Punica grantum l and ziziphuas mauritiana mitigate anemia in cancer
Journal name: World Journal of Pharmaceutical Research
Original article title: Punica grantum l and ziziphuas mauritiana mitigate anemia in cancer
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Somayeh Afsah Vakili Ph.D and Dr. Meera Sumanth
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World Journal of Pharmaceutical Research:
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Full text available for: Punica grantum l and ziziphuas mauritiana mitigate anemia in cancer
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201610-7185
Copyright (license): WJPR: All rights reserved
Summary of article contents:
Introduction
Anemia is a prevalent issue among cancer patients, often resulting from malnutrition, chronic illness, or as a side effect of cancer therapies such as chemotherapy and radiotherapy. Literature indicates that anemia can affect between 30% and 90% of cancer patients, with especially high occurrences (55%-100%) among those undergoing chemotherapy. This condition not only reduces the quality of life but can also diminish survival duration in affected individuals. Given the limitations of conventional treatments in managing chemotherapy-induced anemia, this research aims to explore the potential benefits of Ayurvedic remedies, specifically the use of Punica grantum (pomegranate) and Ziziphus mauritiana (ber), in alleviating anemia in cancer patients.
The Role of Ayurvedic Remedies
Ayurveda is an ancient Indian medicinal system that utilizes herbs for various health issues, including anemia. According to the study, herbal medicines are believed to enhance immunity and increase hemoglobin levels and red blood cell production. Punica grantum is well-known in both Unani and Ayurvedic practices for its health benefits, including its role in treating anemia. Meanwhile, Ziziphus mauritiana is also recognized for its medicinal properties. This research investigates the specific effects of these plants on tumor-bearing mice modeled for anemia, providing insights into their potential as supportive treatments alongside conventional therapies.
Study Methodology and Extract Preparation
In the study, twelve groups of mice were established for experimentation, including normal controls, Ehrlich ascites carcinoma (EAC) control, and treatment groups receiving various extracts of Punica grantum and Ziziphus mauritiana. The plant extracts were prepared using a Soxhlet apparatus and included aqueous, ethanol, and chloroform extracts. Following treatment, the blood parameters, including red blood cell (RBC) counts and hemoglobin content, were measured. The percentage increase in life span (ILS) of the mice was also tracked to assess the effectiveness of the treatments.
Findings and Efficacy of Plant Extracts
The study found that the ethanol extract from the combination of Punica grantum and Ziziphus mauritiana had a significant positive effect on hemoglobin and RBC counts, along with a notable increase in life span among treated mice. Specifically, the combined extract demonstrated the highest percentage increase in life span compared to other treatment groups. The findings suggest a marked improvement in hematological parameters, making a compelling case for the use of these herbal extracts as a supportive treatment for anemia induced by cancer therapies.
Conclusion
The research concludes that the ethanol extracts of Punica grantum and Ziziphus mauritiana can effectively mitigate anemia in cancer models, suggesting their utility as supportive therapies alongside conventional cancer treatments. The positive outcomes in both hemoglobin levels and lifespan highlight the need for further exploration into herbal remedies in managing the side effects of chemotherapy. The study's findings contribute to the growing body of evidence supporting the integration of traditional medicine into modern healthcare practices for better patient outcomes in cancer care.
FAQ section (important questions/answers):
What is the main purpose of the research conducted?
The research aimed to investigate whether Ayurvedic therapies using Punica grantum and Ziziphus mauritiana could effectively alleviate anemia in cancer patients caused by chemotherapy.
How was the study conducted on the mice?
Mice were divided into 12 groups, with some receiving extracts of the plants and others not. Treatments were administered orally for nine days, and various hematological parameters were measured afterward.
What did the results indicate about the extracts used?
The ethanol extract combination of Ziziphus mauritiana and Punica grantum significantly improved red blood cell count and hemoglobin content, leading to a notable increase in survival rates in tumor-bearing mice.
What specific extracts were tested in the study?
The study tested aqueous, ethanol, and chloroform extracts of both Punica grantum and Ziziphus mauritiana, as well as a combination of the two plants.
Why is anemia a concern for cancer patients undergoing chemotherapy?
Anemia often results from myelosuppression due to chemotherapy, which decreases red blood cell production, thus adversely affecting the patient's quality of life and survival rates.
What is the conclusion drawn from this research?
The ethanol extracts of Punica grantum and Ziziphus mauritiana were successful in alleviating anemia in cancer-affected mice and showed potential for use as supportive therapy during chemotherapy.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Punica grantum l and ziziphuas mauritiana mitigate anemia in cancer”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth, often leading to the formation of tumors. It poses significant health risks and is a major focus of medical research. Patients undergoing treatment frequently experience side effects such as anemia, emphasizing the need for supportive therapies to mitigate these effects.
2) Ziziphus mauritiana:
Ziziphus mauritiana, commonly known as 'Ber' or 'Kola,' is a plant used in traditional medicine, particularly in Ayurvedic practices. This plant is noted for its properties that may help in the treatment of various ailments, including anemia. In the context of cancer treatment, its extracts show promise in supporting blood health.
3) Animal:
Animals, particularly those used in research studies like Swiss albino mice, play a crucial role in scientific experiments. They help researchers understand the effects of treatments on biological systems, especially in studies investigating the efficacy of herbal extracts for conditions such as cancer-related anemia, enhancing our understanding before human trials.
4) India:
India is a country with a rich tradition of herbal medicine, prominently featuring systems like Ayurveda. Research conducted in India explores the therapeutic potential of indigenous plants such as Punica grantum and Ziziphus mauritiana. The country's diverse flora is integral to studies aimed at establishing natural remedies for health issues.
5) Blood:
Blood is vital for transporting oxygen and nutrients throughout the body. In the context of anemia—often found in cancer patients—issues such as low red blood cell and hemoglobin counts can be serious. Understanding and improving blood parameters are crucial for enhancing patient outcomes and quality of life during treatment.
6) Karnataka:
Karnataka is a state in India known for its rich biodiversity, including various medicinal plants used in traditional and modern medicine. Research institutions in Karnataka explore the health benefits of native flora. This state is key for studies on the efficacy of plants like Punica grantum and Ziziphus mauritiana in treating ailments.
7) Life:
Life, particularly in medical research, often pertains to the quality and longevity of individuals affected by diseases like cancer. The aim of therapies, including those tested in this study, is not only to extend life but also to improve its quality by alleviating symptoms such as anemia caused by treatments.
8) Chemotherapy:
Chemotherapy is a common cancer treatment that utilizes drugs to inhibit tumor growth. However, it often leads to side effects such as anemia from bone marrow suppression. Understanding these side effects and finding complementary therapies, such as herbal extracts, can significantly improve patient outcomes by enhancing blood parameters.
9) Science (Scientific):
Science serves as the foundation for research and exploration of medical therapies. In this study, scientific methods are applied to assess the effects of herbal extracts on cancer-related anemia. Through carefully controlled experimentation, scientific inquiry aims to establish evidence-based remedies that can improve health outcomes.
10) Pharmacology:
Pharmacology is the branch of medicine that focuses on the study of drugs and their effects on biological systems. This research falls under pharmacology as it evaluates herbal extracts' potential to mitigate anemia in cancer patients, emphasizing how natural compounds can be utilized to enhance therapeutic effects.
11) Water:
Water plays a critical role as a solvent in various biological processes and is essential for life. In the context of herbal extraction, water serves as a medium to obtain active compounds from plants like Ziziphus mauritiana and Punica grantum, vital for assessing their medicinal properties in research.
12) Drug:
Drugs are substances that have a physiological effect on living organisms. In cancer treatment, drugs can alleviate symptoms or combat the disease. This study explores natural alternatives to conventional drugs, including herbal extracts, highlighting the importance of finding safer, effective options to manage side effects in patients.
13) Radiotherapy:
Radiotherapy is a therapeutic approach that uses high-energy radiation to kill cancer cells. While effective, like chemotherapy, it can result in adverse effects such as anemia due to bone marrow damage. Research into supportive therapies aims to help patients manage these effects and improve their overall well-being during treatment.
14) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing illnesses. Historical practices, such as Ayurveda, emphasize herbal and natural remedies. This study illustrates how traditional medicinal approaches can support modern cancer treatments, especially in managing complications like anemia in patients undergoing aggressive therapies.
15) Cage:
Cages are used in laboratory settings to house animals during experiments. They ensure that research subjects, like mice, are kept in a controlled environment, facilitating observation and treatment. The conditions within cages can affect the health and behavior of the animals, thus impacting study outcomes and research validity.
16) Malnutrition:
Malnutrition results from an inadequate intake of nutrients and can significantly affect immune response and overall health. In cancer patients, malnutrition may exacerbate conditions such as anemia. Addressing nutritional deficiencies is crucial in supportive care, underscoring the importance of integrating dietary interventions in treatment plans.
17) Discussion:
Discussion in research refers to the analysis and interpretation of results. It allows researchers to contextualize findings, evaluate their implications, and draw conclusions based on data. The discussion section also addresses limitations and suggests future research directions, contributing to the body of knowledge in medicinal therapies for cancer patients.
18) Depression:
Depression is a common psychological condition that can affect cancer patients, often exacerbating feelings of fatigue and malaise. The interplay between anemia and depression can significantly impact patient quality of life. Addressing emotional health is essential in comprehensive cancer care, promoting well-being alongside the management of physical symptoms.
19) Container:
Containers are used to hold and store various materials, including herbal extracts. For research, ensuring the integrity of these extracts is paramount; thus, containers must be airtight and adequately labeled. Proper storage conditions preserve the efficacy of active compounds for reliable testing of their medicinal properties.
20) Suffering:
Suffering encompasses the physical and emotional pain experienced by individuals, particularly in the context of chronic illness like cancer. Understanding patient suffering is essential in developing compassionate healthcare approaches. Research aims to mitigate such suffering, particularly through supportive therapies that address both physical and psychological challenges faced by patients.
21) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine that emphasizes holistic health through natural remedies, including herbs. It plays a significant role in traditional healing practices, especially in managing conditions like anemia in cancer patients. This research highlights the potential of Ayurvedic plants as adjuncts to modern treatments.
22) Hygiene (Hygienic):
Hygienic conditions are essential in laboratory settings to prevent contamination and ensure reliable results. Maintaining cleanliness in animal housing, including cages used for research, is crucial for the health of experimental subjects. Proper hygiene practices enhance the credibility of research findings and promote the welfare of laboratory animals.
23) Quality:
Quality refers to the standard of health and well-being experienced by individuals. In medical research, improving patient quality of life is a primary goal, particularly for those undergoing treatments like chemotherapy that have debilitating side effects. Interventions that alleviate discomfort contribute to an overall enhancement of patient quality of life.
24) Kerala:
Kerala is a state in India known for its rich biodiversity and traditional agricultural practices. It also features prominently in healthcare research, including studies on herbal remedies. The center from which EAC cells were obtained for this study underlines the collaboration between traditional medicine and contemporary research methodologies.
25) Powder:
Powder refers to the finely ground form of substances, such as herbal materials used for extraction. In this research, the powdered form of seeds from plants like Punica grantum and Ziziphus mauritiana is essential for preparing extracts that can be tested for their potential to alleviate anemia in cancer patients.
26) Indian:
Indian refers to the rich cultural and medicinal traditions originating from India. Indian systems, especially Ayurveda, place significant emphasis on using local flora to manage health conditions. This research reflects the importance of recognizing and validating indigenous medical practices and plants in contemporary health science.
27) Amala:
Amala (or Amalaki) is a term related to traditional medicine and is often associated with health benefits. Although not directly mentioned in this study, it represents the broader context of Ayurvedic healing practices. Understanding the diverse application of plants in Ayurveda underscores the cultural significance of herbal remedies.
28) Ulcer:
Ulcers are open sores or lesions that can occur in various parts of the body and often require treatment. Some herbal plants, including those studied here, have traditional uses in treating ulcers, demonstrating the broader therapeutic potential of natural remedies in addressing diverse health challenges beyond cancer.
29) Table:
Tables organize data systematically, allowing for clearer presentation and comparison of results in research. The table summarizing hematological parameters is crucial for illustrating the effects of treatments on red blood cell counts and hemoglobin levels. Well-structured tables enhance readability and facilitate the interpretation of experimental outcomes.
30) Study (Studying):
Study refers to the systematic investigation of a phenomenon, conducted to discover new insights or validate existing knowledge. This research focuses on the efficacy of herbal extracts in addressing anemia in cancer patients, contributing to the growing body of evidence that supports integrating traditional remedies into modern therapeutic practices.
31) Kola:
Kola is a regional name for the plant Ziziphus mauritiana, emphasizing its use in traditional medicine contexts. The recognition of local terminology highlights the cultural significance associated with the plant's medicinal properties. Understanding these connections enriches the research narrative of how indigenous plants are incorporated into health practices.
32) Anar:
Anar is the regional name for Punica grantum, commonly known as pomegranate. Like 'Kola,' the term reflects its importance within traditional healing practices. This connection underscores the plant's role in addressing health challenges, particularly anemia in patients undergoing cancer treatments, and emphasizes the relevance of local knowledge in research contexts.
33) Line:
Line often pertains to a sequence or a row of data in tables or figures in research publications. In this context, it could signify the categorization of treatments or results in the study, allowing for comparison and analysis of effects across different experimental groups, contributing to the understanding of outcomes.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Punica grantum l and ziziphuas mauritiana mitigate anemia in cancer’. Further sources in the context of Science might help you critically compare this page with similair documents:
Ziziphus mauritiana, Life-span, Hematological Parameters, Institutional animal ethics committee, Supportive therapy, Ayurvedic therapies, Standard drug, Ethanol extract, Chemotherapy side effects, Ehrlich ascites carcinoma, Red Blood Cell, Tumor bearing mice, Combined therapies, Material and method.