Green coffee extract improves human health

a systematic review

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Green coffee extract improves human health
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a systematic review

Original source:

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Author:

Rajeev Ranjan, Kaushal Kishore, Pavan Kumar, Rajesh Ranjan, Nitesh Kumar


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Green coffee extract improves human health

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr201612-7415

Copyright (license): WJPR: All rights reserved


Download the PDF file of the original publication


Summary of article contents:

Introduction

Green Coffee Extract (GCE) is derived from unroasted green coffee beans and is acclaimed for its potential health benefits. Unlike roasted coffee, which loses many active compounds during the heating process, GCE preserves chlorogenic acid, a significant ingredient believed to confer various health advantages. Recent studies suggest that GCE can aid in weight loss, lower blood pressure, and reduce the risk of certain cancers and diabetes. However, the mechanisms through which chlorogenic acid operates are still being researched and not fully understood.

Weight Management and Metabolic Health

One key benefit of GCE is its role in weight management. The chlorogenic acids present in GCE may assist in reducing body weight among overweight and obese individuals by influencing glucose metabolism and promoting the release of fat for energy. Studies indicate that GCE can inhibit glucose-6-phosphatase in the liver, a critical enzyme involved in glucose production, leading to decreased blood sugar levels. This multifactorial effect not only helps in fat reduction but also improves insulin sensitivity, making it a favorable supplement for those struggling with metabolic syndrome and related disorders.

Antioxidant Properties and Cancer Prevention

Another significant aspect of GCE is its antioxidant capacity, primarily attributed to chlorogenic acid, which combats oxidative stress in the body. Oxidative stress is a critical factor in the development of numerous chronic diseases, including cancer. The antioxidants in GCE are believed to scavenge free radicals and reduce cellular damage, potentially lowering the risk of cancers such as liver, colon, breast, and skin cancers. Moreover, the molecular mechanisms by which chlorogenic acid exerts these chemopreventive effects are still under study, focusing on its ability to modulate various biochemical pathways related to carcinogenesis.

Cardiovascular Benefits

GCE is also recognized for its antihypertensive properties, contributing to heart health. The presence of chlorogenic acid may improve blood circulation and reduce high blood pressure by enhancing the bioavailability of nitric oxide, a compound that promotes vascular health. By decreasing homocysteine levels, a known risk factor for cardiovascular diseases, GCE further supports heart function. Regular supplementation could be particularly beneficial for individuals managing hypertension and those seeking to improve their overall cardiovascular health.

Conclusion

Overall, the comprehensive analysis of Green Coffee Extract illustrates its potential as a powerful functional food that aids in weight management, enhances metabolic health, provides significant antioxidant benefits, and supports cardiovascular function. With its active components like chlorogenic acid, GCE could play a pivotal role in reducing the risk of various lifestyle-related diseases. As research continues to unfold, the incorporation of GCE into health regimens may become increasingly common, particularly for individuals looking to improve their health through natural means.

FAQ section (important questions/answers):

What are the health benefits of Green Coffee Extract (GCE)?

Green Coffee Extract is associated with weight loss, improved glucose metabolism, reduced risk of Type 2 diabetes, and antioxidant properties that may help prevent various cancers and cardiovascular diseases.

How does chlorogenic acid in GCE help with weight loss?

Chlorogenic acid may reduce body weight by inhibiting carbohydrate absorption and promoting fat metabolism in the liver. It also helps regulate glucose levels and enhances satiety.

What are the components found in Green Coffee Extract?

GCE primarily contains chlorogenic acid, caffeine, trigonelline, various vitamins, minerals, and dietary fiber. These compounds can provide health benefits such as antioxidant activity and improved metabolic functions.

Are there any risks associated with Green Coffee Extract consumption?

While generally safe, some individuals might experience allergies or side effects due to caffeine. Moderation is essential to avoid potential issues such as anxiety or digestive upset.

Can Green Coffee Extract help reduce blood pressure?

Yes, GCE may lower blood pressure due to its content of chlorogenic acid, which enhances vasoreactivity and inhibits inflammation in blood vessels, potentially promoting overall cardiovascular health.

Is there scientific evidence supporting the effectiveness of GCE?

Numerous studies indicate that GCE can positively impact health by reducing weight, improving insulin sensitivity, protecting against oxidative stress, and lowering risks for diseases like diabetes and certain cancers.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Green coffee extract improves human health”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Disease:
Disease refers to a pathological condition of a biological system that leads to impaired bodily function. In the context of this research, it encompasses disorders like hypertension, obesity, and diabetes, highlighting the need for lifestyle interventions and potential dietary supplements like Green Coffee Extract for prevention and management.

2) Cancer:
Cancer is a group of diseases characterized by uncontrolled cell division and growth. The text discusses how Chlorogenic Acid from Green Coffee Extract may lower the risk of various cancers, including liver, colon, breast, skin, and rectal cancers, although the complexities of its molecular mechanisms require further investigation.

3) Blood:
Blood is a vital fluid carrying oxygen and nutrients throughout the body. The relevance of blood in the text pertains to its role in various health conditions, including the impact of Green Coffee Extract on blood pressure, serum triglycerides, and overall cardiovascular health through its components like Chlorogenic Acid and caffeine.

4) Mineral:
Minerals are inorganic substances essential for various bodily functions. In the context of Green Coffee Extract, minerals contribute to the overall nutritional profile of coffee and may influence health outcomes, as trace elements can vary based on soil composition, affecting both the plant's growth and the bioactive compounds present.

5) Activity:
Activity encompasses the actions or processes occurring in a biological system. In this research, it relates to the antioxidant, antihypertensive, and anti-inflammatory activities of Green Coffee Extract, underscoring how these physiological activities contribute to the therapeutic benefits associated with its consumption.

6) Species:
Species refers to distinct groupings of organisms sharing common characteristics. The text discusses two significant coffee species, Coffea arabica and Coffea canephora, noting their contributions to global coffee production and differences in chemical composition, affecting the efficacy and health benefits derived from each species.

7) Food:
Food provides essential nutrients to sustain life and health. Green Coffee Extract is categorized as a health-promoting food product or supplement, with potential benefits in weight management, blood pressure regulation, and reducing diabetes risk, signifying the importance of dietary sources in disease prevention.

8) Account:
Account can refer to a description or narrative. In this review, accounts of various studies and clinical research are discussed, which illustrate the health benefits of Green Coffee Extract, enhancing our understanding of its biochemical properties and role in disease management.

9) India:
India is a country with a rich history and culture of coffee consumption. The researchers mentioned in the text are affiliated with various Indian academic institutions, indicating that part of the research and its implications may be particularly relevant for the Indian population and its health challenges.

10) Animal:
Animals, particularly in research contexts, are often subjects of studies to understand biological mechanisms and effects. In this review, animal studies demonstrate the benefits of Green Coffee Extract, such as its antihypertensive properties and impact on obesity, assisting in understanding human health implications.

11) Toxicology:
Toxicology is the study of the adverse effects of chemical substances on living organisms. In the context of Green Coffee Extract, understanding potential toxicities is crucial since certain components may cause allergic reactions, indicating the need for careful assessment of its safety in food and supplements.

12) Pharmacology:
Pharmacology is the science of drugs and their effects on biological systems. The review provides insights into the pharmacological actions of compounds in Green Coffee Extract, including their potential therapeutic benefits, emphasizing the role of natural substances in disease treatment and health management.

13) Family:
In biological classification, 'family' groups related plant species. The mention of the Rubiaceae family introduces the coffee plant, linking its botanical characteristics to the health benefits explored in the review, emphasizing the interconnectedness of plant taxonomy and nutritional value.

14) Kumar:
Kumar appears as one of the contributing researchers of the study. The contributions of individual authors are critical in academic research for presenting findings and influencing future studies related to Green Coffee Extract and its health benefits, particularly in the Indian context.

15) Sugar:
Sugar, particularly in relation to glucose, plays a significant role in metabolism. The text discusses how Chlorogenic Acid from Green Coffee Extract may inhibit glucose formation in the liver, highlighting its relevance in managing blood sugar levels and reducing the risk of Type 2 diabetes.

16) Tree:
The coffee plant is described as a small tree that produces coffee cherries. Understanding the biological structure of the coffee plant helps contextualize the source of Green Coffee Extract and its chemical composition, which underpins its health benefits and medicinal properties.

17) Soil:
Soil plays a vital role in the growth of coffee plants, affecting their chemical composition and nutrient profiles. This affects the quality of coffee and its extracts, reinforcing the importance of agronomic practices and environmental factors in producing health-beneficial compounds in coffee beans.

18) Transformation (Transform, Transforming):
Transformation refers to the changes or alterations that occur in organisms or substances. In this review, the transformation of various bioactive compounds in Green Coffee Extract during metabolism and their effects on health underline the dynamic interactions between diet and physiological responses.

19) Substance:
Substance refers to a physical material with distinct properties. The study highlights various bioactive substances in Green Coffee Extract, such as Chlorogenic Acid and caffeine, and their roles in health benefits, showcasing the relevance of these compounds in nutrition and pharmacology.

20) Learning:
Learning involves gaining knowledge or skills through experience. The text mentions cognitive benefits associated with coffee consumption, implying that constituents like caffeine and Chlorogenic Acid may positively influence learning by enhancing alertness and cognitive functions, vital for everyday activities.

21) Quality:
Quality denotes the standard of excellence of a product or service. The review addresses the quality of Green Coffee Extract in terms of its health benefits and chemical composition, indicating how quality control in production can influence effectiveness and safety for consumers.

22) Ranjan (Ramjan):
Ranjan is another co-author of the study, highlighting the collaborative nature of research. The work of individual researchers is crucial to advancing knowledge in the field of pharmacology and nutrition, particularly regarding the benefits of Green Coffee Extract for public health.

23) Water:
Water is essential for life and affects plant growth and development. It impacts the physiological characteristics of coffee plants, which can influence the nutritional composition of coffee beans, further emphasizing the environmental significance in producing health-beneficial coffee extracts.

24) Table:
A table is used to present data systematically. The review includes tables that compare the chemical composition of different coffee species, aiding in the visual representation of differences in bioactive compounds that are critical for understanding their health implications.

25) Fight:
To fight refers to engaging in a struggle against an adversary. The text emphasizes that Green Coffee Extract may fight against oxidative stress, chronic diseases, and cancer by neutralizing free radicals, pointing to its advantage in health management and disease prevention.

26) Genu:
Genu may refer to a pointed part of a leg or knee but is not explicitly detailed in the context of this text. The term may be associated with anatomical references or context that needs clarification, suggesting a potential topic of further exploration within the study's framework.

27) Ripe:
Ripe refers to the stage of fruit development indicating readiness for harvest. In coffee plants, ripe cherries produce quality beans critical for extracting health-beneficial compounds. This concept connects agricultural practices to the final product's nutritional profile and its health advantages.

28) Hand:
Hand signifies manual labor or assistance in agricultural contexts. The significance of handpicking ripe coffee cherries is emphasized, showcasing the role of human labor in quality control of coffee production, ultimately affecting the nutritional value of extracts.

29) Life:
Life refers to the condition that distinguishes living organisms from inorganic matter. The text ties life to health, indicating that consuming products like Green Coffee Extract may enhance quality of life by preventing chronic diseases and supporting metabolic health.

30) Antibiotic (Antibacterial):
Antibacterial refers to the capability to inhibit bacterial growth. The review mentions the potential antibacterial properties of coffee compounds, which could have implications for treating infections or supporting immune function, highlighting the broader health benefits of coffee consumption.

31) Accumulation (Accumulating, Accumulate):
Accumulated signifies something that has been gathered or built up over time. The text touches on the accumulation of potentially harmful substances and fats in the body, indicating how Green Coffee Extract may assist in mitigating these through its biological actions.

32) Inflammation:
Inflammation is a biological response to harmful stimuli. The text mentions the potential of Green Coffee Extract to reduce inflammation related to various diseases, suggesting its role in preventive health strategies targeting chronic inflammatory conditions.

33) Performance:
Performance relates to the execution of tasks or functions. In the context of this study, it refers to the effects of coffee consumption on physical and cognitive performance, indicating how specific compounds can enhance stamina, focus, and overall well-being.

34) Surrounding:
Surrounding refers to the environment around an organism. In agricultural terms, surrounding conditions such as soil health and climate directly affect the growth, chemical composition, and health benefits of coffee plants, highlighting the integrative aspect of ecology in nutrition.

35) Alcoholism:
Alcoholism is a chronic disease characterized by an inability to control drinking behavior. The link to Green Coffee Extract suggests its potential role in helping manage related health conditions, although the mechanism and effects warrant further investigation to validate any claims.

36) Science (Scientific):
Scientific refers to a methodical approach to understanding phenomena based on empirical evidence. The text emphasizes the scientific basis of studies supporting the health benefits of Green Coffee Extract, indicating the importance of rigorous research in validating its applications in healthcare.

37) Harvesting (Harvest):
Harvest denotes the gather of mature crops from the field. This term emphasizes the agricultural practice crucial for obtaining quality coffee beans, directly impacting the properties and health benefits of Green Coffee Extract derived from these beans.

38) Toxicity:
Toxicity refers to the degree to which a substance can harm organisms. Understanding the potential toxicity of constituents in Green Coffee Extract is crucial for ensuring its safety for consumption, highlighting the need for thorough evaluations in nutraceutical formulations.

39) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. The review contextualizes Green Coffee Extract within medicinal applications, discussing its role as a dietary supplement in preventing chronic diseases related to lifestyle factors.

40) Vomiting:
Vomiting is the expulsion of the contents of the stomach through the mouth. The text touches on the unpleasant effects associated with the consumption of unprocessed coffee, suggesting that some individuals may experience nausea or vomiting, impacting its acceptability and consumption.

41) Grafting:
Grafting is a horticultural technique used to propagate plants by joining parts from different specimens. This technique may enhance coffee cultivation and result in improved plant characteristics, indicating the agricultural practices involved in producing quality coffee beans for health benefits.

42) Cutting:
Cutting refers to a method of plant propagation. It highlights alternative techniques to traditional sowing in coffee cultivation, suggesting approaches that can improve the efficiency and quality of coffee production, thereby impacting the effectiveness of Green Coffee Extract.

43) Anxiety:
Anxiety refers to feelings of worry or apprehension. The text correlates the consumption of caffeine from coffee with potential negative effects such as increased anxiety in sensitive individuals, underscoring the importance of understanding the full spectrum of coffee's effects on mental health.

44) Surface:
Surface relates to the outermost layer of an object. In coffee beans, the surface properties, including lipid content, affect stability and oxidation, indicating that chemical characteristics on the surface of green coffee have significance for maintaining bioactive properties in extracts.

45) Nausea:
Nausea is a sensation of unease and discomfort in the stomach often leading to vomiting. The text mentions nausea associated with the smell of roasted green coffee, reflecting consumer experiences and the importance of processing methods in enhancing palatability and acceptability.

46) Bitter:
Bitter describes a strong, sharp taste often unpleasant to consumers. The bitterness of coffee can be attributed to various compounds, including caffeine and trigonelline, which may influence consumer preferences and experience, as well as highlight attributes of raw versus roasted coffee beans.

47) Nature:
Nature encompasses the intrinsic qualities or characteristics inherent to something. In this context, the nature of compounds found in Green Coffee Extract relates to their biochemical and health properties, affecting their potential applications in preventive health strategies.

48) Insect:
Insects can significantly impact agricultural practices, particularly in coffee farming. The text implies potential pests affecting coffee plants, leading to considerations for employing pest control measures, to maintain crop integrity and subsequently improve the quality of coffee beans.

49) Kappa:
Kappa may refer to a specific biochemical term or protein. While its relevance in this text is not explicit, it likely relates to broader discussions in molecular biology associated with the actions of specific molecules in physiological processes, particularly in relation to disease.

50) Pavan:
Pavan is cited as one of the researchers involved in the study. The contributions of various individuals are essential for scientific research progress, underscoring collaborative efforts in investigating the health benefits and applications of Green Coffee Extract.

51) Aroma (A-roma):
Aroma refers to the distinctive smell of substances. In coffee, aroma plays a crucial role in sensory experiences and consumer preferences. The text suggests that the aromatic compounds present in coffee contribute to its appeal and overall experience, affecting how coffee extract is perceived.

52) Honey:
Honey is a natural sweetener recognized for its health benefits. Though not directly discussed in the coffee study, the mention of honey as a healthful food illustrates the broader landscape of dietary products that may complement the health-promoting properties of Green Coffee Extract.

53) Study (Studying):
A study refers to a systematic investigation to discover or interpret facts. The text revolves around studies that explore the biochemical properties and health benefits of Green Coffee Extract, emphasizing the importance of scientific inquiry in establishing dietary supplement efficacy and safety.

54) Beta:
Beta often refers to a specific type of protein or compound in biological contexts. While not explicitly noted in the text, its mention signifies broader discussions in pharmacological research regarding active compounds that may influence health outcomes, linking to Green Coffee components.

55) Diet:
Diet denotes the customary intake of food that influences health and wellness. The review underscores the importance of including health-promoting foods like Green Coffee Extract in a balanced diet to mitigate risks associated with lifestyle diseases such as diabetes and obesity.

56) Wine:
Wine is an alcoholic beverage made from fermented grapes. While not directly relevant, the mention of wine suggests a comparative context where varying dietary components such as coffee and wine can influence health outcomes, highlighting the need for moderation and consideration of overall dietary patterns.

57) Rich (Rch):
Rich describes an abundance or high levels of a particular quality. The review implies that Green Coffee Extract is rich in beneficial compounds, particularly Chlorogenic Acid, which may impart numerous health benefits, urging consideration of its role in a healthy diet.

58) Salt (Salty):
Salt refers to a mineral substance commonly used in food. Although not extensively discussed in the text, salt intake's relationship with health, particularly in hypertension, aligns with the review's focus on managing cardiovascular conditions via dietary factors such as Green Coffee Extract.

59) Drug:
Drug refers to a chemical substance used for medical treatment, diagnosis, or prevention of diseases. The research suggests that components of Green Coffee Extract may occupy similar roles, presenting the potential for dietary supplements to function as preventive agents against chronic diseases and conditions.

60) Mud:
Mood denotes the temporary state of mind or feeling. The influence of caffeine from coffee on mood illustrates its psychoactive properties, suggesting that certain bioactive compounds in Green Coffee Extract may have implications for mental health and overall well-being.

61) Viru:
Viru may refer to a specific virus, but its context in this review is not clearly defined. The relevance could relate to potential discussions on how certain nutrients might support immune function against viral infections, requiring further clarification in a health context.

62) Pur:
Poor denotes a lack of quality or deficiency. In the text, it may refer to individuals' health states as a result of poor dietary choices, highlighting the importance of implementing healthful dietary strategies, such as incorporating Green Coffee Extract, to combat lifestyle-related diseases.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Green coffee extract improves human health’. Further sources in the context of Science might help you critically compare this page with similair documents:

Coffea arabica, Chronic disease, Oral ingestion, Blood-pressure, Body composition, Chemical composition, Antioxidant activity, Insulin resistance, Chronic liver disease, Oxidative stress, Serum glucose, Metabolic syndrome, Reactive oxygen species, Antihypertensive effect, Neurodegenerative disorder, Anticancer activity, Type 2 Diabetes Mellitus, Dietary fiber, Lifestyle related disease, Hypertension, Antioxidant capacity, Free fatty acid, Hydrogen peroxide, Dietary supplement, Weight loss, Gamma-aminobutyric acid, Liver disease, Insulin sensitivity, Blood glucose level, Total antioxidant capacity, Antioxidant therapy, Blood glucose, Caffeine consumption, Weight Management, Type II Diabetes, Nutritional component, Visceral fat, Moderate Physical Activity, Free Radical, Vascular endothelium, Antioxidant defense, Essential amino acid, Enzyme Activity, Glycogenesis, Hydroxyl radical, Caffeine, Health benefit, Galactomannan, Volatile compound, Metabolic Byproduct, Cytochromes P450, Antioxidant ability, Polyphenol compound.

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