A critical review on nanoparticle synthesis
physicochemical v/s biological approach
Journal name: World Journal of Pharmaceutical Research
Original article title: A critical review on nanoparticle synthesis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: physicochemical v/s biological approach
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Rajesh Singh Tomar, Pallavi Singh Chauhan & Vikas Shrivastava
World Journal of Pharmaceutical Research:
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Full text available for: A critical review on nanoparticle synthesis
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Nanotechnology is an innovative field focusing on the development and application of materials at the nanoscale, typically ranging from 1 to 100 nanometers. The synthesis of nanoparticles has garnered significant research interest due to their unique properties and diverse applications, particularly in biomedicine, electronics, and material science. This review article explores different methods of nanoparticle synthesis, emphasizing the advantages of biological approaches over traditional physical and chemical methods, which often involve hazardous chemicals and complex processes.
Biological Synthesis of Nanoparticles
One of the essential concepts discussed in the article is the biological synthesis of nanoparticles, which employs natural resources such as microorganisms, plants, and enzymes. This eco-friendly method is cost-effective and leads to low-energy consumption during the synthesis process, eliminating toxic by-products. Microorganisms, including bacteria and fungi, can reduce metal ions to form nanoparticles by using specific enzymes such as NADH-dependent reductase. Additionally, plants exhibit a remarkable ability to synthesize nanoparticles using their metabolites, making this method a viable alternative to classical approaches.
Top-down and Bottom-up Approaches
The synthesis of nanoparticles can be categorized into two primary approaches: the "Top-down" and "Bottom-up" methods. The Top-down approach involves breaking down bulk materials into nanoscale particles using techniques like grinding and milling. Conversely, the Bottom-up approach focuses on assembling nanoparticles from atoms or molecules, facilitating self-assembly into functional structures. Both methods present unique advantages and challenges, including control over nanoparticle size, shape, and purity, which are crucial for their intended applications.
Characterization of Nanoparticles
Another crucial concept highlighted in the review is the characterization of nanoparticles, which is essential to understand their structural, optical, and thermal properties. Various techniques are employed for characterization, including X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-visible spectroscopy, and Fourier Transform Infrared Spectroscopy (FTIR). Each technique provides valuable insights into the nanoparticles' morphology, size distribution, and chemical composition, aiding in their targeted application in fields like medicine and electronics.
Conclusion
In conclusion, the successful synthesis and application of nanoparticles depend significantly on choosing appropriate methods that minimize environmental impact. This review underscores the potential of biological synthesis techniques as sustainable alternatives to traditional methods. By harnessing natural biological processes, researchers can achieve environmentally friendly approaches to producing nanoparticles that meet the diverse needs of modern technology, particularly in biomedical applications. The development of innovative solutions in nanoparticle synthesis is imperative for future advancements in various scientific fields.
FAQ section (important questions/answers):
What is nanotechnology and its significance in material production?
Nanotechnology involves the design, production, and application of materials at the nanoscale, allowing for enhanced control over the properties of materials, which opens up numerous applications across various scientific and technological fields.
What are the two main approaches to synthesizing nanoparticles?
Nanoparticle synthesis can be classified into two main approaches: the 'Top-down' process, which involves breaking down bulk materials, and the 'Bottom-up' process, where atoms self-assemble to form nanoparticles.
What are Janus particles, and why are they important?
Janus particles have distinct hydrophilic and hydrophobic surfaces, allowing them to stabilize emulsions effectively. They can self-assemble at water/oil interfaces and mimic solid surfactants, which is beneficial in various applications.
How do biological synthesis methods differ from chemical synthesis methods?
Biological synthesis methods use living organisms or extracts to produce nanoparticles, offering eco-friendly and cost-effective alternatives to traditional chemical methods, which often involve hazardous materials and complex procedures.
What are some key applications of nanoparticles in biomedicine?
Nanoparticles are used in biomedicine for drug delivery, antimicrobial assays, tumor targeting, and enhancing MRI contrast. Their unique properties enable effective interaction with biological systems for improved health outcomes.
Why is there a growing interest in eco-friendly nanoparticle synthesis methods?
There is increasing awareness of the environmental impact of traditional nanoparticle synthesis. Eco-friendly approaches, such as biological methods, are sought to reduce toxicity and improve sustainability while maintaining efficiency in production.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A critical review on nanoparticle synthesis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Surface:
In nanotechnology, the 'surface' refers to the area of nanomaterials that is exposed to their environment. As nanoparticles decrease in size, the surface area to volume ratio increases, leading to enhanced reactivity, catalytic properties, and interactions with biological systems, which are crucial for applications like drug delivery and diagnostics.
2) Wall:
The 'wall' in the context of nanoparticles often refers to the structure that contains or interacts with the nanoparticles, such as the cell wall in microorganisms or the containment vessel in synthesis processes. Understanding the properties of these walls is essential for enhancing nanoparticle synthesis efficiency and functionality.
3) Gold (Golden):
Gold is a highly researched and favored material in nanoparticle synthesis due to its unique optical, electronic, and catalytic properties. Gold nanoparticles are used in various biomedical applications, including drug delivery, imaging, and as contrast agents, making them a critical component in nanomedicine and diagnostics.
4) Silver:
Silver nanoparticles are well-known for their antibacterial properties, making them invaluable in medical and healthcare-related applications. They are used in wound dressings, coatings, and various consumer products to prevent bacterial growth, thus highlighting their importance in improving sanitation and promoting healing.
5) Water:
Water serves as a fundamental medium in both biological and chemical nanoparticle synthesis. It can act as a solvent for reactants, a reducing agent, or a vehicle for transporting nanoparticles. Its role is critical in determining the properties and stability of synthesized nanoparticles.
6) Drug:
In the context of nanoparticles, 'drug' refers to therapeutic agents whose delivery can be enhanced using nanotechnology. Nanoparticles can encapsulate drugs, improving their bioavailability, targeting specific tissues, and controlling release rates. This makes nanoparticles a vital tool in modern medicine, particularly in oncology and targeted therapies.
7) Activity:
The term 'activity' refers to the various biological and chemical functions exhibited by nanoparticles, such as antibacterial, antifungal, or catalytic actions. Understanding these activities is essential for developing effective nanoparticle applications in therapeutic contexts, diagnostics, and environmental remediation.
8) Field:
Field refers to the broad area of study and application in which nanoparticles are utilized. This includes cross-disciplinary areas like medicine, materials science, and environmental engineering. Research in these fields focuses on the synthesis, characterization, and application of nanoparticles for innovative solutions.
9) Gwalior:
Gwalior is a city in India that houses the Amity Institute of Biotechnology, where significant research on nanoparticles is conducted. It serves as the location for academic initiatives that explore nanotechnology's potential in various applications, establishing the region as a center for scientific advancement.
10) Salt (Salty):
In nanoparticle synthesis, 'salt' often refers to metallic salts used as precursors. These salts, when reduced, can lead to the formation of metal nanoparticles. Understanding the chemical behavior of these salts is crucial for developing effective procedures for nanoparticle generation.
11) Transformation (Transform, Transforming):
Transform refers to the process of changing one state or form into another, which is fundamental in the synthesis of nanoparticles. This can involve converting bulk materials or molecular precursors into nanoparticles through various methods, illustrating the versatility and effectiveness of nanotechnology.
12) Chauhan:
Chauhan refers to Dr. Pallavi Singh Chauhan, one of the authors contributing to the research on nanoparticle synthesis. Her work underscores the collaborative efforts in academia to advance our understanding of nanotechnology and its applications, highlighting the role of scientists in developing innovative solutions.
13) Powder:
In the context of nanotechnology, 'powder' typically describes the form in which nanoparticles can be produced and stored. Powders of nanoparticles allow for easy handling and integration into various applications, including coatings, composites, and pharmaceuticals, reinforcing their significance in manufacturing processes.
14) Antibiotic (Antibacterial):
Antibacterial properties are critical for nanoparticles, particularly those composed of silver or other metals. These properties are harnessed in medical applications, such as wound dressings and coatings, to prevent infection and promote healing, showcasing the functional benefits of utilizing nanoparticles in healthcare.
15) Transmission:
Transmission in the context of nanotechnology often refers to transmission electron microscopy (TEM), a vital characterization technique used to analyze the structure and morphology of nanoparticles. This technique provides detailed insights into size, shape, and distribution, essential for optimizing nanoparticle applications.
16) Purification:
Purification is an important step in the synthesis of nanoparticles, ensuring that the final product is free from contaminants and unreacted precursors. High levels of purity are critical for consistent performance in applications, particularly in biomedical uses where the presence of impurities can affect safety and efficacy.
17) Srivastava (Sri-vastava, Shrivastava, Shri-vastava):
Shrivastava refers to Dr. Vikas Shrivastava, a key author in the research on nanoparticle synthesis. His contributions emphasize the importance of collaborative research in advancing nanotechnology, facilitating new discoveries and applications across various fields.
18) Container:
A 'container' in nanoparticle synthesis refers to the vessel used to hold the reactants during the synthesis process. The material and design of the container can influence the reaction conditions and the properties of the resulting nanoparticles, highlighting the need for careful selection in experimental setups.
19) Heating:
Heating is a common technique employed in nanoparticle synthesis, often used to facilitate reactions or control the physical state of materials. Proper heating methods can significantly affect nanoparticle size and morphology, making it a critical parameter in optimizing synthesis processes.
20) Science (Scientific):
Scientific pertains to the rigorous methodology employed in nanotechnology research. This includes hypothesis formulation, experimentation, and validation of results, ensuring that findings are based on reliable evidence and reproducibility, which are essential for advancing knowledge in the field.
21) Purity:
Purity in the context of nanoparticles refers to the absence of contaminants and undesired substances in the synthesized nanoparticles. Achieving high purity is vital for reliable performance in applications, especially in biomedical contexts, where contaminants may lead to adverse effects or reduced efficacy.
22) Nature:
Nature encompasses the biological resources used in the synthesis of nanoparticles, particularly through green chemistry methods. Utilizing natural processes and materials contributes to environmentally friendly practices in nanoparticle production, reducing reliance on harmful chemicals and promoting sustainability.
23) Medium:
In nanoparticle synthesis, 'medium' refers to the environment in which the reacted materials are processed. This includes the solvent or solution used, which can significantly influence the reaction dynamics, particle formation, and final properties of the nanoparticles, making the choice of medium critical.
24) Filling (Filled):
Filled often describes how a container is used in the synthesis of nanoparticles, where it is filled with reactants and solvents. Proper filling ensures adequate mixing and interaction of materials, essential for achieving the desired reaction outcomes and uniformity in nanoparticle production.
25) Study (Studying):
The 'study' refers to the systematic investigation of nanoparticle synthesis, focusing on methodologies, properties, applications, and implications. Such studies contribute to the growing knowledge base in nanotechnology, fostering innovations and discoveries that can have significant societal impacts.
26) Cage:
Cage refers to structures such as fullerenes in nanotechnology, which are spherical arrangements of carbon atoms. These unique molecular structures possess distinct properties that have valuable applications in materials science, electronics, and nanomedicine, showcasing the potential of nanoscale designs.
27) Observation:
Observation in the context of nanoparticle synthesis and characterization refers to the careful examination of physical and chemical properties. Techniques like microscopy and spectroscopy are used to observe nanoparticles, enabling researchers to understand their behavior and optimize synthesis routes.
28) Metallurgy:
Metallurgy, the study of metals and their properties, plays a significant role in the synthesis of metal nanoparticles. Understanding the principles of metallurgy can lead to better control over the size, shape, and properties of nanoparticles, enhancing their functionality in various applications.
29) Discussion:
Discussion typically refers to the analytical portion of research where results, methodologies, and implications are explored. In nanoparticle research, this can involve comparing different synthesis techniques, their effectiveness, and potential applications in various fields, fostering a deeper understanding of the subject.
30) Attending:
Attending refers to participation in workshops, seminars, or conferences by researchers and students in the field of nanotechnology. Such events are critical for knowledge exchange, collaboration, and the dissemination of new findings, driving the progress of research and innovation.
31) Composite:
Composite materials are formed by combining different substances to enhance properties such as strength, durability, or conductivity. In nanotechnology, composites often incorporate nanoparticles to improve performance, making them essential in creating advanced materials for various applications.
32) Flavonoid:
Flavonoids are a group of natural compounds often involved in the biological synthesis of nanoparticles. Their reducing properties are leveraged to convert metal ions into nanoparticles, showcasing their role in green chemistry and sustainable practices in nanotechnology.
33) Medicine:
Medicine encompasses the application of nanoparticle technology in healthcare, including drug delivery systems, imaging, and diagnostics. Nanotechnology offers innovative solutions to improve patient outcomes, treatment efficiency, and the development of new therapeutic agents.
34) Dressing:
Dressing in a medical context refers to materials used to cover and protect wounds. Nanoparticles incorporated into dressings can enhance their antibacterial properties, promoting faster healing and minimizing infection risks, which is crucial for effective patient care.
35) Relative:
Relative refers to the comparative nature of research findings in nanotechnology. It often highlights the importance of evaluating different methods, materials, or properties to determine the most effective applications and potential advantages or disadvantages in specific contexts.
36) Disease:
Disease refers to conditions that nanoparticle applications aim to improve, particularly in medicine. Nanotechnology holds potential for targeted treatment, early diagnosis, and effective management of diseases, thereby transforming current healthcare practices and enhancing patient care.
37) Species:
Species often refers to different types of microorganisms or plants utilized in the biosynthesis of nanoparticles. Each species can exhibit unique properties and mechanisms for synthesizing nanoparticles, making biodiversity a valuable resource for developing sustainable nanoparticle production processes.
38) Madhya:
Madhya refers to Madhya Pradesh, a state in India where significant research institutions like Amity University are located. This connection emphasizes the regional contributions to advancements in nanotechnology, supporting education and research in this rapidly evolving field.
39) Sharman (Sarma, Sharma, Sarman):
Sharma refers to Lt. Gen. V.K. Sharma, who plays a pivotal role in overseeing research and academic initiatives at Amity University. His leadership fosters a conducive environment for scientific inquiry and advancements in disciplines such as nanotechnology.
40) Kumar:
Kumar typically refers to Dr. Ashok Kumar Chauhan, a prominent figure in the academic and administrative landscape of Amity University. His vision and commitment to research excellence enable significant advancements in fields like nanotechnology and beyond.
41) Glass:
Glass is a material often involved in the synthesis of nanoparticles, particularly in containment or reactor vessels. Understanding the properties of glass ensures safe storage and handling of nanoparticles, which is vital in both research and commercial applications.
42) Sugar:
Sugar, particularly in the form of reducing sugars, can serve as a natural reducing agent in the synthesis of nanoparticles. Its role in facilitating the reduction of metal salts to form nanoparticles highlights the potential for eco-friendly synthesis processes.
43) Pulse:
Pulse refers to the rapid application of energy, such as with laser ablation in nanoparticle synthesis. This technique allows for precise control over nanoparticle formation, enabling researchers to tailor their properties for specific applications.
44) Natan:
Natan relates to Sargassum natans, an alga explored for its properties in nanoparticle synthesis. This marine organism can facilitate the production of nanoparticles, showcasing the potential of utilizing natural resources for sustainable nanotechnology.
45) Janu:
Janu, as a term, typically does not have a specific context within the document's framework. However, it can imply the significance of utilizing local knowledge and resources in biological synthesis methods, reflecting a broader theme of sustainability.
46) Tree:
Tree, symbolically referenced when discussing dendrimers in nanoparticle synthesis, illustrates the branching structure of these synthetic polymers. Dendrimers resemble tree-like structures and are important in drug delivery applications, demonstrating the versatility of nanoscale designs.
47) Boat:
Boat could suggest the containers or vessels like boats used in processes such as physical vapor deposition during nanoparticle synthesis. The context emphasizes the importance of specialized equipment in successfully manipulating materials in nanotechnology.
48) Burning (Burn, Burned, Burnt):
Burn refers to the immediate care for injuries, where nanoparticle-laden dressings can play a crucial role. These advanced dressings can promote healing and reduce infections in burn injuries, showcasing the practical applications of nanoparticles in medical treatments.
Other Science Concepts:
Discover the significance of concepts within the article: ‘A critical review on nanoparticle synthesis’. Further sources in the context of Science might help you critically compare this page with similair documents:
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