Anti urolithiatic herbs and effective siddha formulations

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Journal name: World Journal of Pharmaceutical Research
Original article title: Anti urolithiatic herbs and effective siddha formulations
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Author:

Nalini Sofia.H, Manickavasakam.K, Vetha Merlin Kumari.H, Thomas M.Walter and Mohan. S


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Anti urolithiatic herbs and effective siddha formulations

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research

Copyright (license): WJPR: All rights reserved


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Summary of article contents:

Introduction

Urinary stones, also known as kidney stones, have been a persistent health issue throughout human history, characterized by the formation of hard masses from crystallized substances in urine. Various factors contribute to kidney stone formation, including elevated levels of calcium, uric acid, oxalate, and magnesium deficiencies. Traditional herbal medicine offers a promising avenue for managing urolithiasis due to its broad range of biological and medicinal effects, along with a lower likelihood of side effects compared to synthetic drugs. This review highlights numerous medicinal plants and Siddha formulations recognized for their antiurolithiatic properties, discussing their botanical profiles, phytochemical constituents, and therapeutic potential in treating kidney stones.

Phytochemical and Therapeutic Profiles of Key Herbs

One noteworthy herb is Tribulus terrestris, which has demonstrated significant diuretic and antiurolithiatic effects. Studies show that its aqueous extract can increase urine volume and reduce the retention of stone-forming constituents such as calcium oxalate and uric acid in the body. Experimental results indicate that the herb inhibits the crystallization process and reduces kidney injury caused by oxalate exposure. Additionally, it has shown effectiveness in clinical settings, impacting urinary chemistry positively in patients with urolithiasis, thus solidifying its role as a potential treatment option for kidney stones.

Siddha Formulations and Their Efficacies

Another critical aspect of the review is the exploration of various Siddha formulations traditionally used for treating urolithiasis. For instance, Nerunjil kudineer, a Siddha product containing Tribulus terrestris, has been shown to improve urinary output and lower serum urea levels in rat models of urolithiasis. Other formulations such as Vediuppu chunnam and Nandukkal parpam have exhibited significant efficacy, as evidenced by reduced deposition of calcium oxalate in the kidneys and enhanced urinary excretion of stone-forming substances. These clinical studies indicate the relevance of Siddha practices in managing kidney stones and provide a pathway for future clinical applications.

Mechanisms of Action in Anti-Urolithiasis

The antiurolithiatic effects of the discussed herbs are largely attributed to their phytoconstituents, which exhibit a variety of biological activities. For example, chemical compounds extracted from Moringa oleifera and Momordica charantia have been shown to effectively reduce urinary levels of oxalates, calcium, and phosphates. Many of these plants act as diuretics, promoting increased urine production, which helps dilute stone-forming substances. Furthermore, their antioxidant properties may mitigate oxidative stress in renal tissues, contributing to their protective role against stone formation. The underlying mechanisms highlight the multifaceted nature of these natural therapies.

Conclusion

The evidence presented in this review underscores the potential of herbal and Siddha medicinal strategies in treating urolithiasis. The traditional knowledge surrounding these plants, complemented by modern scientific evaluation, emphasizes their pharmacological significance. The wide variety of documented diuretic, lithotriptic, and nephroprotective effects reinforce the idea that these herbal remedies can serve as effective alternatives or complements to conventional treatments for kidney stones. Continued research and integration of these natural therapies into mainstream medical practice could enhance treatment outcomes for individuals suffering from urolithiasis and related health issues.

FAQ section (important questions/answers):

What is the main focus of the review article on urolithiasis?

The review focuses on the botanical information, phytochemistry, therapeutic uses, and pharmacological effects of various herbs and Siddha formulations used to treat urinary stones.

How do herbal medicines compare to conventional treatments for urolithiasis?

Herbal medicines are considered more cost-effective, have fewer side effects, and are increasingly recognized for their therapeutic potential, especially in treating conditions like urolithiasis.

What are some commonly used herbs for treating kidney stones?

Common herbs include Solanum xanthocarpum, Tribulus terrestris, Moringa oleifera, and Momordica charantia, which have shown significant antiurolithiatic properties in studies.

What are the effects of Tribulus terrestris on kidney stones?

Tribulus terrestris has diuretic effects, aiding in the expulsion of urinary stones and showing potential in inhibiting calcium oxalate crystal formation.

What role do Siddha formulations play in treating urolithiasis?

Siddha formulations, like Nerunjil kudineer, have demonstrated effective diuretic and lithotriptic properties, increasing urinary output and reducing serum creatinine levels in studies.

What conclusions can be drawn about using herbal remedies for kidney stones?

Herbs exhibit diuretic, lithotriptic, and nephroprotective effects, indicating their potential as effective treatments for kidney stones and related urinary tract issues.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Anti urolithiatic herbs and effective siddha formulations”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Nalini (Nalini°):
Nalini refers to Dr. Nalini Sofia.H, the leading author of the research paper that focuses on anti-urolithiatics in the Siddha system of medicine. Her contributions are significant in validating traditional medicine practices through scientific methods and showcasing the potential of herbal remedies for kidney stone treatment.

2) Siddha:
Siddha is an ancient system of medicine originating in South India, known for its holistic approach to health and healing. It encompasses a variety of herbal treatments, formulations, and therapies aimed at restoring balance and health, especially regarding management of conditions like urolithiasis.

3) Activity:
Activity refers to the pharmacological effects observed in herbal medicines. Particularly, this includes the anti-urolithiatic activity of various plants studied in the review, which denotes their effectiveness in preventing or treating urinary stones via diuretic or litholytic properties.

4) Male:
Male typically denotes the sex of certain study subjects in the research. In many pharmacological studies, male rats are frequently used as they provide a controlled biological environment for assessing the effects of treatments, including the anti-urolithiatic effects of herbal extracts.

5) Tribulus terrestris:
Tribulus terrestris is a plant whose extract has demonstrated potential diuretic and anti-urolithiatic effects in the research. The studies highlight its role in increasing urinary output and inhibiting the formation of calcium oxalate crystals, essential for treating kidney stones.

6) Drug:
Drug encompasses both conventional pharmaceutical products and herbal remedies being researched. In this context, it relates to Siddha formulations and plant extracts that exhibit therapeutic potential against urinary stones, illustrating how various substances can alleviate disease symptoms.

7) Disease:
Disease signifies pathological conditions that affect the human body, specifically referring to urolithiasis in this review. Urolithiasis, characterized by the formation of stones in the urinary tract, showcases the necessity for effective treatments and herbal remedies to manage this condition.

8) Animal:
Animal refers to the test subjects used in the pharmacological studies, particularly Wistar albino rats. Animal testing is crucial for understanding the efficacy and safety of herbal extracts before clinical application in humans, providing preliminary data on treatment effects.

9) Trigonella foenum-graecum:
Trigonella foenum-graecum, also known as fenugreek, is studied for its anti-urolithiatic properties. The research notes its impact on preventing calcium oxalate stone formation, demonstrating the significance of traditional herbs in modern medicine for treating urinary disorders.

10) Dolichos biflorus:
Dolichos biflorus, commonly known as horse gram, is highlighted for its medicinal properties related to kidney stone prevention. Its extracts are shown to dissolve stone-forming crystals, emphasizing the potential of this plant in managing and treating urolithiasis effectively.

11) Rubia cordifolia:
Rubia cordifolia, or Indian madder, is acknowledged for its anti-urolithiatic activity. Its extracts have demonstrated ability to diminish calcium deposits in the kidneys, reinforcing its traditional use in kidney stone treatment and highlighting its potential as a herbal remedy.

12) Flavonoid:
Flavonoid refers to a class of polyphenolic compounds found in many plants, including those studied in the review. These compounds are known for their antioxidant and anti-inflammatory properties, contributing to the overall therapeutic effects of the herbal preparations against urolithiasis.

13) Medicine:
Medicine denotes the science and practice of diagnosing and treating health issues. This review integrates traditional knowledge of Siddha medicine with modern pharmacology, promoting the exploration of herbal remedies in tackling diseases like urolithiasis.

14) Chennai:
Chennai is a major city in India and home to the National Institute of Siddha. This location is significant for the development and research of Siddha medicine and herbal treatments, providing a cultural and academic backdrop for the studies pursued in the review.

15) Study (Studying):
Study refers to the systematic research conducted to evaluate the anti-urolithiatic properties of various herbs. The findings contribute to the understanding of how traditional medicines can be integrated into modern healthcare to address urolithiasis.

16) Solanum xanthocarpum:
Solanum xanthocarpum is examined for its pharmacological benefits in treating kidney stones. This plant's active compounds have shown promising results in inhibiting urolithiasis, illustrating the viability of traditional herbs in contemporary medical applications.

17) Terminalia chebula:
Terminalia chebula is recognized for its therapeutic potential against kidney stones, with studies highlighting its efficacy in lowering oxalate and phosphate levels in urine. This plant's role in Siddha medicine emphasizes its value in treating urolithiasis.

18) Cynodon dactylon:
Cynodon dactylon, or Bermuda grass, is noted for its diuretic effects. The extract from this grass shows promise for renal health and has potential applications in managing urolithiasis by assisting in the elimination of stone-forming components through increased urine output.

19) Asparagus racemosus:
Asparagus racemosus, commonly known as shatavari, is evaluated for its diuretic properties in treating urinary stone disease. Its extracts have shown potential in reducing serum levels of calcium and other constituents that contribute to urinary stones.

20) Benincasa hispida:
Benincasa hispida, or wax gourd, is assessed for its ability to manage oxalate levels in the body. Its extracts can lower renal retention of calcium and oxalate, highlighting its significance in alleviating the risk of urolithiasis.

21) Raphanus sativus:
Raphanus sativus, known as radish, is included in the research for its diuretic activity. Its extracts have shown efficacy in reducing urinary stone weight, supporting its application in traditional medicine for treating urolithiasis.

22) Hordeum vulgare:
Hordeum vulgare, or barley, is explored for its health benefits, particularly its role in reducing urinary constituents associated with stone formation. This aligns with the study's aim to identify effective herbal remedies for urolithiasis management.

23) Mimusops elengi:
Mimusops elengi is evaluated for its anti-urolithiatic effects in this research, showcasing its potential in lowering levels of oxalate, calcium, and phosphate in urine. Its incorporation into herbal treatments demonstrates the relevance of diverse plant species.

24) Punica granatum:
Punica granatum, or pomegranate, is highlighted for its therapeutic properties. Extracts from this fruit exhibit favorable effects against kidney stones and underscore the importance of incorporating nutraceuticals into treatment regimens.

25) Water:
Water is fundamental in the context of kidney stone formation and treatment. Adequate hydration plays a crucial role in preventing urolithiasis, enhancing the effectiveness of herbal remedies studied in the research by promoting urine output and dilution of stone-forming constituents.

26) Pharmacological:
Pharmacological relates to the study of how herbal remedies affect biological systems. This review emphasizes the pharmacological evaluation of various plants, demonstrating their potential mechanisms in preventing and treating urolithiasis through scientific methodologies.

27) Fever:
Fever can be a symptom associated with urinary tract infections or other conditions related to urolithiasis. The presence of inflammation or infection in patients with kidney stones highlights the need for effective treatment regimens incorporating herbal medicines.

28) Blood:
Blood examination plays a pivotal role in diagnosing kidney-related diseases, including urolithiasis. The monitoring of serum levels of various constituents (like urea and creatinine) helps assess the effectiveness of the herbal treatments outlined in the review.

29) Salt (Salty):
Salt levels in the diet can influence kidney stone formation. Certain herbs studied in this paper may help moderate salt levels in urine, contributing to the prevention of urolithiasis and encouraging the development of effective dietary recommendations.

30) Rheumatoid arthritis:
Rheumatoid arthritis is included here as a broader context of inflammatory diseases. Some herbs with anti-inflammatory properties may simultaneously provide benefits for patients with both urolithiasis and rheumatoid arthritis.

31) Dysmenorrhea (Dysmenorrhoea):
Dysmenorrhoea, a condition characterized by painful menstruation, is often treated through herbal remedies. While not directly connected to urolithiasis, the overlap of herbal treatments for women’s health issues is relevant in traditional medicine contexts.

32) Civilization:
Civilization signifies human culture and the evolving practices of herbal medicine throughout history. The knowledge of using plants to treat conditions like urolithiasis has been passed down through generations, reflecting a deep-rooted aspect of societal health practices.

33) Tuberculosis:
Tuberculosis represents a significant health concern historically and in contemporary medicine. The mention of this disease highlights the need for a comprehensive approach to illness management, where herbal remedies could play supportive roles alongside conventional treatments in broader health contexts.

34) Developing:
Developing refers to countries or regions where traditional medicine practices, such as Siddha, may hold more significance due to lower access to conventional healthcare. This highlights the importance of effective herbal treatments in such contexts for managing health conditions.

35) Antibiotic (Antibacterial):
Antibiotic relates to the ability of certain plants to exhibit antimicrobial properties, potentially supporting the treatment of infections related to urolithiasis. Understanding the dual role of herbal extracts allows integration in broader therapeutic strategies.

36) Substance:
Substance refers to the active components derived from plants that contribute to their effectiveness in herbal medicine. The study aims to identify specific bioactive substances in the herbs that exhibit anti-urolithiatic properties.

37) Bleeding:
Bleeding may occur in relation to urinary tract infections accompanying kidney stones. The management of such symptoms highlights the multifaceted nature of urolithiasis and the importance of comprehensive herbal treatments that address several health concerns.

38) Epilepsy:
Epilepsy appears here as a representative neurological condition that may be addressed by herbal remedies. Some plants evaluated may offer benefits beyond urolithiasis, showcasing the broader therapeutic potential of traditional medicinal approaches.

39) Hysteria:
Hysteria represents historical understanding of mental health conditions where certain herbal treatments may have been used. The inclusive approach of traditional medicine highlights the diverse applications of plants in addressing various human ailments across contexts.

40) Burning (Burn, Burned, Burnt):
Burning refers to urinary symptoms often associated with urolithiasis. Herbal remedies are traditionally utilized to alleviate such uncomfortable sensations, demonstrating the practical applications of herbs in managing symptoms effectively.

41) Science (Scientific):
Science denotes the methodological approach taken to validate traditional knowledge through research, particularly focusing on the pharmacological properties of herbs. This scientific endeavor aims to bridge the gap between ancient practices and modern healthcare needs.

42) Surface:
Surface refers to the interactions of herbal extracts with biological membranes and systems. Understanding these interactions is crucial for evaluating the pharmacological effects of traditional remedies in the context of treating urolithiasis.

43) Thomas:
Thomas may refer to a researcher or contributor involved in the study, emphasizing the collaborative nature of scientific research. Team efforts are essential in exploring and validating the efficacy of herbal treatments in medicine.

44) Kumari:
Kumari may signify a contributor to the research, pointing to the importance of teamwork in gathering and analyzing data. Equal contributions from various authors enhance the credibility and depth of the study findings.

45) Family:
Family here refers to the classification of plants in the botanical taxonomy. Understanding plant families helps in identifying similar medicinal properties among related species and the broader application of traditional remedies in treating urolithiasis.

46) Cancer:
Cancer represents a significant health challenge often requiring comprehensive treatment approaches. The examination of anti-cancer properties among certain herbs showcases the multi-dimensional capabilities of traditional medicine in addressing various diseases, including urolithiasis.

47) Powder:
Powder denotes the form in which many herbal remedies are prepared for administration. This method of preparation is central to traditional medicine, utilizing powdered herbs for effective dosages in treatments for conditions such as urolithiasis.

48) Vetha:
Vetha may refer to Vetha Merlin Kumari.H, a co-author of the study. The contributions of researchers underscore the importance of collective expertise in broadening the understanding of herbal treatments in modern pharmacology.

49) Glass:
Glass may relate to laboratory procedures where crystallization or stone formation is studied. Investigating crystal growth on glass models aids in understanding the mechanisms of urolithiasis, central to developing effective treatments.

50) Kollu:
Kollu refers to Dolichos biflorus, an important plant studied for its health benefits. Its traditional and medicinal applications in preventing kidney stones highlight the relevance of various plants in herbal pharmacology.

51) Table:
Table signifies the structured presentation of information, summarizing key findings regarding the plants studied. This organization facilitates understanding of the comparative effectiveness of different herbs in the treatment of urolithiasis.

52) House:
House may refer metaphorically to the concept of traditional medicinal practices that exist within communities. These practices represent a 'house' of knowledge, combining cultural insights with therapeutic uses of herbs.

53) Ripe:
Ripe refers to the maturity of fruit or plant parts used in traditional remedies. The selection of ripe materials is crucial for maximizing their therapeutic properties, especially in herbal formulations addressing conditions like urolithiasis.

54) Rich (Rch):
Rich signifies the abundance of active compounds in various plants studied for their medicinal properties. The richness of these extracts supports their efficacy in treating conditions like urolithiasis, illustrating the value of herbal medicine.

55) Pain:
Pain is a significant symptom associated with urolithiasis, necessitating effective relief strategies. The review explores the potential of herbal treatments not only to address kidney stones but also to alleviate the pain associated with this condition.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Anti urolithiatic herbs and effective siddha formulations’. Further sources in the context of Science might help you critically compare this page with similair documents:

Rubia cordifolia, Terminalia chebula, Trigonella foenum-graecum, Aerva lanata, Asparagus racemosus, Benincasa hispida, Carica papaya, Hordeum vulgare, Hypericum perforatum, Lagenaria siceraria, Lawsonia inermis, Nigella sativa, Punica granatum, Raphanus sativus, Cynodon dactylon, Dolichos biflorus, Therapeutic action, Therapeutic use, Traditional treatment, Clinical study, Anti-inflammatory activity, Phytochemistry, Renal calculi, Ethics committee, Anti oxidant, Diuretic effect, Moringa oleifera, Diuretic activity, Indian materia medica, Hydro alcoholic extract, Urinary stone disease, Anti-hyperlipidemic activity, Anti-oxidant potential, Urinary stone, Kidney disease, Crataeva nurvala, Moringa oleifera Lam, Phyllanthus niruri, Urinary Excretion, Hyperoxaluria, Indigenous Drug, Siddha formulation, Boerhaavia diffusa, Coleus aromaticus, Calcium oxalate crystal, Calcium oxalate urolithiasis, Phytoconstituent, Mean standard deviation, Renal tissue.

Concepts being referred in other categories, contexts and sources.

Mimusops elengi.

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