Stabilized vitamin A palmitate in multivitamin syrup formulation
Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and evaluation of stabilized vitamin a palmitate in multivitamin syrup
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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M. Rajesh, Nadar Anton Prisca Jeyapaul, P. Ramkumar and A. S. William Arputha Sundar
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Formulation and evaluation of stabilized vitamin a palmitate in multivitamin syrup
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Doi: 10.20959/wjpr201612-7450
Copyright (license): WJPR: All rights reserved
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Summary of article contents:
Introduction
In liquid oral formulations, the stability of active and inactive ingredients is crucial, as active ingredients often exhibit lower stability in aqueous forms compared to solid dosage forms. This paper presents research focused on developing and stabilizing Vitamin A Palmitate in a multivitamin syrup. Three different formulations were created and evaluated on various physical and chemical parameters, leading to the identification of an optimized formulation that maintained the stability of Vitamin A even in the presence of additional multivitamins.
Stability of Vitamin A Palmitate
Vitamin A palmitate, an essential fat-soluble vitamin, is susceptible to oxidation, which can significantly diminish its beneficial properties. The study detailed the formulation of three syrup types: V1 contained Vitamin A palmitate alone, V2 included stabilizers and antioxidants, and V3 was a multivitamin formulation with both Vitamin D and E. The results indicated that formulation V1 demonstrated poor stability, with significant degradation of Vitamin A, likely due to the absence of stabilizing agents. Conversely, formulation V2 confirmed that the inclusion of stabilizers and antioxidants effectively preserved Vitamin A's integrity.
Multivitamin Incorporation
The optimized formulation, V2, was further enhanced by the introduction of additional vitamins, resulting in formulation V3. This new formula maintained the stability of Vitamin A palmitate while integrating Vitamins D and E. Stability testing of formulation V3, conducted under varying temperature and humidity conditions, revealed that the presence of these additional vitamins did not compromise Vitamin A's stability. This finding highlights the potential for creating more comprehensive multivitamin syrups without sacrificing the efficacy of individual components.
Evaluation of Physical and Chemical Parameters
The evaluation process for the formulations included assessing general, physical, and chemical parameters, such as appearance, pH, viscosity, and drug content. The stability reports indicated that formulations V2 and V3 retained their expected characteristics throughout the testing period, unlike formulation V1, which exhibited changes in color and a decline in drug content. This consistent stability across formulations underscores the importance of using appropriate stabilizing agents to ensure the effectiveness of liquid vitamin formulations.
Conclusion
In summary, the study confirms that a stable multivitamin syrup formulation containing Vitamin A palmitate (V3) can be successfully developed. The formulations exhibited good stability under controlled conditions over two months, validating the use of stabilizers, antioxidants, and buffering agents in preserving the integrity of Vitamin A. Furthermore, the integration of additional vitamins like D and E did not compromise the stability of Vitamin A, pointing towards the feasibility of formulating effective multivitamin syrups that meet nutritional needs.
FAQ section (important questions/answers):
What was the objective of this study on Vitamin A Palmitate?
The study aimed to develop and stabilize Vitamin A Palmitate in a multivitamin syrup form, addressing the stability challenges of active ingredients in liquid oral formulations.
What three formulations of Vitamin A Palmitate syrup were created?
The three formulations included V1 (without stabilizers), V2 (with stabilizers and antioxidants), and V3 (multivitamin syrup with Vitamin D and E), each designed to evaluate stability.
How did V1 formulation perform compared to V2 and V3?
Formulation V1 showed poor stability and degradation in drug content, while V2 and V3 maintained good stability for the evaluated parameters.
What parameters were used to evaluate the formulations?
The formulations were evaluated for general, physical, and chemical parameters, including appearance, pH, viscosity, and drug content over two months.
What was the significance of stabilizers and antioxidants in V2?
The inclusion of stabilizers and antioxidants in formulation V2 significantly improved the stability of Vitamin A Palmitate compared to the unstabilized V1.
What conclusions were drawn about the stability of formulation V3?
Formulation V3 demonstrated stability with Vitamin A Palmitate, Vitamin D, and Vitamin E, indicating that the combined formulation is viable for effective supplementation.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Stabilized vitamin A palmitate in multivitamin syrup formulation”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'Drug' refers to any chemical substance that can alter physiological functions within the body. In the context of the study, Vitamin A Palmitate is classified as a drug because it possesses significant therapeutic properties essential for various metabolic processes. Understanding its stability during formulation is crucial for ensuring efficacy and safety in pharmaceutical applications.
2) Table:
A 'Table' in this context serves as a systematic presentation of data, typically summarizing specific findings related to the formulation and evaluation of the Vitamin A Palmitate syrup. Tables are essential for organizing information clearly, allowing for quick reference and comparison of various formulations and their characteristics during the study.
3) Water:
'Water' is a key solvent in pharmaceutical formulations, including syrups. In the context of this study, its role is paramount as it helps dissolve other ingredients, providing a medium for stability and preservation of active compounds like Vitamin A Palmitate. Its properties significantly influence the overall formulation efficacy.
4) India:
'India' is the geographical and cultural context where the research and development of the Vitamin A Palmitate syrup took place. The regulatory environment, market needs, and availability of resources in India directly affect the study's dynamics, emphasizing the importance of local factors in pharmaceutical research and formulations.
5) Study (Studying):
'Study' refers to the systematic investigation into the formulation and evaluation of Vitamin A Palmitate. It involves research methodologies designed to understand the stability, compatibility, and performance of the syrup. Insights gained from the study contribute to pharmaceutical science, guiding future research and product development.
6) Tamilnadu (Tamil-nadu):
'Tamil Nadu' is the state in India where the research was conducted. Recognizing the local context highlights the availability of resources, cultural practices, and pharmaceutical industries in the region that may influence the study’s outcomes. Tamil Nadu’s educational institutions also contribute to this field of research.
7) Reason:
'Reason' pertains to the justifications or explanations behind the observed results during the study. Identifying the reasons for the stability or instability of Vitamin A Palmitate in the formulations helps researchers understand underlying chemical interactions, aiding in the optimization of the syrups for practical use.
8) Tamil:
'Tamil' relates to the language spoken in Tamil Nadu, providing cultural context to the study. This connection underscores the importance of local language and culture in scientific research dissemination and accessibility, making it relevant for community engagement and education on health topics covered in the study.
9) Nadu:
'Nadu' translates to 'land' in Tamil, forming part of the name Tamil Nadu. Its significance here indicates regional identity and heritage, emphasizing the geographical focus of the research. This reflects how local identity interweaves with scientific inquiry and the pursuit of knowledge within specific cultural contexts.
10) Chennai:
'Chennai' is the capital city of Tamil Nadu, serving as the location for significant pharmaceutical and educational institutions involved in the research. Its urban infrastructure supports research activities, industry partnerships, and the development of health products, rendering it a critical hub for pharmaceutical studies in India.
11) Discussion:
'Discussion' is a segment in research papers where results are interpreted and contextualized. In the context of this study, it refers to the analysis of findings related to the stability of Vitamin A Palmitate syrups, providing insights and implications for the field of pharmaceutical science and formulation technology.
12) Rajasthan:
'Rajasthan' is another Indian state mentioned in the affiliations of the authors. Its significance lies in the broader context of Indian educational and research frameworks, highlighting the collaboration among institutions across different states in advancing pharmaceutical sciences and providing a wider perspective on regional contributions to the study.
13) Substance:
'Substance' refers to any material or compound, in this case, Vitamin A Palmitate, which is being formulated into syrup. The understanding of its chemical makeup, properties, and interactions with other excipients is crucial for developing effective pharmaceutical products with desired shelf life and therapeutic benefits.
14) Species:
'Species' in a scientific context typically refers to a category of organisms. While not explicitly related to the study's main focus, it can imply the biological relevance of vitamins within nutrition. In broader discussions, it reflects how the pharmacological properties of substances interact with different species in ecological and health scenarios.
15) Company:
'Company' denotes the collaborative involvement of various organizations, such as Piramal Healthcare and BASF Chemicals, in the study. Their contributions provide essential materials and support, highlighting the role of industry partnerships in advancing pharmaceutical research and ensuring the availability of quality components in drug formulation.
16) Nature:
'Nature' refers to the inherent characteristics and behaviors of substances like Vitamin A Palmitate. Understanding its physical and chemical nature is vital for researchers to predict its behavior in formulations and interactions with environment, which ultimately impacts stability, efficacy, and safety of pharmaceutical products.
17) Filling (Filled):
'Filled' refers to the action of packaging or preparing the formulated syrup for storage and analysis. This process is critical in pharmaceuticals, as ensuring the correct filling techniques can affect drug stability, effectiveness, and consumer usability, making it a key aspect of formulation development and quality control.
18) Tiru (Thiru):
'Thiru' is an honorific prefix used in Tamil culture, denoting respect. Its mention in the context of this research acknowledges the contribution of individuals in a professional setting, reflecting cultural norms and respect for authority within academic and pharmaceutical communities, which can enhance collaborative efforts in research.
19) Alvar (Arvar, Alwar):
'Alwar' is a city in Rajasthan, India, mentioned in connection with one of the academic authors. Its inclusion highlights the geographic diversity among researchers and institutions, indicating cross-state collaborations that contribute to the broader landscape of pharmaceutical research and education in India.
20) Cina:
'China' denotes the source of some ingredients used in the study, emphasizing global supply chains in pharmaceutical formulation. The mention illustrates how international collaborations and resources play vital roles in research and development, providing insights into the evolving landscape of global pharmaceutical practices.
21) Food:
'Food' relates to the content of vitamins within dietary sources necessary for maintaining good health. This context underscores the relationship between nutrition and pharmaceutical sciences, emphasizing how formulations like vitamin syrups are essential in providing dietary supplements to achieve health goals related to deficiencies or requirements.
22) Male:
'Male' references gender-specific nutritional requirements, particularly for Vitamin A intake. This highlights the importance of understanding demographic differences in dietary needs, which can influence formulation choices in pharmacology. Tailoring formulations based on gender can enhance efficacy and safety, addressing specific health concerns relevant to different populations.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Stabilized vitamin A palmitate in multivitamin syrup formulation’. Further sources in the context of Science might help you critically compare this page with similair documents:
Solubility Test, Drug development, Antioxidant, Organoleptic properties, Room temperature, Physical parameter, Indian Pharmacopoeia, Sucrose, General Parameters, Chemical Parameter.