Crude and ethanol extracts of anacardium occidentale and dennettia tripetala

effects on oral organisms and possible inclusion in toothpastes.

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Crude and ethanol extracts of anacardium occidentale and dennettia tripetala
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: effects on oral organisms and possible inclusion in toothpastes.

Original source:

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Author:

Kyrian-Ogbonna Evelyn A., Nwobu Reuben A.U., Chidi-Onuorah Lilian C., Okafor Ugochukwu C. and Ilikannu Samuel O.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Crude and ethanol extracts of anacardium occidentale and dennettia tripetala

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Doi: 10.20959/wjpr201612-7359

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

The research conducted by Kyrian-Ogbonna et al. (2016) investigates the antimicrobial properties of extracts from two plants, Anacardium occidentale (cashew) and Dennettia tripetala, in combating oral infections caused by bacteria like Streptococcus mutans and Staphylococcus aureus. Despite advancements in oral hygiene, dental caries and other oral infections remain significant health concerns. The study aims to explore natural alternatives to synthetic antibiotics by evaluating the effectiveness of these plant extracts when used in dental products, particularly toothpaste.

Antimicrobial Efficacy of Plant Extracts

The study highlights the varying degrees of antimicrobial activity exhibited by different extracts of A. occidentale and D. tripetala. Ethanol extracts of A. occidentale displayed the highest activity against S. mutans, showing an inhibition zone of 26.5 mm, indicating a strong bactericidal effect. in contrast, D. tripetala exhibited generally lower antimicrobial activity. The research shows that both extracts contain bioactive compounds that contribute to their effectiveness against oral pathogens, supporting their potential use in dental care products.

Formulation and Testing of New Toothpaste

A newly formulated toothpaste (NT) was prepared using standard ingredients and subsequently tested for antimicrobial activity, both independently and in combination with the plant extracts. The results revealed that the new toothpaste had limited activity against oral bacteria. However, when combined with extracts of A. occidentale, the antimicrobial properties of the toothpaste improved significantly, suggesting a synergistic effect. It was determined that while the commercially prepared toothpaste has utility, the inclusion of these natural extracts could enhance its efficacy against oral bacteria.

Significance of Natural Antimicrobial Agents

The findings emphasize the increasing societal preference for natural ingredients in dental care products. The safety profile and antimicrobial potential of plant extracts like those from A. occidentale align with a growing trend towards using herbal and alternative remedies in oral health. Additionally, the study underlines the importance of isolating active components from these natural sources to maximize their beneficial effects. Such insights not only encourage the use of traditional remedies but also challenge the dominance of synthetic compounds in the dental industry.

Conclusion

The research concludes that extracts from A. occidentale and D. tripetala demonstrate promising antimicrobial activities against oral pathogens, supporting their potential inclusion in toothpaste formulations. Although D. tripetala showed lower effectiveness, its pleasant aroma may still contribute positively to the sensory quality of dental products. Overall, the study advocates for further investigation into the active compounds within these plant extracts, alongside animal studies, to better understand and validate their roles in dental care. Emphasizing the importance of a balanced oral flora, the research paves the way for the development of more natural and effective dental hygiene products.

FAQ section (important questions/answers):

What was the aim of the study on Anacardium occidentale and Dennettia tripetala?

The study aimed to investigate the antimicrobial effects of Anacardium occidentale and Dennettia tripetala on oral organisms and explore their potential inclusion in toothpaste formulations.

How were the antimicrobial effects tested in the study?

The antimicrobial effects were tested using the Kirby-Bauer disc diffusion method on various clinical bacterial isolates obtained from patients.

What were the main findings regarding the extracts' antimicrobial activity?

Ethanol extracts of Anacardium occidentale showed the highest antimicrobial activity, particularly against Streptococcus mutans, while extracts of Dennettia tripetala demonstrated generally lower effects.

How effective was the newly formulated toothpaste with the extracts?

The newly formulated toothpaste exhibited some antimicrobial activity, especially when combined with the extracts, enhancing its effectiveness against the tested microorganisms.

What is the significance of using natural extracts in toothpaste?

Using natural extracts in toothpaste can minimize reliance on synthetic antibiotics and offer additional health benefits due to their antimicrobial properties.

What future studies are recommended based on the findings?

Further studies are suggested to isolate active components of the extracts and conduct animal studies to authenticate their effects on living organisms.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Crude and ethanol extracts of anacardium occidentale and dennettia tripetala”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the capability or functioning of a substance to elicit a biological response or effect, particularly in pharmacology and microbiology. In this context, it pertains to the antimicrobial effectiveness of plant extracts against oral pathogens, highlighting their potential as natural alternatives in health care, particularly for oral hygiene products.

2) Table:
In research, a table is a systematic arrangement of data in rows and columns that facilitates comparison and analysis. The tables in the study present critical experimental results, such as antimicrobial activity, Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC) of various extracts against specific bacteria, providing clear and concise information.

3) Aureus:
Aureus commonly refers to Staphylococcus aureus, a bacterium known for causing a range of infections. In this study, it is significant as one of the test organisms against which the antimicrobial effects of the plant extracts are measured, underlining the importance of understanding its response to potential natural treatments in dental care.

4) Water:
Water serves as a crucial solvent in laboratory procedures and is involved in preparing plant extracts. Its role in the study illustrates how aqueous extraction can lead to the isolation of bioactive compounds, which may contribute to the antimicrobial properties of the tested plants, emphasizing its significance in herbal medicine.

5) Study (Studying):
Studying is the process of investigating or examining a subject to gain knowledge. The study exemplifies a scientific investigation into the antimicrobial properties of traditional plants, enriching the body of knowledge on natural remedies and their application in modern health care practices, particularly for dentistry.

6) Teaching:
Teaching in the context of this article refers to the educational aspect of medical and microbiological research. The study serves as a resource for academic institutions, enhancing the understanding of natural antimicrobial agents, and can be used to inform curricula in applied microbiology, thereby integrating practical knowledge with theoretical learning.

7) Medium:
Medium refers to a nutrient solution used to cultivate microorganisms in laboratory settings. In the study, it is crucial for the growth of test organisms, enabling the assessment of the antimicrobial properties of the extracts in a controlled environment, thus ensuring the reliability of results for scientific analysis.

8) Substance:
A substance is a specific chemical compound or mixture that can exhibit certain properties. In this study, substances refer to the extracts derived from the plants and the active components within them, which are evaluated for their antimicrobial activities, revealing their potential for pharmaceutical applications in oral hygiene.

9) Disease:
Disease pertains to a pathological condition that adversely affects the function of the body. The research addresses oral diseases like dental caries, highlighting the need for effective treatments, and explores the therapeutic potential of natural extracts to combat microbial infections, contributing to overall health advancements.

10) Powder:
Powder refers to the fine, dry, solid particles often obtained by grinding. In this study, powdered plant materials are used to prepare extracts, facilitating the release of bioactive compounds that demonstrate antimicrobial properties, thereby underscoring the role of physical state in enhancing therapeutic efficacy.

11) Rich (Rch):
Rich denotes an abundance of a particular quality or element. In the context of this study, it describes the phytochemical diversity present in the plant extracts, suggesting a wide range of potentially beneficial compounds that could contribute to their antimicrobial effectiveness, and enriching the scientific knowledge in herbal medicine.

12) Antibiotic (Antibacterial):
Antibiotics are substances that inhibit bacterial growth or destroy bacteria. The investigation into plant extracts offers insights into potential natural antibiotics, highlighting an alternative approach in dental care that could reduce reliance on synthetic antibiotics, particularly in the context of growing antibiotic resistance issues.

13) Attending:
Attending refers to the act of being present or participating in a particular environment or event. In this study, it highlights patients visiting a dental clinic, from whom microbial samples are collected, emphasizing the relevance of real-life conditions in assessing the efficacy of natural antimicrobial treatments.

14) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. This study contributes to the field by investigating the antimicrobial properties of traditional plants, suggesting their integration into modern medical practices, particularly in oral health, thus bridging traditional and contemporary therapeutic approaches.

15) Surface:
Surface refers to the outermost layer of an object. In oral health, the surfaces of teeth are significant as they harbor diverse microbial communities. This study's focus on antimicrobial effects aims to improve oral hygiene by targeting these surfaces, showcasing the importance of maintaining a healthy oral microbiome.

16) Sage:
Sage is a well-known herb with various therapeutic properties. Although not the primary focus of this study, its mention contextualizes the broader scope of herbal medicine and serves as an example of plants traditionally used for oral health, highlighting the potential for combining various natural substances in dentistry.

17) Pharmacological:
Pharmacological relates to the study of drug action and the effects of substances on biological systems. The study investigates the pharmacological properties of natural extracts, contributing to the knowledge of alternative medicinal applications and the development of new formulations for dental care as potential adjuncts to traditional pharmaceuticals.

18) Phytochemical:
Phytochemical refers to the chemical compounds produced by plants, often with medicinal properties. In this research, the phytochemicals found in A. occidentale and D. tripetala are key to understanding their antimicrobial effects, indicating the importance of plant-derived compounds in developing natural therapeutic agents for oral health.

19) Observation:
Observation is the act of closely monitoring or assessing something. In scientific research, observations are essential for documenting findings and results. This study relies on systematic observations of the antimicrobial activity of plant extracts, contributing to a comprehensive understanding of their potential applications in dentistry.

20) Discussion:
Discussion is a critical analysis and interpretation of research findings. In this study, the discussion section contextualizes the results within existing literature, explores implications for the use of the extracts in oral health, and provides insights into the future direction of research, enhancing the overall contribution of the study.

21) Container:
A container is an object used to hold or store materials. In the context of the study, containers are significant for storing plant extracts during preparation and testing, ensuring that the integrity and quality of the extracts are maintained for valid experimental results.

22) Flavonoid:
Flavonoids are a group of bioactive compounds found in plants known for their antioxidant and antimicrobial properties. The presence of flavonoids in the studied extracts suggests a potential mechanism behind their efficacy against oral pathogens, underscoring the significance of these compounds in herbal medicine and natural product research.

23) Vomiting:
Vomiting is a physiological response often associated with adverse reactions to certain substances, including medications. The study addresses concerns about side effects linked to synthetic mouthwashes and toothpastes, highlighting the demand for natural alternatives that minimize health risks while effectively promoting oral health.

24) Colouring (Coloring):
Coloring refers to the addition of dyes or pigments to a product. In the context of toothpaste formulations, coloring is relevant for aesthetic appeal. However, knowledge about natural plant extracts informs the potential for using herbal substances safely, contributing to consumer preferences for fewer synthetic ingredients in personal care products.

25) Hygiene (Hygienic):
Hygiene refers to practices that promote health through cleanliness and disease prevention, particularly oral hygiene in this study. Understanding the antimicrobial effects of certain plant extracts contributes to improving oral hygiene practices, suggesting natural alternatives to synthetic products that could enhance overall oral health and well-being.

26) Science (Scientific):
Science is the systematic study of the natural world through observation and experimentation. This research employs scientific methods to investigate the efficacy of plant extracts, underscoring the role of science in validating traditional uses of plants and promoting the development of effective natural healthcare solutions.

27) Family:
Family in the botanical context refers to a group of related plants sharing common characteristics. Understanding plant families aids in identifying species with potential health benefits, assisting researchers in targeting specific plants, like Dennettia tripetala from the Annonaceae family, for their antimicrobial properties in dental care.

28) Nature:
Nature encompasses the physical world and its phenomena. This study recognizes the intrinsic value of natural products in health care, highlighting the desire for herbal alternatives to synthetic agents, which aligns with growing public interest in nature-based solutions for health, especially in dental care and hygiene.

29) Animal:
Animal refers to living organisms that are not plants or microorganisms. In the context of this study, animal studies are suggested for future research to assess the safety and effectiveness of the plant extracts in living organisms, providing evidence for their potential use in therapeutic applications.

30) Desire:
Desire indicates a strong feeling of wanting something. The study reflects society's increasing desire for natural over synthetic products in healthcare, especially in dentistry. This shift towards natural alternatives signals a demand for solutions that balance efficacy with safety, promoting the exploration of traditional medicinal plants.

31) Botany:
Botany is the scientific study of plants. In this research, knowledge from botany aids in understanding the properties and potential uses of the plants studied, contributing to evidence-based practices in medicine, particularly regarding the use of plant extracts in oral healthcare therapies.

32) Aroma (A-roma):
Aroma refers to a distinctive fragrance, often perceived as pleasant. In the context of dentistry, aromas from natural extracts like those from D. tripetala could enhance the sensory experience of dental products, aligning with consumer preferences for pleasant-smelling, natural remedies over synthetic alternatives to promote oral health.

33) Fever:
Fever is a common medical symptom that signifies an underlying infection or illness. The reference to its treatment with plants like D. tripetala emphasizes the traditional use of these plants in folk medicine, further supporting the interest in their potential therapeutic properties and broadened application in health care.

34) Lemon:
Lemon is a citrus fruit known for its flavor and health benefits. Though it is not a primary focus of the study, its mention connects to the broader spectrum of natural compounds researched for their antimicrobial and therapeutic effects, reflecting consumer interest in using familiar, natural ingredients in health care formulations.

35) Pose:
Pose refers to the act of presenting a situation or condition. In this study, oral infections pose a significant challenge to health despite advancements in hygiene practices. Addressing this issue through the exploration of natural remedies highlights the necessity of ongoing research into effective solutions for oral healthcare.

36) Drug:
Drug refers to a substance used for medical purposes, particularly to diagnose, treat, or prevent disease. This study investigates natural plant extracts for their potential as alternative drugs in treating oral infections, illustrating the importance of diversifying therapeutic options beyond conventional synthetic medications.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Crude and ethanol extracts of anacardium occidentale and dennettia tripetala’. Further sources in the context of Science might help you critically compare this page with similair documents:

Anacardium occidentale, Phytochemical, Synthetic antibiotic, Oral hygiene, Statistical analysis, Antibacterial activity, Antimicrobial activities, Bioactive substances, Plaque control, Antimicrobial activity, Minimum inhibitory concentration, Streptococcus mutans, Dental caries, Dental plaque, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Animal studies, Mechanism of action, Mechanical plaque control, Minimum inhibitory concentration (MIC), Antimicrobial potential, Alcoholic extract, Phytochemical composition, Lactobacillus acidophilus, Mueller Hinton Agar, E. coli, Minimum bactericidal concentration, In Vitro Antimicrobial Activity, Kirby-Bauer disc diffusion method, Test microorganism, Oral biofilm, Active component, Sodium fluoride, Dental clinic, Oral bacteria, Oral infection, Herbal dentifrice, Turbidity standard.

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