Microsponges as a modified drug delivery system
Journal name: World Journal of Pharmaceutical Research
Original article title: Microsponges as a modified drug delivery system
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Deore Mayuri B, K.S.Salunkhe, G. Pawbake, S.R. Chaudhari and Gaikwad P.R.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Microsponges as a modified drug delivery system
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
Introduction
The field of drug delivery technology is witnessing rapid advancements, particularly with the development of the microsponge delivery system (MDS). This innovative system is designed for the controlled release of drugs, primarily in topical applications, with the aim of maintaining localized drug effects and minimizing systemic absorption. Microsponges are patented porous microspheres that can encapsulate various active ingredients, allowing them to absorb skin secretions and release drugs in a controlled manner. This method addresses the challenges often encountered with conventional topical preparations, such as irritation and limited patient compliance.
Optimized Drug Delivery
One critical feature of the microsponge delivery system is its ability to retain and gradually release active ingredients. Microsponges consist of an interconnected network of tiny pores, which hold the active compounds while allowing for a controlled release over time. This design offers several advantages over traditional topical formulations that can cause drug accumulation and associated side effects. By regulating the release rate of the active ingredients, microsponges provide an efficient means of drug delivery, enhancing the overall therapeutic effect while reducing irritation at the application site.
Versatility and Applications
The microsponge delivery system is remarkably versatile and can accommodate a wide range of active ingredients. This adaptability enables the formulation of various products, including gels, lotions, creams, and powders, suitable for both topical and oral administration. Moreover, the system offers the potential to improve the solubility of poorly water-soluble drugs, thereby increasing their efficacy. Additionally, microsponges can be incorporated into formulations to reduce oiliness on the skin by absorbing excess secretions, further enhancing patient comfort and compliance.
Stability and Safety
Another compelling aspect of microsponges is their stability and safety profile. The microsponge formulations are stable at a wide range of temperatures and pH levels, making them suitable for diverse formulation conditions. Their small pore size protects against bacterial contamination, as these microorganisms cannot penetrate the microsponge structure. This self-sterilizing nature ensures that microsponges can deliver active ingredients without introducing safety concerns related to contamination, thus contributing to their appeal in pharmaceutical and cosmetic applications.
Conclusion
In summary, the microsponge delivery system represents a promising advancement in the realm of drug delivery technologies. By facilitating controlled release, enhancing the stability of formulations, and improving patient compliance, microsponges provide significant benefits over traditional delivery methods. The potential for broad applications, paired with a favorable safety profile, makes this technology an emerging field worth exploring further for pharmaceutical and cosmetic formulations. As research continues, microsponge systems might redefine how active ingredients are delivered to achieve optimal therapeutic outcomes.
FAQ section (important questions/answers):
What are microsponges and how do they function in drug delivery?
Microsponges are porous polymeric microspheres that entrap active ingredients and provide controlled release. They can absorb skin secretions, reducing irritation and ensuring the active ingredients remain localized at the application site.
What advantages do microsponge systems have over traditional topical preparations?
Microsponge systems prevent excessive accumulation of active ingredients, minimizing skin irritation. They offer controlled release, reducing the need for high concentrations of drugs and improving patient compliance due to reduced greasy textures.
What types of active ingredients can be used with microsponges?
Active ingredients must be water immiscible or slightly soluble and stable during polymerization. Common examples include benzoyl peroxide, ibuprofen, and retinol, allowing for versatile application in various therapeutic formulations.
How are microsponges prepared for drug delivery applications?
Microsponges can be prepared using methods like liquid-liquid suspension polymerization or quasi-emulsion solvent diffusion. These methods involve creating a solution of monomer and active ingredients, followed by polymerization to form the porous structure.
What are the key characteristics of an effective microsponge formulation?
An effective microsponge formulation should have stability across a wide pH range, be compatible with various vehicles, and possess the ability to absorb skin secretions while maintaining a high payload of active ingredients.
What are some marketed formulations utilizing microsponge technology?
Marketed formulations include Retin-A-Micro for acne treatment, Carac Cream for actinic keratosis, and Retinol cream aimed at reducing skin irritation. These products benefit from the controlled release properties of microsponge technology.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Microsponges as a modified drug delivery system”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
The term 'Drug' refers to a biologically active compound used for therapeutic purposes, aimed at alleviating illness or symptoms. In the context of microsponge delivery systems, the drug is embedded within the microsponge to enhance controlled release and minimize systemic side effects, addressing challenges of traditional drug delivery methods.
2) Surface:
The 'Surface' refers to the outer layer of the microsponge particles, which is critical as it influences the interaction with the formulation vehicle and skin. The porous nature of the surface allows for gradual release of the active ingredient, enhancing the therapeutic effect while reducing local irritations.
3) Water:
'Water' is a crucial component in many pharmaceutical formulations, particularly in the context of drug solubility and delivery. The presence of water can trigger the release of drugs from microsponges, affecting the dissolution rate and absorption of the therapeutic agents applied topically.
4) Irritation:
'Irritation' highlights a significant concern in dermatological treatments, where traditional formulations might cause adverse reactions on the skin. The microsponge delivery system is designed to minimize irritation while ensuring effective drug release, thus improving patient compliance and overall treatment outcomes.
5) Patel:
'Patel' likely refers to a contributing author and researcher in the field of pharmaceutical sciences. The name appears in the context of various studies and publications revealed in the article, underscoring the collaborative effort in advancing knowledge on microsponge technology and its applications in drug delivery.
6) Nature:
'Nature' alludes to the characteristics or properties of materials, including the microsponge's composition and behavior in various formulations. Understanding the nature of both the active and the delivery system is essential for optimizing therapeutic effects while minimizing unwanted side effects during treatment.
7) Accumulation (Accumulating, Accumulate):
'Accumulation' describes the build-up of active ingredients at the application site, which can lead to irritation or adverse effects. The design of the microsponge delivery system aims to prevent excessive accumulation, ensuring a controlled release that optimizes therapeutic efficacy while reducing potential side effects.
8) Powder:
'Powder' indicates the physical state of the microsponge or active ingredients therein. The microsponge delivery systems can be incorporated into various formulations, including powders, which offer flexibility in application forms for topical therapies. This adaptability is crucial for different therapeutic needs and patient preferences.
9) Medium:
'Medium' pertains to the environment or vehicle in which the microsponge and drug are formulated. The choice of medium impacts the solubility, release rate, and absorption of the active ingredient. It’s essential to select a medium that complements the microsponge's controlled release properties for effective topical therapy.
10) Kumar:
'Kumar' is another name of a contributor recognized in pharmaceutical literature. Researchers like Kumar play a vital role in exploring and enhancing the understanding of microsponge technologies, advocating for innovations that improve drug delivery systems and patient outcomes in the pharmaceutical sector.
11) Table:
'Table' typically refers to organized data representation, possibly displaying information such as the combination of active drugs, polymers, and excipients used in microsponge formulations. Such tabular representations are critical for comparing properties, performance, and classifications, aiding researchers and pharmacists in formulation development.
12) Study (Studying):
'Study' encompasses research activities aimed at understanding the effectiveness and properties of drug delivery systems, including microsponge technology. Studies underpin the scientific evidence supporting the advantages, mechanisms, and applications of microsponge systems in improving therapeutic outcomes in topical medications.
13) Surrounding:
'Surrounding' pertains to the context or environment in which the microsponge system is applied. This can include the skin's surface layers and the effects of its microenvironment on the release profile of active ingredients, significantly influencing the efficiency and effectiveness of drug delivery.
14) Science (Scientific):
'Scientific' denotes the systematic investigation and application of methods to explore and validate theories or concepts within pharmaceutical research. The scientific approach is fundamental to developing and optimizing microsponge delivery systems, drawing on empirical evidence to guide clinical applications and validate findings.
15) Transformation (Transform, Transforming):
'Transform' indicates the potential of microsponge technology to change traditional approaches to drug delivery. By improving the stability, efficacy, and release profiles of medications, these systems can help to revolutionize therapeutic strategies, providing patients with better outcomes and reduced side effects.
16) Amravati:
'Amravati' could refer to a place that is significant in the context of research or publication. It indicates the geographical interest or base of researchers like Amravati-based institutions that contribute to advancements in drug delivery technology and pharmaceutical sciences.
17) Pradhan:
'Pradhan' identifies another author or researcher in the pharmaceutical field. Contributions by researchers like Pradhan highlight collaborative efforts in microsponge technology, emphasizing the importance of teamwork in driving developments and innovations in drug delivery systems.
18) Account:
'Account' relates to documentation or reporting of findings in scientific studies. It can refer to detailed descriptions of methodologies, results, and discussions in research articles that help to convey the advances and discoveries in microsponge technology and its applications.
19) Sharman (Sarma, Sharma, Sarman):
'Sharma' signifies the name of a researcher who likely contributes to the body of literature on drug delivery systems. Collaborative efforts by researchers like Sharma are integral to the scientific community, sharing insights that contribute to improving therapeutic strategies in pharmaceuticals.
20) Saha (Shaha):
'Shaha' is yet another contributor involved in the research and development of drug delivery systems. The presence of authors like Shaha in literature indicates a collaborative effort across different research areas to enhance understanding and application of microsponge technology.
21) Kadam:
'Kadam' refers to a contributing author, emphasizing the collaborative nature of research efforts in pharmaceutical sciences. Involvement by various researchers, including Kadam, is essential for conducting extensive investigations that delve into the nuances of drug delivery mechanisms, including microsponges.
22) Field:
'Field' signifies a specialized area of study within the broader context of pharmaceutical sciences. Research and formulation of microsponge delivery systems fall within this field, focusing on innovative drug delivery technologies that improve the therapeutic efficacy of medications.
23) Svamin (Swami, Svami, Swamin):
'Swami' is another name of a researcher contributing to the literature on drug delivery systems. Recognition of authors like Swami underscores the collective expertise contributing to advancements in pharmaceutical research, particularly in developing controlled release systems such as microsponges.
24) Sah:
'Shah' indicates a contributor involved in the research development of drug delivery systems. The acknowledgment of researchers like Shah within the literature signifies the essential collaborative approach necessary for exploring innovative solutions in pharmaceutical formulations.
25) Wall:
'Wall' can refer to the structural characteristics of the microsponge that contain the active ingredients. The formulation and integrity of the wall affect the release profile of drugs and play a critical role in how effectively the active ingredients are delivered to the targeted site.
26) Gold (Golden):
'Gold' could symbolize the high standards in research and development or possibly refer to techniques like gold-coating for evaluating particle morphology through methods such as scanning electron microscopy (SEM). This detail is crucial for researchers looking to understand the structural properties of microsponges.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Microsponges as a modified drug delivery system’. Further sources in the context of Science might help you critically compare this page with similair documents:
Cosmetic, Bioavailability, Particle size, Bacterial contamination, Cost effective, Active ingredient, Controlled release, Compatibility studies, Chemical stability, ALLERGIC REACTION, Patient compliance, Controlled drug delivery, Marketed formulation, Dissolution studies, Non-toxic, Particle size determination, Drug release profile, Release mechanism, Topical drug delivery, Active drug, Aqueous phase, Non-Mutagenic, Pore size, Topical gel, Polymerization process, Innovative drug delivery system, Non irritating.