"Lekhna Basti vs. Atorvastatin in Dyslipidemia Management Study"

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Journal name: World Journal of Pharmaceutical Research
Original article title: Effect of lekhana basti and tab.atorvastatin in the management of dyslipidemia –a comparative clinical study
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Pooja B.A, Santoshkumar Bhatted, Meera K.Bhojani


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Effect of lekhana basti and tab.atorvastatin in the management of dyslipidemia –a comparative clinical study

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

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Summary of article contents:

Introduction

Dyslipidemia, a lifestyle disorder linked to faulty habits and insufficient physical activity, is characterized by abnormal lipid levels in the blood, leading to various health issues such as coronary heart disease (CHD). In Ayurveda, dyslipidemia is correlated with Medo Dosha and Medoroga, representing an imbalance of fat metabolism due to deranged Agni. The study aims to compare the efficacy of Lekhana Basti, an Ayurvedic treatment, with Atorvastatin, a modern statin, in managing dyslipidemia. The clinical trial involved 60 patients divided into two groups, with assessments of lipid profiles conducted after treatment and follow-up over 90 days.

The Role of Lekhana Basti in Dyslipidemia Management

Lekhana Basti is an Ayurvedic treatment designed to correct imbalances in Vata Dosha, which plays a crucial role in the pathogenesis of Medoroga. The treatment involves the administration of specially prepared enemas that utilize various herbal ingredients known for their lipid-lowering properties. In this study, a modified Kala Basti schedule was followed, incorporating more Niruha Basti (cleansing enemas) than Anuvasana Basti (oleation enemas) to maximize therapeutic effect. The results demonstrated a significant reduction in serum cholesterol, triglycerides, LDL, and VLDL levels, indicating that Lekhana Basti effectively manages dyslipidemia while subduing the underlying conditions associated with abnormal lipid metabolism.

Analysis of Statins in Treating Dyslipidemia

Atorvastatin, a commonly prescribed statin, serves as the modern counterpart to the traditional Ayurvedic treatment. Statins work primarily by inhibiting the enzyme HMG-CoA reductase, which is crucial in cholesterol synthesis in the liver. While Atorvastatin is effective in lowering lipid levels, its long-term use can introduce potential adverse effects, including myopathy and cognitive issues. In the clinical trial, patients taking Atorvastatin also showed significant reductions in cholesterol and triglycerides, although the results indicated that the traditional Ayurvedic method of Lekhana Basti offered comparable, if not superior results in some cases, particularly regarding overall lipid profile improvement.

The Statistical Impact of Treatment Efficacy

The comparative analysis revealed that both treatments yielded significant results in lowering lipid levels, but the statistical performance indicated that Lekhana Basti (Group A) provided better outcomes than Atorvastatin (Group B). For instance, in terms of serum cholesterol reduction, the results were statistically significant, emphasizing the potential of Ayurveda in treating dyslipidemic conditions effectively. The study highlighted the importance of integrating both traditional and modern health practices, showcasing how Ayurvedic approaches can complement current medical treatments.

Conclusion

In conclusion, dyslipidemia, with its associations to severe health risks, necessitates effective management strategies. The study illustrates that Lekhana Basti is a promising option in correcting lipid profiles, particularly in its ability to reduce total cholesterol and improve overall metabolic function. Compared to Atorvastatin, Lekhana Basti not only provides a holistic approach but also addresses the root causes related to Vata Dosha imbalances, emphasizing the relevance of Ayurvedic treatments in contemporary health care. The findings advocate for further research and integration of Ayurvedic practices within modern therapeutic frameworks to enhance patient outcomes in managing dyslipidemia and related disorders.

FAQ section (important questions/answers):

What is the purpose of the study on Lekhana Basti and Atorvastatin?

The study aimed to compare the effectiveness of Lekhana Basti, an Ayurvedic treatment, with Atorvastatin, a modern statin medication, in managing dyslipidemia, a disorder related to abnormal lipid levels.

What are the diagnostic criteria for dyslipidemia in the study?

The criteria included abnormal serum lipid levels and clinical features like fatigue, shortness of breath, sweating, and heaviness in extremities, indicating the presence of dyslipidemia and Medoroga.

How many patients were involved in the clinical study?

A total of 60 patients diagnosed with dyslipidemia were selected for the study, divided into two groups of 30 patients each.

What treatments were administered to the two study groups?

Group A received Lekhana Basti, while Group B was prescribed Atorvastatin 10 mg once daily. The study lasted for 90 days.

What were the key findings regarding lipid profiles post-treatment?

The study found significant reductions in serum cholesterol, triglycerides, LDL, and VLDL levels in both groups, with Lekhana Basti showing better results compared to Atorvastatin.

What are the implications of the study's findings?

The results suggest that Lekhana Basti may be more effective than Atorvastatin for treating dyslipidemia, offering a potentially safer and more natural alternative in lipid management.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “"Lekhna Basti vs. Atorvastatin in Dyslipidemia Management Study"”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Basti:
Basti is a therapeutic procedure in Ayurveda that involves the administration of medicinal solutions into the rectum. It is primarily used to balance Vata dosha and is essential in the management of various conditions, particularly those related to imbalances in fat metabolism, manifesting as diseases like Dyslipidemia.

2) Lekhana:
Lekhana refers to a therapeutic Ayurvedic approach aimed at scraping or reducing excess bodily substances, particularly Medo Dhatu (fat tissue). In the context of the study, Lekhana Basti is used to manage Dyslipidemia by promoting the reduction of harmful lipids in the blood.

3) Dosha (Dosa):
In Ayurveda, Dosha refers to the three fundamental energies (Vata, Pitta, and Kapha) that govern physiological processes. An imbalance in these doshas can lead to health issues. The study focuses on the role of Vata and Kapha dosha in the development of Dyslipidemia.

4) Vata:
Vata is one of the three doshas in Ayurveda, representing qualities associated with air and space, such as movement and dryness. An imbalance of Vata is crucial in conditions like Dyslipidemia, as it affects the body’s ability to metabolize fats and affects digestion and elimination processes.

5) Drug:
In modern medicine, a drug refers to a substance used to diagnose, treat, or prevent disease. Within the study, Atorvastatin is referenced as a pharmaceutical drug for managing Dyslipidemia, highlighting the contrast between conventional and Ayurvedic treatment approaches in lipid management.

6) Vatadosha (Vatadosa, Vata-dosha):
Vata-dosha specifically refers to the combination of qualities and attributes associated with Vata. Disorders related to Vata-dosha can affect bodily processes, leading to conditions like Dyslipidemia. Understanding Vata-dosha is essential for formulating treatment strategies that involve balancing this energy.

7) Disease:
A disease signifies a pathological condition of a bodily part, system, or organism resulting from various causes. Dyslipidemia is defined as an abnormal lipid profile, which can lead to serious health issues such as cardiovascular diseases, highlighting the importance of managing lipid levels.

8) Pooja:
Pooja is the name of the lead author of the study, a Ph.D. scholar involved in research at the National Institute of Ayurveda. Her contributions are fundamental to the understanding of Ayurvedic treatments for Dyslipidemia, combining traditional and modern medical insights.

9) Dravya:
Dravya refers to the medicinal substances or herbal compounds used in Ayurveda for treatment. In the context of the study, various dravyas like Triphala Taila and other herbal combinations play a crucial role in the formulation of Lekhana Basti.

10) Medoroga (Medas-roga):
Medo-roga signifies disorders related to excessive fat accumulation or metabolic dysfunction. The study centers on understanding Medo-roga concerning Dyslipidemia and emphasizes treating it through Ayurveda's holistic approaches.

11) Dhatu:
Dhatu are the seven fundamental tissues in Ayurveda that are essential for maintaining health. Medo dhatu, specifically, pertains to fat and lipid tissue. The study correlates Dyslipidemia to an abnormal state of Medo dhatu, emphasizing the need for therapeutic interventions.

12) Niruhabasti (Niruha-basti):
Niruha-basti is a type of Basti therapy that involves administering a decoction or medicated liquid to cleanse and eliminate excessive dosha or fat in the body. It is employed in the study as part of Lekhana Basti to treat Dyslipidemia.

13) Bastikarman (Bastikarma, Basti-karman, Basti-karma):
Basti-karma refers to the therapeutic procedure of performing Basti, which is fundamental in Ayurvedic detoxification and treatment protocols. It is highlighted in the study as a vital component in managing Dyslipidemia caused by imbalances in fatty tissue metabolism.

14) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating in India, focusing on balancing the body’s energies. Its principles guide treatment approaches in the study, which contrasts Ayurvedic methods like Lekhana Basti with conventional treatments for lipid disorders.

15) Niruha:
Niruha refers to the medicated enema procedure that facilitates detoxification and cleansing of bodily channels. In the context of Lekhana Basti, it contributes significantly to the reduction of lipid levels and is integral to the treatment of Dyslipidemia.

16) Karma (Karman):
Karma in Ayurveda refers to therapeutic actions or interventions aimed at restoring balance and health. The study involves various karmas such as Basti and dietary adjustments designed to alleviate Dyslipidemia by addressing Vata and Kapha dosha.

17) Study (Studying):
The study represents a comparative clinical trial aimed at evaluating the effectiveness of Lekhana Basti versus Atorvastatin in managing Dyslipidemia. It explores both Ayurvedic and modern treatment approaches to provide insights into lipid management.

18) Anuvasanabasti (Anuvasana-basti):
Anuvasana-basti is a type of Basti involving the retention of oil-based substances in the rectum for therapeutic purposes. In the context of the study, it is employed to complement Niruha-basti and manage Vata imbalance, critical for treating Dyslipidemia.

19) Anuvasana:
Anuvasana specifically relates to the retention enema therapy used to nourish and balance the body's doshas, especially Vata. It forms part of the dual approach in Basti therapy aimed at improving conditions like Dyslipidemia.

20) Triphala (Tri-phala):
Triphala is a well-known herbal formulation in Ayurveda composed of three fruits. It is used for its synergistic benefits on digestion and lipid metabolism and plays a key role in the Basti administered in the study to regulate lipid levels.

21) Life:
Life refers to the everyday experiences and lifestyle choices that influence health. The study emphasizes the impact of modern lifestyles on dyslipidemia, highlighting how diet and physical activity contribute to the prevalence of lipid disorders in society.

22) Jaipur:
Jaipur is a city in Rajasthan, India, and the location of the National Institute of Ayurveda, where the study is conducted. The geographical and cultural context of Jaipur is relevant for understanding lifestyle factors contributing to Dyslipidemia in the local population.

23) Rajasthan:
Rajasthan is a state in India where the study takes place. It represents the cultural backdrop influencing the dietary habits and lifestyle factors that contribute to the prevalence of Dyslipidemia and the responsiveness to Ayurvedic treatments.

24) Taila (Thaila):
Taila refers to oil, specifically medicated oil in Ayurveda used in various treatments and therapies. In Lekhana Basti, the use of Triphala Taila serves therapeutic purposes to support lipid metabolism and address Vata dosha imbalances.

25) Food:
Food represents the dietary intake that significantly impacts health. In the study, dietary modifications alongside Ayurvedic therapies aim to address dyslipidemia, showcasing the critical link between nutrition, Ayurvedic treatment, and overall health outcomes.

26) Saindhavalavana (Saindhava-lavana, Saimdhavalavana):
Saindhava-lavana, or rock salt, is used in Ayurvedic formulations due to its beneficial properties. It enhances the efficacy of Basti dravyas and assists in the treatment of conditions related to excess Kapha and Medo dhatu.

27) Samshodhana (Samsodhana):
Samshodhana refers to the process of purification or detoxification in Ayurveda. It encompasses various therapies including Basti that aim to eliminate toxins from the body, making it fundamental in treating Dyslipidemia and restoring metabolic balance.

28) Yavakshara (Yava-kshara, Yavaksara):
Yavakshara is an herbal alkaline preparation used in Ayurvedic medicine. Its addition to Basti formulations provides therapeutic benefits for lipid management, allowing for more effective treatment of Dyslipidemia by influencing metabolic processes.

29) Saindhava (Saimdhava):
Saindhava, synonymous with Saindhava-lavana, refers to rock salt. This ingredient is commonly included in Ayurvedic treatments for its ability to support digestion and enhance the action of herbal mixtures used in Basti therapies.

30) Gomutra (Go-mutra):
Gomutra, or cow urine, is utilized in various Ayurvedic treatments. Its role in Lekhana Basti underscores the holistic approach of Ayurveda in managing dyslipidemia through natural substances believed to contribute to lipid reduction and metabolic regulation.

31) Lavana:
Lavana, meaning salt, is highlighted for its therapeutic properties in Ayurveda. Particularly, Saindhava-lavana is used to balance bodily functions and promote the efficacy of Basti therapies in treating lipid-related disorders like Dyslipidemia.

32) Nature:
Nature encompasses the intrinsic qualities and attributes of substances in Ayurveda. The study refers to the natural actions of various herbs and preparations that contribute to the therapeutic effects seen in treatments for Dyslipidemia.

33) Kapha:
Kapha is one of the three doshas associated with earth and water elements in Ayurveda. Together with Vata, Kapha is considered in the pathophysiology of Dyslipidemia, influencing fat metabolism and necessitating holistic treatment approaches.

34) Honey:
Honey or Madhu, is highlighted in the study as an ingredient in the Basti formulation due to its medicinal properties, particularly its ability to reduce cholesterol and triglyceride levels while possessing a soothing effect on the digestive system.

35) Table:
In the study, tables present numerical data related to patient demographics and treatment outcomes. This structured presentation of findings is critical for analyzing the efficacy of Lekhana Basti compared to Atorvastatin in managing Dyslipidemia.

36) Agni:
Agni represents the digestive fire in Ayurveda, essential for healthy metabolism. The concept of Agni Vaishamya is key in understanding Dyslipidemia, as impairment in Agni leads to ineffective digestion and accumulation of fat in the body.

37) Kala:
Kala refers to the time period or schedule in which certain treatments are administered. In this study, a modified Kala Basti schedule was employed to optimize the effects of Lekhana Basti in managing Dyslipidemia.

38) Yashtimadhu (Yastimadhu, Yashti-madhu):
Yastimadhu, or licorice root, is known for its therapeutic properties in Ayurveda, particularly its role in balancing lipid levels. Its inclusion in Lekhana Basti contributes to the holistic treatment of Dyslipidemia by supporting metabolic functions.

39) Green gram:
Green gram is a nutritious legume mentioned in dietary recommendations during the study. As a light and easily digestible food, it is advised in post-Basti diets to support recovery and complement the efficacy of the treatment.

40) Shilajatu (Silajatu, Shila-jatu):
Shilajatu, a mineral pitch found in the Himalayas, is utilized in Ayurveda for its rejuvenating properties. Its inclusion in Basti formulations is believed to enhance lipid metabolism, playing a significant role in treating Dyslipidemia.

41) Sthaulya:
Sthaulya is a term referring to obesity or excess body weight in Ayurveda, which can be associated with imbalances in Medo dhatu. The study recognizes Sthaulya as a condition relevant to the development of Dyslipidemia and explores treatment options.

42) Kaphaja:
Kaphaja refers to ailments arising from an imbalance in Kapha dosha. In the context of Dyslipidemia, Kaphaja characteristics, including sluggish metabolism and fat accumulation, are crucial in shaping treatment strategies such as Lekhana Basti.

43) Tikshna (Tiksna):
Tikshna refers to qualities that are sharp and penetrating in Ayurvedic formulations. Its inclusion in treatments indicates effects such as enhanced absorption and action at therapy sites, playing a crucial role in managing lipid disorders.

44) Channel:
In Ayurveda, channels refer to the pathways through which substances circulate in the body, including blood and lymphatics. Understanding the pathways is crucial to addressing conditions like Dyslipidemia and ensuring effective therapeutic interventions.

45) Vikara:
Vikara signifies abnormal changes or afflictions that occur within the body. The correlation between Vikara and conditions like Dyslipidemia underscores the need to identify and treat underlying imbalances, restoring health through appropriate modalities.

46) Bhasma (Bhasman):
Bhasma refers to calcined herbal substances used in Ayurveda for their medicinal properties and effectiveness. Their role in formulations often enhances the action of treatments, specifically in managing Dyslipidemia and other metabolic disorders.

47) Kvatha:
Kvatha is a decoction made by boiling herbs in water, utilized in Ayurvedic therapies for its medicinal properties. In the study, Kvatha forms part of the Basti formulations, contributing to its therapeutic outcomes in Dyslipidemia management.

48) Srotas (Shrotas):
Srotas signifies channels or passages in the body through which bodily substances flow. Patency of Srotas is crucial for maintaining metabolic balance, and their obstruction can lead to disorders like Dyslipidemia, necessitating cleansing therapies.

49) Reason:
Reason refers to the underlying causes or mechanisms of a condition. The study seeks to address the reasons for Dyslipidemia from both Ayurvedic and modern perspectives to formulate effective treatment strategies.

50) Kalka:
Kalka refers to a paste form of medicinal herbs utilized in Ayurvedic treatments. The preparation of Kalka contributes to the therapeutic efficacy of Basti formulations, particularly in addressing lipid metabolism issues linked to Dyslipidemia.

51) Hingu (Himgu):
Hingu, or asafoetida, is an ingredient known for its digestive properties in Ayurveda. Its inclusion in formulations is aimed at enhancing digestive function, aiding in the overall treatment of Dyslipidemia through improved metabolism.

52) Water:
Water is essential for the preparation of various Ayurvedic formulations, including Basti. It serves dual purposes of medium and solvent, facilitating the absorption of medicinal properties while also assisting the body's cleansing process.

53) Blood:
Blood represents the bodily fluid that supports life by transporting oxygen and nutrients. In the context of Dyslipidemia, the lipid profile of the blood is critical for assessing health and determining the effectiveness of treatments.

54) Roga:
Roga generally signifies a disease or illness in Ayurveda. This term emphasizes the aim of the study to explore treatments for Dyslipidemia, presenting both a condition requiring intervention and an opportunity for healing.

55) Rasa (Rasha):
Rasa refers to the taste, essence, or quality of a substance in Ayurveda. Understanding the Rasa of various treatments aids practitioners in selecting appropriate herbs and ingredients for managing conditions like Dyslipidemia.

56) Gana:
Gana is a classification used in Ayurveda to group herbs based on similar qualities and therapeutic effects. This classification helps practitioners in formulating effective treatments for various conditions, including Dyslipidemia.

57) Rice (Rce):
Rice is a staple food that often represents dietary choices. In the study, it emphasizes dietary modifications in the management of Dyslipidemia, showcasing the significance of nutrition in overall health and lipid regulation.

58) Hand:
Hand refers to the human body part often involved in administering treatments or performing procedures. It symbolizes the physical interaction between practitioners, patients, and therapeutic techniques in Ayurveda, highlighting the importance of personalized care.

59) Cow urine (Cow's urine):
Cow urine, or Gomutra, is traditionally used in Ayurvedic medicine for its believed therapeutic properties. The study integrates its use in Basti formulations, underscoring the role of unconventional substances in treating Dyslipidemia.

60) Kshudrashvasa (Ksudrasvasa, Kshudra-shvasa):
Kshudra-shvasa refers to shallow or minor breathing issues, which can manifest as symptoms of Dyslipidemia. Such comorbidities illustrate the systemic effects of lipid disorders and the multifaceted approach needed for treatment.

61) Shatapushpa (Satapuspa, Shata-pushpa):
Shatapushpa is an herb used in Ayurvedic medicine, known for its benefits in digestion. Integrating Shatapushpa into treatments aims to improve digestive health, which is essential in correcting metabolic disorders like Dyslipidemia.

62) Angagaurava (Anga-gaurava):
Angagaurava refers to a feeling of heaviness in the body, often seen in individuals with Dyslipidemia. Such symptoms signal the need for therapeutic measures to relieve excess fat accumulation and restore bodily balance.

63) Svedadhikya (Sveda-adhikya):
Svedadhikya denotes an increase in sweating, which can be associated with metabolic disturbances. Monitoring this symptom in patients with Dyslipidemia provides essential insight into their overall physiological state and treatment response.

64) Atisthaulya:
Atisthaulya refers to the condition of obesity or excessive body weight. The study explores the relationship between Atisthaulya and dyslipidemia, emphasizing the importance of addressing weight-related health concerns for improved outcomes.

65) Kaphadosha (Kaphadosa, Kapha-dosha):
Kapha-dosha represents the dosha associated with structure, stability, and fluid retention. In Dyslipidemia, Kapha-dosha imbalances play a significant role in the accumulation of fat, necessitating targeted therapeutic interventions.

66) Accumulation (Accumulating, Accumulate):
Accumulated refers to the buildup of substances in the body, such as excess lipids in Dyslipidemia. Addressing the issues of accumulation is central to treatment approaches that aim for detoxification and balance.

67) Observation:
Observation refers to the systematic assessment of treatment effects and patient responses in the clinical trial. Accurate observations are essential for determining the effectiveness of treatments like Lekhana Basti versus conventional drugs like Atorvastatin.

68) Shleshmala (Slesmala):
Shleshmala refers to the quality associated with Kapha, indicating a certain heaviness and thickening in the body. The presence of Shleshmala characteristics in patients can signify imbalances contributing to Dyslipidemia, guiding treatment strategies.

69) Pakvashaya (Pakvasaya, Pakva-ashaya):
Pakvashaya denotes the large intestine within the context of Ayurveda. Its role in digestion and elimination is critical for managing conditions like Dyslipidemia as it functions in the excretion of excess fats.

70) Utsahahani:
Utsahahani refers to a feeling of low enthusiasm or fatigue often associated with metabolic disorders. Recognition of Utsahahani in patients with Dyslipidemia highlights how lipid imbalances can affect overall energy levels and motivation.

71) Discussion:
Discussion provides a section within the study where findings are evaluated in the context of existing literature. It serves to clarify the implications of the results and establish a framework for future research directions in dyslipidemia management.

72) Depression:
Depression signifies a mental health condition that can manifest alongside physical ailments, including Dyslipidemia. Understanding the interplay between mood disorders and lipid metabolism is essential for delivering comprehensive care.

73) Prakshepa (Praksepa):
Prakshepa refers to the action of administering herbal preparations in Ayurveda. In the context of the study, the correct prakship of ingredients into Basti formulations is crucial for achieving the desired therapeutic outcomes on lipid levels.

74) Container:
Container refers to the vessel used to prepare and hold medicated solutions for Basti therapies. Choosing the proper container ensures optimal preparation and administration of herbs and ingredients necessary for lipid management treatments.

75) Cleansing:
Cleansing refers to the process of detoxifying the body, integral in Ayurvedic treatments like Basti. The study focuses on cleansing through herbal therapies to remove accumulated lipids and restore balance in patients with Dyslipidemia.

[Note: The above list is limited to 75. Total glossary definitions available: 107]

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Discover the significance of concepts within the article: ‘"Lekhna Basti vs. Atorvastatin in Dyslipidemia Management Study"’. Further sources in the context of Science might help you critically compare this page with similair documents:

Ayurveda, Yashtimadhu, Medoroga, Gomutra, Medodosha, Niruhabasti, Anuvasanabasti, Atisthaulya, Bastikarman, Vatadosha, Saindhavalavana, Medodhatu, Physical exercise, Adverse effect, Kashaya Rasa, Statistical analysis, Follow-up, Inclusion criteria, Exclusion criteria, Clinical trial, Statistically Significant, Basti Dravya, Serum cholesterol, Dyslipidemia, Lipid profile, High-density lipoprotein, Low-density lipoprotein, Cardiovascular disease, Vata dushti, Lifestyle disorder, Lekhana Basti, Lekhna Basti, Very low density lipoprotein, Samshodhana Chikitsa, Serum triglyceride, Atorvastatin, Agni Vaishamya, Serum VLDL, Serum HDL, Triphala Taila, Laghutrayi, Serum LDL, Rooksha Guna, Chedana property, Maharoga Adhyaya, Statin, Kaphaja Nanatmaja Vikara.

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