Pharmacological activities of chenopodium album linn.- a review

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Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmacological activities of chenopodium album linn.- a review
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Shaneza Aman, Avijit Mazumder, Umesh Kumar Gupta and Amit Nayak


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Pharmacological activities of chenopodium album linn.- a review

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr201610-7127


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Summary of article contents:

Introduction

Chenopodium album, commonly known as Bathua, is a widely distributed herbaceous plant belonging to the family Chenopodiaceae. It is primarily found in regions of India, South Africa, Australia, and the Americas. This plant is rich in various phytochemicals such as saponins, flavonoids, glycosides, and tannins, which contribute to its diverse medicinal properties. Traditionally, Chenopodium album has been employed in several cultures for its health benefits, and modern pharmacological studies have confirmed its potential in treating various ailments, including cancer, liver diseases, and infections.

Anticancer Potential of Chenopodium album

Recent studies have highlighted the anticancer properties of Chenopodium album, particularly its methanolic and ethanolic extracts, which have shown effectiveness in inhibiting the growth of cancer cell lines. For instance, when tested on human breast cancer cell lines MDA-MB-468 and MCF-7, the methanol extract demonstrated significant cytotoxic effects, with an IC50 value indicating substantial inhibitory potency. The observed effects suggest the presence of bioactive compounds responsible for this antiproliferative activity, offering a promising avenue for future cancer treatments utilizing this plant.

Pharmacological Benefits and Traditional Uses

In addition to its anticancer properties, Chenopodium album possesses a range of pharmacological benefits, including antibacterial, anti-inflammatory, and hepatoprotective effects. The leaves have been traditionally used to treat ailments such as stomachache, wounds, arthritis, and gastrointestinal disorders. Scientifically, the plant's extracts have been shown to reduce ulcer formation, enhance liver protection against toxic substances, and exhibit antibacterial activity against various pathogenic bacteria. These findings corroborate the traditional uses of the plant in folk medicine, emphasizing its multifaceted therapeutic potential.

Nutritional and Chemical Composition

The nutritional profile of Chenopodium album further supports its medicinal use. Its seeds and leaves are rich in vital nutrients, including proteins, minerals, and glycosides. The presence of essential compounds such as β-sitosterol and various essential oils also contributes to the plant's therapeutic effects. Furthermore, the abundant antioxidant potential found in this plant has been studied using various assays, revealing significant activity that can be harnessed for health benefits. This highlights not only its utility as a medicinal plant but also as a functional food ingredient.

Conclusion

Chenopodium album stands out as an important medicinal plant with a broad spectrum of pharmacological activities that have been validated through various scientific studies. Its traditional applications, combined with its rich chemical profile, suggest that this plant holds significant promise in the prevention and treatment of diseases. Continued exploration of Chenopodium album may lead to the discovery of novel therapeutic agents and further enhance its importance in both traditional and modern medicine. The growing body of research underlines the need for integrating such beneficial plants into contemporary healthcare practices.

FAQ section (important questions/answers):

What is Chenopodium album commonly known as?

Chenopodium album is commonly known as Bathua in India. This herbaceous plant is widely recognized for both its vegetable uses and its medicinal properties.

What are the major pharmacological activities of Chenopodium album?

Chenopodium album exhibits various pharmacological activities, including antibacterial, anti-inflammatory, anticancer, antiulcer, hepatoprotective, antioxidant, and anthelmintic properties, making it important in traditional and modern medicine.

Where is Chenopodium album commonly found?

Chenopodium album is widely distributed and commonly found in India, South Africa, Australia, and the Americas, especially in nitrogen-rich soils and around agricultural lands.

What are the main chemical constituents of Chenopodium album?

The main chemical constituents of Chenopodium album include glycosides, alkaloids, saponins, fixed oils, tannins, and various other phytochemicals responsible for its medicinal properties.

How is Chenopodium album used in traditional medicine?

In traditional medicine, Chenopodium album is used for treating ailments such as stomach issues, arthritis, and infections. Its leaves are used as poultices, and the plant is regarded as a blood purifier.

What effects does Chenopodium album have on cancer?

Studies indicate that extracts from Chenopodium album, particularly from the leaves, show significant anticancer activity against various human cancer cell lines, suggesting its potential in cancer therapy.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Pharmacological activities of chenopodium album linn.- a review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the various biological effects that a substance, particularly a medicinal plant like Chenopodium album, can exert on biological systems. These activities can include antibacterial, anti-inflammatory, anticancer, and more. Understanding these activities is essential for validating the therapeutic potential and utilization of medicinal plants in healthcare and pharmaceutical industries.

2) Aman (A-man):
Aman is the surname of the lead author, Shaneza Aman, who contributed to the research and review of Chenopodium album's pharmacological properties. The author's contributions underline the importance of academic collaboration in advancing knowledge and providing insights into the medicinal benefits of various herbal plants for pharmaceutical research.

3) Pharmacological:
Pharmacological pertains to the study of drugs and their effects on biological systems. In the context of this document, it highlights the investigation of Chenopodium album and its various pharmacological activities, emphasizing the importance of understanding how the active compounds in plants can be used in therapeutic interventions for different diseases.

4) Medicine:
Medicine refers to the science or practice of diagnosing, treating, and preventing disease. In this article, it focuses on herbal medicine and traditional medicinal systems, showcasing the therapeutic roles of plants like Chenopodium album in treating ailments, which exemplifies the integration of cultural practices and modern medical science.

5) India:
India is highlighted in the review as a rich source of medicinal plants and traditional systems of medicine, such as Ayurveda and Siddha. The country’s diverse flora plays a crucial role in providing natural remedies that have been utilized for centuries, contributing significantly to global herbal medicine knowledge and practices.

6) Study (Studying):
Study signifies the systematic investigation into the properties and effects of Chenopodium album. This encompasses reviewing literature and conducting various pharmacological experiments to validate the plant's medicinal effects, helping establish scientific evidence that supports its traditional uses and potential for incorporation into modern medicine.

7) Antibiotic (Antibacterial):
Antibacterial refers to the properties of a substance that inhibit bacterial growth or destroy bacteria. The article discusses the antibacterial activity of Chenopodium album against various pathogenic bacteria, indicating its potential use in developing natural antimicrobial agents for treating infections, which is crucial in combating antibiotic resistance.

8) Aureus:
Aureus is derived from Staphylococcus aureus, a significant pathogenic bacterium discussed in the article. Its mention underscores the importance of evaluating natural extracts' effectiveness against common and dangerous bacteria, like S. aureus, informing potential therapeutic applications of plant extracts in addressing serious bacterial infections.

9) Cancer:
Cancer is a major health concern, characterized by uncontrolled cell growth. The document details the anticancer properties of Chenopodium album, emphasizing its potential as a natural therapeutic option for cancer treatment. The exploration of plant-based therapies has become increasingly relevant in cancer research for safe and effective treatments.

10) Species:
Species refers to a group of organisms that can interbreed. In the context of the article, it pertains to Chenopodium album as a particular weed species with notable medicinal properties. Understanding species classification is vital in pharmacological research to identify and differentiate beneficial plants for therapeutic potential.

11) Line:
Line in this context may refer to the cell lines used in various pharmacological evaluations, such as BHK-21 or MCF-7 used to assess the anticancer activity of Chenopodium album. Cell lines serve as model systems that enable researchers to study drug effects in a controlled environment, leading to meaningful insights.

12) Phytochemical:
Phytochemical refers to bioactive compounds found in plants that exhibit biological activity, which contribute to medicinal properties. The article highlights the presence of phytochemicals in Chenopodium album, emphasizing their significance in understanding the plant's therapeutic potential and guiding further research in herbal medicine.

13) Substance:
Substance denotes any material with a definite composition, including medicinal herbs like Chenopodium album. In pharmacology, the specific substances present in medicinal plants are critical in determining their efficacy and safety, guiding the appropriate use and formulation of herbal remedies in healthcare practices.

14) Family:
Family in botany denotes a classification rank that groups related plants. Chenopodium album is classified under the Chenopodiaceae family, which includes several plants known for their medicinal properties. Understanding family relationships aids in categorizing plants and recognizing shared traits useful in pharmacological studies.

15) Water:
Water is essential for life and plays a significant role in plant physiology. In the context of the review, water may refer to methods exploring the effects of aqueous extracts of Chenopodium album, highlighting how various extraction methods can influence the retrieval of active compounds for medicinal applications.

16) Ulcer:
Ulcer refers to a sore or lesion in the skin or mucous membrane resulting from inflammation, often discussed in the context of gastrointestinal maladies. The review indicates Chenopodium album's antiulcer activity, demonstrating its potential usefulness in treating conditions like peptic ulcers while emphasizing herbal medicine's role in addressing common ailments.

17) Rich (Rch):
Rich denotes abundant resources or elements, particularly in reference to India's diversity in medicinal plants. This richness emphasizes the country's potential in contributing natural remedies to modern medicine, where traditional knowledge and contemporary scientific research can blend to enhance the understanding and application of herbal therapies.

18) Bronchial asthma:
Bronchial asthma is a chronic condition characterized by inflammation and narrowing of airways, making breathing difficult. The review examines the immune response and therapeutic implications of Chenopodium album in alleviating asthma symptoms, showcasing the importance of continued exploration of herbal plants for treating respiratory conditions.

19) Swelling:
Swelling refers to an abnormal enlargement of a body part, often due to inflammation. The mention of swelling in the review indicates potential formulations of Chenopodium album that might address inflammatory conditions, underlining the significance of anti-inflammatory activities in herbal medicine for providing symptom relief.

20) Mineral:
Mineral refers to inorganic substances essential for various physiological functions in the body. The review highlights the presence of essential minerals in Chenopodium album, which may contribute to its nutritional profile and health benefits, reinforcing the plant's role in traditional diets and remedies as a source of nutrition.

21) Summer:
Summer refers to the seasonal growth conditions under which Chenopodium album thrives. Understanding seasonal growth patterns is crucial for cultivation and harvesting methods in medicinal plant studies, contributing to optimizing the yield of active constituents necessary for effective herbal medicinal applications.

22) Powder:
Powder involves the form in which herbal extracts may be processed, often for easier use in remedies. The review discusses the use of various forms of Chenopodium album, including powdered preparations for medicinal use, highlighting the importance of dosage forms in optimizing therapeutic benefits in patients.

23) Sugar:
Sugar indicates carbohydrates found in plants that can serve as energy sources. The article mentions the sugar content present in Chenopodium album seeds, critical for understanding its nutritional value and potential influence on metabolic processes; knowledge important in traditional diets and medicine.

24) Crop:
Crop refers to cultivated plants grown for food or other uses, like Chenopodium album as a vegetable. The discussion of agricultural practices highlights the role of traditional crops in providing nutrition and medicine, fostering local biodiversity and promoting sustainable agriculture through the use of traditional and herbal knowledge.

25) Salt (Salty):
Salt, particularly in the context of medicines, usually refers to mineral salts that contribute to various physiological processes. The presence of salts in Chenopodium album is indicative of the plant’s mineral richness, relevant in understanding its health benefits and role in herbal therapies in traditional practices.

26) Flavonoid:
Flavonoid represents a class of bioactive compounds with antioxidant and anti-inflammatory properties. The article touches on the significance of flavonoids present in Chenopodium album, highlighting their relevance in pharmacology for their potential health benefits and the relationship between plant compounds and therapeutic efficacy.

27) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine originating from India, emphasizing holistic healing through natural remedies, including herbal plants. The review connects Chenopodium album to Ayurvedic practices, showcasing the integration of ancient knowledge with contemporary science, reinforcing the importance of traditional medicine in modern healthcare.

28) Seedling:
Seedling represents the young plant stage crucial for cultivation practices of medicinal weeds like Chenopodium album. Understanding seedling growth and requirements is essential for optimizing cultivation for medicinal use, ensuring sustainable harvesting of plant parts rich in active medicinal compounds.

29) Sanskrit:
Sanskrit is an ancient language of India, historically used in traditional texts related to medicine and philosophy. Its mention signifies the cultural heritage surrounding herbal medicine, with many traditional names and descriptions for plants like Chenopodium album originating from Ayurvedic texts, emphasizing the importance of historical knowledge in modern practices.

30) Vastuka (Vashtuka):
Vastuka is the Sanskrit term for Chenopodium album, particularly in the context of traditional medicine. The inclusion of vernacular names reflects the cultural significance of the plant in Indian herbal medicine systems, showcasing how traditional knowledge is essential in recognizing and utilizing medicinal flora.

31) Marathi:
Marathi refers to the language spoken in the state of Maharashtra, India. The mention of Marathi vernacular names for Chenopodium album highlights the local importance of this plant in diverse cultural practices and its recognized medicinal value across different regions and languages in India.

32) Bengali:
Bengali pertains to the language of the Bengal region, which also recognizes Chenopodium album by local names. Including various regional languages underlines the widespread relevance of this plant in traditional medicine across India, promoting the plant's importance in local cultural practices and dietary use.

33) Habitat:
Habitat refers to the natural environment in which a plant grows. The article discusses the habitats of Chenopodium album, emphasizing its adaptability and prevalence in various ecological settings. Understanding the habitat is crucial for conservation efforts and sustainable harvesting practices for medicinal plants.

34) Disease:
Disease denotes any pathological condition affecting a living organism. The focus on disease in the article illustrates the potential role of Chenopodium album in treating various ailments, reinforcing the significance of medicinal plants in disease management, prevention, and holistic health.

35) Kashmir:
Kashmir is a region mentioned in the article as part of Chenopodium album's distribution. Its mention emphasizes the geographical diversity of medicinal plants and the ecological relevance of specific locations in promoting rich biodiversity, which is significant for traditional medicine practices.

36) Siddha:
Siddha is another traditional system of medicine originating from Southern India, akin to Ayurveda. The reference to Siddha highlights the cultural dimensions of herbal medicine in India and how different traditional practices converge, reinforcing the importance of integrating diverse medicinal knowledge in enhancing healthcare.

37) Madhya:
Madhya refers to Madhya Pradesh, a state in India. Its mention indicates the geographical distribution of Chenopodium album and emphasizes regional variations in traditional plant use. It underscores the importance of localized knowledge in utilizing herbal plants effectively within community health practices.

38) Gupta:
Gupta is a common surname in India, notably associated with Umesh Kumar Gupta, the contribution signifies the collaborative efforts in the research on Chenopodium album. Collaboration among researchers enhances the robustness of studies, leading to comprehensive evaluations of plant medicinal properties.

39) Kumar:
Kumar is a common Indian surname, associated with Umesh Kumar Gupta, indicating the collaborative nature of the research presented. Research collaborations often strengthen findings and insights regarding the utilization of medicinal plants in traditional and modern medical practices.

40) Nayak:
Nayak is another surname linked to one of the authors, Amit Nayak, illustrating contributions from diverse specialists in the field of medicinal plant research. Such collaborations enhance the depth of research on pharmacological activities of plants like Chenopodium album.

41) Edema (Oedema):
Edema refers to the excessive accumulation of fluid in bodily tissues, often indicating an underlying health condition. The review highlights anti-inflammatory properties of Chenopodium album, suggesting its therapeutic potential in treating conditions like edema, reinforcing the relevance of herbal remedies in managing such health issues.

42) Hindi (Himdi):
Hindi is one of the primary languages spoken in India, and its mention highlights the vernacular knowledge surrounding Chenopodium album. The use of local names emphasizes the cultural heritage of medicinal plants, portraying their importance in traditional health practices across linguistic communities.

43) Fever:
Fever is a common medical symptom indicating infection or illness. The mention in relation to Chenopodium album suggests its potential application in treating febrile conditions, showcasing the plant's role in traditional medicine for alleviating common yet significant health issues.

44) Tamil:
Tamil is a language spoken predominantly in the Indian state of Tamil Nadu. The reference to Tamil names for Chenopodium album illustrates the plant’s widespread recognition and use within diverse cultural contexts, promoting the understanding of regional adaptations in medicinal practices across India.

45) Blood:
Blood refers to the vital fluid in the body that transports nutrients and oxygen. The article discusses Chenopodium album’s use in traditional medicine concerning blood purification, showcasing the plant’s perceived benefits in addressing hematological conditions and its broader significance in herbal remedies.

46) Katu:
Katu is a term indicating bitterness in Sanskrit and is associated with traditional medicinal plants. Including regional terminologies like Katu highlights the cultural significance of plants such as Chenopodium album, emphasizing their multifaceted roles in herbal medicine within different traditional practices.

47) Genu:
Genu commonly refers to the knee joint in anatomical terms. The term may relate to traditional uses of Chenopodium album in treating joint-related ailments or suggesting the plant's relevance in addressing musculoskeletal conditions, exemplifying its role in traditional herbal remedies.

48) Food:
Food denotes any nutritious substance consumed for sustenance. In this review, the reference to Chenopodium album as both a medicinal herb and a food source underscores the plant's versatility in providing health benefits and nutrition, bridging the gap between diet and medicine in traditional practices.

49) Hind:
Hind may refer broadly to the Indian culture and traditional systems of medicine. The inclusion of the term highlights the link between cultural heritage and herbal practices, showcasing how traditional knowledge and community practices shape the understanding and utilization of medicinal plants.

50) Pain:
Pain is an unpleasant sensory experience signifying injury or illness. The article discusses the analgesic properties of Chenopodium album, indicating its potential therapeutic role in pain management therapies, showcasing herbal medicine's relevance in alleviating various types of physical discomfort.

51) Worm:
Worm refers to parasitic organisms that may infect humans or animals, causing various health issues. The mention of Chenopodium album's anthelmintic activity against worms emphasizes the historical and current importance of plant-based remedies in treating parasitic infections within traditional medicine frameworks.

52) Burning (Burn, Burned, Burnt):
Burn denotes damage to skin or tissue, usually from heat or chemicals. The article explores the traditional uses of Chenopodium album for treating burns, illustrating the importance of herbal remedies in managing wound care and offering holistic approaches to healing in traditional practices.

53) Drug:
Drug refers to any substance used in the diagnosis, treatment, or prevention of disease. The discussion around Chenopodium album highlights its potential as a natural drug source, emphasizing the role of traditional medicine in discovering new therapeutic agents alongside chemically synthesized medications.

54) Soil:
Soil represents the natural medium in which plants grow, affecting their growth and medicinal properties. The reference to soil conditions where Chenopodium album thrives underscores the ecological considerations in understanding plant cultivation and highlights the significance of sustainable practices in harvesting medicinal plants.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Pharmacological activities of chenopodium album linn.- a review’. Further sources in the context of Science might help you critically compare this page with similair documents:

Medicinal plant, Essential oil, Traditional medicine, Antibacterial activity, Anti-inflammatory activity, Antioxidant activity, Pharmacological activities, Traditional use, Hepatoprotective activity, Anthelmintic activity, Phytomedicine, Chemical constituent.

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