Pharmacognostic and physicochemical study of durvadi ghrita.
Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacognostical and physicochemical analysis of durvadi ghrita – an ayurvedic polyherbal formulation
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Krishna Kumar V., Harisha C. R., Shukla V. J. and Manjusha R.
World Journal of Pharmaceutical Research:
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Full text available for: Pharmacognostical and physicochemical analysis of durvadi ghrita – an ayurvedic polyherbal formulation
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr20169-6965
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Diabetic retinopathy (DR) is a significant complication of diabetes mellitus and a leading cause of visual impairment among diabetics. The condition is characterized by retinal changes resulting from damage to the microcirculation, leading to hemorrhages and potential blindness. Traditional Ayurvedic medicine offers treatments such as Durvadi Ghrita, a polyherbal formulation, which is documented in Sahasrayoga for addressing bleeding disorders associated with DR. This study focuses on the pharmacognostical and physico-chemical analysis of Durvadi Ghrita to establish the quality and authenticity of its ingredients.
Pharmacognostical Identification of Ingredients
The pharmacognostical evaluation of Durvadi Ghrita included a detailed study of its components through organoleptic features, macroscopic properties, and powder microscopy. Various aspects such as color, taste, and odor were carefully noted for individual powdered ingredients like Durva, Utpala kinjalaka, and Manjistha, verifying their authenticity and quality. The microscopy revealed cellular characteristics, including the presence of specific fibers and crystals, providing insight into the raw materials employed in the formulation. This systematic identification is crucial for ensuring that the ingredients meet the required standards for efficacy and safety.
Physico-Chemical Analysis of Durvadi Ghrita
The study also included a thorough physicochemical analysis of Durvadi Ghrita, assessing parameters such as acid value, saponification value, refractive index, iodine value, and specific gravity. These parameters are essential for determining the quality and stability of the Ghrita formulation. Findings indicated that the acid value was 1.6850, and the saponification value was 232.16, which reflects the formulation's quality and its suitability for medicinal use. It was determined that the prepared Ghrita was not rancid even after seven months, affirming its quality.
Organoleptic and Quality Control Evaluation
The organoleptic assessment of Durvadi Ghrita classified it as a fine, thick, orange-yellow liquid with aromatically sweet and astringent properties. Such sensory evaluations are an integral part of quality control in herbal formulations. This study's organoleptic and physicochemical examination reinforces the significance of establishing standard quality control parameters for Ayurvedic formulations, particularly concerning the safety and efficacy of treatments for conditions like diabetic retinopathy.
Conclusion
The comprehensive study on Durvadi Ghrita confirms the authenticity and quality of its ingredients through both pharmacognostical identification and physicochemical analysis. The data obtained serve as a reference for future research and validate the use of Durvadi Ghrita as a potential therapeutic agent in managing bleeding disorders associated with diabetic retinopathy. This research underscores the need for systematic investigation of traditional herbal formulations to bridge the gap between ancient practices and modern scientific validation.
FAQ section (important questions/answers):
What is Durvadi Ghrita and its primary use?
Durvadi Ghrita is a polyherbal Ayurvedic formulation primarily used for treating bleeding disorders, specifically to manage blood loss in conditions like diabetic retinopathy.
What are the key ingredients in Durvadi Ghrita?
Key ingredients include Durva, Utpala kinjalaka, Manjistha, Elvaluka, Shita, Usheera, Musta, Chandana, Padmakam, along with goat's ghee, goat's milk, and tandulodaka.
What methods were used for the analysis of Durvadi Ghrita?
The study employed pharmacognostical and physicochemical analyses, including organoleptic evaluations, powder microscopy, and standardization of specific parameters like acid value and saponification value.
What does the physicochemical analysis of Durvadi Ghrita reveal?
The physicochemical analysis revealed specific gravity of 0.9416, acid value of 1.6850, and other metrics that indicate the quality and standardization of the formulation.
How was the authenticity of the ingredients ensured?
Authenticity was ensured through collective identification and authentication in the Pharmacognosy Laboratory, along with organoleptic and powder microscopic evaluations of each ingredient.
What conclusion was drawn from the pharmacognostical study?
The conclusion confirmed the presence of specified ingredients in Durvadi Ghrita, asserting that the formulation meets quality standards based on its physicochemical parameters.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Pharmacognostic and physicochemical study of durvadi ghrita.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Ghrita (Ghrta):
Ghrita is a clarified butter used in Ayurvedic medicine, known for its therapeutic properties. In the context of the study, it serves as a base for the formulation 'Durvadi ghrita', acting as a medium for the active ingredients. Its preparation and quality control are essential for the efficacy of the herbal mixture.
2) Durvadi:
Durvadi refers to a specific Ayurvedic formulation intended to address bleeding disorders, especially in relation to diabetic retinopathy. It is composed of various herbal ingredients, each selected for its unique therapeutic properties, indicating the formulation's holistic approach to treating complex health issues.
3) Powder:
In this context, 'powder' refers to the processed form of raw herbal ingredients used in the formulation. Powdering these ingredients enables easier mixing and dosage, enhancing their bioavailability and effectiveness in therapeutic applications, especially in traditional Ayurvedic practices.
4) Krishna (Krsna):
Krishna Kumar V. is the lead author involved in the research and analysis of 'Durvadi ghrita'. His role as a PhD scholar highlights the academic and scientific interest in validating traditional Ayurvedic formulations through pharmacognostical and physicochemical studies.
5) Drug:
The term 'drug' in this context pertains to the herbal components of 'Durvadi ghrita'. In Ayurvedic medicine, these drugs are defined based on their specific properties and therapeutic effects, catering to various ailments, especially those related to blood and vision.
6) Study (Studying):
The study focuses on the pharmacognostical and physicochemical analysis of 'Durvadi ghrita'. By examining its composition and properties, the research aims to provide scientific validation for the efficacy and authenticity of this traditional Ayurvedic formulation in treating medical conditions.
7) Pharmacognostical:
Pharmacognostical analysis involves the identification and evaluation of medicinal plants and their constituents. In this study, it is crucial for determining the quality and authenticity of each ingredient in 'Durvadi ghrita', reinforcing the importance of traditional knowledge combined with scientific methods.
8) Gujarat:
Gujarat is the location of the Gujarat Ayurved University, where the study took place. This region is known for its rich cultural traditions in Ayurvedic practices, providing a backdrop for research into the authenticity and efficacy of herbal formulations like 'Durvadi ghrita'.
9) Utpala:
Utpala, or Nymphaea caerulea, is one of the key ingredients in 'Durvadi ghrita'. This sacred lotus has various therapeutic properties, including anti-inflammatory effects, making it relevant for the formulation aimed at treating bleeding disorders and other health complications.
10) Durva:
Durva, or Cynodon dactylon, is an important herb in 'Durvadi ghrita', known for its healing properties. Its incorporation into the formulation aligns with Ayurvedic principles, emphasizing its role in balancing bodily doshas and addressing specific health issues.
11) Musta (Mushta):
Musta, or Cyperus rotundus, serves as another vital ingredient in the formulation. Known for its astringent and digestive properties, Musta contributes to the overall therapeutic profile of 'Durvadi ghrita', which targets bleeding disorders effectively.
12) Table:
Tables in the document present organized data regarding the ingredients, organoleptic characteristics, and physicochemical parameters of 'Durvadi ghrita'. They serve as a visual tool for readers to easily understand and compare the research findings and results.
13) Quality:
Quality is crucial in the context of 'Durvadi ghrita', referring to the standards of the raw materials and the final product. Ensuring high quality is essential for the therapeutic efficacy and safety of the Ayurvedic formulation, impacting its clinical uses.
14) Manjishtha (Manjistha, Mamjishtha):
Manjishtha, another name for Rubia cordifolia, is critical for its therapeutic role in blood purification. Its presence in 'Durvadi ghrita' reinforces the formulation's utility in treating blood-related disorders, showcasing the importance of ingredient selection in Ayurvedic medicine.
15) Sita (Shita):
Sita refers to sugar in the Ayurvedic context and is an important ingredient in 'Durvadi ghrita'. Its role not only enhances flavor but also contributes to the overall integrity and therapeutic effect of the formulation.
16) Tandulodaka (Tandula-udaka):
Tandulodaka, or rice water, serves as an ingredient in 'Durvadi ghrita' that enhances the preparation's consistency and digestibility. Its role reflects Ayurvedic approaches to balance elements, providing additional therapeutic value to the formulation.
17) Kalka:
Kalka refers to the paste made from crushed herbal ingredients used in the preparation of 'Durvadi ghrita'. This form maximizes the extraction of active compounds, ensuring that the therapeutic properties of each ingredient are effectively utilized in the final product.
18) Ghi (Ghee):
Ghee is the primary base in which 'Durvadi ghrita' is prepared. It is valued in Ayurveda not only for its medicinal benefits but also as a carrier to enhance the absorption of herbs, amplifying the overall therapeutic effects.
19) Milk:
Milk, specifically goat's milk in the context of 'Durvadi ghrita', is used as an important ingredient due to its nourishing properties. It serves to enhance the formulation and provide additional nutrients beneficial for health.
20) Cyperus rotundus:
Cyperus rotundus, known as Musta, is one of the primary herbal ingredients used in 'Durvadi ghrita'. Its properties assist in managing conditions related to bleeding and digestive issues, aligning with Ayurvedic treatment paradigms.
21) Cynodon dactylon:
Cynodon dactylon, or Durva, is included in 'Durvadi ghrita' for its reputed health benefits. This grass is often used in Ayurvedic practices for its ability to balance bodily functions, making it an essential component of the formulation.
22) Santalum album:
Santalum album, or Chandana, is a valuable ingredient known for its soothing and cooling properties. Its inclusion in 'Durvadi ghrita' enhances the formulation's effectiveness, particularly in conditions involving inflammation or bleeding.
23) Vetiveria zizanioides:
Vetiveria zizanioides, or Usheera, is an aromatic herb incorporated into 'Durvadi ghrita'. It is valued for its grounding and cooling effects, contributing to the holistic nature of the formulation aimed at balancing bodily conditions.
24) Nymphaea caerulea:
Nymphaea caerulea, or Utpala, adds to the therapeutic profile of 'Durvadi ghrita'. This sacred plant is traditionally used for its soothing and calming effects, particularly in eye-related ailments linked to diabetic complications.
25) Discussion:
The discussion section of the study contextualizes the findings and interprets the results of the pharmacognostical and physicochemical analyses. It reflects on the relevance of the research in validating traditional concepts through modern scientific methodologies, emphasizing conclusions drawn about 'Durvadi ghrita'.
26) Elvaluka:
Elvaluka, identified as Aloe vera in the formulation, represents herbs known for their healing properties. Its inclusion in 'Durvadi ghrita' contributes to skin and mucosal health, aligning with Ayurvedic principles of holistic treatment.
27) Bleeding:
Bleeding, the primary condition that 'Durvadi ghrita' aims to address, is an acute health issue, especially in diabetic patients. The formulation's ingredients are specifically chosen for their beneficial properties in controlling bleeding and promoting overall wellness.
28) Nymphaea:
Nymphaea refers to the genus encompassing plants like Utpala. The flowers of this genus are included in 'Durvadi ghrita' for their medicinal qualities that support ocular health and provide relief from inflammation, particularly useful in conditions like diabetic retinopathy.
29) Surface:
In the context of this study, 'surface' may refer to the physical characteristics of the powders and the microscopic observations of the ingredients. Understanding the surface characteristics helps ascertain the quality of the raw materials used in Ayurvedic formulations.
30) Rakta:
Rakta refers to blood in Ayurvedic terminology. The term 'Raktapitta', highlighted in the study, relates to pathologies associated with bleeding and blood disorders, which 'Durvadi ghrita' aims to alleviate by using its carefully chosen herbal components.
31) Kumar:
Kumar refers to Krishna Kumar V., the lead author of the study, whose research is crucial for documenting the pharmacognostical analysis of 'Durvadi ghrita'. His involvement showcases the academic effort to bridge traditional practices with scientific validation.
32) Rubia cordifolia:
Rubia cordifolia, or Manjistha, is acknowledged for its blood-purifying effects. In 'Durvadi ghrita', it plays an essential role in enhancing the formulation's effectiveness, particularly in addressing issues linked to blood and circulatory health.
33) Pharmacological:
Pharmacological aspects examine the effects of the ingredients in 'Durvadi ghrita' on bodily functions. This study bridges traditional Ayurvedic knowledge with modern science, exploring how the herbal constituents interact biochemically to promote healing.
34) Raktapitta (Rakta-pitta):
Raktapitta refers to a specific Ayurvedic condition characterized by bleeding disorders. 'Durvadi ghrita' directly addresses this condition, emphasizing its relevance for patients suffering from related ailments, particularly in the context of diabetic complications.
35) Collecting:
Collecting pertains to the meticulous gathering of raw materials for 'Durvadi ghrita', a crucial step in preparation. This process ensures the authenticity and quality of the ingredients, underlining the importance of sourcing in Ayurvedic medicine.
36) Science (Scientific):
Scientific analysis validates traditional Ayurvedic formulations through systematic study. This research employs rigorous methodologies to provide empirical evidence for the safety and efficacy of 'Durvadi ghrita', bridging the gap between traditional practices and modern medicine.
37) Urdhvanga:
Urdhvanga, referring to the upper part of the body, signifies the Ayurvedic approach to treatment targeting specific bodily regions. In the context of 'Durvadi ghrita', it connects to the therapeutic benefits for conditions affecting vision and blood.
38) Blindness:
Blindness is a severe outcome associated with diabetic retinopathy, a condition targeted by 'Durvadi ghrita'. The formulation aims to mitigate vision loss using a blend of herbs recognized in Ayurveda for their eye health benefits.
39) Manjusha (Manjusa, Mamjusa, Mamjusha):
Manjusha is another author noted in the study. Her contributions, alongside others, emphasize the collaborative nature of research that seeks to investigate and validate the effects of traditional herbal formulations like 'Durvadi ghrita'.
40) Toxicity:
Toxicity relates to the potential harmful effects of substances due to oxidation and rancidity in 'Durvadi ghrita'. The study emphasizes the importance of physicochemical parameters to ensure safety, reflecting a critical aspect of quality control in herbal medicines.
41) Medicine:
Medicine, in this context, refers to the holistic approach of Ayurvedic treatments embodied by 'Durvadi ghrita'. This formulation showcases how traditional wisdom integrates with scientific methodology to provide health solutions leveraging botanical ingredients.
42) Padmaka:
Padmaka, or Prunus puddum, is another ingredient in 'Durvadi ghrita'. Valued for its medicinal properties, it contributes to the formulation's overall effectiveness, particularly in aligning with Ayurvedic practices aimed at restoring health and balance.
43) Harisha (Harisa):
Harisha C. R. is a co-author of the study who collaborates in the research process. Her contributions in pharmacognosy highlight the multi-disciplinary teamwork involved in the analysis and validation of Ayurvedic formulations like 'Durvadi ghrita'.
44) Falling:
Falling may reference the slow viscosity of 'Durvadi ghrita', as described in sensory evaluations. Understanding the physical properties helps ascertain the formulation's character, crucial for both consumer acceptance and effective dosing.
45) Siddhi:
Siddhi relates to the successful achievement of specific therapeutic goals in Ayurveda. In the preparation of 'Durvadi ghrita', reaching 'Sneha Siddhi' indicates the formulation’s readiness and efficacy based on traditional Ayurvedic preparation techniques.
46) Shukla (Sukla):
Shukla V. J. is another author contributing to the study. His expertise in pharmaceutical chemistry enhances the understanding of 'Durvadi ghrita' regarding its chemical properties and quality assurance, indicating a comprehensive examination of the formulation.
47) Timira:
Timira refers to eye disorders in Ayurvedic terminology. The study links 'Durvadi ghrita' to conditions like diabetic retinopathy, emphasizing its relevance in treating vision-related ailments through herbal formulations.
48) Sneha:
Sneha implies the oleaginous nature of 'Durvadi ghrita', indicating the medicinal properties derived from its fat base. This concept is central to Ayurvedic preparations, which utilize fats to enhance the absorption and efficacy of herbal medicines.
49) Water:
Water is referenced concerning the immiscibility of 'Durvadi ghrita'. Its inability to blend signifies the distinct properties of the formulation, which are essential for its absorption and applicability in treating specific health conditions.
50) Sugar:
Sugar is mentioned as part of the formulation process for 'Durvadi ghrita'. Its inclusion aids in enhancing flavor and acts as a natural preservative, indicating the intricacies involved in crafting effective herbal remedies.
51) Vati:
Vati represents a dosage form in Ayurveda, typically tablets or pills. Though not directly related to 'Durvadi ghrita', understanding different forms of herbal preparations provides a broader perspective on how Ayurvedic medicines are delivered to patients.
52) Food:
Food in this context could refer to the nutritional aspect of 'Durvadi ghrita' as it contains various herbs that promote health. Understanding its role highlights Ayurveda's emphasis on diet in conjunction with herbal therapy for optimal health.
53) Wall:
Wall may refer metaphorically to the integrity of blood vessel walls, which are affected in conditions like diabetic retinopathy. 'Durvadi ghrita' aims to strengthen these walls, illustrating the interconnectedness of Ayurvedic treatments and anatomical health.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Pharmacognostic and physicochemical study of durvadi ghrita.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Sahasrayoga, Physico-chemical analysis, Herbal Ingredient, Diabetic Retinopathy, Pharmacognostical study, Pharmacognosy laboratory, Organoleptic features, Raw drug, Durvadi Ghrita, Microscopic Analysis, Quality control parameter.