Efficacy of biodegradable Ayurvedic patch in rat wound model study.

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: An experimental study to assess the efficacy of biodegradable patch impregnated with compound ayurvedic drug in excisional wound model of albino rat
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Awadhesh Kumar Pandey, PathakMeenakshiS.N., Prof.M.Sahu, Dr.Vijay Kumar


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: An experimental study to assess the efficacy of biodegradable patch impregnated with compound ayurvedic drug in excisional wound model of albino rat

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research


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Summary of article contents:

Introduction

This study investigates the efficacy of a biodegradable patch impregnated with a compound Ayurvedic drug for promoting wound healing in an excisional wound model using albino rats. Proper wound healing is critical for restoring the integrity and function of damaged tissues. The healing process occurs in three phases: inflammation, cellular proliferation, and remodeling. Recent advancements have introduced dermal patch technology as a promising method for drug delivery, enhancing the rate and effectiveness of healing in wounds while minimizing invasiveness and side effects.

Enhanced Wound Healing with Biodegradable Patches

The core concept of this study revolves around the preparation and utilization of biodegradable patches made from a combination of synthetic polymers, specifically Poly(lactic acid) (PLA) and Poly Caprolactone (PCL). These polymers serve as carriers for an aqueous extract of four Ficus species, which are known for their medicinal properties. The study demonstrated that the application of these patches led to a significant reduction in wound size and healing time when compared to control groups treated with normal saline. The results indicated enhanced epithelialization and tissue regeneration, confirming the potential of these biodegradable patches in wound management.

Reduction in Healing Time

Another significant finding from the study is the substantial reduction in healing time associated with the use of the biodegradable patches. Various groups of rats were treated with patches made from different polymer compositions, and results showed that the most effective group, treated with PLA, exhibited the shortest healing times. The control group displayed prolonged healing durations, whereas groups receiving the PLA-based patches showed a remarkable decrease in unit healing time as wounds progressed towards closure. This highlights the effectiveness of incorporating PLA as a substrate for drug delivery in the context of wound healing.

Efficacy of Compound Ayurvedic Drugs

The study emphasizes the importance of compound Ayurvedic drugs in enhancing the healing process. The aqueous extracts derived from the stem bark of four Ficus species were central to the observed healing benefits. The integration of these natural compounds into the biodegradable patches not only contributed to better wound closure and regeneration of granulation tissue but also provided a synergistic effect that facilitated quicker recovery. This illustrates the potential of traditional Ayurvedic treatments when combined with modern biodegradable technology for therapeutic applications in wound care.

Conclusion

In conclusion, the research presents promising evidence supporting the use of biodegradable patches containing Ayurvedic compounds as an effective modality for enhancing wound healing. The significant reduction in wound size and healing time demonstrates the potential of this treatment approach. Given the observed results indicating negligible systemic absorption and minimal side effects, there is a strong case for conducting clinical trials to evaluate the efficacy of these biodegradable patches in human patients with wound healing needs. The integration of ancient medicinal practices with contemporary drug delivery systems could pave the way for innovative solutions in wound management.

FAQ section (important questions/answers):

What is the purpose of the study on biodegradable patches?

The study aims to assess the wound healing activity of biodegradable patches impregnated with Ayurvedic drugs on excisional wound models in albino rats, demonstrating enhanced rates of wound contraction and reduced healing times.

What materials were used to prepare biodegradable patches?

The biodegradable patches were prepared using aqueous extracts from four Ficus species and polymers such as Poly(lactic acid) and Poly Capro lactone, which serve as the substrate for drug impregnation.

How were the effects of the patches measured in the study?

The effects were measured by comparing the surface area of the wounds and the unit healing time across different groups of treated and untreated rats over specified time intervals.

What significant results were observed with the biodegradable patches?

The results indicated that the patch using Poly(lactic acid) was significantly more effective in reducing wound surface area and healing time compared to control and other treatment groups.

What implications does the study have for wound treatment?

The study suggests that biodegradable patches could provide an effective, safe local treatment for wounds using Ayurvedic compounds, indicating the need for further clinical trials.

What key advantages does the topical application of patches offer?

Topical application of patches can effectively deliver medication with minimal systemic absorption and side effects, providing a convenient and localized method for wound healing.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Efficacy of biodegradable Ayurvedic patch in rat wound model study.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
The term 'Drug' refers to a substance used for medical treatment, specifically to bring about a physiological effect on the body. In the context of the study, compound Ayurvedic drugs were integrated into biodegradable patches to enhance wound healing in albino rats, demonstrating their efficacy as therapeutic agents.

2) Surface:
The word 'Surface' pertains to the outermost layer of an object, such as a wound on the skin. This study measured the surface area of wounds to evaluate the healing progress after treatment with different biodegradable patches, facilitating the assessment of the efficacy of various formulations.

3) Biodegradable:
The term 'Bio-degradable' highlights materials that can be decomposed by living organisms or biological processes. The focus on bio-degradable patches in the study is significant for wound healing as they provide a temporary scaffold while breaking down safely within the body, thus promoting healing without adverse effects.

4) Animal:
In this context, 'Animal' refers specifically to the albino rats used in the research. The study employed these animal models to simulate wound healing processes and evaluate the effectiveness of the biodegradable patches in a controlled environment, thus providing valuable insights into potential human applications.

5) Table:
The term 'Table' in the study presents organized data, typically summarizing findings like surface area reduction and healing times across different experimental groups. Tables facilitate comparisons and convey results clearly, aiding in the analysis of the efficacy of various treatments in the wound healing process.

6) Study (Studying):
'Study' refers to the systematic investigation of a specific hypothesis or question. This particular study was designed to evaluate the efficacy of biodegradable Ayurvedic drug-infused patches in enhancing wound healing in albino rats, contributing to the field of wound management and regenerative medicine.

7) Patanjali:
'Patanjali' refers to the Patanjali Bharteeya Ayurvigyan Avum Anusandhan Sansthan, the research institution associated with the study, known for its contributions to Ayurveda and herbal medicine. The institution plays a vital role in promoting traditional healing practices through scientific research and verification of Ayurvedic principles.

8) Tantra (Tamtra, Tantrism):
'Tantra' in this context refers to a branch of Ayurveda focused on surgical practices and treatments. The study pertains to Shalya Tantra, which encompasses the medicinal and procedural aspects of wound healing, aligning with Ayurvedic principles to enhance natural healing through innovative techniques.

9) Shalyatantra (Salyatantra, Shalya-tantra, Shalyatamtra):
'Shalya-tantra' is a traditional Ayurvedic discipline that specializes in surgery and trauma management. The research involving biodegradable patches for wound healing falls under this field, aiming to integrate modern biomedical technologies with ancient surgical practices to improve patient outcomes in wound care.

10) Substance:
The word 'Substance' denotes a material or compound with specific physical or chemical properties. In the study, the substances referred to include the Ayurvedic extracts and polymers used in developing biodegradable patches, which are engineered to facilitate targeted healing effects on the wound sites.

11) Shalya (Salya):
'Shalya' is an Ayurvedic term associated with surgery and treatment of wounds. It signifies the importance of surgical methods and healing practices that align with Ayurvedic principles, as explored in the study through the development of innovative biodegradable patches for effective wound management.

12) Kumar:
'Kumar' is a common surname in India and serves as part of the name of Dr. Awadhesh Kumar Pandey, the lead author of the study. His affiliation with Ayurvedic research and teaching enhances the credibility of the study in traditional medicine practices.

13) Activity:
In this context, 'Activity' refers to the functional effect or response elicited by the biodegradable patches on the wound healing process. The study measures biological activities including rate of wound contraction and tissue regeneration as indicators of the efficacy of the treatment.

14) Dressing:
'Dressing' refers to the material applied to wounds to promote healing and protect against infection. This study compares conventional dressings with biodegradable patches, assessing how each method influences the healing process and recovery time in the albino rats.

15) Species:
'Species' usually categorizes living organisms. In the study, it refers to the different Ficus species (such as Ficus bengalensis and Ficus religiosa) from which Ayurvedic extracts were derived for impregnating biodegradable patches, indicating the significance of plant selection in therapeutic efficacy.

16) Post:
'Post' pertains to the time after an event, in this study often indicating observations or results recorded after treatments, such as post-treatment surface area measurements of wounds. This timing is crucial for assessing the effectiveness of various interventions in wound healing.

17) Ficus religiosa:
Ficus religiosa, commonly known as the sacred fig, is a tree species revered in many cultures. As one of the Ficus plants used in the study, its extracts demonstrate potential medicinal properties for wound healing, emphasizing the relevance of traditional plant knowledge in modern research.

18) Inflammation:
'Inflammation' is the body's biological response to injury or harmful stimuli. In wound healing, inflammation is a necessary early phase that helps coordinate the repair process. The study likely assesses how biodegradable patches affect this phase, facilitating an optimal environment for recovery.

19) Discussion:
'Discussion' is a section of the study where researchers interpret results, draw conclusions, and suggest implications of their findings. It reflects on the efficacy of biodegradable patches, comparing them to control treatments and evaluating the significance of the outcomes in wound healing.

20) Irritation:
'Irritation' refers to discomfort or adverse reactions that can occur with certain topical treatments. The study briefly mentions irritation assessments to ensure that the biodegradable patches are safe and deliver therapeutically without causing harmful side effects on the skin.

21) Ayurveda (Ayus-veda):
'Ayurveda' is an ancient system of natural healing originating from India, emphasizing a holistic approach to health. This study is rooted in Ayurvedic principles, exploring the wound healing potentials of Ayurvedic formulations, thereby integrating traditional wisdom with modern scientific methodologies.

22) Varanasi (Varanashi):
'Varanasi' is a city in India known for its cultural and historical significance, particularly in education and medicine. The affiliation of some authors with Banaras Hindu University in Varanasi highlights the academic environment that fosters research on Ayurvedic practices and innovations.

23) Udumbara:
'Udumbara' is another species of Ficus used in the study. The relevance of including different Ficus species, like Udumbara, rests in their historical medicinal applications in Ayurveda, exploring their healing properties within the context of the biodegradable patches being researched.

24) Toxicity:
'Toxicity' refers to the degree to which a substance can harm organisms. In the context of this study, assessing the toxicity of the biodegradable patches is crucial to ensure that they are safe for therapeutic use in wound healing without causing adverse effects.

25) Medicine:
'Medicine' encompasses a broad field of practice relating to the diagnosis, treatment, and prevention of illness. The study integrates aspects of traditional Ayurvedic medicine with modern research methods, exploring innovative approaches to enhance wound healing efficacy using biodegradable technology.

26) Prasuti:
'Prasuti' is an Ayurvedic term referring to obstetrics and gynecology. While not directly the focus of the wound healing study, its inclusion highlights the variety of disciplines within Ayurveda, showcasing the diversity of therapeutic areas explored by practitioners and researchers.

27) Plaksha (Plaksa):
'Plaksha' is yet another Ficus species utilized in the study for its medicinal properties. Similar to other Ficus plants examined, it underscores the exploration of various Ayurvedic sources in developing effective treatments for wound healing through innovative patch formulations.

28) Disease:
'Disease' refers to any disorder of a structure or function within the body. The study indirectly addresses disease by focusing on wounds, which are a common medical concern, and seeks to provide an effective treatment using biodegradable patches derived from Ayurvedic principles.

29) Science (Scientific):
'Science' is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. The study exemplifies the scientific method by evaluating traditional Ayurvedic practices through rigorous research to validate their efficacy in wound healing.

30) Glass:
'Glass' is a material commonly used in laboratory settings, such as beakers or sheets for film application in this study. Its relevance lies in providing a clean, stable surface for the formation of biodegradable patches, essential for ensuring accurate experimental results.

31) Water:
'Water' serves multiple functions in the study, specifically as a medium for preparing aqueous extracts of the Ficus species. Its solvent properties are crucial for extracting active compounds from plant materials, thereby influencing the effectiveness of the drug formulations utilized in experimental patches.

32) Ulcer:
'Ulcer' denotes a sore that develops on the skin or mucous membranes due to tissue loss. The study relates to wound healing as it aims to improve treatments for such conditions. The biodegradable patches may serve as an innovative solution for promoting healing in ulcerative scenarios.

33) House:
'House' in this context refers to the animal housing facility where the albino rats were kept during the study. Maintaining a controlled environment, such as temperature and humidity, is essential for the health of experimental animals and the validity of research findings.

34) Paddy:
'Paddy' refers to the husks or residues used as bedding in the animal housing units. Its usage reflects a natural, sustainable approach to animal care in laboratory settings, aligning with the environmentally-friendly aspect of biodegradable products being studied.

35) Vata:
'Vata' is an Ayurvedic term associated with the bioenergy of movement and communication within the body. Including Ficus species named Vata in the study underscores Ayurveda's holistic approach wherein different plants are considered for their energetic properties in wound healing treatments.

36) Food:
'Food' represents the nutrition provided to the animals during the study. Proper nourishment is crucial for the health of experimental subjects, ensuring that they are in optimal condition for testing the efficacy of the biodegradable patches in wound healing.

37) Sahu:
'Sahu' is a surname of Prof. M. Sahu, one of the significant contributors to the study. His expertise in Ayurveda and involvement in the research emphasize the collaborative nature of the project, merging traditional wisdom with contemporary scientific inquiry.

38) Cage:
'Cage' refers to the containment units used to house the albino rats during the study. Appropriate caging is vital for ensuring the well-being and ethical treatment of laboratory animals, thereby supporting the integrity of the research process.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Efficacy of biodegradable Ayurvedic patch in rat wound model study.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Animal model, Wound healing activity, Wound contraction, Surgical Procedure, Unit healing time, Administration of drug, Normal saline, Epithelialization, Tissue regeneration, Skin irritation.

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