Antifungal avtivities in roots extracts of decalepis hamiltonii
Journal name: World Journal of Pharmaceutical Research
Original article title: Antifungal avtivities in roots extracts of decalepis hamiltonii
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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S.Kalaivani, Mrs.B.Latha and Dr. Padmavathy
World Journal of Pharmaceutical Research:
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Full text available for: Antifungal avtivities in roots extracts of decalepis hamiltonii
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The study conducted by S. Kalaivani and colleagues focuses on the antifungal activities of root extracts from the plant Decalepis hamiltonii, which is endemic to peninsular India. Recognized for its medicinal properties in Ayurvedic practices, the plant is commonly referred to as "Makaliber" in Kannada and "Magali Kizhangu" in Tamil. The research aimed to investigate the effectiveness of various extracts of the plant's roots against the fungus Rhizoctonia solani, highlighting the potential of these extracts in combating fungal infections.
Antifungal Activity of Different Extracts
The study examined three types of extracts: root hot extracts, root cold extracts, and peel hot extracts, each prepared using distinct methods. The root hot extracts and peel hot extracts exhibited significant antifungal activity against Rhizoctonia solani, while the root cold extracts demonstrated only mild antifungal effects. The effectiveness of the extracts was measured by their ability to inhibit the growth of the fungal biomass, indicating that these extracts could contain potent antifungal compounds.
Extraction Methods and Their Implications
The extraction process involved both hot and cold methods, which were critical in determining the yield and efficacy of the antifungal agents present in the plant. The root hot extract was prepared by boiling the roots in 50% aqueous ethanol for one hour, while the root cold extract involved soaking the roots in 80% aqueous ethanol for a duration of 24 hours. The differential extraction techniques utilized here are essential, as they contribute to the varying results in antifungal activity observed among the extracts, suggesting that temperature and time play significant roles in the extraction of phytochemicals.
Phytochemical Analysis
A preliminary phytochemical investigation revealed the presence of flavonoids in the extracts, indicating that these compounds may be responsible for the antifungal properties observed in the study. Flavonoids are known for their therapeutic benefits, including their roles as antioxidants and anti-inflammatory agents. The identification of these phytochemical constituents adds a layer of understanding to the mechanisms by which Decalepis hamiltonii may exert its antifungal effects, warranting further investigation into their specific roles and potential applications.
Conclusion
The study concludes that both the root hot extract and peel hot extract of Decalepis hamiltonii possess significant antifungal properties against Rhizoctonia solani. The results underscore the potential of utilizing these plant extracts as natural antifungal agents, which could contribute to alternative therapeutic strategies in managing fungal infections. Future research is encouraged to isolate and identify the specific antifungal compounds present in these extracts, further enhancing our understanding of their medicinal value and practical applications in pharmacology.
FAQ section (important questions/answers):
What was the focus of the study conducted by Kalaivani et al.?
The study investigated the antifungal activities in root extracts of Decalepis hamiltonii against the fungus Rhizoctonia solani, comparing hot and cold extracts.
What plant is Decalepis hamiltonii commonly known for?
Decalepis hamiltonii is known as Makaliber in Kannada and Magali Kizhangu in Tamil. It is endemic to peninsular India and used in traditional Ayurvedic medicine.
What methods were used to extract compounds from the plant roots?
The study utilized three extraction methods: boiling chopped roots with ethanol for hot extracts and soaking roots in ethanol for cold extracts.
How effective were the root hot and cold extracts against fungal activity?
The root hot extract showed a high degree of antifungal activity, while the root cold extract exhibited only mild antifungal activity at a concentration of 500 ppm.
What was the control fungal biomass in the study?
The control showed a biomass of 1500 mg for Rhizoctonia solani, while the root hot, cold, and peal hot extracts demonstrated significantly lower biomass levels.
What conclusion can be drawn regarding the extracts' antifungal compounds?
The study concluded that the root hot extract and peal hot extract possess antifungal compounds, which warrant further investigation and isolation for potential applications.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antifungal avtivities in roots extracts of decalepis hamiltonii”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In the context of this research, 'activity' refers to the efficacy of the root extracts from Decalepis hamiltonii in inhibiting the growth of the fungus Rhizoctonia solani. Measuring antifungal activity helps determine the potential medicinal properties of the plant and its application in pharmaceutical formulations for treating fungal infections.
2) Trichy:
Trichy, or Tiruchirapalli, is a city in Tamil Nadu, India, where this research was conducted. It is significant as a location for academic study in botany and chemistry, providing access to a diverse range of flora for the examination of pharmacological properties, including those of Decalepis hamiltonii.
3) Medium:
The term 'medium' in this research refers to the Czapek Dox Agar, a nutrient-rich substrate used for culturing fungi. It is essential for facilitating the study of fungal growth and assessing the antifungal properties of plant extracts by providing the necessary nutrients for the fungi.
4) Disease:
The study mentions various diseases that the roots of Decalepis hamiltonii can help treat, such as dysentery and skin diseases. Understanding its potential to alleviate symptoms or cure diseases is crucial for exploring traditional medicines and developing new therapeutics from natural sources.
5) Species:
Decalepis hamiltonii is described as the sole species in its genus. Recognizing species is vital in botanical studies for understanding biodiversity and the unique properties of individual plants, which can be significant for phytochemical research and developing herbal remedies.
6) Family:
The family Apocynaceae includes Decalepis hamiltonii. Identifying the plant family aids in understanding its characteristics, including shared biochemical and morphological traits, which can lead to insights into potential medicinal uses based on properties observed in related species.
7) Botany:
Botany, the scientific study of plants, plays a crucial role in this research as it involves the identification and analysis of Decalepis hamiltonii. Knowledge in botany is essential for exploring plant properties, contributing to advancements in pharmaceuticals, and enhancing traditional medicine practices.
8) India:
India is the geographical context for Decalepis hamiltonii, highlighting its endemic nature to the region. Understanding regional flora and their uses in traditional medicine enriches research in ethnobotany and promotes the importance of conservation and sustainable use of native plant species.
9) Blood:
In this study, the root extracts are noted for their blood-purifying properties. This highlights the traditional medicinal uses of Decalepis hamiltonii as a remedy for various ailments, emphasizing the relevance of exploring plants for their potential in blood-related health issues.
10) Study (Studying):
The term 'study' refers to the systematic investigation conducted to assess the antifungal properties of Decalepis hamiltonii. This research approach is critical for validating traditional medicinal claims and understanding the scientific basis for the use of plant extracts in pharmacology.
11) Phytochemical:
Phytochemicals are bioactive compounds derived from plants, such as flavonoids found in Decalepis hamiltonii. Identifying phytochemicals is crucial as they contribute to the therapeutic effects of plants, offering potential for developing new drugs and natural health products.
12) Discussion:
In research, the 'discussion' section interprets the findings and contextualizes them within existing literature. It allows researchers to articulate the significance of their results, explore implications for future work, and highlight the contributions made to the field of phytochemistry and antifungal research.
13) Flavonoid:
Flavonoids are a class of phytochemicals identified in the study, known for their health benefits, including antioxidant and anti-inflammatory effects. Their presence in Decalepis hamiltonii underscores the plant's therapeutic potential and invites further investigation into their specific roles in antifungal activity.
14) Medicine:
The mention of 'medicine' reflects the application of the research findings in the development of new treatments. Understanding the medicinal properties of Decalepis hamiltonii could lead to advancements in complementary medicine and enhance existing pharmaceutical options for treating infections.
15) Vomiting:
Vomiting is highlighted as one of the ailments treated by the root of Decalepis hamiltonii. This points to the medicinal properties attributed to the plant in traditional practices, emphasizing the need for scientific studies to validate these uses and potentially refine therapeutic applications.
16) Debility:
Debility signifies weakness or lack of vitality, for which the roots of Decalepis hamiltonii are traditionally used. Understanding the plant’s effects on conditions like debility is significant for exploring its potential in enhancing overall health and addressing nutritional deficiencies.
17) Kannada:
Kannada is one of the regional languages of India, spoken predominantly in the state of Karnataka. The acknowledgment of names for Decalepis hamiltonii in Kannada illustrates the cultural significance of the plant, as well as the importance of local languages in documenting traditional medicinal knowledge.
18) Science (Scientific):
The term 'science' underscores the methodological and empirical approach taken in the study. Conducting scientific research on plants like Decalepis hamiltonii bridges traditional knowledge and modern scientific methods, promoting innovations in pharmacology grounded in empirical evidence.
19) Nagali (Magali):
Magali Kizhangu is the Tamil name for Decalepis hamiltonii, emphasizing the local significance of the plant in traditional medicine. Understanding local nomenclature enriches knowledge on cultural practices and facilitates communication regarding the plant's uses and benefits within communities.
20) Thirst:
Thirst is mentioned as a condition for which Decalepis hamiltonii is considered beneficial. This underscores the plant's use in traditional practices for promoting hydration and alleviating discomfort, adding relevance to its research for potential health benefits related to hydration.
21) Water:
Water plays an essential role in the extraction process of the plant materials and is a critical element in sustaining life. The research's focus on plant extracts that potentially aid in hydration or related conditions reflects the broader importance of water in health and wellness.
22) Fever:
Fever, mentioned in the context of diseases treated with Decalepis hamiltonii, signifies the plant's traditional utility in managing such health conditions. Understanding its mechanism of action against fever can lead to further exploration of its pharmacological significance in modern medicine.
23) Tamil:
Tamil is a prominent regional language in India, especially in Tamil Nadu, reflecting the cultural context of Decalepis hamiltonii. Recognizing local terminology enhances the understanding of traditional practices and facilitates communication within the community regarding medicinal uses of the plant.
24) Latta:
Mrs. B. Latha is cited as an Assistant Professor in the Department of Chemistry, involved in this research. Her role signifies the academic collaboration essential in scientific studies, highlighting the importance of mentorship and partnership in advancing research in pharmaceutical sciences.
25) Genu:
The term 'genus' pertains to the classification of Decalepis hamiltonii within the broader taxonomical hierarchy. Identifying the genus is crucial for understanding the plant's relationship to other species, its biological characteristics, and its potential applications in phytochemistry and herbal medicine.
Other Science Concepts:
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Decalepis hamiltonii, Blood-purifier, Sodium nitrate, Academic references, Plant material, Research article, Antifungal activity, Fungal culture, Phytochemical Investigation, Distilled water, Extract preparation, Ferrous sulphate, Antifungal activities, Preliminary phytochemical investigation, Potassium dihydrogen phosphate, Article received, Department of Chemistry, Department of Botany, Rhizoctonia solani, Magnesium sulphate, Potassium chloride, Phyto-constituent, Cooling agent.