Pharmacology and Phytochemistry Review of Rheum emodi (Rhubarb)

a review on pharmacology and phytochemistry

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Rheum emodi
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a review on pharmacology and phytochemistry

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Author:

Amandeep Kaur, Satvinder Kaur, Manpreet Kaur, Anu Mahajan and Sujit Bose


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Rheum emodi

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Rheum emodi, commonly known as Himalayan Rhubarb, is a perennial medicinal herb belonging to the Polygonaceae family. This plant is traditionally utilized for various pathological ailments such as ulcers, fevers, bacterial infections, and diuretic purposes. Distributed throughout the Himalayan region of India, Rheum emodi has garnered attention for its significant role in traditional medicine systems like Ayurveda and Unani. This review provides comprehensive details about its pharmacological activities and phytochemistry by consolidating information from various research journals, books, and pharmacopoeias.

Pharmacological Activities

One of the most notable pharmacological activities of Rheum emodi is its antiulcer effect. Research indicates that it effectively prevents the occurrence of gastric ulcers induced by various factors, such as ethanol and reserpine, in animal models. In a study conducted by Amandeep Kaur et al., oral administration of an ethanolic extract at a dose of 100 mg/kg resulted in the significant reduction of ulcer indices while increasing the pH of gastric fluid. This evidence highlights the plant's potential in potentiating gastric defenses and provides a strong rationale for its traditional use in managing gastric ailments.

Antioxidant and Antidiabetic Properties

Rheum emodi has been shown to possess impressive antioxidant activities, which have protective effects against oxidative stress-related injuries and inflammatory diseases. A study revealed that isolated compounds from the plant demonstrated significant radical scavenging activity, which may be attributed to the presence of certain chemical constituents, particularly stilbenoids like piceatannol. Additionally, Rheum emodi exhibits notable antidiabetic properties, enhancing peripheral glucose utilization and correcting impaired glycolysis in diabetic models. This multifaceted action underscores the plant's versatile therapeutic potential.

Hepatoprotective and Nephroprotective Effects

The hepatoprotective properties of Rheum emodi have been highlighted in studies demonstrating its efficacy against liver damage induced by paracetamol. Methanolic extracts showed significant protective effects by maintaining serum enzyme levels and providing an overall improvement in liver function. Similarly, research on its nephroprotective effects revealed that the plant capable of mitigating nephrotoxicity caused by heavy metals through its antioxidant properties. This aspect emphasizes the importance of Rheum emodi in protecting vital organ functions, further validating its traditional usage.

Conclusion

Overall, Rheum emodi emerges as a plant of considerable pharmacological interest, evidencing various medicinal properties including antiulcer, antioxidant, antidiabetic, hepatoprotective, and nephroprotective effects. While the current literature supports its traditional uses, further extensive research is essential to confirm these therapeutic effects and explore the full potential of this remarkable plant. As it stands, Rheum emodi represents a significant reservoir of phytochemicals with diverse applications in modern medicine, reinforcing the value of integrating traditional plant knowledge into contemporary health practices.

FAQ section (important questions/answers):

What is Rheum emodi commonly known as?

Rheum emodi is commonly known as Himalayan Rhubarb and belongs to the Polygonaceae family.

What are the traditional uses of Rheum emodi?

Traditionally, Rheum emodi is used as a laxative, tonic, diuretic, and to treat ulcers, diarrhea, fever, cough, and indigestion.

What are the major constituents of Rheum emodi?

The major constituents include anthraquinones, flavonoids, tannins, stilbene, and a small amount of alkaloids.

What pharmacological activities does Rheum emodi possess?

Rheum emodi exhibits anticancer, antioxidant, antidiabetic, antifungal, antiulcer, hepatoprotective, nephroprotective, and immunoenhancing properties.

How does Rheum emodi demonstrate antiulcer activity?

Rheum emodi shows antiulcer activity by protecting the gastric lining and reducing ulcer formation in various models.

What are the findings related to Rheum emodi's antioxidant activity?

Rheum emodi has protective effects against oxidative stress, with isolated compounds showing significant antioxidant properties in various assays.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Pharmacology and Phytochemistry Review of Rheum emodi (Rhubarb)”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the specific effects exerted by compounds or extracts of plants like Rheum emodi. In the context of pharmacology, it highlights the beneficial or therapeutic actions against healthcare issues such as ulcers, cancer, inflammation, and more, showcasing the plant's potential as a natural remedy.

2) Study (Studying):
Study indicates systematic research and experimentation to understand specific aspects of a subject, such as the pharmacological effects of Rheum emodi. Scientific studies validate traditional uses, investigate mechanisms of action, and assess efficacy in treating various ailments, forming a critical base for medical applications.

3) Pharmacological:
Pharmacological pertains to the study of drugs and their interactions with biological systems. In the context of Rheum emodi, it encompasses exploring the plant's bioactive compounds, elucidating their mechanisms of action, and their therapeutic potentials in treating various diseases, fundamental for drug development and clinical uses.

4) Disease:
Disease refers to a pathological condition that disrupts normal body function. Rheum emodi has been investigated for its effects on diseases like cancer, diabetes, and liver disorders. Understanding its impact on disease mechanisms aids in developing therapeutic interventions that leverage natural products for health benefits.

5) Ulcer:
Ulcer refers to a sore that develops on the lining of the stomach or other organs, often involving pain and discomfort. Rheum emodi demonstrates antiulcer properties, reducing symptoms and promoting healing, thus representing a valuable natural option for managing this digestive issue effectively.

6) India:
India is a country rich in biodiversity and traditional medicine practices, including Ayurveda. The study of plants like Rheum emodi, native to Himalayan regions, falls under this context, highlighting India's heritage of using natural resources for healthcare and the significance of such plants in modern pharmacology.

7) Punjab:
Punjab is a region in India where Rheum emodi is cultivated and used traditionally. Being the home of various medicinal plants, its geographical and cultural significance plays a crucial role in the exploration of indigenous pharmacological practices and phytochemical research in the context of traditional medicine.

8) Reason:
Reason relates to the motivating factors behind using Rheum emodi for medicinal purposes. The availability of research supporting its efficacy in treating various ailments and its historical use in traditional medicine provide compelling reasons to further investigate its pharmacological properties and potential clinical applications.

9) Indian:
Indian refers to the context of traditional practices and medicinal knowledge indigenous to India. The exploration of Rheum emodi within this framework highlights the significance of localized plant species in healthcare, emphasizing the integration of traditional herbal remedies into contemporary medical practices and pharmacological research.

10) Phytochemical:
Phytochemical refers to the bioactive compounds found in plants that have health-promoting properties. In Rheum emodi, these include anthraquinones, flavonoids, and tannins. Studying these compounds is essential for understanding the therapeutic effects of the plant and developing natural drugs derived from its phytochemical constituents.

11) Pharmacology:
Pharmacology is the branch of science concerned with the study of drugs and their effects on biological systems. Investigating the pharmacology of Rheum emodi involves examining its mechanisms of action, therapeutic activities, and potential uses in modern medicine, expanding knowledge on plant-based treatments.

12) Flavonoid:
Flavonoid refers to a group of potent antioxidant compounds found in various plants, including Rheum emodi. These compounds contribute to the plant's health benefits, such as anti-inflammatory and anticancer properties, and understanding their role is vital in appreciating the full pharmacological potential of herbal remedies.

13) Medicine:
Medicine encompasses a broad field focused on diagnosing, treating, and preventing illnesses. The significance of Rheum emodi in traditional medicine systems highlights its contributions to health, reflecting how integrating natural compounds can lead to effective treatments and understanding the plant's role within medical practices.

14) Water:
Water is a critical solvent and medium for biological processes and is often involved in the extraction of phytochemicals from plants. The aqueous extracts of Rheum emodi have shown pharmacological activities, underscoring the role of water in preparing herbal formulations and assessing their therapeutic potential.

15) Fever:
Fever is a common symptom of various illnesses and indicates an immune response. Rheum emodi has historical applications in treating fevers within traditional medicine, and understanding its effects can enhance knowledge of its pharmacological use in managing such health conditions effectively, widening therapeutic options.

16) Drug:
Drug refers to a substance used for medical purposes, including prevention, diagnosis, and treatment. The exploration of Rheum emodi's pharmacological properties aims to establish its potential as a drug, facilitating the development of natural alternatives to synthetic medications based on its beneficial bioactive components.

17) Inflammation:
Inflammation is the body's localized response to injury or infection, often linked to chronic diseases. Rheum emodi's anti-inflammatory properties position it as a potential therapeutic agent, warranting further investigation to appreciate its role in combating inflammatory disorders and enhancing overall health.

18) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine emphasizing balance and holistic healing. The historical use of Rheum emodi in Ayurvedic practices illustrates the significance of traditional herbal medicine in promoting health and wellness, guiding contemporary herbal research toward validating these age-old applications.

19) Gujarati:
Gujarati refers to the language and culture of the Gujarati people in India, where traditional knowledge of medicinal plants like Rheum emodi may vary. Understanding the regional context allows for exploring diverse applications and local practices surrounding the use of plants for health, enriching pharmacological studies.

20) Himalaya (Hima-alaya):
Himalaya refers to the majestic mountain range that provides a unique ecological zone, nurturing diverse flora. Rheum emodi, endemic to this region, showcases the significance of Himalayan herbs in traditional medicine and their potential contributions to modern pharmacology and maintaining cultural medicinal knowledge.

21) Bleeding:
Bleeding pertains to the loss of blood from the circulatory system, often requiring urgent medical intervention. Some studies highlight the antiplatelet and anticoagulant properties of Rheum emodi, suggesting its potential role in managing bleeding disorders and enhancing cardiovascular health through its bioactive compounds.

22) Sanskrit:
Sanskrit is an ancient Indian language rich in historical texts on medicine and philosophy. Terms related to medicinal plants like Rheum emodi are often found in Ayurvedic literature, highlighting the importance of understanding traditional nomenclature and cultural significance in the context of plant-based healthcare approaches.

23) Bengali:
Bengali denotes the cultural context and language of Bengalis, residing mainly in the Indian state of West Bengal and Bangladesh. The knowledge of Rheum emodi and its medicinal properties may be culturally significant, illustrating the importance of regional awareness in evaluating and utilizing traditional healing practices throughout India.

24) Kashmir:
Kashmir is a region in northern India known for its unique flora and traditional medicine practices. Rheum emodi is found here, and its local application emphasizes the necessity of understanding how geographical and cultural contexts shape the use of medicinal plants in therapeutic practices.

25) Surface:
Surface refers to the outer layer or exterior of an object or substance, relevant in the context of plant studies such as the fracturing of Rheum emodi roots that reveal phenolic compounds. Understanding surface characteristics can aid in processing and extracting phytochemicals for further pharmacological research.

26) Family:
Family in a botanical context relates to the classification of plants sharing common characteristics. Rheum emodi belongs to the Polygonaceae family, and understanding its taxonomic classification plays a vital role in identifying related species, leading to discoveries of similar therapeutic properties in herbal medicine.

27) Cancer:
Cancer denotes a group of diseases characterized by uncontrolled cell growth. The study of Rheum emodi focuses on its potential anticancer properties, driven by its phytochemical constituents, which inspires further investigation into the plant's efficacy and mechanisms of action in combatting diverse cancer types.

28) Animal:
Animal pertains to living organisms within the kingdom Animalia, which are commonly used in scientific studies. The evaluation of Rheum emodi's pharmacological effects often employs animal models to assess therapeutic efficacy and safety, providing vital data before clinical applications in humans.

29) Aroma (A-roma):
Aroma refers to the scent or fragrance resulting from the volatile compounds present in plants. The aromatic properties of Rheum emodi enhance its appeal in traditional medicine and may contribute to its therapeutic benefits, influencing patient acceptance in herbal treatments and applications.

30) Hindi (Himdi):
Hindi represents one of the prominent languages in India, where the cultural amalgamation influences traditional medicine. This linguistic aspect highlights the significance of regionally relevant terminologies for plants like Rheum emodi, facilitating communication and dissemination of indigenous medicinal knowledge throughout different parts of India.

31) Alam (Alaṁ):
Alam, referring to a specific author or researcher, indicates the contribution of individual studies to the overall understanding of the pharmacological activities of Rheum emodi. Acknowledging different researchers is essential for recognizing the various approaches and findings regarding the plant's efficacy in therapeutic applications.

32) Hair:
Hair pertains to the fine, thread-like strands growing from the skin of animals and humans. In botanical contexts, it may refer to the surface textures of plants such as Rheum emodi, which can influence the extraction processes and the plant's overall therapeutic profile, impacting its pharmacological research.

33) Rich (Rch):
Rich signifies abundance or a wealth of resources or qualities. In the context of plant studies, referring to humus-rich soil, it illustrates the fertile conditions necessary for optimal growth of Rheum emodi, emphasizing the importance of environmental factors in cultivating medicinal plants for their healthcare benefits.

34) Wall:
Wall often refers to a barrier or protective structure, but in botanical studies, it can indicate the cellular or anatomical structures of plants. Understanding the cellular 'wall' components in Rheum emodi contributes to comprehending its phytochemistry and potential extraction of bioactive substances for research.

35) Line:
Line may signify a sequence or a series of related concepts. In research contexts, it often pertains to lineage or evolutionary connections. Understanding the genetic 'line' of Rheum emodi becomes essential for phylogenetic studies, elucidating evolutionary traits and potential therapeutic characteristics among related species.

36) Cai (Caí):
Chai, which means tea in Hindi, symbolizes cultural practices surrounding consumption of herbal infusions. The relevance here extends to advocating traditional drinks utilizing Rheum emodi and promoting wellness, blending traditional knowledge with modern lifestyles, enriching the discourse around herbal medicine as part of daily health practices.

37) Soil:
Soil is the organic material found on the Earth's surface, essential for plant growth. The humus-rich soil in which Rheum emodi thrives contributes to its phytochemical content, thus impacting the efficacy of the plant's extracts, emphasizing the interconnection between environmental conditions and the quality of medicinal herbs.

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Medicinal plant, Antioxidant activity, Phytochemistry, Pharmacological activities, Phytochemical screening, Preclinical studies, Traditional use, Hepatoprotective activity, Antidiabetic activity, Antifungal activity, Nephroprotective Activity, Nephroprotective, Anticoagulant activity, Antiulcer activity, Antiplatelet activity, Ayurveda and Unani, Potent antioxidant, Pharmacopeia.

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