Hémodya: A Phytomedicine for Managing Sickle Cell Disease in Cameroon
a phytomedecine for sickle cell disease management in cameroon
Journal name: World Journal of Pharmaceutical Research
Original article title: “hémodya”
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Subtitle: a phytomedecine for sickle cell disease management in cameroon
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Agbor A. G.; Kotué T. C.; ; Mouotsouo J. P.; Nanfack P.; Nkam M.;Ngogang Y. J.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: “hémodya”
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Copyright (license): WJPR: All rights reserved
Summary of article contents:
Introduction
Sickle cell disease is a genetic disorder characterized by abnormalities in hemoglobin, leading to significant morbidity and mortality. This condition is prevalent among various populations, particularly in Africa, where approximately 40% of individuals are carriers of the sickle cell gene. The disease results in increased oxidant susceptibility in sickle red blood cells, contributing to complications such as hemolysis and microvascular occlusion. In this context, the study explores "Hémodya," a traditional phytomedicine used in Cameroon for managing sickle cell disease, assessing its antioxidant properties and potential benefits for patients.
Antioxidant Properties of Hémodya
One of the central findings of the study was that “Hémodya” exhibits significant antioxidant activity. This was evaluated through various assays measuring its ability to scavenge free radicals such as DPPH and superoxide. The results indicated that “Hémodya” could effectively reduce the concentration of free radicals, highlighting its potential as a natural antioxidant. Notably, at lower concentrations, "Hémodya" demonstrated a high percentage of radical scavenging, confirming its capability to combat oxidative stress associated with sickle cell disease.
Impact on Lipid Profiles
The study further assessed the effects of "Hémodya" on lipid parameters in the blood of sickle cell patients. Results showed a significant increase in total cholesterol and HDL cholesterol levels after incubation with “Hémodya.” This suggests a potential role of the phytomedicine in mitigating dyslipidemia commonly observed in sickle cell patients. Conversely, it was noted that "Hémodya" reduced the rigidity of erythrocytes by affecting their cholesterol content, which may enhance blood flow and reduce the occurrence of sickle cell crises.
Prevention of LDL Oxidation
Another significant aspect of the study was the evaluation of “Hémodya” in preventing the oxidation of low-density lipoprotein (LDL) cholesterol. Findings demonstrated that “Hémodya” had a notably lower IC50 value compared to the standard antioxidant vitamin E, indicating that a smaller concentration of “Hémodya” was required to inhibit LDL oxidation by 50%. This enhancement in oxidation resistance could be beneficial for managing oxidative stress in sickle cell patients, further establishing “Hémodya” as a compound of interest in therapeutic strategies.
Conclusion
In conclusion, the study supports the traditional use of "Hémodya" as a promising phytomedicine for the management of sickle cell disease. Its antioxidant properties, along with its ability to positively influence lipid profiles and prevent LDL oxidation, offer potential avenues for alleviating the oxidative stress faced by sickle cell patients. The favorable outcomes of "Hémodya" in improving blood parameters and reducing erythrocyte rigidity underscore its relevance in both traditional medicine and as a potential complementary treatment in modern therapeutic approaches to sickle cell disease.
FAQ section (important questions/answers):
What is 'Hémodya' and what is its purpose?
'Hémodya' is a phytomedicine used in Cameroon for managing sickle cell disease, potentially reducing crisis frequency and improving patients' general health.
How does 'Hémodya' demonstrate antioxidant properties?
'Hémodya' shows antioxidant activity by scavenging free radicals and reactive oxygen species, and it prevents LDL cholesterol oxidation more effectively than alpha tocopherol.
What are the key components present in 'Hémodya'?
'Hémodya' contains phenolic compounds such as gallic and catechic tannins, flavonoids, and alkaloids, which contribute to its medicinal properties.
What effects does 'Hémodya' have on lipid levels in patients?
'Hémodya' significantly increases plasma total cholesterol and HDL cholesterol levels while reducing membrane lipids, improving fluidity of sickle red blood cells.
What was the method used to study 'Hémodya's' effects?
The study involved incubating blood samples from sickle cell patients with 'Hémodya' and analyzing lipid parameters and antioxidant activity.
Are there any side effects associated with 'Hémodya'?
According to reports, the oral administration of 'Hémodya' does not induce significant toxic effects in patients.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Hémodya: A Phytomedicine for Managing Sickle Cell Disease in Cameroon”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
The term 'activity' relates to the functional capacity or efficacy of a substance, such as 'hémodya', in exerting effects on biological systems. In the context of the study, it refers to the antioxidant, free radical scavenging, and lipid-modulating effects of 'hémodya' in sickle cell disease management.
2) Disease:
The word 'disease' indicates a pathological condition or disorder affecting normal bodily functions. In this context, it is used to describe sickle cell disease, a genetic disorder characterized by abnormal hemoglobin, leading to complications such as hemolysis and vascular occlusion, significantly impacting patients' health.
3) Blood:
The term 'blood' refers to the vital fluid that circulates in the body, delivering nutrients and oxygen to tissues while removing waste products. In the study, blood samples of sickle cell patients were analyzed to evaluate the effects of 'hémodya' on biochemical parameters and lipid profiles.
4) Study (Studying):
The word 'studying' refers to the systematic investigation or analysis of a subject. In the context of the article, studying refers to the research process employed to evaluate 'hémodya' as a phytomedicine, its effects, and how they contribute to the understanding of sickle cell disease management.
5) Table:
The term 'table' refers to a structured arrangement of data, typically in rows and columns, used to present findings concisely. In the study, tables were utilized to summarize experimental results, such as lipid parameters and radical scavenging activity, aiding in the clear communication of statistical analyses.
6) Science (Scientific):
The word 'science' encompasses the systematic study of the natural world through observation, experimentation, and analysis. In this article, it is relevant as the study leverages scientific inquiry to analyze the phytochemical properties of 'hémodya' and its effects on sickle cell disease treatment.
7) Medicine:
The term 'medicine' pertains to the practice of diagnosing, treating, and preventing illness. In the context of the study, it highlights the role of 'hémodya' as a phytomedicine in managing sickle cell disease, showcasing traditional and complementary approaches to health care in Cameroon.
8) Species:
The word 'species' refers to distinct groups of organisms classified based on shared characteristics. In this study, it indirectly relates to the botanical sources of 'hémodya', which is derived from medicinal plants, each belonging to specific species known for their therapeutic properties.
9) Measurement:
The term 'measurement' involves quantifying properties or behaviors using standardized methods. In the context of the study, measurement techniques are employed to assess lipid parameters, radical scavenging activity, and phenolic content in 'hémodya', providing objective data to support its efficacy in sickle cell management.
10) Genetic disorder:
The phrase 'genetic disorder' describes diseases caused by abnormalities in genetic material. In this study, sickle cell disease is identified as a genetic disorder resulting from mutations affecting hemoglobin structure, leading to clinical complications that the study aims to alleviate through phytomedicine.
11) Phytochemical:
The term 'phytochemical' refers to bioactive compounds derived from plants, often associated with health benefits. In the study, phytochemicals in 'hémodya' are analyzed for their potential antioxidant and therapeutic effects, emphasizing the importance of plant-based remedies in the management of sickle cell disease.
12) Discussion:
The word 'discussion' indicates an analytical conversation that interprets and debates research findings. In the context of this study, the discussion section highlights the implications of 'hémodya's effects on antioxidant activity, lipid profiles, and treatment potential, placing the research within the broader scientific narrative.
13) Developing:
The term 'developing' relates to countries or regions experiencing economic growth or progress, often facing unique health challenges. In this study, it underscores the significance of traditional medicine practices in developing contexts like Cameroon, where 'hémodya' is utilized for managing sickle cell disease.
14) Testimony:
The word 'testimony' refers to personal accounts or evidence provided by individuals. In the study, patient testimonies about 'hémodya' emphasize its perceived benefits in managing sickle cell disease, offering qualitative support to the quantitative research findings regarding its effects on health.
15) Substance:
The term 'substance' denotes a particular kind of matter with distinct properties. In the context of this study, it primarily refers to 'hémodya', whose chemical and biological properties are examined to evaluate its effectiveness as a phytomedicine in treating sickle cell disease.
16) Transformation (Transform, Transforming):
The word 'transform' signifies a significant change in form, appearance, or character. In the study, it relates to the alteration of red blood cell membranes or biochemical parameters induced by 'hémodya', potentially leading to improved functionality in sickle cell patients.
17) Teaching:
The term 'teaching' refers to the act of imparting knowledge or skills. While not directly addressed in the study, it highlights the educational aspect of disseminating findings about 'hémodya' and its effectiveness in managing sickle cell disease to healthcare practitioners and the community.
18) Quality:
The term 'quality' pertains to the standard or degree of excellence of a substance or process. In this study, evaluating the quality of 'hémodya' involves assessing its antioxidant properties and effects on lipid profiles, critical to determining its efficacy in treating sickle cell disease.
19) Account:
The word 'account' refers to a detailed report or narrative of events or experiences. In the context of the study, it may relate to patient experiences or testimonies regarding the effects of 'hémodya', adding qualitative depth to the quantitative findings presented in the research.
20) Water:
The term 'water' is crucial as it serves as a solvent in biological systems. In the study, its role is implied during the extraction and preparation of 'hémodya', highlighting its significance in preparing phytomedicines for therapeutic use in managing conditions like sickle cell disease.
21) Venu:
The term 'venu' likely refers to 'venipuncture', a medical procedure for obtaining blood samples. Its relevance in the study is underscored by the method of collecting blood from sickle cell patients to investigate the effects of 'hémodya', illustrating the procedural aspects of clinical research.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Hémodya: A Phytomedicine for Managing Sickle Cell Disease in Cameroon’. Further sources in the context of Science might help you critically compare this page with similair documents:
Medicinal plant, Traditional medicine, Clinical evaluation, Antioxidant activity, Acute Toxicity Studies, Oxidative stress, Free radical scavenging, Reactive oxygen species, In vitro, Lipid peroxidation, Phenolic compound.