Study on systemic and dermal toxicity of biodegradable wound patches.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Study on systemic and dermal toxicity of biodegradable wound patches.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
In this study, the drug refers to the compound Ayurvedic formulation derived from the barks of various Ficus species. This drug is assessed for its wound healing properties and safety when applied to the skin, emphasizing traditional medicinal applications and potential therapeutic benefits in modern clinical settings.

2) Toxicity:
Toxicity is a critical assessment metric in this research. It evaluates the compound Ayurvedic drug's safety, determining if prolonged exposure through the biodegradable dermal patch causes harmful effects in the test subjects, specifically looking at systemic and dermal toxicological changes in the animals involved.

3) Biodegradable:
The term biodegradable in this study emphasizes the patch's environmental and practical benefits, allowing the drug to be delivered effectively while also ensuring that the materials used do not contribute to long-term waste, aligning innovation in drug delivery with sustainability principles.

4) Study (Studying):
The study represents a systematic investigation to assess the safety and efficacy of the compound Ayurvedic drug when used as a wound dressing. It follows strict OECD guidelines to ensure reliability and validity of the findings, contributing to the field of Ayurvedic medicine and biomedical research.

5) Water:
Water is essential for various biological processes, including wound healing and drug delivery. In this research, the animals were provided with unrestricted access to drinking water, ensuring their hydration, which is a crucial aspect of maintaining overall health during experimental procedures.

6) Post:
Post refers to the period following the application of the treatment. In the context of this study, 'post dermal administration' indicates the analyses and observations conducted after the application of the drug-impregnated biodegradable patch, crucial for evaluating the outcomes and effects of the treatment.

7) Substance:
The substance in this research context refers specifically to the Compound Ayurvedic Drug. It highlights the tested material's nature and its intended pharmacological effects when used in a biodegradable patch for dermal application, linking traditional medicine with modern experimental methodologies.

8) Dressing:
Dressing pertains to the material applied to wounds to promote healing. This study utilizes a novel biodegradable dressing made from poly(lactic acid) incorporated with the Ayurvedic drug, examining its efficacy in supporting wound healing while ensuring safety for the treated tissues.

9) Animal:
Animal refers to the test subjects used, specifically Wistar albino rats, which are commonly used in toxicological studies for their reproducibility and ease of care. Their use aims to provide reliable data regarding the safety and efficacy of the compound Ayurvedic drug.

10) Patanjali:
Patanjali refers to the institution involved in this research, known for integrating traditional Indian medicine and modern science. It emphasizes the commitment to exploring Ayurvedic practices and herbal formulations within a contemporary research framework, aiming to promote holistic health and wellness.

11) Varanasi (Varanashi):
Varanasi is a significant city in India, often linked with spirituality and ancient knowledge, particularly Ayurvedic traditions. This study’s connection to Varanasi underscores the cultural and historical importance of the region as a center for traditional medicinal practices.

12) Samhita:
Samhita refers to ancient texts, in this context primarily referring to 'Sushruta Samhita,' a foundational text in Ayurvedic medicine. It contains vital information on surgical techniques and herbal treatments, thus providing a traditional basis for the interventions investigated in this study.

13) Tantra (Tamtra, Tantrism):
Tantra in this context relates to the classical texts within Ayurveda detailing medical and medicinal practices. It indicates a structured approach to treatment and healing, emphasizing the systematization of knowledge that informs the composite treatment strategies in the study.

14) Shalyatantra (Salyatantra, Shalya-tantra, Shalyatamtra):
Shalya-tantra is a branch of Ayurvedic medicine that focuses on surgery and wound management. It is especially relevant here as the study examines a drug designed to enhance wound healing, linking traditional surgical principles with modern research methodologies.

15) Sanskrit:
Sanskrit is the ancient language of India in which many Ayurvedic texts, including those used in this research, were written. Understanding Sanskrit is crucial for accessing original Ayurvedic knowledge and nuances, enriching the study of these traditional treatments.

16) Species:
Species refers to the specific types of Ficus trees used for their bark extracts in the study. Understanding the species involved emphasizes the botanical aspects of the research, focusing on the traditional use of these plants in Ayurvedic healing practices.

17) Shalya (Salya):
Shalya signifies the aspect of Ayurveda concerned with surgical interventions and treatments for injuries. This study’s exploration of a biodegradable patch aligns with Shalya's principles, integrating traditional surgical wisdom with innovative, non-invasive treatment approaches for wounds.

18) Kumar:
Kumar refers to Dr. Awadhesh Kumar Pandey, the lead author of the study. His contributions highlight the human element behind the research, bringing expertise from the field of Ayurveda into the design and execution of the experimental study.

19) Ficus religiosa:
Ficus religiosa, also known as the sacred fig, is one of the four Ficus species studied for its medicinal properties. Its inclusion underscores the focus on historically significant plants in Ayurveda and their potential benefits in modern medicinal applications.

20) Observation:
Observation refers to the systematic monitoring of effects and reactions in the test subjects throughout the study. It is a critical aspect of conducting research, ensuring accurate data collection and validity of the results regarding the treatment's efficacy and safety.

21) Cleansing:
Cleansing pertains to the action of cleaning a wound to prevent infection and promote healing. The study’s investigation into the Ayurvedic drugs’ cleansing properties supports the holistic approach of Ayurveda to wound management, addressing both prevention and healing.

22) Ayurveda (Ayus-veda):
Ayurveda is a traditional system of medicine originating in India, emphasizing holistic healing and the use of natural substances. This study aims to bridge Ayurveda with scientific exploration through rigorous testing of compound Ayurvedic drugs intended for wound healing.

23) Udumbara:
Udumbara is another Ficus species included in the study, highlighting the variety of plants used in Ayurvedic formulations. Its participation showcases the richness of herbal resources employed in traditional medicine and their relevance in modern therapeutic applications.

24) Plaksha (Plaksa):
Plaksha refers to yet another Ficus species used in the compound Ayurvedic drug. Its inclusion emphasizes the diversity of botanical sources leveraged in Ayurvedic treatments, illustrating the holistic approach to healing by utilizing multiple plant-based healing agents.

25) Edema (Oedema):
Oedema refers to swelling caused by excessive fluid accumulation in the body's tissues. The study monitored signs of oedema to assess any adverse skin reactions to the biodegradable patch, ensuring the treatment's safety and effectiveness.

26) Vata:
Vata is a basic concept in Ayurveda indicating the dynamic elements of energy within the body related to movement and circulation. This concept is essential in Ayurvedic medicine, influencing treatment choices and helping guide assessments in the context of wound management.

27) Sign:
Sign refers to observable indications of any effects resulting from the treatment with the biodegradable patch. Clinical signs were systematically recorded in this study to evaluate both the safety and efficacy of the treatment over the established observation period.

28) Sushruta-samhita (Susruta-samhita):
Sushruta-samhita is one of the principal ancient texts of Ayurvedic surgery and medicine. The study's referencing of this text illustrates the foundational knowledge upon which the modern experimentation of treatments is built, linking traditional wisdom with contemporary methods.

29) Meenakshi:
Meenakshi refers to another author of the study, contributing collaborative expertise in the subject area. The inclusion of multiple authors highlights the interdisciplinary effort behind the research, crucial for properly addressing the complexities of integrating Ayurveda with scientific validation.

30) Nighantu (Nighamtu):
Nighantu refers to a type of Ayurvedic lexicon containing the nomenclature and classifications of plants and substances. Its relevance in the study underlines the importance of accurate identification and understanding of medicinal plants used in traditional healing practices.

31) Medicine:
Medicine represents the branch of science that studies the diagnosis, treatment, and prevention of disease. This study bridges this definition with Ayurvedic practices, examining how traditional drugs can be validly integrated into modern medical understanding and application.

32) Activity:
Activity in the research context refers to the biological effects and functions exhibited by the compound Ayurvedic drug, particularly its wound healing properties. It frames the expectations of therapeutic outcomes tied with traditional claims and modern scientific validation.

33) Relative:
Relative, in this context, signifies the importance of comparing the findings of the study with known standards or controls. It ensures that the results are interpreted in context to existing knowledge and practices within the field of medicine and Ayurvedic treatments.

34) Prasuti:
Prasuti pertains to the branch of Ayurveda that focuses on obstetrics and gynecology. While not the central theme of this study, its mention broadens the scope of Ayurvedic knowledge and highlights the multidimensional aspects of traditional practices within the healing paradigm.

35) Science (Scientific):
Science represents the systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. This study attempts to integrate Ayurvedic traditional knowledge within modern scientific frameworks, validating its effectiveness through empirical investigation and rigorous methodologies.

36) Ropana:
Ropana refers to the Ayurvedic concept of healing. Understanding Ropana is vital in the context of this research, as it assesses the efficacy of the Compound Ayurvedic Drug in promoting wound healing, aligning well with its traditional theoretical framework.

37) Glass:
Glass refers to the microscopic slides utilized in histopathological examinations within the study. The use of glass slides for tissue samples is a standard practice in laboratory settings, highlighting the methodological rigor applied in the assessment of treatment effects post-administration.

38) Ulcer:
Ulcer denotes a specific type of wound characterized by a loss of epithelial tissue. The study focuses on the use of the biodegradable patch for wound management, reinforcing the importance of healing various ulcer types through effective therapeutic methods.

39) Sahu:
Sahu refers to one of the authors and contributors to the study, indicating the collaborative effort in completing the research. His participation emphasizes the shared responsibility of advancing knowledge regarding Ayurvedic treatments and their scientific validation.

40) Tree:
Tree refers to the source of the barks used in the compound Ayurvedic drug formulation. The focus on tree species highlights the importance of natural materials harvested for medicinal use, representing a core principle of Ayurveda that emphasizes plant-based treatments.

41) Diet:
Diet signifies the nutritional provisions provided to the test animals during the study. Proper diet management helps maintain health and well-being, ensuring that results from the experiments are based on the effects of the treatment alone, not influenced by nutritional deficiencies.

42) Cage:
Cage refers to the polypropylene housing provided for the test animals. It is essential for ensuring a controlled environment during the study, emphasizing ethical considerations in animal research and providing a stable setting for accurate observations and data collection.

43) Male:
Male specifies the gender of the rats utilized in the study. Gender can influence biological responses, thus highlighting its relevance in the study context where both male and female rats may be examined for any potential gender-related variations in treatment outcomes.