Anti-urolithiatic unani drugs – a review
Journal name: World Journal of Pharmaceutical Research
Original article title: Anti-urolithiatic unani drugs – a review
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Mohammad Shamim Khan, Qamrul Hasan Lari and Mahmood Ahmad Khan
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Anti-urolithiatic unani drugs – a review
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201612-7409
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
Urolithiasis, commonly referred to as kidney stones, is a prevalent urologic disorder affecting approximately 15% of the global population and 2.3% in India. Historical accounts trace the existence of urinary stones back to 4000 BC, with references from significant figures in ancient medicine such as Hippocrates and Galen. Despite modern advancements in medical treatments for stone removal, the challenge of recurrent stone formation remains significant. The Unani system of medicine offers a holistic approach to treating urolithiasis using natural herboanimomineral compounds that exhibit litholytic, lithotriptic, diuretic, and nephroprotective properties.
The Unani Concept of Urolithiasis
According to Unani philosophy, urolithiasis arises from an imbalance involving the bodily humors, prominently addressed by notable scholars like Ibn-e-Sina and Zakaria Razi. They attribute stone formation to factors related to abnormal body humors, asserting that weakened renal function and the presence of viscous substances contribute to the retention of lithic matter in the kidneys. Within this framework, the health of the kidneys is paramount, with stone formation linked to both an overabundance of specific body fluids and adverse alterations in renal conditions. Treatments focus not only on expelling stones but also on rectifying the underlying humor imbalances within the body.
Unani Pharmacotherapy Mechanisms
Unani pharmacotherapy, or Ilaj Bid-Dawa, emphasizes treating nephrolithiasis by increasing the expulsion of morbid humors via enhanced urinary output. Unani remedies are built around the principles of litholysis and diuresis, facilitated by the use of herbs and herbo-mineral concoctions that promote kidney health. These treatments work by breaking down stones into smaller particles, augmenting urine volume, and mitigating inflammation. The complex mechanisms of action of these drugs uphold the synergistic roles of litholytic and diuretic effects, while also addressing the balance between crystallization inhibitors and promoters in the urinary system, essential for preventing future stone formation.
Herbal Remedies in Unani Medicine
Unani pharmacotherapy predominantly employs herbal and mineral-based treatments for managing urolithiasis. Various plants, such as Diospyros ebenum (Aabnoos) and Prunus cerasus (AaluBalu), along with mineral forms like Hajr-ul-Yahood and animal derivatives, are utilized for their effective litholytic and diuretic properties. The concerted action of these remedies targets not just the immediate expulsion of stones but also aims at enhancing overall renal health and preventing recurrence. Some key formulations include Majun Aqrab and Sharbat Alu Balu, noted for their efficacy in clinical results, where significant proportions of patients experiencing stone passage during the treatment duration.
Conclusion
The documentation of Unani drugs reveals a rich tradition of herbal remedies specifically formulated for combating urolithiasis. With minimal side effects and a focused strategy on both treatment and prevention, the Unani system provides a valuable alternative approach to managing kidney stones. The therapeutic efficacy of these natural treatments calls for broader recognition and encourages establishing trust in the Unani system as a viable method for addressing stone-related ailments. Continued research and validation of these traditional remedies could pave the way for their integration into contemporary medical practices, enhancing the overall treatment landscape for urolithiasis.
FAQ section (important questions/answers):
What is urolithiasis and how common is it?
Urolithiasis, also known as Hisat-e-Bauliyah, is a common urological disorder affecting about 15% of the global population and 2.3% in India, characterized by stone formation in the urinary system.
What are the main causes of urolithiasis?
The causes include high concentrations of substances like calcium and oxalate, dietary factors, genetic predisposition, vitamin deficiencies, and environmental factors like hot and dry climates.
What types of stones are associated with urolithiasis?
Approximately 80% of stones are calcium oxalate or calcium phosphate stones, while the rest include uric acid, struvite, and cystine stones.
How does Unani medicine approach the treatment of urolithiasis?
Unani medicine focuses on herbal and mineral treatments with properties like litholytic, lithotriptic, and diuretic, aimed at breaking down and expelling stones with minimal side effects.
What are some commonly used Unani drugs for urolithiasis?
Some common Unani drugs include Aabnoos, Baladar, and Habb-ul-Qilt, each targeting stone dissolution, inflammation reduction, and diuretic effects.
What scientific evidence supports the effectiveness of Unani treatments for urolithiasis?
Multiple studies have demonstrated the efficacy of Unani drugs in reducing stone size and promoting passage, highlighting their potential as effective treatment options.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Anti-urolithiatic unani drugs – a review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
In the context of Unani medicine, 'drug' refers to substances derived from natural sources—plants, minerals, or animals—used for therapeutic purposes. Researchers emphasize the importance of specific Unani drugs that exhibit anti-urolithiatic properties, aiding in the disintegration and elimination of urinary stones, while ensuring minimal side effects.
2) Science (Scientific):
The term 'scientific' implies systematic investigation and validation through rigorous research methodologies. In the study of Unani drugs, scientific evidence supports their efficacy in treating urolithiasis. Clinical trials and preclinical studies establish the pharmacological mechanisms underlying the therapeutic benefits of these traditional remedies, thus enhancing their credibility in contemporary medicine.
3) Table:
In this context, 'table' refers to tabulated data representing the various Unani drugs employed in the treatment of urolithiasis. Such tables categorize medicines based on their origin, actions, and pharmacological benefits, facilitating easy reference and understanding for practitioners and researchers interested in herbal therapeutics related to kidney stones.
4) Medicine:
'Medicine' encompasses the disciplines and practices involved in diagnosing, treating, and preventing illness. The Unani system of medicine offers a holistic approach to conditions like urolithiasis using herbal remedies, dietary changes, and lifestyle modifications, while promoting the delicate balance of bodily humors to maintain health.
5) Activity:
'Activity' refers to the biological effects or actions of the Unani drugs on the body, especially concerning their role in preventing and managing urolithiasis. Understanding the activities of these herbal compounds—such as litholytic, diuretic, and anti-inflammatory—provides insight into their therapeutic mechanisms and overall impact on urinary health.
6) India:
'India' is significant as it is the geographical context wherein Unani medicine, originating from ancient Greece and later developed in the Middle East, has flourished. The prevalence of urolithiasis in India necessitates effective treatments, thereby fostering research into traditional remedies that aim to address this common health issue.
7) Honey:
'Honey' is often included in Unani formulations for its medicinal properties. It serves as a natural sweetener and has been credited with various health benefits, particularly anti-inflammatory and antiseptic effects. In the context of urolithiasis treatment, honey may aid in dilution and improve the palatability of herbal medications.
8) Pharmacological:
The word 'pharmacological' pertains to the study of how drugs interact within biological systems. Unani drugs have distinct pharmacological properties that facilitate their role in treating urolithiasis, such as enhancing diuresis, dissolving stones, and alleviating related symptoms through various biochemical mechanisms, which are critical for effective therapy.
9) Cucumis melo:
Cucumis melo, commonly known as muskmelon or cantaloupe, is highlighted in Unani therapy for its diuretic properties. Its use in formulations aims to aid renal function, prevent stone formation, and provide hydration, which is essential for flushing out kidney stones and maintaining urinary tract health.
10) Tribulus terrestris:
Tribulus terrestris is a plant known for its efficacy in traditional medicine systems. In the context of urolithiasis, it is recognized for its litholytic properties, assisting in the breakdown of stones and facilitating their expulsion from the urinary tract while promoting kidney health through its diuretic effects.
11) Raphanus sativus:
Raphanus sativus, or radish, is another important herb in Unani medicine. It is valued for its anti-urolithiatic qualities, particularly in enhancing diuresis. Radish aids in increasing urine output and potentially altering urine composition to prevent the crystallization of stones—all crucial aspects in managing kidney health.
12) Substance:
'Substance' refers to any material used in pharmacotherapy. In Unani medicine, various substances (e.g., herbal, mineral) play pivotal roles in treatments for conditions like urolithiasis. Each substance’s unique properties contribute to its therapeutic actions, making it essential for effective treatment regimens.
13) Disease:
'Disease' denotes pathological conditions that impair normal bodily function. Urolithiasis is a prevalent disease affecting renal health. The Unani approach focuses on understanding the disease's underlying causes and developing treatments aimed at restoring balance and promoting the safe expulsion of urinary calculi.
14) Sugar:
In the context of dietary recommendations, 'sugar' relates to the potential influence of dietary sugars on stone formation. Unani medicine may recommend moderating sugar intake while highlighting natural sources of sweetness like honey, which can enhance palatability without fostering conditions conducive to stone formation.
15) Burning (Burn, Burned, Burnt):
'Burning' refers to a painful sensation commonly associated with urinary issues, including urolithiasis. Unani pharmacotherapy often incorporates soothing herbs and formulations aimed at alleviating burning sensations during urination, focusing on enhancing comfort while treating the underlying causes of stone formation.
16) Sang:
The term 'Sang' in this context refers to stones, particularly in relation to urolithiasis. In Unani pharmacotherapy, various herbal and mineral substances, including traditional 'sang' (stones) are utilized to manage and dissolve renal calculi, highlighting the holistic approach of the system to treat ailments.
17) Dolichos biflorus:
Dolichos biflorus, known as horse gram, is valued in Unani medicine for its effectiveness against urolithiasis. It possesses diuretic and litholytic properties, helping to break down and expel kidney stones while providing nutritional benefits that support overall renal function in traditional treatments.
18) Crocus sativus:
Crocus sativus, or saffron, is referred to in Unani for its medicinal attributes, including anti-inflammatory and diuretic effects. It can provide synergistic benefits when included in urolithiasis formulations, contributing to stone dissolution and comfort during treatment due to its holistic properties.
19) Pharmacotherapy:
'Pharmacotherapy' pertains to the use of drugs to treat diseases. In Unani medicine, pharmacotherapy encompasses various herbal, animal, and mineral substances tailored to address conditions like urolithiasis. The holistic attributes of these therapies support both symptom management and prevention of recurrences.
20) Animal:
The term 'animal' refers to certain animal-derived remedies in Unani practices, which are believed to have healing properties. These substances can be rich in minerals or other compounds that support overall renal health and aid in effectively addressing urolithiasis when included in traditional formulations.
21) Khali:
'Khali' is a term that might represent a concept or condition in Unani medicine, highlighting the importance of balance in bodily humors. An imbalance, where humors may be 'khali' (empty or lacking), could contribute to ailments like urolithiasis, prompting the need for restorative treatments.
22) Ulcer:
'Ulcer' pertains to pathological lesions that may occur in different body parts, including the kidneys. In Unani medicine, conditions like kidney ulcers are viewed as potential contributors to urolithiasis, thus requiring targeted treatment strategies that address both underlying and symptomatic aspects of the disease.
23) Wall:
The term 'wall' can metaphorically refer to anatomical structures within the urinary system, such as the bladder wall. Recognition of how stones affect these walls informs the understanding of pain and symptoms in urolithiasis, underscoring the importance of holistic treatment strategies in Unani pharmacotherapy.
24) Salt (Salty):
'Salt' in the context of urolithiasis refers to various forms of sodium compounds that could influence stone formation. Unani texts often detail how different salts affect body humor balance, thereby impacting kidney function, requiring careful dietary management for effective preventive strategies.
25) Rock salt:
'Rock salt' is a specific type of salt used in traditional remedies and dietary practices. Its relevance in Unani therapy addresses its unique properties and potential involvement in managing urinary health, as well as being discussed in the context of preventing kidney stones through moderation.
26) Rajasthan:
Rajasthan, a state in India, is significant as the region where educated practitioners apply Unani medicine. The climactic and dietary habits in Rajasthan could potentially influence the prevalence of urolithiasis, leading to a localized emphasis on developing effective herbal treatments and preventive strategies.
27) Scorpion:
In Unani pharmacotherapy, 'scorpion' refers to a specific animal-derived remedy. The burnt form of scorpion is noted for its purported litholytic and anti-inflammatory properties, making it a valuable component in formulations aimed at treating kidney stones effectively, showcasing traditional medicinal knowledge.
28) Mineral:
'Mineral' pertains to inorganic substances from the Earth utilized in herbal medicine. Unani practice includes minerals like 'Hajr-ul-Yahood,' recognized for their therapeutic benefits in treating urolithiasis, exemplifying how these substances integrate into holistic health strategies in traditional pharmacological uses.
29) Indian:
The term 'Indian' emphasizes the cultural significance and utilization of Unani medicine in the Indian context. This highlights the country's historical embrace of traditional healing systems, treating prevalent conditions like urolithiasis using herbal remedies that combine local knowledge with Unani principles.
30) Kota:
'Kota' is a city in Rajasthan, India, known for its Unani dispensaries and practitioners. The region's traditional medical practices involve the use of local herbal remedies, emphasizing the application of Unani medicine to manage prevalent conditions, including urolithiasis among its residents.
31) Fish:
'Fish' may reference unique medicinal properties derived from certain fish. In Unani context, specific fish-derived components could provide nutrients or health benefits that support kidney function and contribute to diuretic effects in treating and preventing the formation of stones.
32) Post:
In this context, 'post' may refer to evaluations of remedies that come after treatment or research findings. It indicates follow-up assessments to gauge the effectiveness of Unani treatments, particularly observing how specific herbs or minerals impact the management of conditions like urolithiasis.
33) Cina:
'Sina' refers to Ibn Sina (Avicenna), a historical figure in medicine whose work laid the foundations for various medical practices, including Unani medicine. His insights into the causes and treatments of diseases like urolithiasis continue to influence traditional medical systems, combining empirical observation with theoretical knowledge.
34) Glycyrrhiza glabra:
Glycyrrhiza glabra, known as licorice, is significant in Unani for its soothing and demulcent effects. Its incorporation into urolithiasis treatments exploits its potential to alleviate irritation in the urinary tract, aiding in symptom management and supporting overall renal health.
35) Saussurea lappa:
Saussurea lappa, or costus, is valued in Unani pharmacotherapy for its broad therapeutic properties. Recognized for its potential diuretic and anti-inflammatory effects, it is used in formulations targeting urolithiasis, contributing to effective management strategies against kidney stone formation through holistic approaches.
36) Mesua ferrea:
Mesua ferrea, also known as nutmeg flower, is a plant recognized for its medicinal properties in Unani practices. Its inclusion in treatments for urolithiasis is appreciated for its purported benefits in promoting kidney health, contributing to the overall efficacy of herbal formulations addressing stone issues.
37) Piper cubeba:
Piper cubeba, known as cubeb or tailed pepper, is recognized in Unani for its diverse medicinal uses. Its reported diuretic properties make it a valuable addition to urolithiasis treatments, facilitating urinary function and helping in the reduction and expulsion of renal stones.
38) New Delhi:
New Delhi, the capital city of India, serves as a hub for both modern and traditional medicine practices, including Unani. The presence of research institutions and healthcare providers promotes the integration of Unani pharmacotherapy into contemporary healthcare paradigms, particularly addressing prevalent health issues like urolithiasis.
39) Commiphora mukul:
Commiphora mukul is known for its uses in Unani medicine, particularly for its purported anti-inflammatory and litholytic properties. As a component in formulations for urolithiasis, it aids in reducing inflammation and promoting the disintegration of stones, thus illustrating the efficacy of herbal treatments.
40) Inflammation:
'Inflammation' describes the body's response to injury or disease, often leading to pain and swelling. In urolithiasis, the inflammatory process can exacerbate symptoms, necessitating treatments that include anti-inflammatory agents, crucial in Unani formulations to alleviate discomfort and promote healing.
41) Suffering:
The term 'suffering' reflects the physical pain and discomfort experienced by individuals with urolithiasis. Unani pharmacotherapy aims to address this suffering through a combination of herbal remedies that alleviate pain, promote kidney health, and facilitate the natural expulsion of urinary stones.
42) Vomiting:
'Vomiting' is a common symptom experienced by patients with urolithiasis due to pain and irritation. In Unani medicine, remedies often focus on addressing nausea and vomiting through holistic approaches, which may include dietary adjustments and herbal treatments that soothe the gastrointestinal tract.
43) Crushing:
'Crushing' refers to the process of breaking down kidney stones into smaller fragments to facilitate their passage. In Unani medicine, specific litholytic drugs are employed, showcasing how traditional methodologies integrate physical and herbal strategies to manage and treat urolithiasis effectively.
44) Lucknow:
Lucknow, a major city in India, is notable for its historical and cultural significance in medicine, including Unani practices. The city hosts educational institutions and practitioners dedicated to preserving and promoting Unani medicine, emphasizing the relevance of these practices in addressing common health issues.
45) Bhasma (Bhasman):
'Bhasma' refers to the calcined powders of minerals or metals used in Unani medicine. Used in specific formulations, bhasma is believed to enhance the therapeutic properties of various compounds, serving as an integral part of effective treatments for urolithiasis through potency and purity.
46) Castor:
The term 'castor' may refer to castor oil or the castor bean plant, both utilized in traditional medicine. In Unani systems, castor oil's properties could relate to its laxative effects and potential benefits in alleviating gastrointestinal discomfort, indirectly supporting overall health in urolithiasis management.
47) Family:
'Family' references the systematic classification of plants or substances used in medicinal practices. Understanding a plant's family can provide insights into its properties and uses; for instance, plants within the same family may share similar beneficial compounds utilized in Unani treatments for stone-related ailments.
48) Nausea:
'Nausea' is a common symptom associated with urolithiasis, often leading to vomiting. In Unani pharmacotherapy, addressing nausea is crucial for patient comfort. Herbal remedies with soothing properties are utilized to manage these symptoms, ensuring more effective compliance with treatment and improved patient well-being.
49) Powder:
In the context of Unani medicine, 'powder' refers to finely ground forms of herbs or minerals, commonly used in formulations. These powders enhance the bioavailability and effectiveness of the active components in treatments for various ailments, including urolithiasis, facilitating easier consumption and absorption.
50) Phlegm:
'Phlegm' refers to mucus secretion that can accumulate in the body, potentially leading to various health issues. In Unani theory, an excess of phlegm in the body can contribute to the formation of stones; thus, treatments often focus on balancing humor to prevent such conditions.
51) Delhi:
Delhi, as India's capital, serves as a focal point for traditional and modern medical practices, including Unani. The city fosters education, research, and healthcare initiatives that support the integration of Unani medicine into wider healthcare systems, especially in response to conditions like urolithiasis.
52) Varga:
'Varga' potentially refers to groups or categories within herbal medicine that denote the classification of plants or drugs based on specific properties. An understanding of these classifications aids practitioners in selecting appropriate herbs or formulations for the effective treatment of urolithiasis.
53) Glass:
The term 'glass' may be referenced in scientific studies concerning kidney stones, often used in the context of experimental models to study the interactions of various substances with stone formation. Understanding these interactions helps inform effective treatment strategies in both modern and traditional medicine.
54) Water:
'Water' is essential not only as a bodily fluid but also in treatment regimens for urolithiasis, emphasizing hydration's role in preventing stone formation. In Unani medicine, adequate water intake is encouraged as a fundamental measure to support kidney health and promote the flush of urinary stones.
55) Sora (Shora):
'Shora' refers to potassium nitrate, recognized for its use in Unani medicine, particularly in formulations targeting urolithiasis. Its pharmacological properties contribute to diuretic effects and assist in managing the formation and expulsion of kidney stones, showcasing traditional medicinal practices.
56) Earth:
'Earth' may symbolize the grounding aspects of traditional medicine, emphasizing natural remedies derived from the earth's resources. Unani medicines often leverage these natural elements, connecting them to holistic approaches that dignify the symbiotic relationship between the body and earth's offerings in health practices.
57) Blood:
'Blood' in Unani medicine reflects the importance of humoral balance in the body. Conditions like urolithiasis may arise from disturbances in physical humors, including those associated with blood. Treatments aim to restore balance, promoting effective healing and addressing the complexities of stone formation.
58) Study (Studying):
'Study' underlines the emphasis on empirical research in validating the effectiveness of Unani treatments. Scientific studies provide evidence-based insights into the pharmacological actions of traditional remedies for urolithiasis, enriching the understanding of how these therapies function and addressing contemporary health concerns.
59) Borax:
'Borax' may represent a mineral substance used in Unani remedies, appreciated for its therapeutic properties. Its inclusion in treatments for urolithiasis reflects the broader approach of combining mineral-based therapies with herbal ingredients to enhance effectiveness and address various renal challenges.
60) Hina:
'Hina' refers to henna, a plant utilized in various traditional practices, including Unani medicine. Known for its cooling properties, henna may be incorporated into treatments that aim to restore balance, alleviate symptoms related to heat in the body, and support overall urinary health.
61) Shada (Sada, Sadas):
'Sada' could refer to a type of formulation or specific aspect in Unani therapies, denoting simplicity or purity in preparation. This term reflects the philosophy of using straightforward, effective remedies for treating conditions like urolithiasis, ensuring patients receive holistic and uncomplicated care.
62) Tora:
'Tora' may refer to specific components or significant elements within herbal therapies, underlining the focus on combining various plants and ingredients to create comprehensive solutions for conditions like urolithiasis. This integration enhances therapeutic outcomes in traditional Unani practices.
63) Shan (San):
'Shan' could symbolize specific aspects used in formulations, signifying quality or type within Unani medicine. This term emphasizes the need for precise selection of ingredients based on their properties to form synergistic effects in treating ailments like kidney stones effectively.
64) Gond:
'Gond' typically refers to natural gum resins derived from various trees, utilized for their healing properties. In Unani therapy, gond plays a role in formulating remedies for urolithiasis, contributing viscosity or binding properties that assist in effective delivery of herbal therapeutics.
65) Diet:
Diet refers to the nutritional intake that individuals maintain. In the context of urolithiasis, dietary modifications are crucial. Unani medicine promotes balanced diets rich in specific nutrients while avoiding excessive intake of stone-forming substances, believing that proper nutrition supports kidney function and prevents stone formation.
66) Rich (Rch):
'Rich' pertains to the abundance of nutrients and properties in certain substances, which are beneficial. In Unani pharmacotherapy, 'rich' implies the valued components in natural remedies that enhance therapeutic efficacy, aiding in effective management of conditions such as urolithiasis and promoting overall health.
67) Pain:
Pain is a fundamental concern for patients suffering from urolithiasis. Managing pain is a critical component of treatment, and Unani approaches often utilize a combination of herbal remedies and dietary modifications to relieve discomfort, ensuring effective and holistic care for individuals experiencing renal calculi.
68) Worm:
'Worm' generally may refer to traditional remedies derived from certain species in Unani medicine. In various formulations, elements from earthworms are regarded for their therapeutic potential, illustrating the diversity of Unani practices that encompass both plant-based and animal-derived treatments for health concerns.
69) Kham (khams, Khaam):
'Kham' could refer to certain aspects within a systemic approach in treatments. This term symbolizes the simplicity or clarity of formulations, where the focus remains on utilizing straightforward and potent remedies in Unani practices for managing diverse health ailments and chronic conditions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Anti-urolithiatic unani drugs – a review’. Further sources in the context of Science might help you critically compare this page with similair documents:
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