Pharmaceutical evaluation of kukkutand, mukta shukti, and godanti bhasm.
Journal name: World Journal of Pharmaceutical Research
Original article title: Pharmaceutical and comparative evaluation of three sudhavargiya drugs named kukkutand twaka bhasm, mukta shukti bhasm and godanti bhasm
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Dr. Rajni Bala, Dr. Vikas Chandra Gupta and Dr. Nitin Pandey
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Pharmaceutical and comparative evaluation of three sudhavargiya drugs named kukkutand twaka bhasm, mukta shukti bhasm and godanti bhasm
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The study presented in this research article focuses on the pharmaceutical and comparative evaluation of three Ayurvedic drugs, specifically Kukkutanda Twaka Bhasma, Mukta-Shukti Bhasma, and Godanti Bhasma. These formulations are part of a specialized branch of Ayurveda known as Rasashastra, which deals with the therapeutic use of metals, minerals, and herbal combinations. The research aims to analyze the physical and chemical properties of these Sudhavargiya drugs, which are known for their richness in calcium and their potency in various therapeutic applications.
Physical and Chemical Analysis of Kukkutanda Twaka Bhasma
Kukkutanda Twaka, or egg shell, undergoes a meticulous purification and incineration process to be transformed into Bhasma. The study details the Shodhana (purification) procedure, which involves boiling the shells in saltwater and Nausadar, followed by drying. Subsequent tests reveal a loss of weight during purification, indicating the effectiveness of the procedure. Following purification, the sample is triturated and subjected to multiple rounds of heating in a Gajaputa furnace. The final Bhasma maintains high calcium content and showcases significant loss in weight through the incineration process, emphasizing its preparation's effectiveness.
Mukta-Shukti Bhasma Production and Evaluation
Mukta-Shukti Bhasma, derived from Indian pearl oysters, also undergoes a rigorous purification process involving scrabbling and boiling in Kanji, a fermented rice solution. The weight loss analysis post-purification indicates the efficiency of the Shodhana procedure. Once purified, these pieces are treated with Aloe Vera juice and subjected to repeated heating, reflecting a traditional preparation method to enhance its therapeutic properties. The analysis highlights the Alkalinity and the final calcium content of Mukta-Shukti Bhasma, establishing its medicinal significance in the Ayurvedic pharmacopoeia.
Godanti Bhasma: A Unique Mineral Preparation
Godanti, which is essentially Gypsum, has a unique preparation process distinguished from animal-derived Bhasmas. The purification involves boiling small pieces in lemon juice before being subjected to repeated Gajaputa treatments. The data gathered show a gradual loss in weight and maintain their physical characteristics throughout the process. A comprehensive analysis of Godanti Bhasma showcases its mineral composition and the potential therapeutic effects for various health conditions, solidifying its place in Ayurvedic medicine.
Conclusion
This research meticulously evaluates the pharmaceutical qualities of Kukkutanda Twaka, Mukta-Shukti, and Godanti Bhasmas, aligning with established Ayurvedic standards for drug formulation. The comprehensive physical and chemical analyses reveal valuable insights into the preparation methods, the potency regarding calcium content, and overall effectiveness of these formulations. The findings underscore the significance of traditional Ayurvedic practices and reinforce the need for further investigations to validate and standardize various formulations to enhance their therapeutic applications in modern medicine.
FAQ section (important questions/answers):
What is Rasashastra in Ayurvedic medicine?
Rasashastra is a unique Ayurvedic branch that focuses on metals, minerals, and herbal combinations. It emphasizes therapeutic uses of substances known as Bhasmas, which are believed to have potent pharmacological actions.
What are the three Sudhavargiya drugs evaluated in the study?
The study evaluated Kukkutanda Twaka (egg shell), Mukta-Shukti (pearl oyster shell), and Godanti (gypsum), all rich in calcium and classified under Sudhavargiya in Ayurvedic medicine.
How is Kukkutanda Twak Bhasma prepared?
Kukkutanda Twak Bhasma is prepared by boiling the eggshells in saline water, purifying them through multiple heating and trituration processes with lemon juice, and then incinerating to create the final Bhasma.
What is the significance of calcium content in these Bhasmas?
Calcium content is significant as it determines the therapeutic potential of the Bhasmas. Kukkutanda Twak Bhasma contains the highest calcium level at 60.83%, indicating its strong nutritional and health benefits.
What methods were used for the analysis of the Bhasmas?
The analysis employed various methods including organoleptic evaluations, pH testing, ash value determination, qualitative and quantitative analysis, and atomic absorption spectrophotometry to ensure the quality and efficacy of the Bhasmas.
What were the findings on the organoleptic properties of the Bhasmas?
All evaluated Bhasmas were found to be white, smooth, tasteless, and odorless, indicating consistent quality. These properties are crucial for their acceptance and therapeutic use in Ayurvedic treatments.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Pharmaceutical evaluation of kukkutand, mukta shukti, and godanti bhasm.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Bhasma (Bhasman):
Bhasma refers to the ash-like powder produced through the incineration (Marana) of specific substances, particularly in Ayurvedic medicine. It is believed to enhance the therapeutic effects of the ingredients used and is considered potent for various diseases. Bhasma is characterized by fine particle size and unique properties that make it effective in treatments.
2) Shukti (Sukti, Su-ukti):
Shukti stands for the oyster shell, particularly from Indian pearl oysters. In Ayurvedic pharmacology, Shukti is processed to produce Mukta-Shukti or pearl bhasma, which is utilized for its rich calcium content and therapeutic benefits. Shukti represents the animal-derived element in Sudhavargiya drugs, showcasing the importance of marine resources in traditional medicine.
3) Mukta:
Mukta translates to 'pearl' in Sanskrit and is obtained from oysters. In Ayurvedic formulations, Mukta is processed into a fine powder known as Mukta-Bhasma, which is valued for its high calcium content and healing properties. This mineral is significant in treating conditions related to calcium deficiency.
4) Puta:
Puta refers to the process of incineration or calcination performed on Ayurvedic substances. This method is essential for transforming raw ingredients into medicinal forms, enhancing bioavailability and efficacy. The Puta method, often repeated several times, maximizes the therapeutic potential of Bhasma being produced, ensuring safety and potency.
5) Rajni:
Rajni is likely referring to Dr. Rajni Bala, one of the authors of the study discussed in the text. Her contributions underline the academic efforts to evaluate Ayurvedic pharmaceuticals, showcasing the collaboration of medical professionals in advancing traditional practices through scientific methodologies and research.
6) Water:
Water is utilized in various processes within Ayurvedic pharmaceutics, especially in purification (Shodhana) and incineration (Marana) methods. It enhances the extraction of beneficial components from herbs and minerals, helping to dissolve and prepare substances before further processing into medicines, ensuring the final product's safety and efficacy.
7) Drug:
In the context of this study, a drug denotes any medicinal substance used for treating or preventing disease, particularly those derived from Ayurvedic practices. The research evaluates the safety, efficacy, and quality of these drugs, contributing to their standardization and acceptance in modern medicine.
8) Observation:
Observation refers to the systematic recording and analysis of the outcomes and characteristics of Ayurvedic preparations during the study. This method ensures that the results are reliable and valid, allowing practitioners and researchers to assess the effectiveness of the formulations and make informed decisions.
9) Shuktibhasma (Suktibhasma, Shukti-bhasma):
Shukti-bhasma is the incinerated product derived from oyster shells, known as Mukta or pearls. This ash is rich in calcium and is utilized in Ayurvedic treatments for various ailments, showcasing the integration of marine sources in Indian traditional medicine. Its preparation involves specific rituals to enhance its therapeutic effects.
10) Haridra:
Haridra translates to turmeric, which is used in the Nambure Phased Spot Test (N.P.S.T.) to assess the different properties of calcium Bhasmas. Turmeric contains active compounds that exhibit varying color changes when exposed to different pH levels, highlighting its role as an indicatory agent in Ayurvedic pharmacology.
11) Purification:
Purification (Shodhana) is a crucial process in Ayurveda aimed at eliminating impurities and enhancing the therapeutic potentials of raw materials. The purification methods increase the safety of substances used in Bhasmas, ensuring they are free from toxic elements while amplifying their medicinal properties through careful procedures.
12) Indian:
The term Indian signifies the geographical and cultural context of the Ayurvedic practices discussed. It highlights the traditional Indian medicinal system that employs natural resources and holistic approaches for health and wellness. The study reflects India's rich heritage in using minerals and herbs for therapeutic purposes.
13) Study (Studying):
The study is a detailed scientific examination of the physical and chemical properties of Sudhavargiya drugs, specifically evaluating Bhasma formulations. It aims to establish standardization, confirm therapeutic benefits, and assess their relevance within modern pharmacological contexts, emphasizing the blend of traditional knowledge and contemporary research methodologies.
14) Rasa (Rasha):
Rasa is a foundational concept in Ayurveda that pertains to the medicinal essence or intrinsic quality of substances, especially in Rasashastra. It distinguishes various drugs based on their therapeutic effects, guiding practitioners in choosing appropriate treatments for specific ailments through a deep understanding of drug properties.
15) Cow dung:
Cow dung is traditionally used in Ayurvedic procedures, particularly during the incineration (Marana) process, where it serves as a fuel source for heating. Its application reflects ecological sustainability in Ayurveda and emphasizes the importance of animal byproducts in enhancing the potency of Ayurvedic medicines.
16) Ayurveda (Ayus-veda):
Ayurveda is an ancient Indian system of medicine that emphasizes balance among body, mind, and spirit through natural therapies. It integrates herbs, minerals, and lifestyle practices in its healing approach, representing a holistic understanding of health that is being increasingly integrated with modern healthcare practices.
17) Gajaputa (Gaja-puta):
Gajaputa refers to a traditional Ayurvedic furnace used for incinerating substances. It typically involves a specific construction with heat generated from cow dung cakes. This method is crucial for ensuring uniform heating during the preparation of Bhasmas, significantly influencing their efficacy and therapeutic range.
18) Mineral:
Minerals play a pivotal role in Ayurveda as fundamental components of various formulations. They are classified under Rasashastra and used for their therapeutic benefits, including addressing deficiencies and improving overall health. This study particularly evaluates Sudhavargiya drugs with mineral origins, like Godanti.
19) Dravya:
Dravya means substance or material in Ayurvedic terminology, encompassing both herbal and mineral elements used in formulations. It reflects the basic building blocks of Ayurvedic medicines, emphasizing the importance of quality and characteristics in determining the therapeutic value of different combinations used in treatments.
20) Marana:
Marana signifies the incineration process in Ayurvedic system where substances are transformed into Bhasma, enhancing their therapeutic properties. This process must be conducted carefully following prescribed methods to achieve effective results, making Marana a fundamental aspect of preparing potent Ayurvedic formulations.
21) Powder:
Powder signifies the final form of Bhasma after processing, characterized by its fine particle size conducive for easy assimilation and enhanced bioavailability. The transition from raw material to a fine powder is essential for efficacy in Ayurvedic treatments, showcasing traditional knowledge in pharmaceutical preparation.
22) Sudha:
Sudha refers to elements classified as 'pure' or 'noble' substances in Ayurvedic practices signifying a category of drugs with high therapeutic potential. Sudhvargiya drugs like Mukta and Kukkutanda are recognized for their purity and effectiveness in treatments, especially those aimed at improving calcium levels.
23) Lemon:
Lemon, known for its sour juice, is frequently used in Ayurvedic pharmacology for its ability to enhance the properties of Bhasmas during preparation. The acidic nature of lemon is believed to facilitate better absorption and efficacy of the medicinal compounds being processed, reinforcing the traditional formulation methods.
24) Salt (Salty):
Salt is utilized in various purification processes (Shodhana) of Ayurvedic drugs. It serves both as a cleaning agent to remove impurities and as a facilitator to enhance the therapeutic properties of the substances through its unique chemical interactions in the preparation phases.
25) Rasashastra (Rasa-shastra, Rasasastra):
Rasashastra is the ancient Ayurvedic science of alchemy and pharmacology focusing on the medicinal use of metals, minerals, and herbal combinations. This field seeks to enhance therapeutic potentials through specific preparation methods, grounding Ayurvedic practices in a systematic and rigorous theoretical framework.
26) Container:
Container refers to the vessels or instruments in which Ayurvedic materials are processed or stored, which is vital for maintaining their efficacy and protective properties. The choice of container can affect the quality of Bhasma produced, ensuring that substances are free from contaminants during preparation.
27) Shastra (Sastra):
Shastra means 'science' or 'scripture' in Sanskrit. In the context of Rasashastra and Ayurveda, it represents the codified knowledge and methodologies applied in the practice of traditional medicine. It embodies the systematic approaches adopted in treating diseases through detailed protocols and principles.
28) Chandra:
Chandra likely refers to Dr. Vikas Chandra Gupta, a contributor to the study. His involvement showcases the collaborative nature of Ayurvedic research and reflects the scholarly efforts aimed at validating traditional practices through scientific inquiry and rigorous analysis.
29) Heating:
Heating is a critical component in various Ayurvedic processes, particularly in Marana and Bhasmikarana. It activates the molecular qualities of substances, ensuring their transformation into effective medicinal forms. Proper heating techniques are vital to achieving optimal therapeutic benefits from the preparations.
30) Sharman (Sarma, Sharma, Sarman):
Sharma often denotes a surname, likely referring to Dr. Sadananda Sharma or others involved in research or medical practice. Such individuals play key roles in the interpretation and application of Ayurvedic principles, driving forward the scientific validation and acceptance of traditional healing methodologies.
31) Gupta:
Gupta, commonly a surname, refers to Dr. Vikas Chandra Gupta, one of the authors of the research study. His participation indicates a systematic and rigorous academic framework employed in assessing Ayurvedic formulations, focusing on the reliability and safety of traditional medicinal practices.
32) Glass:
Glass is a material used in Ayurvedic preparation processes, especially in containers and apparatus for grinding or mixing substances. It represents the transition from traditional to more modern laboratory tools, ensuring precision and safety in handling medicinal ingredients during formulation.
33) Hari (Harin):
Hari in this context might relate to the name of the Ayurvedic college or individual involved in the study. It signifies the connection to traditional Indian medicine's academic background, fostering research that bridges ancient knowledge with contemporary scientific methodology.
34) Road:
Road, in this context, refers to the glass rod often used in Ayurvedic preparations, particularly during grinding and mixing processes. It facilitates uniform blending of substances, ensuring the quality of the formulation. Proper tools like the glass road are crucial for achieving desired consistency in preparations.
35) Samudraphala:
Samudraphala refers to marine-derived substances used in Ayurvedic formulations. It symbolizes the diverse resources incorporated into traditional healing practices, highlighting the importance of oceanic contributions to the holistic approach embraced by Ayurveda for effective therapeutic solutions.
36) Bhasmikarana:
Bhasmikarana denotes the overall process of preparing Bhasmas through incineration, emphasizing the critical transformation of raw materials into potent medicinal powders. This technique is integral in Ayurvedic practice, where the efficacy and safety of medicines rely on the meticulous execution of Bhasmikarana procedures.
37) Pharmacology:
Pharmacology studies the interactions between substances and living organisms, crucial for understanding the efficacy and safety of Ayurvedic medicines. The integration of pharmacological principles helps bridge traditional Ayurvedic practices with modern scientific validation, ensuring that formulations can be safely used in contemporary healthcare contexts.
38) Dravyaguna (Dravya-guna):
Dravya-guna refers to the study of the properties and effects of substances within Ayurveda. It correlates to how various Dravyas exert therapeutic action, forming an integral part of traditional medicinal practice. Understanding Dravya-guna is essential for practitioners to effectively tailor treatments to individual patients' needs.
39) Bhaishajya (Bhaisajya):
Bhaishajya denotes remedies or medical interventions in Ayurveda. It represents the practical application of Ayurvedic principles and formulations for treating ailments, emphasizing comprehensive approaches to health and wellness that incorporate various aspects of lifestyle and medication within traditional practices.
40) Discussion:
Discussion reflects the critical examination and interpretation of findings in the research study. It allows researchers and practitioners to analyze the implications of results, compare them with existing literature, and identify areas for further exploration within the context of Ayurvedic medicine and its applications.
41) Substance:
Substance refers to the raw materials, whether herbal or mineral, used in Ayurvedic formulations. Understanding the characteristics, properties, and therapeutic potentials of these substances is essential in developing effective remedies tailored to address specific health issues within the Ayurvedic framework.
42) Sadananda (Sadanamda, Sada-ananda):
Sadananda likely refers to Sri Sadananda Sharma, a prominent figure in Ayurvedic literature, credited with referencing various substances in Ayurvedic texts. His contributions strengthen the foundation of Rasashastra by documenting essential processes and properties of medicinal materials, influencing contemporary Ayurvedic practices.
43) Sambuka (Shambuka):
Shambuka represents one of the substances mentioned within the context of Sudhavargiya drugs in Ayurveda. While not extensively detailed, it illustrates the breadth of materials recognized in Ayurvedic practices for their medicinal applications, contributing to the holistic understanding and treatment methodologies within this field.
44) Shodhana (Sodhana):
Shodhana signifies the purification processes essential for detoxifying and enhancing the therapeutic efficacy of Ayurvedic substances. This step is critical in preparing raw materials, ensuring safety, and maximizing the potential health benefits of the final Ayurvedic formulations for patient use.
45) Varatika:
Varatika refers to a class of drugs in Ayurveda recognized for specific therapeutic properties related to calcium and mineral content. It signifies the classification of substances used in Ayurvedic practice, highlighting the detailed categorization that aids in the appropriate selection of remedies.
46) Medicine:
Medicine encompasses the various forms of treatment and healing practices, including those rooted in traditional systems like Ayurveda. It emphasizes the significance of holistic approaches in addressing health issues, integrating natural resources, and ancient wisdom in promoting well-being.
47) Turmeric:
Turmeric known as Haridra, is a significant ingredient in Ayurveda, valued not only for its taste but also for its medicinal properties. Its active compounds, especially curcumin, are recognized for anti-inflammatory and antioxidant effects, reinforcing its incorporation in various Ayurvedic formulations and practices.
48) Sukshma (Suksma, Shukshma):
Sukshma translates to 'subtle' in Sanskrit, referring to the intricate and fine nature of substances or processes within Ayurveda. This concept affirms the emphasis on understanding relationships at a molecular level in Ayurvedic pharmacology, especially concerning the action of drugs on the body.
49) Khatika:
Khatika refers to a category of substances in Ayurveda that are used similarly to Sudhavargiya drugs. It showcases the importance of diverse sources from the natural world in ancient healing practices, emphasizing the integration of various elements in creating effective Ayurvedic therapies.
50) Pottali:
Pottali signifies a cloth pouch or bundle used in Ayurvedic processes, especially for holding substances during purification or preparation. This traditional tool emphasizes the practical aspects of Ayurveda, combining ritualistic and scientific knowledge in the handling of medicinal materials.
51) Sindura (Simdura):
Sindura refers to specific formulations rich in metals or minerals, often associated with potent Ayurvedic practices. It represents the broader context of Rasashastra and the use of specialized techniques to prepare these substrates, affirming their significance in Ayurvedic therapeutics.
52) Kalpana:
Kalpana translates to 'formulation' in Ayurveda and denotes the creative processes involved in preparing herbal or mineral remedies. This term encapsulates the art and science of Ayurvedic pharmacy, bridging traditional knowledge with the systematic approach to creating effective medications.
53) Shankha (Sankha, Samkha, Shamkha):
Shankha refers to conch shells, which are mentioned as important elements in Ayurvedic practices and formulations. They symbolize the diversity of natural materials used in Ayurvedic medicine, highlighting the potential benefits of various animal-derived and marine substances in traditional healing practices.
54) Dealing:
Dealing refers to the process of managing or engaging with specific substances or practices in Ayurveda. It highlights the practitioners' role in utilizing their knowledge to appropriately select, prepare, and administer medications, ensuring holistic and effective healthcare alternatives.
55) Siddha:
Siddha indicates the perfected or accomplished state in Ayurvedic practices, often associated with the expertise required for sophisticated medicinal preparations. It underscores the importance of knowledge, experience, and technique in achieving optimal results through Ayurvedic methodologies and treatments.
56) Mishra (Misra):
Mishra likely refers to Sidhinandan Mishra, an author referenced within Ayurvedic literature and pharmacology. His contributions to documenting traditional knowledge enhance the foundation upon which contemporary Ayurvedic practices rest, showcasing the importance of scholarly research in the evolution of this healing art.
57) Rajika:
Rajika refers to a specific kind of ingredient (likely a seasoning) used in Ayurvedic formulations, particularly in the context of purification. Its inclusion reflects the emphasis on natural resources in Ayurveda and their potential benefits in creating holistic healing practices.
58) Animal:
Animal refers to sources derived from animals, such as Egg Shells (Kukkutanda) and oyster shells (Shukti), utilized in Ayurvedic formulations. The use of animal-derived materials highlights the diverse origin of medicinal substances within Ayurveda and the importance of including various natural elements in treatment preparations.
59) Kanji (Kamji):
Kanji is a fermented solution made from cooked rice and salt, traditionally used in Ayurveda for various preparations, including purification. It illustrates the innovative use of common ingredients for enhancing the medicinal properties of herbs and minerals, showcasing the holistic approach of Ayurvedic medicine.
60) Varga:
Varga denotes a classification or group of substances in Ayurveda, particularly in the context of Sudhavargiya drugs. It signifies the detailed categorization within Ayurvedic pharmacology that supports effective therapeutic interventions through the systematic selection of remedies based on their properties.
61) India:
India highlights the geographical and cultural roots of Ayurveda, emphasizing its ancient heritage in natural healing practices. As the birthplace of this medical system, India signifies the longstanding relationship between holistic health and natural wisdom while illustrating the ongoing evolution of Ayurvedic practices.
62) Pearl:
Pearl, in the Ayurvedic context, refers to the Mukta, derived from oysters. Pearls are processed into bhasma for their calcium-rich properties, illustrating the incorporation of marine-derived elements in Ayurvedic medicine. Their use exemplifies the blend of nature's treasures into the therapeutic practices of Ayurveda.
63) Bala:
Bala, which means strength or vigor, can relate to the author Dr. Rajni Bala or the concept in Ayurveda that pertains to the enhancement of health and vitality. It emphasizes the goal of Ayurvedic treatments in restoring or maintaining physical and mental well-being.
64) Mala:
Mala means impurity or waste in Sanskrit and is often used in Ayurvedic contexts referring to unwanted substances that need to be eliminated from materials. The concept of mala emphasizes the importance of purification processes in creating safe and effective Ayurvedic remedies.
65) Guna:
Guna refers to the inherent qualities or properties of substances in Ayurveda that influence their effect on health. Understanding the guna of various medicinal ingredients is essential for appropriate combinations in formulations, leading to effective treatment outcomes through tailored therapeutic practices.
66) Mani:
Mani refers to a jewel or precious object, symbolizing valuable ingredients or substances within Ayurvedic practices. It signifies the respect and worth attributed to traditional remedies derived from nature, emphasizing the significant role of these materials in promoting health and wellness.
67) Rice (Rce):
Rice plays a significant role in various Ayurvedic preparations, particularly in fermentation processes like Kanji, enhancing the bioavailability of nutrients. Its utilization reflects the integration of common grains in therapeutic contexts, showcasing the holistic approach of Ayurveda towards health and nutrition.
68) Rich (Rch):
Rich signifies the abundance of specific components, particularly in the context of Ayurvedic formulations. It may refer to high concentrations of therapeutic elements like calcium in the substances used, indicating the potency of certain Bhasmas and affirming their efficacy in addressing health concerns.
Other Science Concepts:
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Bhasma, Gajaputa, Indian system of medicine, Loss on drying, Ash value, Qualitative analysis, Water soluble ash, Calcium content, Quantitative analysis, Physico Chemical Study, Chemical analysis, Organoleptic character, Kukkutanda twak bhasma, Iron content, Mukta Shukti Bhasma, PH measurement, Kukkutand Twak Bhasma, Godanti Bhasma, Pharmacopial standards, Chemical constituent.