of pidangunaari kudineerchooranam siddha formula

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Journal name: World Journal of Pharmaceutical Research
Original article title: Standardization of pidangunaari kudineerchooranam- a classical siddha formulation
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

P. Elankani, R. Ganesan, M. Padmasornasubramaniyam, K. Vinayagamoorthy


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Standardization of pidangunaari kudineerchooranam- a classical siddha formulation

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr20169-6972

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

The standardization of herbal formulations is critical for assessing the quality of drugs, focusing on the concentration of active principles along with physical and chemical standards. This study focuses on the standardization of Pidangunaari KudineerChooranam (PKC), a classical Siddha formulation used to treat splenomegaly. Standardization processes include various physical and physicochemical assessments to ensure quality, which is essential for the greater acceptance of traditional medicinal products in modern healthcare systems. Regulatory bodies are working to establish standards for these formulations, particularly in India, where efforts are being made by the Ministry of AYUSH.

Importance of Standardization

Standardization serves as a fundamental process for ensuring the quality of herbal drugs, reducing variations between batches, and confirming the identity and consistency of formulations. Increasing global reliance on herbal medications highlights the need for quality assurance, emphasizing the necessity for standard operating procedures to base assessments on modern techniques. The study identifies physico-chemical and phytochemical standards for PKC, which can lead to the establishment of pharmacopeial standards, thereby enhancing the quality and safety of traditional medical practices.

Proximate Analysis and Heavy Metal Assessment

The study presents a comprehensive proximate analysis of PKC, encompassing various physico-chemical parameters such as moisture content, ash values, and pH levels. These parameters give insights into the drug's composition and stability. The analysis also included assessing heavy metals, critical for safety, as elevated levels can pose health hazards. The findings show that PKC adheres to accepted limits for heavy metals, indicating its safety, while the various ash values assist in establishing quality benchmarks for this herbal formulation.

HPTLC Fingerprinting for Quality Control

High-Performance Thin Layer Chromatography (HPTLC) was utilized to create a fingerprint profile of PKC, an essential tool for determining the product's identity and purity. HPTLC analysis revealed significant components of the formulation, helping to fix quality standards based on chemical profiles. The results indicated one major component with a specific Rf value, affirming the usefulness of this technique in quality control for herbal products, ensuring consistency in potency and effectiveness.

Conclusion

The study successfully establishes the physico-chemical and phytochemical standards for Pidangunaari KudineerChooranam, thereby contributing to the body of knowledge necessary for developing standardized herbal treatments. By ensuring that formulations meet quality requirements, these standards can alleviate variability and enhance the credibility of traditional medicine in public health systems. The findings align with the WHO's emphasis on integrating traditional medicine with modern practices, promoting the safe and effective use of herbal formulations globally.

FAQ section (important questions/answers):

What is Pidangunaari KudineerChooranam (PKC) used for?

PKC is a classical Siddha formulation used to treat splenomegaly, also known as pileegaviruthi. It is recognized in the Siddha Formulary of India.

Why is standardization of herbal formulations important?

Standardization is essential to assess the quality of herbal drugs based on their active principles and to ensure safety, efficacy, and compliance with regulatory standards.

What methods were used for standardizing PKC in the study?

The study employed physico-chemical analyses, HPTLC fingerprinting, and heavy metal analysis to standardize PKC and establish quality parameters as per WHO guidelines.

What are the key ingredients of Pidangunaari KudineerChooranam?

PKC consists of three main ingredients: fresh leaves of Premna tomentosa, dried rhizomes of Curcuma longa, and the outer rind of Terminalia chebula fruits.

How do the heavy metal levels in PKC compare to safety limits?

The levels of heavy metals in PKC, including lead, cadmium, and mercury, were found to be within the safe limits recommended by WHO.

What does HPTLC fingerprinting reveal about PKC?

HPTLC fingerprinting provides a visual profile of the components in PKC, helping to determine its identity, purity, and quality, with specific Rf values for various compounds.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Standardization of pidangunaari kudineerchooranam siddha formula”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
The term 'drug' refers to any substance used for medical treatment, especially those that can alter physiological functions. In the context of herbal formulations like Pidangunaari KudineerChooranam (PKC), the drug plays a crucial role in addressing health conditions such as splenomegaly, emphasizing the need for quality standardization to ensure efficacy and safety in use.

2) Siddha:
Siddha is a traditional system of medicine originating from Southern India, primarily Tamil Nadu. It encompasses various healing practices, including the use of herbal formulations like PKC. The Siddha system emphasizes holistic approaches, blending physical, mental, and spiritual health to foster overall well-being, thus holding significant cultural relevance in India.

3) Quality:
Quality in the context of herbal formulations refers to the consistency and safety of the product. It encompasses the assurance that products are free from contaminants and have the correct concentration of active ingredients. Quality controls are vital to meet pharmaceutical standards, ensuring that practitioners and patients receive effective and safe products.

4) Medicine:
Medicine encompasses various practices aimed at treating diseases and maintaining health. Traditional medicine, including Siddha, utilizes natural substances to promote wellness. It emphasizes holistic healing through natural remedies, which can include plants, minerals, and animal products, presenting an alternative approach to conventional medicine in therapeutic practices.

5) India:
India is home to diverse traditional medical systems, including Siddha, Ayurveda, and Unani. The nation is a significant player in the global herbal market, both as a supplier and consumer. This highlights the importance of standardizing herbal formulations, ensuring safety, efficacy, and quality within the realm of Indian traditional medicine.

6) Table:
In academic and scientific writing, tables serve as a structured means to present data concisely. They facilitate easy comparison of results, like those illustrating the physico-chemical parameters of PKC. Tables enhance clarity and communication, making complex information accessible and understandable to researchers, practitioners, and regulatory bodies.

7) Study (Studying):
This term pertains to systematic investigation aimed at increasing understanding and knowledge about a specific subject. The study in focus involves the standardization of PKC, emphasizing scientific methods to analyze its properties thoroughly. Such research is vital for validating traditional remedies and ensuring their compliance with modern pharmaceutical standards.

8) Chennai:
Chennai is a major city in Tamil Nadu, India, recognized for its contribution to traditional medicine, including Siddha. It is home to institutions like the Siddha Central Research Institute, where research and standardization of herbal formulations occur. The city's cultural and historical ties to Siddha practice underline its relevance in medicine.

9) Water:
Water is a crucial component in the formulation and standardization of herbal drugs. Its presence can influence the stability and efficacy of a drug. In the context of PKC, the analysis of water-soluble ash and moisture content helps ascertain the quality and safety of the herbal preparation.

10) Phytochemical:
Chemical compounds found in plants are referred to as phytochemicals, which are often responsible for the therapeutic effects of herbal drugs. The analysis of phytochemicals in formulations like PKC is essential for identifying active ingredients that contribute to medicinal properties and ensuring the efficacy of the traditional medication.

11) Curcuma longa:
Curcuma longa, commonly known as turmeric, is an important ingredient in many herbal formulations due to its medicinal properties, including anti-inflammatory and antioxidant effects. It plays a significant role in Siddha medicine and is evaluated for its contribution to the overall efficacy and safety profile of PKC.

12) Tiruvannamalai (Thiruvannamalai):
Thiruvannamalai is a town in Tamil Nadu known for its spiritual significance and traditional medicinal practices. It serves as a hub for Siddha medicine, offering resources such as trained practitioners and institutions. Its geographical and cultural context enriches the understanding of Siddha, facilitating research and application of herbal formulations.

13) Discussion:
Discussion sections in scientific literature serve to interpret results, contextualize findings within existing knowledge, and explore implications. In the context of PKC, the discussion addresses the significance of standardization, the relevance of quality controls, and the potential for improving the acceptance of Siddha medicines in modern healthcare systems.

14) Developing:
Developing refers to the process of improving or advancing something, often through research and innovation. In the context of herbal medicines in India, developing standard operating procedures for traditional formulations is a crucial step for ensuring their quality and safety, thereby fostering broader acceptance in contemporary medical practices.

15) Tamilnadu (Tamil-nadu):
Tamil Nadu is a state in southern India known for its rich cultural heritage and contributions to traditional medicine, particularly Siddha. The state's historical significance in herbal practices and extensive biodiversity supports the development and standardization of traditional medicines, fostering deeper integration into national healthcare systems.

16) Pesticide:
Pesticides are substances used to kill or control pests, including harmful insects and weeds, which can inadvertently contaminate herbal medicines. The relevance of monitoring pesticide residues in herbal formulations is paramount for ensuring safety and efficacy, as these residues pose health risks if present in medicinal products like PKC.

17) Purity:
Purity in herbal formulations signifies the absence of contaminants, including heavy metals and synthetic chemicals, which is essential for safety and efficacy. The standardization process for PKC and similar Siddha formulations emphasizes establishing purity parameters, ensuring that these traditional remedies can be safely used in modern medical contexts.

18) Police:
In the context of this article, the reference to 'police' could relate metaphorically to regulatory frameworks that oversee the quality and distribution of herbal medicines. It is crucial to ensure quality control measures are in place, akin to law enforcement, to protect public health and uphold standards in herbal product safety.

19) Ayus (Ayush):
Ayush stands for Ayurveda, Yoga & Naturopathy, Unani, Siddha, and Homoeopathy. This initiative by the Government of India aims to promote traditional medicine systems and ensure quality control and standardization. The AYUSH ministry plays a critical role in integrating traditional medicine into the national health system, enhancing public trust and safety.

20) Glass:
Glass is often used in laboratory settings for holding, mixing, or analyzing substances. In the context of herbal formulation studies like PKC, glass containers and apparatus ensure chemical interactions are observed without contamination from reactive materials. Its use emphasizes the importance of maintaining controlled environments during pharmacological studies.

21) Tamil:
Tamil refers to the language and culture of Tamil Nadu, where the Siddha system originated. The use of Tamil in documenting traditional medical practices ensures that knowledge is preserved and passed down through generations. Moreover, the cultural relevance of Siddha practices is deeply interwoven with Tamil identity.

22) Nadu:
Nadu is derived from the Tamil word for 'land' or 'country,' often used in administrative contexts in Tamil Nadu. Its inclusion in terms like Tamil Nadu signifies geographical and cultural identity and highlights the region's significance in the practice and promotion of traditional systems like Siddha medicine.

23) Pose:
In the context of herbal medicines, 'pose' often refers to the potential risk or challenge presented by contaminants, including heavy metals or pesticides. The presence of such contaminants poses health risks, making it crucial for researchers and practitioners to implement rigorous standardization and testing protocols for traditional formulations.

24) Salt (Salty):
Salt, in herbal medicine, often refers to the inorganic minerals found in plant materials. It plays a fundamental role in assessing the purity and composition of herbal drugs. The ash value and its components provide insight into the quality of formulations like PKC, ensuring they meet the necessary pharmaceutical standards.

25) Soil:
Soil is the medium where plants grow, containing various nutrients essential for their development. In herbal medicine, the quality of the soil affects the phytochemical constituents of plants. Understanding soil conditions helps ascertain the quality of herbal ingredients, influencing the efficacy of formulations like PKC.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Standardization of pidangunaari kudineerchooranam siddha formula’. Further sources in the context of Science might help you critically compare this page with similair documents:

Quality assessment, Loss on drying, Heavy metal analysis, World Health Organization, Herbal formulation, Moisture content, Physico-chemical properties, Acid insoluble ash, TLC pattern, Standardization procedure, Pharmacognostic studies, HPTLC Fingerprint Profile, Siddha Formulary of India, Siddha Medicinal Plants Garden, Phytochemical parameter, Standardization of herbal drug, Pharmacopeial standard.

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