A review on bhasma kalpana andamp; standardization of tamra bhasma

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Journal name: World Journal of Pharmaceutical Research
Original article title: A review on bhasma kalpana & standardization of tamra bhasma
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Dikshit Manishha and Saxena GK


World Journal of Pharmaceutical Research:

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Full text available for: A review on bhasma kalpana & standardization of tamra bhasma

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research


Summary of article contents:

Introduction

The pharmaceutical process of Sanskara in Ayurveda emphasizes the transformation of metals and minerals into medicinal forms known as Bhasmas, which are finely processed ashes obtained from incinerated materials. This comprehensive review, authored by Dikshit Manishha and Saxena GK, focuses specifically on Tamra Bhasma (copper ash) and the methods to standardize this ancient remedy. The article discusses the various purification (Shodhana) and incineration (Maarana) techniques that enhance the therapeutic qualities of the metals, ensuring their bioavailability and efficacy for medicinal use.

The Concept of Bhasma Kalpana

Bhasma Kalpana refers to the intricate preparation process of converting metals and minerals into clinically effective forms through purification and calcination. The text highlights that Bhasmas underwent multiple stages of purification (Shodhana) to remove impurities, both physically and chemically. Each metal, once purified, is subjected to the process of Maarana, which involves the burning and transformation into nano-sized particles. This size reduction significantly boosts absorption and assimilation in the body, making metallic remedies potent yet administered in minimal doses.

Importance of Standardization

The article stresses the necessity of standardizing Bhasmas to confirm their purity, quality, and therapeutic efficacy. Various physical and chemical tests are essential in this standardization process. Examples of such tests include the ability of Bhasma to float on water, maintain luster, and pass certain chemical reactions with other materials. Furthermore, methods such as atomic absorption spectrophotometry and thin-layer chromatography are proposed to ensure the quality of the final products, with Tamra Bhasma serving as a case study in the review.

The Process of Tamra Bhasma Preparation

The preparation of Tamra Bhasma follows classical methods outlined in Rasa Tarangini and Rasa Ratna Samuchhay. Initially, the copper undergoes Shodhana by dipping in various herbal liquids, followed by Maarana, which involves incinerating layered pellets in a controlled environment. The results from the incineration process reveal that upon completion, the Bhasma transforms into a compost with unique properties, suitable for therapeutic use. The review emphasizes not only the importance of these methods but also the outcomes that confirm the Bhasma's quality for medicinal purposes.

Conclusion

The article concludes that understanding the manufacturing processes of Bhasmas, particularly Tamra Bhasma, is essential for ensuring safety, efficacy, and uniformity in traditional medicinal practices. The detailed processes of purification and calcination significantly enhance the therapeutic qualities of these minerals and metals. The necessity for modern analytical techniques to standardize Bhasmas is underscored, creating a foundation for confidence in their use while leveraging historical knowledge for contemporary medical needs. This standardization ultimately aims at establishing Bhasmas as legitimate and effective components of Ayurvedic treatment regimens.

FAQ section (important questions/answers):

What is the significance of Bhasma Kalpana in Ayurveda?

Bhasma Kalpana refers to the preparation of Bhasma, an ash obtained from incinerated metals and minerals. It enhances drug efficacy, bioavailability, and is processed through purification and calcination, making it an important aspect of Ayurvedic medicinal practices.

What are the common processes involved in Bhasma preparation?

The preparation involves Shodhana (purification) and Maarana (calcination) processes. Shodhana eliminates impurities while Maarana transforms the material into nano-sized particles, which improve absorption and therapeutic effects.

What is Tamra Bhasma and its medicinal uses?

Tamra Bhasma is prepared from copper and is used to treat liver disorders, arthritis, and leucoderma. Its properties include being sweet and astringent, which balance the body's doshas.

How is the quality of Bhasma determined?

Quality control involves various tests, including physical tests for particle size and chemical tests to analyze for heavy metals. Techniques like thin-layer chromatography and atomic absorption spectrophotometry ensure safety and efficacy.

How is Shodhana different from Maarana in Bhasma preparation?

Shodhana focuses on purifying the raw materials, removing physical and chemical impurities. Maarana, on the other hand, involves calcination, reducing the size of the particles to enhance their medicinal properties.

Why is standardization of Bhasma important in Ayurvedic medicine?

Standardization ensures consistency in potency, safety, and efficacy of Bhasma. It builds confidence among practitioners and users regarding the medicinal use of these preparations, ensuring they meet quality control measures.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “A review on bhasma kalpana andamp; standardization of tamra bhasma”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Bhasma (Bhasman):
Bhasma refers to the ash obtained from the incineration of metals and minerals in Ayurvedic medicine, which is believed to possess therapeutic properties. It signifies a transformative process where the metal undergoes purification and calcination, converting it into an effective medicinal form that enhances bioavailability and therapeutic efficacy.

2) Tamra:
Tamra is the Sanskrit term for copper, a metal often used in Ayurvedic formulations. Its significance lies in its traditional uses in treating various ailments. Due to its properties such as being Madhur (sweet) and Kashaya (astringent), it is integrated into formulations aimed at restoring balance in the body.

3) Tamrabhasma (Tamra-bhasma):
Tamra-bhasma is the incinerated form of copper used in Ayurvedic medicines. It combines the therapeutic properties of Tamra with the benefits derived from the Bhasma process, ensuring that the copper is readily absorbable and effective for treating conditions like liver disorders, arthritis, and more.

4) Rasa (Rasha):
Rasa translates to 'taste' in Sanskrit, but in context, it refers to the essence or therapeutic effect of a substance used in Ayurveda. It is a fundamental concept in Rasa Shastra that dictates how different substances can affect the body's balance of doshas.

5) Shodhana (Sodhana):
Sodhana is synonymous with the purification process in Ayurveda. It is vital to refining metals and minerals, ensuring the removal of unwanted impurities, enhancing the safety and therapeutic effectiveness of the resulting medicinal substances.

6) Drug:
In the context of Ayurveda, a drug refers to any medicinal substance derived from plants, minerals, or animals used for therapeutic purposes. The formulation and preparation of these drugs, such as Bhasma, are essential for optimizing their effects and enhancing their bioavailability in the body.

7) Mineral:
Minerals are naturally occurring inorganic substances essential to various health functions. In Ayurveda, metals and minerals are used extensively, and their therapeutic benefits are detailed in texts like Rasa Shastra. They form the foundational ingredients for preparing Bhasmas and other Ayurvedic formulations.

8) Purification:
Purification is a vital aspect of Ayurvedic medicine that involves refining substances to eliminate unwanted impurities. In processes such as Shodhana, purification enhances both safety and effectiveness, transforming raw materials into forms suitable for medicinal use, therefore allowing for higher therapeutic availability.

9) Puta:
Puta refers to the specific fire parameter or heating method utilized in the preparation of Bhasma. It is a controlled burning process essential for converting metals and minerals into ash. Different types of Puta create distinctive effects on the final therapeutic properties of the Bhasma.

10) Ayurveda (Ayus-veda):
Ayurveda is an ancient system of medicine originating from India, emphasizing a holistic approach to health. It focuses on balancing the body, mind, and spirit through natural remedies, lifestyle changes, and therapies, helping to restore harmony and promote wellness in individuals.

11) Rasashastra (Rasa-shastra, Rasasastra):
Rasa-shastra is a specialized branch of Ayurveda focusing on the study of metals, minerals, and their therapeutic applications. It encompasses techniques of purification, preparation, and the medicinal use of Bhasmas, guiding practitioners on how to effectively utilize these substances in healing.

12) Shastra (Sastra):
Shastra means 'scripture or treatise.' In Ayurvedic context, it refers to the vast body of knowledge and guidelines that delineate the theoretical and practical aspects of Ayurvedic medicine, including the preparation and use of Bhasmas and other medicinal compounds.

13) Kalpana:
Kalpana translates to 'formulation' or 'preparation.' In Ayurveda, it refers to the art of preparing various medicinal forms from herbs, minerals, and metals. This process is integral to creating effective therapeutics, including the regulated manufacture of Bhasmas for specific health conditions.

14) Silver:
Silver (Rajat in Sanskrit) is one of the metals utilized in Ayurvedic formulations, appreciated for its therapeutic qualities. It is incorporated into Bhasmas and medicines, known to alleviate various ailments and enhance vitality, contributing to the overall healthcare strategy in Ayurveda.

15) Quality:
Quality refers to the attributes and standards that ensure a substance's efficacy and safety in Ayurvedic medicine. It encompasses aspects such as purity, particle size, and bioavailability, ensuring that preparations like Bhasma meet the expected therapeutic standards for patient use.

16) Surface:
In the context of nanomedicine, surface properties significantly impact the absorption and effectiveness of herbal and mineral formulations. The surface area increases when these substances are prepared in nano-sized particles, enhancing their interaction with biological systems and improving their therapeutic action.

17) Dhatu:
Dhatu translates to 'metal' or 'element' in Ayurveda, and more specifically refers to the seven primary metals recognized in classical texts: gold, silver, copper, lead, tin, iron, and mercury. Each metal has unique therapeutic properties and is used in various medicinal formulations.

18) Medicine:
Medicine refers to substances used for the treatment of diseases and the maintenance of health. In Ayurveda, this includes a range of natural products such as herbs, minerals, and animal derivatives, carefully prepared through methods like Bhasma to ensure their safety and efficacy.

19) Samhita:
Samhita refers to the ancient texts of Ayurveda that compile knowledge about health, medicine, and philosophy. Classic Samhitas, like Charaka Samhita and Susruta Samhita, provide foundational guidelines for Ayurvedic practices, including the preparation and use of medicinal substances.

20) Maran:
Maaran is the process of calcification in Ayurveda, a crucial method of transforming purified metals and minerals into their therapeutic forms. This step enhances the desired properties of the substances, often involving specific heating and grinding techniques to achieve effective formulations.

21) Dosha (Dosa):
Dosha represents the energies or fundamental biological forces inherent in Ayurvedic philosophy that govern bodily functions: Vata, Pitta, and Kapha. Maintaining balance among these doshas is essential for health, and Ayurvedic treatments aim to correct any imbalances through various medicinal interventions.

22) Ratna:
Ratna translates to 'gem' or 'precious stone' in Sanskrit. In Ayurveda, certain gems and minerals are recognized for their medicinal properties, often used in therapeutic practices alongside metals. Their inclusion can augment the benefits of Ayurveda treatments due to their unique vibrational energies.

23) Apunarbhava (Apunar-bhava):
Apunarbhava means a state beyond return or irreversible transformation. In Ayurvedic terminology, it signifies the process where metals, through purification and burning, are converted into Bhasma, signifying their transformation into a form that cannot revert to their original state.

24) Patanjali:
Patanjali is revered as an ancient sage, credited with compiling foundational texts in Yoga and Ayurveda. His contributions significantly shaped Ayurvedic philosophy and practice, emphasizing holistic well-being and the use of natural remedies for health improvement and disease management.

25) Bhaishajya (Bhaisajya):
Bhaisajya translates to 'medicine' or 'remedy' in Sanskrit. This term encompasses all healing substances used within Ayurvedic practice, emphasizing the importance of therapeutic preparations and their roles in restoring health and alleviating various ailments through natural means.

26) Substance:
In Ayurvedic context, substance refers to any material—be it plant, mineral, or animal-derived—that is used for therapeutic purposes. Efficient preparation and formulation of such substances are crucial to ensure their effectiveness in treating various health conditions.

27) Gandhaka (Gamdhaka):
Gandhaka means 'sulfur' in Sanskrit. In Ayurveda, sulfur is often used in therapeutic preparations such as Bhasmas, revered for its powerful properties in detoxifying and promoting the body's innate healing processes, particularly in conjunction with metals and minerals.

28) Samanya:
Samanya refers to 'general' or 'common' purification methods used in Ayurveda to prepare metals and minerals for medicinal purposes. This standard technique aims to ensure the safety and effectiveness of the product, making it a foundational step in therapeutic formulation.

29) Heating:
Heating is a crucial process in the preparation of Ayurvedic medicines, especially in the context of Bhasma preparation. Controlled heating transforms metals and minerals through processes like calcination, enhancing their therapeutic qualities and making them suitable for medicinal use.

30) Disease:
Disease in Ayurveda is understood as an imbalance of doshas or bodily functions. Ayurvedic medicine seeks to diagnose and treat disease by restoring balance through natural remedies, dietary adjustments, and lifestyle modifications, focusing on holistic healing rather than merely alleviating symptoms.

31) Animal:
Animal derivatives including products like bones, horns, and feathers play a unique role in Ayurvedic medicine, often incorporated into formulations like Bhasma. These materials carry specific properties believed to enhance therapeutic benefits, representing an important component in the diverse medicinal repertoire of Ayurveda.

32) Mukta:
Mukta translates to 'pearl' in Sanskrit and refers to certain forms of Bhasma derived from pearls. These preparations are believed to enhance health due to their specific properties, often used in formulations that aim to balance and rejuvenate the body.

33) Takra:
Takra means 'buttermilk' in Sanskrit and is frequently referenced in Ayurvedic purification methods. Its use during the Shodhana (purification) process helps detoxify and enhance the properties of metals, signifying its importance in preparing effective medicinal formulations.

34) Water:
Water is an essential component in Ayurvedic practices, utilized in various therapeutic preparations and purification methods. Its role extends from basic hydration to facilitating biochemical processes essential for the effectiveness of medicines and treatments, establishing a connection with health and vitality.

35) Honey:
Honey, or 'madhu' in Sanskrit, is recognized in Ayurveda as a natural sweetener and therapeutic agent. Its multiple health benefits, including antimicrobial and anti-inflammatory properties, make it an integral part of medicinal preparations and formulations, providing additional therapeutic value.

36) Pearl:
Pearl, or Mukta in Ayurveda, is a precious substance valued not just for its aesthetic appeal but also for its potential health benefits. Its use in Ayurvedic medicine, often in the form of Bhasma, is believed to promote wellness and enhance overall vitality.

37) Loha:
Loha translates to 'iron' or 'metal' in Sanskrit. It represents a crucial category of metals explored in Ayurveda, particularly through Rasa Shastra. The preparation and use of Loha in medicinal formulations highlight the intersection of metal and health in traditional practices.

38) Curd:
Curd, or 'dahi', is an important food product in Ayurveda, recognized for its cooling properties and probiotic benefits. Frequently included in cleansing and purification processes, it assists in enhancing the overall efficacy of Ayurvedic remedies, particularly in conjunction with other therapeutic ingredients.

39) Fire:
Fire is integral to many Ayurvedic processes, especially in the preparation of Bhasma where controlled incineration is necessary. It symbolizes transformation in Ayurveda, allowing the metamorphosis of raw materials into potent medicinal forms essential for therapeutic intervention.

40) Ghi (Ghee):
Ghee, or clarified butter, is revered in Ayurveda for its nourishing and therapeutic qualities. It is often used in preparing medicinals for its ability to enhance bioavailability and provide a base for other ingredients, thus playing a crucial role in Ayurvedic formulations.

41) Gold (Golden):
Gold is considered one of the most auspicious and beneficial metals in Ayurveda. Used in various forms, it is noted for its healing properties and is integrated into certain preparations aimed at rejuvenation and enhancing vitality, reflecting its historical significance in health practices.

42) Peacock feather:
Peacock feather holds a special place in Ayurvedic tradition, often associated with spiritual and physical healing properties. Used in certain formulations, it symbolizes beauty and purity, contributing to the broader holistic healing approach characteristic of Ayurvedic practices.

43) Cow urine (Cow's urine):
Cow urine is an important therapeutic component in Ayurveda, celebrated for its detoxifying and healing properties. Often utilized in purification processes and formulations, it embodies the belief in natural remedies derived from animal products contributing to holistic health.

44) Sushruta-samhita (Susruta-samhita):
Susruta-samhita is an ancient Ayurvedic text attributed to Susruta, a key figure in surgical practices. This treatise covers principles of surgery, medical knowledge, and the use of herbs and minerals, thus providing a foundational understanding of Ayurvedic medicine and its applications.

45) Transformation (Transform, Transforming):
Transformation refers to the fundamental changes that substances undergo during Ayurvedic processing. Whether it's through purification, anesthesia, or calcination, this process is essential for enabling metals and herbs to manifest their therapeutic properties in their final medicinal forms.

46) Amritikarana (Amrtikarana, Amriti-karana):
Amritikarana is a process aimed at enhancing the beneficial properties of a medicinal formulation in Ayurveda. It signifies the transformation or refining of substances to remove residual impurities, improving their efficacy to achieve optimal therapeutic outcomes.

47) Tridoshahara (Tridosahara, Tridosha-hara):
Tridoshahara refers to the therapeutic properties of certain substances that help balance the three doshas—Vata, Pitta, and Kapha—in Ayurveda. These remedies are essential in restoring harmony within the body, thus promoting overall health and well-being.

48) Muktabhasma (Mukta-bhasma):
Mukta-bhasma denotes the Bhasma made from pearls. It is valued in Ayurvedic texts for its unique properties and health benefits, often utilized in formulations intended to balance body energies and enhance vitality through its therapeutic qualities.

49) Civilization:
Civilization reflects the historical context in which Ayurvedic concepts and practices developed. Major contributions to Ayurveda can be traced back to ancient civilizations, highlighting the blending of cultural beliefs, access to medicinal resources, and the evolution of health practices over time.

50) Tamrapatra (Tamra-patra):
Tamra-patra refers to the copper sheet or plate used in Ayurveda during the preparation of Tamra-bhasma. It is a crucial element that undergoes specific processes, ensuring the effective transformation of copper into a therapeutic form suitable for medicinal applications.

51) Conch-shell:
Conch-shell, known as Shankha in Ayurveda, is used for its therapeutic properties and is often included in Bhasma formulations. Sheltered within Ayurvedic practices, it signifies purity and is believed to contribute to holistic wellness and health benefits.

52) Manahshila (Manahsila, Manah-shila, Manas-shila):
Manahshila, representing red arsenic, is a mineral used within Ayurvedic formulations. Its significance stems from its reputed properties to cleanse and purify the body, often utilized in Bhasma preparations aimed at detoxifying and enhancing the healing potential of various substances.

53) Varahaputa (Varaha-puta):
Varahaputa is a specific parameter in the Ayurvedic heating process, involving controlled fire used during the preparation of Bhasma. This method enhances the therapeutic qualities of the substances and establishes optimal conditions for transforming metals safely into their medicinal forms.

54) Metallurgy:
Metallurgy refers to the science of metals, critical in Ayurveda for understanding how metals can be purified and transformed into effective therapeutic agents. The principles of metallurgy inform the practices of Rasa Shastra, detailing how metals contribute to health and remedy formulations.

55) Leucoderma:
Leucoderma, or vitiligo, pertains to a skin condition characterized by loss of pigmentation. Ayurvedic treatment often includes remedies like Tamra-bhasma, which utilize the therapeutic properties of copper, highlighting Ayurveda's holistic approach in managing skin disorders.

56) Collecting:
Collecting refers to the gathering of raw materials required for Ayurvedic formulations and medicines. This process emphasizes the importance of selecting high-quality and appropriate substances necessary for creating effective therapeutic preparations, ensuring the overall efficacy of treatments.

57) Gajaputa (Gaja-puta):
Gaja-puta is a specific fire parameter used for incineration in Bhasma preparation. This method symbolizes the controlled application of heat required for the effective transformation of raw substances into medicinally potent forms, showcasing the intricate practices in Ayurvedic manufacturing.

58) Rasayoga (Rasa-yoga):
Rasa-yoga encompasses the combination of different metals and mineral preparations in Ayurveda, focusing on the synergistic effects of their combination. It serves as a critical aspect of Rasa Shastra, enhancing the therapeutic potential of formulations through carefully designed combinations.

59) Pradhana:
Pradhana refers to the primary or main substance in Ayurvedic formulations, particularly in the process of Maaran. It emphasizes the importance of the original metal or mineral that undergoes calcination, allowing it to attain its therapeutic efficacy and practical application.

60) Pariksha (Pariksa):
Pariksha refers to examination or assessment processes in Ayurveda, used to verify the quality and effectiveness of medicinal substances like Bhasma. These evaluations ensure that the materials meet the established Ayurvedic standards for therapeutic use, safeguarding patient care.

61) Rasayana (Rasa-ayana):
Rasayana denotes the rejuvenative therapy system in Ayurveda focused on nourishing and revitalizing the body. This approach incorporates practices and substances that enhance vitality and longevity while addressing the imbalances of doshas, facilitating overall health and well-being.

62) Bharjana:
Bharjana refers to a specific purification process in Ayurveda where impurities are removed through burning or calcination. It enhances the physical and therapeutic properties of substances, ensuring their safety and effectiveness in medicinal applications.

63) Niruttha (Nir-uttha):
Niruttha is a specific method for testing the quality of Bhasma in Ayurveda. It involves assessing the stability of silver leaf when mixed with Bhasma, indicating the effectiveness of the preparation and the presence of external impurities.

64) Varitara:
Varitara is a quality test for Bhasma, determining its density and ability to float. This property indicates its physical characteristics and purity, providing insight into its potential effectiveness in therapeutic applications and confirming its preparation quality.

65) Elephant:
Elephants are significant in Ayurvedic tradition; their components, such as feet and tusks, are sometimes utilized in therapeutic formulations. The reverence for elephants in Ayurveda emphasizes the holistic understanding and respect for nature's resources in promoting health.

66) Activity:
Activity in Ayurveda refers to the effectiveness and therapeutic action of a medicinal substance. The pharmacological activity of various herbs, minerals, and preparations is assessed to determine their clinical efficacy and potential impact on health outcomes.

67) Parpati:
Parpati is a specific type of Ayurvedic preparation made from minerals and herbs through a meticulous process of heating and combining. This technique highlights the intricate nature of Rasa Shastra, emphasizing a holistic understanding of medicinal properties and their applications in healing.

68) Mardana:
Mardana is a mechanical process involved in the preparation of medicines in Ayurveda, especially in the context of grinding and mixing substances. This method promotes the uniformity of ingredients and contributes to the efficacy of the final therapeutic product.

69) Gairika:
Gairika refers to red chalk or ferrous oxide utilized in Ayurvedic formulations. Its inclusion highlights the significance of minerals in treatment preparations, demonstrating how specific substances can alter therapeutic qualities and help in addressing various ailments.

70) Kajjali:
Kajjali is a specific mixture of purified mercury and sulfur used in Ayurveda, often involved in the preparation of Bhasma. This combination enhances the efficacy of the substances through its unique properties, making it integral to several medicinal formulations.

71) Yashada (Yasada):
Yashada refers to zinc oxide, a mineral solubilized into Bhasma form for therapeutic use in Ayurveda. Its benefits include fostering wound healing and antimicrobial properties, underscoring the diverse applications of different minerals in healing practices.

72) Kashaya (Kasaya):
Kashaya represents decoctions or infusions in Ayurveda, often made from herbs or plants. It is frequently used in the preparation of Bhasma, playing a pivotal role in the purification and enhancement of the therapeutic qualities of the final product.

73) Shankha (Sankha, Samkha, Shamkha):
Shankha translates to 'conch-shell' and is recognized in Ayurveda for its therapeutic applications. Its use often emphasizes purification and promotes health benefits, signifying the significance of natural substances derived from the environment in holistic healing.

74) Peacock:
Peacock feathers play a ceremonial and practical role in Ayurveda. They symbolize grace and purity, and their ashes are sometimes included in formulations due to perceived spiritual benefits and health-promoting properties within the broader context of Ayurvedic treatments.

75) Jaggery:
Jaggery, or 'gur' in Sanskrit, is a natural sweetener used in Ayurveda for its nutritional and therapeutic properties. It is included in various formulations, enhancing the palatability and medicinal effectiveness of remedies while providing additional health benefits.

[Note: The above list is limited to 75. Total glossary definitions available: 114]

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Rasashastra, Tamrabhasma, Medicinal properties, Dosha balance, Ayurvedic literature, Pharmacological activity, Shodhana process, Bioavailability enhancement, Bhasma Kalpana, Quality control of Bhasma, Traditional Puta.

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