Cutaneous drug reactions to antibiotics in Khartoum patients
Journal name: World Journal of Pharmaceutical Research
Original article title: Clinical pattern of common cutaneous drug reactions due to systemic antibiotics in patients attended khartoum dermatology and venereal diseases teaching hospital – sudan
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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Mohammed Helmy Faris Shalayel, Ietimad Abdelsalam Mohamed Ayed and Yousif Mohammed Kordofani
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Clinical pattern of common cutaneous drug reactions due to systemic antibiotics in patients attended khartoum dermatology and venereal diseases teaching hospital – sudan
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201611-7195
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
This study, conducted between October 2015 and April 2016 at the Khartoum Dermatology and Venereal Diseases Teaching Hospital in Sudan, aimed to identify the clinical patterns of cutaneous drug reactions (CDRs) caused by systemic antibiotics. Among the 41 patients analyzed, a predominance of female participants was observed, and most patients had a history of prior drug reactions. The findings pointed towards ciprofloxacin as the primary antibiotic responsible for adverse reactions, while various types of rashes and severe cutaneous adverse reactions (SCARs) were noted among the participants.
Commonly Implicated Antibiotics
The study found that out of the antibiotics used, quinolones, specifically ciprofloxacin, had the highest association with drug reactions, accounting for 57.14% of cases. Following this, drugs containing sulfa such as artesunate and sulfamethoxazole-trimethoprim contributed to 25.71% of adverse effects, while other antibiotics like penicillins accounted for 17.14%. This highlights the importance of cautious antibiotic prescription practices, especially considering the prevalent misuse and the significant percentage of reactions attributed to specific antibiotics.
Types of Cutaneous Reactions
Different clinical manifestations of adverse drug reactions were observed, with maculopapular rash being the most common, seen in 39% of the cases. Other serious forms of skin reactions included Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN), each found in 17.07% of patients. The study emphasized that while many cutaneous reactions are mild, some can be life-threatening, thus necessitating vigilance in monitoring skin responses to antibiotic therapy.
Demographics and Previous Drug Reactions
A demographic analysis indicated that the majority of patients were female and in the age bracket of 41 to 50 years. Most patients reported a history of previous drug reactions, leading to the conclusion that certain populations might be more susceptible to adverse reactions based on their medical history and demographic factors. The study pointed to the need for thorough drug history assessments to identify at-risk individuals effectively.
Conclusion
In conclusion, the study underscores the serious impact of antibiotics on skin health, with a significant percentage of patients experiencing cutaneous drug reactions, particularly associated with quinolones. It highlights the necessity for optimized prescribing practices and patient education regarding the risks of antibiotic use. Future research, especially involving larger sample sizes and pharmacogenomic studies, is essential for enhancing the understanding of adverse drug reactions and improving patient safety in medical settings.
FAQ section (important questions/answers):
What was the objective of the study on cutaneous drug reactions?
The study aimed to identify various clinical types of cutaneous drug reactions caused by systemic antibiotics and determine the most commonly implicated drugs in patients attending Khartoum Dermatology and Venereal Diseases Teaching Hospital.
What was the demographic breakdown of participants in the study?
The study included 41 patients, comprising 28 females (68.3%) and 13 males (31.7%). The mean age was 38.44 years, with a range from 4 to 70 years.
Which antibiotic was most frequently associated with cutaneous reactions?
Ciprofloxacin was identified as the most common offending drug, accounting for 41.5% of adverse reactions in the study.
What types of drug reactions were observed in the patients?
The study observed various reactions, including maculopapular rash (39%), Stevens-Johnson Syndrome (SJS, 17.07%), Toxic Epidermal Necrolysis (TEN, 17.07%), and others.
How were data collected in this study?
Data were collected through a pre-coded questionnaire that included demographic information and drug reaction histories from each participant, ensuring confidentiality.
What is recommended for managing adverse drug reactions in the future?
The study recommends expanded research, including pharmacogenomics studies, to better understand the mechanisms of drug allergies and to develop screening processes for potential severe hypersensitivity reactions.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Cutaneous drug reactions to antibiotics in Khartoum patients”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
Drug refers to any substance that causes a change in physiological or psychological state when consumed. In the context of the study, drugs, especially systemic antibiotics, can cause adverse cutaneous drug reactions, necessitating careful administration and monitoring to ensure patient safety and avoid serious health complications.
2) Antibiotic (Antibacterial):
Antibiotics are a class of drugs used to treat bacterial infections. They are essential for managing infections but can also trigger adverse drug reactions, including cutaneous reactions like rashes. The study aims to identify which antibiotics most frequently cause these adverse reactions among patients in Sudan.
3) Study (Studying):
The study is a prospective descriptive research aimed at identifying the clinical types of cutaneous drug reactions due to systemic antibiotics. It provides valuable insights into the prevalence and characteristics of these reactions among patients, underscoring the importance of monitoring and managing drug-related side effects in clinical settings.
4) Ras (Rash):
Rash is an important clinical symptom associated with various skin conditions, particularly drug reactions. In this study, maculopapular rash is identified as the most common form of adverse reaction among patients receiving antibiotics, highlighting the need for awareness and timely intervention in dermatological practices.
5) Allergy:
Allergy refers to an abnormal immune response to an otherwise harmless substance, such as a drug. In the study, antibiotic allergy can lead to severe cutaneous adverse drug reactions. Understanding these allergies helps clinicians make informed decisions regarding medication prescriptions and manage patient safety effectively.
6) Table:
Tables are used in the study to present structured data clearly and concisely. They summarize important findings such as the age distribution of participants, types of drug reactions, and offending antibiotics, thereby aiding in the analysis and interpretation of data while providing viewers with a quick reference.
7) Male:
Male, in the context of this study, represents one of the genders of the patients involved in the research. The male-to-female ratio can provide insights into demographic variations in adverse drug reactions and inform discussions about gender-related differences in drug metabolism and immune response.
8) Teaching:
Teaching refers to the educational component of patient care and medical practice. In a teaching hospital setting, like Khartoum Dermatology and Venereal Diseases Teaching Hospital, the study emphasizes the role of medical education in managing cutaneous drug reactions and enhancing the quality of patient care and safety.
9) Disease:
Disease refers to a pathological condition affecting the body or mind. The study focuses on dermatological diseases caused by adverse reactions to antibiotics, emphasizing the importance of recognizing these conditions in clinical practice and ensuring proper management to improve patient outcomes.
10) Cutan:
Sudan refers to the geographical location of the study, which is significant as it provides contextual information about the patient population. Regional factors, such as prevalent diseases and available medications, may influence the types and frequency of cutaneous drug reactions seen in this specific demographic.
11) Beta:
Beta refers to a class of compounds, including beta-lactam antibiotics, which are frequently implicated in allergic reactions. Understanding how beta-lactam antibiotics can trigger adverse cutaneous reactions is crucial for developing guidelines around their use, as highlighted in the study findings regarding allergic responses.
12) Life:
Life signifies the health and well-being of individuals affected by adverse drug reactions. The study acknowledges the impact of drug reactions on patients' lives and emphasizes ensuring safe medication practices to enhance patients' quality of life through improved management protocols in healthcare.
13) Science (Scientific):
Science refers to the systematic study of the natural world, which includes medical sciences like pharmacology and dermatology. This study contributes to scientific knowledge by documenting cutaneous adverse drug reactions to antibiotics, thereby enhancing understanding and informing future clinical practices in medicine.
14) Pharmacology:
Pharmacology is the branch of science that studies drug action, interactions, and side effects. This study closely relates to pharmacology as it investigates the adverse cutaneous reactions caused by antibiotics, providing crucial insights that can assist healthcare professionals in prescribing safer medications.
15) Observation:
Observation is a key aspect of clinical research and involves monitoring patients for adverse drug reactions. The study relies heavily on careful observation to gather data on the frequency and types of cutaneous reactions, ultimately aiding in the identification of safe clinical practices.
16) Discussion:
Discussion refers to the analysis and interpretation of study results. This section allows researchers to contextualize their findings within existing literature, explore implications for clinical practice, and propose recommendations for future research and improvements in handling adverse drug reactions.
17) Developing:
Developing relates to the progression of medical knowledge and practices. In the context of the study, it underscores the importance of continuously improving understanding and management of adverse drug reactions, particularly in resource-limited settings like Sudan, where drug safety is critical.
18) Education:
Education is vital in promoting awareness about drug reactions among healthcare providers and patients. This study emphasizes the importance of educating medical staff and patients about adverse drug reactions, ensuring that all involved stakeholders are informed and can make better health decisions.
19) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing diseases. The study contributes to the field of medicine by analyzing the safety of antibiotic use and its related skin reactions, guiding healthcare professionals in making prudent prescribing decisions to optimize patient care.
20) Account:
Account refers to the reporting and documentation of adverse drug reactions experienced by patients. In this study, maintaining accurate accounts of drug reactions is essential for understanding their prevalence and characteristics, ultimately enhancing patient safety and healthcare outcomes.
21) Family:
Family can denote the grouping of related substances, such as a class of drugs. In the study, the term may also encompass the social aspect associated with patients who experience adverse reactions, emphasizing the broader implications on family health and support systems in managing drug-related issues.
22) Reason:
Reason indicates the cause or rationale behind drug reactions. In this study, identifying the reasons for specific cutaneous reactions to antibiotics is crucial for developing effective intervention strategies that minimize risks and improve the overall management of patient care in dermatology.
23) Animal:
Animal refers to the ethical considerations surrounding medical research, including studies involving subjects other than humans. While this study focuses on human patients, ethical guidelines related to animal studies may underline the importance of responsible conduct in research intending to advance medical knowledge.
24) Field:
Field indicates the specific area of study within medical research, such as dermatology or pharmacology. The study contributes to the field of dermatology by focusing on cutaneous adverse drug reactions, bridging the gap between clinical practice and theoretical knowledge, enhancing treatment approaches to improve patient outcomes.
25) Visit:
Visit refers to patients seeking medical attention, often due to adverse reactions they experience. In this study, patient visits to the Khartoum Dermatology and Venereal Diseases Teaching Hospital reflect the real-world relevance of documenting and understanding cutaneous drug reactions to antibiotics.
26) Blood:
Blood is essential for understanding systemic responses to drugs, including adverse reactions. In the context of this study, blood tests may play a role in diagnosing underlying conditions that predispose patients to drug reactions, helping to clarify causative factors in clinical presentations.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Cutaneous drug reactions to antibiotics in Khartoum patients’. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical analysis, Adverse drug reaction, Dermatological examination, Stevens–Johnson syndrome, Toxic epidermal necrolysis, Maculopapular rash, Prospective descriptive study, Systemic antibiotic.