In vitro study of Ayurvedic drug and polymer for biodegradable patch.
Journal name: World Journal of Pharmaceutical Research
Original article title: In vitro analysis of interaction between compound ayurvedic drug and polymer in prepration of biodegradable patch
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Awadhesh Kumar Pandey, Pathakmeenakshis. N., Mr. Arpanvishwas, M. Sahu, P. Maiti and Dr. Vijay Kumar
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: In vitro analysis of interaction between compound ayurvedic drug and polymer in prepration of biodegradable patch
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
1) Introduction
Chronic non-healing wounds pose significant challenges in medical treatment, particularly in regions with limited access to advanced wound care products. The use of biodegradable polymers, especially Poly (Lactic Acid) (PLA), in developing dermal patches has emerged as a promising method for effective drug delivery in wound management. This study by Awadhesh Kumar Pandey et al. explores the interaction between a compound Ayurvedic drug, composed of extracts from various Ficus species, and PLA, aiming to create an effective biodegradable patch for wound healing.
2) The Role of Biodegradable Polymers in Wound Healing
Biodegradable polymers offer several advantages in medical applications, including controlled drug release, biocompatibility, and the ability to degrade in the body without harmful effects. This study highlights how PLA stands out as one of the most accessible and biodegradable options available. The incorporation of biodegradable materials into drug delivery systems ensures that therapeutic agents can be released steadily over time, improving the effectiveness of treatments for wounds. The development of a bilayer dermal patch using PLA allows for moisture balance and infection control, crucial factors in advancing wound healing.
3) The Compound Ayurvedic Drug (CAD)
In the context of Ayurveda, various herbal formulations have been developed to promote wound healing. The compound Ayurvedic drug (CAD) used in this study consists of aqueous extracts from the bark of four Ficus species, which are traditionally known for their wound cleansing and healing properties. The interaction between CAD and the PLA polymer is significant, as it enhances the therapeutic value of the patch. This synergy between traditional medicine and modern polymer technology provides a novel approach to wound management, making it more accessible and effective.
4) Investigation of Interaction Between CAD and PLA
The study investigates the interaction between CAD and PLA through various analytical techniques, including IR and UV spectroscopy. The results indicated significant shifts in the spectral properties of both the –NH group and the carbonyl group, suggesting strong interactions that enhance the stability of the drug-polymer matrix. This interaction is crucial for ensuring that the drug can be effectively released over time, improving the bioavailability of the active compounds within the patch. The physical characteristics of the PLA-CAD composite, such as glass transition temperature and melting point, further confirm the compatibility and interaction between the components, indicating a promising drug delivery system.
5) Conclusion
The research presented indicates a successful method to create a biodegradable patch that leverages the healing properties of the Ayurvedic compound drug in conjunction with PLA polymer. The enhanced interaction between CAD and PLA not only fosters effective drug delivery but also underscores the potential of integrating traditional ayurvedic practices with modern biomedical technology. Through sustained drug release and degradation tailored to the needs of wound environments, this innovative approach addresses a significant gap in wound management solutions, potentially benefiting a large population in India that lacks access to advanced medical treatments.
FAQ section (important questions/answers):
What is the focus of the research presented in the article?
The research focuses on the interaction between a compound Ayurvedic drug and a biodegradable polymer for developing a dermal patch that facilitates wound healing.
What is the significance of biodegradable polymers in wound management?
Biodegradable polymers like Poly (lactic acid) offer controlled drug release, improved healing properties, and minimize waste, making them vital for effective wound management.
What is Compound Ayurvedic Drug (CAD) used in this study?
CAD consists of aqueous extracts from four Ficus species, known for their wound healing and cleansing properties, aimed at enhancing the therapeutic potential of the patches.
How was the biodegradable patch prepared in this study?
The patch was prepared using a solvent casting method, mixing CAD with Poly (lactic acid) in dichloromethane, where the solvent evaporated to leave a film.
How was the drug release from the biodegradable patch studied?
In vitro drug release kinetics were analyzed in phosphate buffer at 37°C, measuring concentration changes using UV-VIS spectroscopic studies.
What were the findings regarding the interaction between CAD and PLA?
The study found significant interactions evidenced by shifts in infrared absorption peaks, indicating greater stability and improved properties of the PLA-CAD composite.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “In vitro study of Ayurvedic drug and polymer for biodegradable patch.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
A drug refers to a chemical substance that has a biological effect on the body. In the context of the study, the Compound Ayurvedic Drug is a blend of bioactive compounds derived from specific plant species known for their wound healing properties. This drug is crucial for the therapeutic efficacy of the biodegradable patch being developed.
2) Biodegradable:
Bio-degradable is synonymous with biodegradable, emphasizing the ability of materials to decompose in the environment through biological processes. The focus on bio-degradable polymers like poly(lactic acid) illustrates the study’s goal to develop environmentally friendly solutions for medical applications, specifically wound healing.
3) Glass:
In this context, glass refers to the glass sheets used during the preparation of the biodegradable patches. The polymer solution is spread over the glass to form the patches. The choice of glass allows for an even surface to create uniform film thickness, essential for consistent drug delivery.
4) Patanjali:
Patanjali is a well-known institute in India that specializes in Ayurvedic research and education. The affiliations of the authors to Patanjali highlight the integration of traditional knowledge of Ayurveda with modern scientific approaches in developing the biodegradable patch tested in this study.
5) Tantra (Tamtra, Tantrism):
Tantra refers to a branch of Ayurveda focusing on surgical procedures and management. In this study, the authors are affiliated with the Department of Shalya Tantra, indicating their expertise in surgical methods and treatment strategies, particularly related to wound healing, which is central to the research.
6) Table:
The term table in the study refers to the organized presentation of data, particularly physicochemical evaluations of the polymer solutions and patches. Tables are crucial for summarizing findings in a concise manner, making it easier for researchers and readers to understand and analyze the experimental results.
7) Shalyatantra (Salyatantra, Shalya-tantra, Shalyatamtra):
Shalya-Tantra is the Ayurvedic branch dedicated to surgery and treatment of wounds and injuries. The study's connection to this discipline underscores the importance of surgical knowledge in the development of effective wound healing solutions, as it combines traditional practices with modern techniques.
8) Depression:
In terms of this study, depression refers to a decrease in melting point observed in the interaction between the Compound Ayurvedic Drug and the polymer. This shift in properties reflects potential changes in the material's stability and performance, which are critical for ensuring the efficacy of the biodegradable patch.
9) Substance:
A substance is any form of matter with a definite composition. In the context of this research, the substances referred to include the polymer, drugs, and any additives used in the preparation of the biodegradable patches. Identifying these substances is essential for understanding their properties and interactions.
10) Relative:
Relative indicates a comparison or relation to something else. In the study, the term is often used to discuss how the interactions between the drugs and polymers influence the overall performance and efficacy of the biodegradable patches compared to previous standards or expectations.
11) Science (Scientific):
Science refers to the systematic study of the structure and behavior of the physical and natural world through observation and experiment. This study applies scientific methodology to investigate the properties and interactions of traditional Ayurvedic drugs and modern biodegradable polymers in wound healing applications.
12) Shalya (Salya):
Shalya pertains to surgery within the Ayurvedic system. In this study, the discipline plays a pivotal role in understanding the surgical aspects of wound management and the therapeutic use of biodegradable patches. This context demonstrates the integration of traditional Ayurvedic knowledge with modern medical practices.
13) Kumar:
Kumar is a common surname in India and is used to identify one of the authors of the study. In the context of academic publications, names denote the contributions and expertise of individuals within the collaborative research work, reflecting their roles and responsibilities within the study.
14) Study (Studying):
The study refers to the systematic investigation conducted to evaluate the effectiveness of the biodegradable patch that integrates Ayurvedic drugs with poly(lactic acid). It encompasses various methodologies including drug release kinetics and interaction assessments, providing insights into wound healing technologies.
15) Performance:
Performance in this study denotes how well the biodegradable patch meets its intended purpose of drug delivery and wound healing. Various factors such as drug release rates, degradation, and efficacy have been assessed to evaluate the overall performance of the new product.
16) Knowledge:
Knowledge encompasses the understanding and information gained through experience or learning. This study reflects a synergy between traditional Ayurvedic knowledge of herbs for wound healing and modern scientific approaches, showcasing how interdisciplinary knowledge can lead to innovative healthcare solutions.
17) Cleansing:
Cleansing refers to the process of cleaning or removing impurities from wounds. In Ayurvedic treatments, specific drugs possess cleansing properties which are incorporated in the patch aimed at managing infected wounds, highlighting the patch's dual functionality in both cleansing and healing.
18) Udumbara:
Udumbara is one of the species of the Ficus tree mentioned in the Ayurvedic literature for its wound healing properties. The presence of Udumbara in the Compound Ayurvedic drug underscores the traditional Ayurvedic principles in selecting effective natural remedies for modern medical applications.
19) Dressing:
Dressing refers to the materials applied to wounds to promote healing. This study focuses on developing an advanced biodegradable dressing that integrates traditional herbal medicines, showcasing the combination of conventional and modern medical approaches in wound care management.
20) Plaksha (Plaksa):
Plaksha is another species within the Ficus genus featured in the Compound Ayurvedic Drug. Each species contributes specific healing properties to the formulation, reflecting the traditional Ayurvedic ethos of using poly herbal combinations to address medical conditions effectively.
21) Species:
Species denote distinct biological classifications within the natural world. In this study, the various Ficus species are recognized for their therapeutic properties and are utilized in formulating the Compound Ayurvedic Drug aimed at enhancing wound healing effectiveness.
22) Surface:
Surface refers to the outermost layer of the polymer patch that interacts with the wound environment. Characterizing the surface properties helps in understanding how the patch will perform in real-life scenarios, including drug release kinetics and biocompatibility.
23) Vata:
Vata is one of the three doshas in Ayurveda that represents air and space elements. In the context of the study, the term relates to the Ayurvedic principles underlying the selection of herbal ingredients, such as the healing properties associated with Vata characteristics in wound management.
24) Human body:
The human body is the biological entity for which the developed biodegradable patches are intended. Understanding the physiological interactions between the patches and the human body is crucial for ensuring safety, effectiveness, and the biocompatibility of the drug delivery systems.
25) Ficus religiosa:
Ficus religiosa, also known as the sacred fig, is one of the species included in the Compound Ayurvedic Drug. Its traditional use in Ayurvedic medicine for wound healing is recognized, contributing to the formulation's effectiveness and aligning with holistic healing practices.
26) Nyagrodha:
Nyagrodha refers to Ficus benghalensis, another significant species incorporated into the study. This tree has long been utilized in traditional medicine for its healing properties, emphasizing the role of local flora in developing effective therapeutic solutions for wound management.
27) Ayurveda (Ayus-veda):
Ayurveda is the traditional Indian system of medicine that employs natural healing methods, including the use of herbs and dietary practices. This study integrates Ayurvedic principles with modern pharmaceutical technology to create innovative wound care solutions, exemplifying the potential of holistic medicine.
28) Nighantu (Nighamtu):
Nighantu refers to traditional medicinal texts that describe various herbs and their uses in Ayurveda. It provides the foundational knowledge for selecting ingredients like the different Ficus species used in the development of the biodegradable patch, emphasizing the relevance of ancient wisdom.
29) Varanasi (Varanashi):
Varanasi is a city in India known for its deep historical and spiritual significance, as well as its educational institutions. The affiliation of some authors to institutions in Varanasi underlines the cultural and academic backdrop of the research being communicated.
30) Prasuti:
Prasuti is a branch of Ayurveda focusing on obstetrics and gynecology. Although not the central theme of this study, including professionals from this field illustrates the interdisciplinary approach taken within the research team, balancing different aspects of Ayurvedic health practices.
31) Ropana:
Ropana defines the healing aspect of Ayurveda, specifically relating to wound healing properties inherent in various drugs. Understanding Ropana properties of the components used in this study is critical in developing an effective therapeutic patch aimed at improving wound recovery.
32) Indian:
Indian refers to materials, practices, and knowledge systems originating from India. This emphasis highlights the study's context within Indian traditional medicine, especially the integration of Ayurveda with contemporary scientific approaches in developing medical solutions.
33) Ulcer:
An ulcer is an open sore or wound typically characterized by inflammation. The study's focus on developing a biodegradable patch is particularly relevant for treating chronic non-healing ulcers, showcasing the application of the researched product for managing difficult-to-treat clinical conditions.
34) Sahu:
Sahu is a surname associated with one of the authors involved in the research. The contribution of each author brings distinct expertise to the study, reflecting the collaborative nature of scientific research that often spans multiple disciplines and backgrounds.
35) Tree:
A tree, in this context, refers to the botanical sources of the herbal ingredients used in the Compound Ayurvedic Drug. The study emphasizes the importance of using natural plant sources, showcasing the role of botanical remedies in modern drug delivery systems.
Other Science Concepts:
Discover the significance of concepts within the article: ‘In vitro study of Ayurvedic drug and polymer for biodegradable patch.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Wound healing, Drug delivery system, Moisture content, Physicochemical characteristics, Chemical structure, UV-Spectroscopy.