Ferulic acid: not a free radical scavenger or health enhancer.

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Ferulic acid – neither “a free radical scavenger” nor “a dietary health maker”- a review
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Ravichandra S, Hari prasath K, Devi Sowjanya K, Nalini G R, Veenaeesh P


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Ferulic acid – neither “a free radical scavenger” nor “a dietary health maker”- a review

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research


Summary of article contents:

1) Introduction

Ferulic acid is a phenolic compound derived from the metabolism of phenylalanine and tyrosine via the Shikimate pathway, and is widely distributed in various plants such as cereals, fruits, and vegetables. This compound has garnered attention as a natural antioxidant due to its ability to neutralize free radicals, which are harmful reactive oxygen species (ROS) that can damage vital cellular components like DNA and proteins. Ferulic acid is often utilized as a dietary supplement, food additive, and is being investigated for its wide-ranging health benefits. Its potential applications span across preventing diseases, improving health, and even serving as a precursor in the manufacture of synthetic flavoring agents like vanillin.

2) Antioxidant and Antimicrobial Properties

Antioxidant Activities of Ferulic Acid
Ferulic acid exhibits significant antioxidant properties due to its capacity to donate hydrogens to free radicals, thanks to its phenolic hydroxyl groups. This ability allows ferulic acid to mitigate oxidative stress, contributing to its protective roles against various diseases, including cancer, neurodegenerative conditions, and cardiovascular diseases. Moreover, studies support its capability to protect cellular structures from oxidative damage, reinforcing its value as a natural antioxidant in both dietary supplements and cosmetics, thus highlighting its relevance in enhancing health and well-being.

3) Role in Disease Prevention

Preventive Effects Against Chronic Diseases
Research indicates that ferulic acid may have a preventive effect on several chronic diseases. Specifically, it has been shown to inhibit the growth of certain cancer cells in vitro, and its administration in rodent models resulted in lower blood sugar levels for diabetic mice. Additionally, evidence suggests that ferulic acid could possess neuroprotective effects, helping to mitigate cognitive decline associated with diseases such as Alzheimer’s by reducing oxidative stress and inflammation. Its bioactive properties lend it potential as a therapeutic agent that can be harnessed for holistic health improvements.

4) Natural Sources and Commercial Applications

Commercial Potential of Ferulic Acid
Ferulic acid is prevalent in various agricultural products and is capable of being extracted from plant sources such as rice bran. Its structural similarities to other important biochemical compounds suggest that it could serve as a renewable resource for creating aromatic compounds and flavoring agents. The ability of microbial conversion processes to transform ferulic acid into natural vanillin further enhances its marketability in the food and cosmetic industries, where it functions as a valuable antioxidant as well. This indicates not only a significant commercial avenue for ferulic acid but also its contributions to nutritional enhancement and health optimization.

5) Conclusion

In conclusion, the review of ferulic acid reveals its significance as a potent phenolic antioxidant with diverse medical and commercial applications. Its ability to mitigate oxidative stress presents a logical rationale for its regular intake, potentially offering substantial protection against various oxidative stress-related diseases. Integrated knowledge of its natural sources, synthesis, pharmacological activities, and potential health benefits underscores the need for continued research into ferulic acid to harness its advantages for improved human health and well-being.

FAQ section (important questions/answers):

What is ferulic acid and where is it commonly found?

Ferulic acid is a hydroxycinnamic acid, a phenolic compound predominantly found in plant cell walls, especially in cereals, fruits, and vegetables. It plays vital roles in plant structure and function.

What are the potential health benefits of ferulic acid?

Ferulic acid exhibits antioxidant, antimicrobial, and anti-cancer properties. It may support cognitive health, improve conditions like hypertension, show neuroprotective effects, and assist in diabetic management.

How is ferulic acid synthesized and extracted?

Ferulic acid can be synthesized through methods like Perkin reaction or enzymatic processes. It’s also extracted from natural sources like rice bran and various plants.

What is the significance of ferulic acid in cosmetics?

In cosmetics, ferulic acid is valued for its antioxidant properties, helping to protect skin from UV damage. It is also used for skin whitening and anti-aging formulations.

What role does ferulic acid play in plant physiology?

In plants, ferulic acid contributes to cell wall rigidity and protects against pathogen invasion. It helps cross-link polysaccharides, enhancing structural integrity and growth control.

Can ferulic acid be used as a food additive?

Yes, ferulic acid is used as a food additive in Japan. It also serves as a natural antioxidant to improve food quality and extend shelf life.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Ferulic acid: not a free radical scavenger or health enhancer.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Disease:
Disease refers to a pathological condition of a bodily part, an organism, or system resulting from various causes, such as infections or genetic defects, and characterized by an identifiable group of signs or symptoms. In the context of ferulic acid, its potential therapeutic effects on diseases like cancer, diabetes, and Alzheimer's are discussed, showcasing its relevance to health.

2) Wall:
In the context of plant biology, the wall typically refers to the cell wall, a critical structure that provides support, protection, and shape to plant cells. Ferulic acid contributes to the rigidity and cross-linking of plant wall components, enhancing the structural integrity and defense mechanisms of plants against pathogens.

3) Activity:
Activity in this context refers to the biological effects of compounds, particularly their pharmacological and antioxidant activities. Ferulic acid exhibits various activities, including its role in scavenging free radicals, enhancing insulin secretion, and providing neuroprotection, which highlights its medicinal potential.

4) Medium:
Medium often denotes the environment or substance used to grow microorganisms, cells, or tissues. In the research mentioned, a minimal medium containing wheat bran serves as a carbon source for microorganisms capable of producing ferulic acid, illustrating the importance of medium for biological production processes.

5) Food:
Food encompasses the substances consumed for nutritional support. Ferulic acid, naturally found in various food sources like rice bran and fruits, is important not only for its antioxidant properties but also for its potential health benefits. Its presence in food highlights dietary considerations for human health.

6) Pharmacology:
Pharmacology is the branch of medicine concerned with the uses, effects, and mechanisms of action of drugs. This field is essential in studying compounds like ferulic acid, evaluating their therapeutic potential and safety in treating conditions like cancer, diabetes, and cardiovascular diseases.

7) Water:
Water is essential for all forms of life and serves as a solvent for biochemical processes. In the context of biological experiments and extraction processes, water is often used to dissolve substances, maintain physiological conditions, and extract valuable compounds such as ferulic acid from plant materials.

8) Blood:
Blood is a vital fluid in living organisms that transports oxygen, nutrients, and waste products. In studies of ferulic acid, its effects on blood-related conditions, such as hypertension and diabetes, underscore its potential role in influencing cardiovascular health and metabolic processes.

9) Cancer:
Cancer is a group of diseases characterized by uncontrolled cell growth. Research on ferulic acid highlights its inhibitory effects on cancer cells in vitro and in vivo, suggesting its relevance as a potential therapeutic agent in cancer prevention and treatment strategies.

10) Study (Studying):
Study refers to a detailed investigation or analysis of a subject. The research surrounding ferulic acid encompasses various studies evaluating its properties, synthesis, and biological effects, contributing to a deeper understanding of its potential health benefits and applications in medicine.

11) Drug:
A drug is a substance used to diagnose, treat, or prevent diseases. Ferulic acid presents potential as a drug candidate with antioxidant properties, implying applications in disease management and therapeutic interventions that warrant further investigation in pharmacological studies.

12) Phytochemical:
Phytochemical denotes bioactive compounds derived from plants that confer various health benefits. Ferulic acid is a prominent phytochemical known for its antioxidant, anti-inflammatory, and anticancer properties, making it a subject of interest in nutraceutical research and dietary recommendations.

13) Medicine:
Medicine is the science of diagnosing, treating, and preventing illness. The exploration of ferulic acid's medicinal properties positions it as a valuable compound for developing new therapeutic agents or supplements aimed at enhancing health and combatting various diseases.

14) Species:
Species refers to a group of individuals that can interbreed and produce fertile offspring. In plant science, ferulic acid is found across various species, indicating its ecological significance and potential variations in health benefits depending on the source organism.

15) Nature:
Nature encompasses the physical world and its phenomena, including plants, animals, and ecosystems. Understanding nature’s compounds, like ferulic acid, aids in bioprospection for developing natural antioxidants and therapeutic agents, emphasizing the importance of biodiversity in pharmacognosy.

16) Sugar:
Sugar commonly refers to sweet-tasting carbohydrates, important in nutrition. In the context of ferulic acid, its interaction with metabolic pathways related to sugar regulation highlights its potential in managing diabetes and influencing insulin sensitivity.

17) Cina:
China is significant in terms of traditional medicine and the use of herbal remedies. Ferulic acid is recognized in Chinese medicine for its cardiovascular benefits, indicating its cultural relevance and application in healthcare practices prevalent in the region.

18) Diet:
Diet encompasses the sum of food consumed by individuals. The presence of ferulic acid in a diet is associated with several health benefits, emphasizing the importance of dietary antioxidants in disease prevention and overall health maintenance.

19) Pharmacological:
Pharmacological refers to the study of drugs and their effects. The pharmacological investigation of ferulic acid entails understanding its mechanisms, therapeutic benefits, and potential side effects, providing insights into its application in health care.

20) Transformation (Transform, Transforming):
Transformed indicates the change in form or structure of a substance. Ferulic acid can be transformed through biological processes into compounds like vanillin, showcasing its versatility and potential application in food and cosmetic industries.

21) Observation:
Observation involves the act of closely monitoring phenomena. In ferulic acid research, observations of its effects on cell cultures and animal models provide critical data necessary for substantiating claims regarding its health benefits and pharmacological properties.

22) Toxicology:
Toxicology is the study of harmful effects of substances on living organisms. Understanding the toxicological properties of ferulic acid is crucial for assessing its safety profile and potential side effects in therapeutic use, ensuring a balance between efficacy and safety.

23) Substance:
A substance is any material with defined properties. Ferulic acid, as a substance, is significant in research due to its antioxidant properties and potential health benefits, warranting its inclusion in dietary supplements and functional foods.

24) Evolution:
Evolution refers to the gradual development of organisms and adaptations. The evolutionary significance of ferulic acid in plants relates to its role in defense mechanisms, suggesting its importance in plant survival and adaptation processes over time.

25) Cuttack:
Cuttack is a city in India, significant here due to research activities undertaken in local institutions. Studies involving ferulic acid conducted in Cuttack contribute to the body of knowledge surrounding its extraction, benefits, and applications, showcasing regional scientific efforts.

26) Quality:
Quality refers to the standard of something as measured against other things of a similar kind. The quality of ferulic acid as a functional ingredient in foods and cosmetics is essential for ensuring efficacy and safety in consumer products.

27) Nalini (Nalini°):
Nalini is likely a reference to one of the authors involved in the research related to ferulic acid. The inclusion of researchers like Nalini signifies collaborative efforts in advancing knowledge about the health benefits and applications of phytochemicals.

28) Aureus:
Aureus, particularly referencing *Staphylococcus aureus*, is a bacterium pertinent in studies assessing the antimicrobial potential of substances like ferulic acid. Understanding its interaction with such organisms informs the development of natural antimicrobial agents.

29) Family:
Family refers to groups of related organisms. In botanical classification, understanding the family of plants that produce ferulic acid can enhance knowledge of its distribution, potential health benefits, and ecological roles within various environments.

30) Animal:
Animal denotes multicellular organisms that are typically motile. Research on ferulic acid often encompasses animal models to assess its physiological impacts, providing insights into its therapeutic potential and applicability in veterinary or human medicine.

31) Botany:
Botany is the scientific study of plants, vital for understanding plant-derived compounds like ferulic acid. The insights gained from botany contribute to agricultural practices, conservation, and the exploration of plant secondary metabolites with health benefits.

32) Pulse:
Pulse refers to the edible seeds of legumes, known for their nutritional value. Plants yielding ferulic acid include pulses, highlighting their significance in human diets and their role as functional foods with potential health benefits.

33) Death:
Death is the cessation of all biological functions that sustain a living organism. In health research, understanding compounds like ferulic acid can provide insights into their roles in preventing oxidative stress-related diseases that may lead to premature death.

34) Hari (Harin):
Hari is another author mentioned in the research study on ferulic acid. It emphasizes teamwork and collaboration within academic and scientific settings to explore the health-related applications of phytochemicals.

35) Devi:
Devi denotes one of the contributors to the research on ferulic acid, underscoring the collaborative nature integral to academic progress in understanding plant-based bioactive compounds.

36) Genu:
Genu is likely part of an author's name as well. Inclusion of multiple names indicates collective contributions in the field of pharmacology, particularly research studies on compounds beneficial for human health.

37) Rice (Rce):
Rice is a staple food crop that contains ferulic acid. Its inclusion in diets not only provides nourishment but also introduces beneficial antioxidants, illustrating the dual role of food crops in nutrition and health.

38) Sage:
Sage, a herb with potential culinary and medicinal applications, also contains phytochemicals. The relevance of sage highlights the wealth of natural sources of antioxidants like ferulic acid, essential for combating oxidative stress.

39) Hull:
Hull refers to the outer covering or shell of seeds. Ferulic acid is abundant in hulls of grains, emphasizing its importance in agricultural byproducts and potential applications in health supplements and bioactive formulations.

40) Post:
Post generally refers to a period after an event. In scientific contexts, post treatment or post irradiative studies can indicate observations made after applying a substance like ferulic acid, highlighting its effects in various experimental settings.

41) Soil:
Soil is the upper layer of earth where plants grow. It is vital for extracting bioactive compounds like ferulic acid through cultivation of specific plants, thereby linking soil health to nutritional and pharmacological outcomes.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Ferulic acid: not a free radical scavenger or health enhancer.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Antioxidant properties, Oxidative stress, Reactive oxygen species, Cardiovascular disease, Clinical pharmacology, Pharmaceutical Research, Ferulic acid.

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