PVC Membrane Electrode for Salicylic Acid in Pharmaceuticals

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Novel pvc membrane selective electrodes for determination of salicylic acid in pharmaceutical preparations
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Bhata R. Chaudhari


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Novel pvc membrane selective electrodes for determination of salicylic acid in pharmaceutical preparations

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr201612-7529


Download the PDF file of the original publication


Summary of article contents:

Introduction

The development of novel coated wire electrodes for the determination of salicylic acid in pharmaceutical preparations marks a significant advancement in analytical chemistry. The study presented in the World Journal of Pharmaceutical Research discusses the innovative use of salicylic acid phosphotungstate ion pair complexes embedded in a PVC matrix to create selective electrodes. These ion-selective electrodes (ISEs) are designed to provide a simple, fast, and cost-effective method for quantifying salicylic acid in various solutions, demonstrating a promising potential in clinical and pharmaceutical applications.

Performance Characteristics of the Sensor

The salicylic acid sensor exhibited a near-Nernstian response within a linear concentration range of 10⁻⁴ to 10⁻² M, with a notable lower limit of detection at 3.7 × 10⁻⁵ M. Its slope of 57.46 ± 0.1 mV/decade indicates strong sensitivity, allowing for quick and reliable readings. The sensor maintained impressive stability over a four-month period and functioned effectively across a wide pH range (4.5-8). These performance characteristics underscored the feasibility of utilizing this sensor in routine analytical procedures.

Selectivity of the Sensor

The selectivity coefficients of the salicylic acid sensor were determined using the separate solution method, showcasing its ability to distinguish between salicylic acid and other interfering ions. The sensor demonstrated minimal interference from common pharmaceutical excipients, such as corn and starch, which further supports its practicality for real-world applications. The findings suggest that while various foreign species exist within pharmaceutical formulations, they do not impede the sensor's ability to detect salicylic acid accurately.

Methodology for Pharmaceutical Analysis

The methodology involved a potentiometric determination of salicylic acid following specific calibration and testing procedures. The electrodes were conditioned in a standard salicylic acid solution prior to use and were analyzed against varying concentration levels. Various pH adjustments were made to assess the sensor's response stability. The research involved practical testing of salicylic acid content in commercially available tablets, demonstrating a recovery rate of 99.1%, thereby confirming the sensor's effectiveness for quality control in pharmaceutical preparations.

Conclusion

The study concludes that the ion-selective electrodes developed for the determination of salicylic acid present major advantages, including simplicity, high selectivity, and the capability for direct application in drug analysis without prior separation. Compared to more sophisticated methods, the proposed sensor stands out due to its reliable performance and ease of use, making it a valuable tool for pharmaceutical research and industry. Its ability to analyze salicylic acid effectively while accounting for the presence of excipients suggests its potential for wider application across various drug formulations.

FAQ section (important questions/answers):

What innovative method was developed for measuring salicylic acid?

Newly developed coated wire electrodes were created, utilizing salicylic acid phosphotungstate ion pair complex in PVC membranes for accurate determination of salicylic acid in pharmaceutical preparations.

What concentration range does the salicylic acid sensor cover?

The sensor exhibits a linear response over a concentration range of 1.0 × 10^-7 to 1.0 × 10^-2 mol/L, demonstrating high effectiveness in detecting salicylic acid.

How stable is the performance of the salicylic acid sensor?

The electrode has a long-term stability of 4 months, showing fast and stable response, hence making it suitable for reliable and prolonged usage in analytical applications.

What are the advantages of using the developed sensor?

The sensor offers high selectivity, fast response times, and the ability to analyze samples directly without prior separation, providing a reliable and efficient means for pharmaceutical analysis.

How does pH affect the sensor's performance?

The sensor performs well between pH 4.5 and 8, with disturbances noted at lower and higher pH levels due to interference from H+ ions affecting EMF readings.

What are the findings related to pharmaceuticals tested?

The sensor successfully determined salicylic acid in pharmaceuticals like Alpyrin, showing an average recovery of 99.1%, with no interference from common excipients in the formulations.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “PVC Membrane Electrode for Salicylic Acid in Pharmaceuticals”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
The term 'Drug' refers to chemical substances used for medical treatment, alleviation of symptoms, or prevention of diseases. In this context, salicylic acid is emphasized as a crucial drug with various therapeutic uses, including pain relief and anti-inflammatory properties, key for pharmacological studies and clinical applications.

2) Table:
In the context of pharmaceutical research, 'Table' often refers to the format used to present experimental data, results, or comparisons. The study features tables summarizing performance metrics, selectivity coefficients, and analytical applications, organizing information for clarity and enabling readers to easily interpret findings from experiments.

3) Water:
The term 'Water' is essential in laboratory practices, particularly for preparing solutions and diluting chemicals. In the context of this study, doubly distilled water is used for all experiments, ensuring purity and consistency in measurements, critical for accurate potentiometric determinations and ion-selective electrode function.

4) Glass:
'Glass' denotes a material commonly used in laboratory equipment, such as beakers and crucibles. In this study, glass items like sintered glass crucibles are employed for filtering and handling samples, providing a neutral medium free from possible contaminants that could affect the chemical reactions or analyses conducted.

5) Performance:
'Performance' relates to the effectiveness and reliability of the developed sensors in measuring salicylic acid concentrations. The study discusses the performance characteristics of the membrane sensors, including their response times, sensitivity, stability, and selectivity, highlighting the importance of these metrics in evaluating their analytical capabilities.

6) Species:
In a pharmacological context, 'Species' refers to different chemical entities or organisms that may interact with the drug under investigation. This study evaluates the selectivity of the salicylic acid sensor against various inorganic and organic species, emphasizing the importance of ensuring that the presence of other substances does not interfere with measurements.

7) India:
'India' is relevant as it indicates the geographic and institutional context of the research. The study is conducted in Dhule, India, at JET’s Z.B. Patil College, which is significant for contextualizing the research environment, available resources, and potential implications for local pharmaceutical analysis and education.

8) Dhule:
'Dhule' is a city in India where the research took place. It provides context regarding the location of the academic institution conducting the study. This can lend cultural and regional significance to the research, indicating where the findings may be applied locally in pharmaceutical applications.

9) Patil:
'Patil' refers to the last name of the college where the research was conducted, JET’s Z.B. Patil College. This institutional association is crucial for recognizing the authorship and origin of the research work, fostering a connection between local educational efforts and advancements in pharmaceutical science.

10) Pain:
'Pain' is a symptom that salicylic acid helps alleviate. Understanding this term is vital as the study discusses the various medicinal uses of salicylic acid, particularly its anti-inflammatory properties that relieve pain, thereby linking the significance of the research directly to pain management in clinical settings.

11) Bhata:
'Bhata' refers to Dr. Bhata R. Chaudhari, the lead researcher and author of the study. Acknowledging the authorship is important for citing the work and attributing credit to the scientists involved in the research, further establishing their qualifications and contributions to the field.

12) Fever:
'Fever' is a common medical condition that can be treated with salicylic acid, which is known for its antipyretic properties. This significance ties the study's focus on salicylic acid's pharmaceutical applications to broader health issues, indicating its relevance in managing systemic inflammatory responses and providing relief.

13) Study (Studying):
'Study' refers to the systematic investigation conducted to develop and analyze the salicylic acid sensors. It encompasses methodology, data collection, results, and discussions on performance characteristics, highlighting the research's scientific rigor and contribution to the understanding and application of ion-selective electrodes.

14) Dish (Dis):
'Dish' typically refers to laboratory equipment, such as petri dishes, used for mixing and preparing samples. In this study, a glass petri dish is utilized to facilitate the preparation of PVC membranes, which are crucial for the ion-selective electrode's construction and overall functionality.

15) Life:
'Life' in this context relates to the durability and stability of the sensors over time, particularly their lifespan when applied in analytical practices. The study emphasizes the sensors' longevity, indicating their practical application for extended periods without the need for frequent replacement or recalibration.

16) Pharmacological:
'Pharmacological' pertains to the branch of medicine relating to drugs and their effects. The study's focus on pharmacological applications of salicylic acid underscores its relevance in drug formulation and therapeutic use, emphasizing the significance of developing accurate methods for determining drug concentrations in various preparations.

17) Measurement:
'Measurement' refers to the quantitative assessment of salicylic acid concentrations using ion-selective electrodes. It highlights the primary objective of the research, facilitating the importance of ensuring accuracy and reliability in tracking drug levels for both pharmaceutical quality control and clinical applications.

18) Discussion:
'Discussion' encompasses the analysis and interpretation of results in the study. It is an essential section where findings are contextualized within existing literature, practical implications are explored, and the significance of the developed sensors is evaluated in relation to salicylic acid determination and its applications.

19) Substance:
'Substance' in the study refers to the chemical composition under analysis, particularly salicylic acid. Understanding this term is crucial as the study aims to innovate methods for detecting and quantifying substances within pharmaceutical formulations, emphasizing the importance of precise measurements for drug efficacy and safety.

20) Medicine:
'Medicine' refers to the science and practice of the diagnosis, treatment, and prevention of disease. This study's focus on salicylic acid as a medicinal compound highlights its therapeutic properties, positioning the research within the broader field of pharmacology and healthcare, contributing to better medical practices.

21) Activity:
'Activity' refers to the efficacy of the salicylic acid ion-selective electrode sensor in detecting the analyte. Highlighting the activity is significant as it pertains to the sensor's responsiveness and the ability to perform reliably in varied conditions, ensuring accurate quantification for pharmaceutical analysis.

22) Filling (Filled):
'Filled' pertains to the action of incorporating solutions or materials into the sensors to create the operational structure. This is crucial in the context of the study, as the filling step directly affects the sensor's ability to provide accurate measurements of salicylic acid concentrations.

23) Surface:
'Surface' concerns the interface at which the chemical reactions occur in the electrode. The study describes how interactions at the surface of the ion-selective membrane affect its performance, emphasizing the role of surface properties in determining the sensor's effectiveness for salicylic acid detection.

24) Powder:
'Powder' refers to the form in which some reactants, such as the salicylic acid ion pair complexes, are prepared. In the study, fine powder is obtained from dried solid compounds, which is integral to creating the membrane for the electrode, thus ensuring proper functionality and sensor performance.

25) Ulcer:
'Ulcer' is a condition that can be treated with salicylic acid, showcasing its medicinal properties. This term emphasizes the clinical relevance of the research, as salicylic acid is frequently used in treatments for skin conditions, linking pharmaceutical applications and therapeutic uses for patient care.

26) Trade:
'Trade' refers to the pharmaceutical trade, encompassing the production and distribution of drugs like salicylic acid. Understanding this term connects the study to industry practices, stressing the importance of reliable analytical methods for ensuring quality and compliance in the pharmaceutical marketplace.

27) Food:
'Food' indicates the context in which salicylic acid is applied, particularly as a preservative. This term is relevant as it positions salicylic acid in various sectors, including the pharmaceutical and food industries, highlighting its importance in health and safety regulations relating to consumption.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘PVC Membrane Electrode for Salicylic Acid in Pharmaceuticals’. Further sources in the context of Science might help you critically compare this page with similair documents:

Pharmaceutical preparation, Drug delivery system, Salicylic acid, Calibration curve, Pharmaceutical formulation.

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