Antimicrobial and phytochemical screening of cordia africana in sudan

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Journal name: World Journal of Pharmaceutical Research
Original article title: Antimicrobial and phytochemical screening of cordia africana in sudan
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Emtinan A. Alhadi, Hassan. S. Khalid, Muddathir. S. Alhassan, Ahmed S. Kabbashi and Mohammed O. Noor


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Antimicrobial and phytochemical screening of cordia africana in sudan

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research


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Summary of article contents:

1) Introduction

The study conducted by Alhadi et al. explores the antimicrobial activity and phytochemical composition of different parts of Cordia africana, a plant native to Sudan. The research involved screening extracts from the leaves, stem, bark, and fruit of the plant against various bacterial and fungal strains. Traditional medicine in Sudan, influenced by diverse cultural heritages, heavily relies on medicinal plants like C. africana for healthcare, emphasizing the significance of such studies in understanding their potential therapeutic properties.

2) Antimicrobial Activity of Cordia africana

One of the key findings of the study is the antimicrobial activity exhibited by the extracts of C. africana against various microorganisms. The methanol extract showed significant inhibitory effects on both Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), as well as fungal strains (Candida albicans and Aspergillus niger). The zones of inhibition ranged from 11 to 30 mm, indicating a potent antimicrobial potential, particularly from the leaves and stem extracts. These results highlight the therapeutic value of C. africana in combating infections.

3) Phytochemical Screening

The study also conducted a comprehensive phytochemical screening of C. africana, identifying a variety of bioactive compounds present in the plant parts. The analysis revealed the presence of saponins, coumarins, tannins, triterpenes, and flavonoids, while anthraquinones glycosides, alkaloids, and cyanogenic glycosides were notably absent. Among the extracts, the stem exhibited the highest concentration of these phytochemicals. This rich profile of compounds contributes to the plant's medicinal properties and underscores its importance in traditional medicine and potential in drug development.

4) Methodological Approach

The research utilized well-established methodologies for both antimicrobial testing and phytochemical screening. The antimicrobial activity was assessed using the cup-plate agar diffusion method, where various concentrations of the extracts were tested against standardized microorganisms. The phytochemical screening involved qualitative analysis, determining the presence or absence of specific compounds through several chemical tests. This methodological rigor ensures the reliability and validity of the findings, providing a solid foundation for future research.

5) Conclusion

In conclusion, the study conducted by Alhadi et al. reinforces the significance of Cordia africana as a valuable source of bioactive compounds with notable antimicrobial properties. The findings contribute to the broader understanding of naturally derived therapeutics and support the continuing exploration of medicinal plants in Sudan. The results advocate for further in-depth studies to isolate and characterize individual compounds, which may lead to the development of new antimicrobial agents, thereby enhancing healthcare options against resistant strains of bacteria and fungi.

FAQ section (important questions/answers):

What was the main purpose of the study on Cordia africana?

The study aimed to investigate the antimicrobial activity and phytochemical screening of different parts of Cordia africana in Sudan, including leaves, stem, bark, and fruit.

Which standard bacteria were tested for antimicrobial activity?

The study tested four standard bacterial strains: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, along with two fungal strains: Candida albicans and Aspergillus niger.

What extraction methods were used for the plant samples?

The crude extracts were prepared using petroleum ether and 80% methanol, followed by a process of filtration and evaporation to yield concentrated extracts for testing.

What were the key findings from the antimicrobial tests?

Most methanol extracts exhibited inhibitory effects against the tested organisms, with inhibition zones ranging from 11-30 mm depending on the specific extract and organism.

Which phytochemicals were identified in the extracts?

Phytochemical screening revealed the presence of coumarins, saponins, sterols, and triterpenes, while anthraquinones, glycosides, alkaloids, and cyanogenic glycosides were absent.

What significance does Cordia africana have in traditional medicine?

Cordia africana is traditionally used for various purposes such as firewood, timber, food, and medicine, indicating its importance in Sudanese traditional medicine and its potential for therapeutic applications.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Antimicrobial and phytochemical screening of cordia africana in sudan”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
The term 'Activity' in this context refers to the biological actions of plant extracts, specifically their effectiveness against microbial organisms. It highlights how extracts from Cordia africana can inhibit growth or kill bacteria and fungi, which is crucial for understanding its potential therapeutic applications in medicine.

2) Phytochemical:
Phytochemicals are bioactive compounds found in plants that contribute to their medicinal properties. In the study, various phytochemicals were screened from different parts of Cordia africana, such as saponins and flavonoids. This screening helps identify valuable substances that could lead to new drug discoveries and health benefits.

3) Flavonoid:
Flavonoids are a group of phytochemicals known for their antioxidant and antimicrobial properties. Their presence in Cordia africana suggests that the plant may offer protective effects against oxidative stress and infectious agents. Flavonoids are significant in herbal medicine due to their potential health-promoting qualities.

4) Table:
Tables in scientific reports organize data systematically, presenting findings clearly for readers. In this study, tables summarize the yields of extracts, their phytochemical contents, and antimicrobial activities. This structured presentation aids in data interpretation and facilitates comparisons across different extracts and test organisms.

5) Cutan:
Sudan refers to the geographical and cultural context of the study. The research conducted in Sudan highlights the region's reliance on traditional medicinal practices and its rich biodiversity. Understanding local flora like Cordia africana can contribute to discovering new medicinal products relevant to public health in Sudan.

6) Aureus:
Aureus, specifically Staphylococcus aureus, is a significant pathogenic bacterium often associated with infections in humans. The study assesses the antimicrobial properties of Cordia africana against this organism. Understanding its interactions with such pathogens is vital for developing natural remedies to combat antibiotic resistance.

7) Medicine:
Medicine is the science of diagnosing, treating, and preventing diseases. The relevance of the study lies in evaluating Cordia africana's potential as a medicinal plant, thereby contributing to pharmacology and developing natural therapies. Traditional medicine uses plants for health, which the study seeks to validate scientifically.

8) Water:
In the context of the study, water plays a critical role as a solvent for extracting phytochemicals from plant materials. Its use in the preparation of extracts and the solvent for fractionation processes is essential for isolating bioactive compounds to evaluate their biological activities against pathogens.

9) Antibiotic (Antibacterial):
Antibiotic denotes substances that inhibit bacterial growth or kill bacteria. As antibiotic resistance rises, studying natural alternatives like Cordia africana becomes increasingly significant. The study explores whether plant extracts can serve as effective antibiotics against various bacterial strains, offering potential future treatment avenues.

10) Study (Studying):
The study represents systematic research aimed at exploring Cordia africana's antimicrobial activity and phytochemical constituents. It provides insights into the efficacy of traditional medicine and contributes to a broader understanding of potential natural therapies. Studies like this are essential for validating and discovering medicinal uses of plants.

11) Species:
Species denotes distinct biological classifications of organisms. The significance of identifying the specific plant species explored in the study emphasizes the importance of biodiversity in medicine. Understanding the unique traits of Cordia africana can reveal its potential health applications in treating various ailments.

12) Drug:
The concept of a drug refers to any substance that, when introduced into the body, alters physiological function. The study aims to investigate if extracts from Cordia africana can serve as a source for developing new natural drugs, thereby expanding therapeutic options available to healthcare providers.

13) Surface:
In this context, surface relates to the physical area of agar plates used during microbial testing. The surface area is critical in quantifying microbial colonies and evaluating the efficacy of plant extracts in inhibiting microbial growth through measurements of inhibition zones.

14) Medium:
Medium refers to the growth substrate used in culturing microorganisms. In this study, nutrient agar or Sabouraud dextrose agar serves as the medium for cultivating bacteria and fungi, respectively. The choice of medium is essential for ensuring optimal growth conditions during antimicrobial testing.

15) Animal:
Animal refers to living organisms that are typically consumers in ecological systems. In phytochemical studies, understanding animal interactions with plants can elucidate potential medicinal benefits. Additionally, historical uses of some plants in traditional veterinary medicine highlight their importance beyond human health.

16) Wall:
Wall may refer to the physical barriers within biological structures, such as cell walls in bacteria or the walls of plates during microbial assays. The integrity and composition of these walls affect how substances interact, influencing the effectiveness of antimicrobial agents derived from plants.

17) Discussion:
The discussion section in a research paper interprets results, compares them to existing literature, and proposes implications of the findings. This section is crucial for contextualizing the importance of the study's outcomes regarding Cordia africana and its potential contributions to medicinal knowledge.

18) Developing:
Developing refers to the process of creating or improving something, in this case, the research into natural medicine. The study aims to expand knowledge on the use of traditional plants in regions like Sudan, emphasizing the importance of developing new, effective therapies from local resources.

19) Furniture:
Furniture represents physical objects made from natural materials, including timber from plants like Cordia africana. Highlighting the diverse uses of the plant shows its economic and cultural significance beyond medicinal applications, emphasizing the importance of sustainable resource management within traditional practices.

20) Mountain:
Mountain could relate to the habitat of certain species, including medicinal plants. Environmental conditions in mountainous areas often foster biodiversity, presenting opportunities for discovering unique plant species that may possess useful medicinal properties, which aligns with the study's objective to explore local flora.

21) Epidemic:
Epidemic indicates a sudden increase in disease occurrences in a specified population. Understanding the antimicrobial properties of local plants like Cordia africana is essential in addressing epidemics, particularly in developing regions where access to modern medicines may be limited, enhancing community health outcomes.

22) Heating:
Heating in the context of phytochemical extraction refers to processes that facilitate the dissolution of compounds from plant materials. Controlled heating can enhance the efficacy of extraction methods, ensuring that the maximum number of active compounds are obtained for subsequent biological evaluations.

23) Disease:
Disease denotes any abnormal condition affecting the body, leading to health deterioration. This study emphasizes the potential application of Cordia africana in treating various diseases, thereby contributing to conventional and alternative medical practices aimed at disease management and prevention.

24) Mineral:
Minerals are inorganic substances vital for biological functions. The study indirectly refers to minerals as part of the broader context of traditional medicine, where plants and mineral products are utilized for health benefits. Understanding their interactions can lead to comprehensive treatment strategies.

25) Gelatin:
Gelatin is a substance derived from collagen that can be used in various applications, including microbiology. The significance of gelatin within the study would pertain to its use in culture media or testing reagents, impacting the overall effectiveness of microbial assays.

26) Family:
Family refers to a grouping of related plant species, typically showing similar characteristics. Recognizing the family of Cordia africana highlights its relevance in botanical and medicinal research. This classification can guide investigations into related species’ properties for future therapeutic potential.

27) Timber:
Timber consists of wood harvested for construction and furniture purposes. The utilization of Cordia africana for timber emphasizes its economic significance, showcasing the dual value of a plant as both a source of traditional medicine and a valuable raw material in various industries.

28) Filling (Filled):
Filled may refer to the process of preparing agar plates, where wells or cups are filled with extracts for antimicrobial testing. The procedure ensures a proper setup that allows for accurate diffusion measurements, an essential aspect in understanding the efficacy of the tested extracts.

29) Sugar:
Sugar, in a broader context, can refer to carbohydrates derived from plant sources. The study’s relevance lies in understanding various extracts that might contain naturally occurring sugars, which can impact the health effects of the studied medicinal plant and its traditional uses.

30) Mulching (Mulch):
Mulch refers to materials spread on the soil surface to retain moisture and promote plant growth. Its inclusion highlights sustainable agricultural practices. In traditional medicine, understanding plant interactions with the environment, such as soil health and water retention, is vital for cultivation strategies.

31) Food:
Food relates to the nutritional aspects derived from plants. Cordia africana provides fruit considered a food source, signifying the plant's dual role in nutrition and medicine. Understanding these aspects promotes overall health, integrating dietary choices with medicinal applications.

32) Line:
Line may signify the correlation or continuity in scientific research, such as the line of evidence supporting the medicinal properties of Cordia africana. Ensuring research follows logical reasoning enhances credibility and allows for the accumulation of knowledge within the field of herbal medicine.

33) Hand:
Hand could metaphorically represent traditional practices and the human element in utilizing plants for medicine. The study honors indigenous knowledge and emphasizes the significance of hands-on methods in harvesting and applying medicinal plants, safeguarding cultural heritage and local wisdom.

34) Salt (Salty):
Salt refers to a mineral essential for physiological functions. In traditional medicine, salt may influence the efficacy of treatments or serve as a component in formulations. Understanding its interactions with plant extracts can enrich the knowledge of therapeutic methods in holistic practices.

35) Soil:
Soil is the natural resource that supports plant growth, including medicinal species. The quality of soil influences the phytochemical composition of plants like Cordia africana. Understanding soil health is essential for sustainable harvesting practices, enhancing both plant growth and its medicinal properties.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Antimicrobial and phytochemical screening of cordia africana in sudan’. Further sources in the context of Science might help you critically compare this page with similair documents:

Medicinal plant, Traditional medicine, Phytochemical screening, Antimicrobial activity, In vitro, Phytochemical Investigation, Yield percentage, Gram positive bacteria, Gram negative bacteria, Volatile oil, Minimum inhibitory concentration (MIC), Herbal drug.

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