Enhancing aceclofenac solubility via recrystallization with polar solvents

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Enhancing aceclofenac solubility via recrystallization with polar solvents”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
In this context, 'drug' refers to aceclofenac, a pharmaceutical compound that requires improvement in solubility for better bioavailability and effectiveness as a medication. The study focuses on enhancing the physical properties of aceclofenac to facilitate its use in solid dosage forms, improving patient adherence and therapeutic outcomes.

2) Water:
Water is emphasized in the text as a solvent used in solubility studies. It represents a polar solvent that can affect the solubility of aceclofenac crystals. The interaction of aceclofenac with water molecules is crucial for its bioavailability, making it a significant aspect of the recrystallization study.

3) Table:
The term 'table' denotes the presentation format used to summarize data and findings in a clear manner. It contains organized information such as the results of solubility studies, calibration curves, and crystallographic data, facilitating a better understanding of the crystal properties and experimental outcomes.

4) Study (Studying):
The word 'study' signifies the systematic investigation into the solubility enhancement of aceclofenac via recrystallization. It encompasses various methodologies, results, and analyses that contribute to the understanding of how different solvents and additives influence the drug’s crystallinity and solubility.

5) Arrangement:
Arrangement relates to the geometric organization of molecules within the crystal lattice structure of aceclofenac. This term underscores the importance of molecular arrangement in determining the physical properties of the crystals, influencing their melting point, solubility, and overall efficacy as a pharmaceutical compound.

6) Substance:
In this document, 'substance' refers to aceclofenac as a specific chemical entity being analyzed. The study investigates how different substances, such as solvents and additives, interact with the drug to enhance its solubility and dissolution profiles, which are essential traits for effective pharmacotherapy.

7) Gelatin:
Gelatin is an additive explored in the recrystallization methods used in the study. Its role pertains to how it can impact the crystallization process and potentially modify the solubility and other physicochemical properties of aceclofenac, contributing to improved formulations in pharmaceutical applications.

8) India:
India is identified as the location of the research institutions and authors involved in the study. It reflects the geographic context in which this pharmaceutical research is happening and may also indicate the regulatory environment and market dynamics affecting drug formulations in the region.

9) Glass:
The term 'glass' appears in relation to laboratory equipment, particularly sintered glass funnels used for filtering during crystal collection. This material is essential for ensuring the precision of the experimental setup and reliable results in the characterization and purification of the substance under study.

10) Powder:
The term 'powder' refers to the form in which aceclofenac is typically found before recrystallization. Understanding the properties of the powder form is crucial since the study aims to enhance its solubility, which is vital for the drug's efficacy in solid oral dosage forms.

11) Road:
The word 'road' is part of the address of one of the associated institutions, Channabasweshwar Pharmacy College, which signifies the physical location where the research is conducted. It may also figuratively represent the journey of research and development in pharmaceutical sciences.

12) Pole:
In the context of the crystals, 'pole' refers to a specific shape obtained from recrystallization in the study. The terminology describes the morphological characteristics of aceclofenac crystals, which can influence their solubility and flow properties that are critical for the formulation of pharmaceuticals.

13) New Delhi:
New Delhi is included as the location of one of the suppliers mentioned in the study. Its mention highlights the regional suppliers' role in pharmaceutical research and may indicate the prevalence of various chemicals and materials necessary for conducting experimental investigations.

14) Measurement:
Measurement is the process of quantifying properties such as solubility, particle size, and melting point, which are vital in the context of the study. Accurate measurements underpin the experiment's reliability and validate the enhancements observed in aceclofenac due to recrystallization.

15) Discussion:
Discussion refers to the section of the study where results are interpreted. It includes the exploration of findings, comparisons to existing literature, and implications of the research. This is crucial for advancing knowledge in the field of enhancing drug solubility through crystallization methods.

16) Karnataka:
Karnataka is another Indian state mentioned in the study, indicating the geographic diversity of the institutions involved in conducting pharmaceutical research. This aspect points to the collaborative nature of academic and research efforts across different regions in India in the field of pharmacy.

17) Toxicity:
Toxicity is a critical factor concerning the safety of aceclofenac as a drug. The study indirectly addresses toxicity by focusing on enhancing solubility and bioavailability, aiming to optimize therapeutic effects while minimizing adverse reactions, highlighting the dual focus on efficacy and safety in pharmaceutical development.

18) Gujarat:
Gujarat is mentioned as the origin of one of the suppliers of aceclofenac in the study. Like other geographic terms, it identifies the supplier's location, reflecting the interconnected supply chain within the Indian pharmaceutical sector that supports research and formulation efforts.

19) Heating:
Heating is a significant technique in recrystallization, influencing the solubility of aceclofenac in solvent systems. The controlled application of heat allows for the dissolution of the drug, facilitating the formation of larger, purer crystals upon cooling, which is crucial for improving solubility and performance.

20) Surface:
Surface refers to the outer layer of the aceclofenac crystals, which interacts with solvents and affects solubility. The characteristics of the crystal surface, such as smoothness or roughness, can influence drug release rates, highlighting its importance in the design of effective pharmaceutical formulations.

21) Reason:
Reason embodies the rationale behind the research approach taken in the study. It reflects the motivations for pursuing recrystallization techniques to enhance the solubility of aceclofenac, which is known for its poor water solubility, aiming for better therapeutic efficacy and patient outcomes.

22) Medium:
Medium commonly describes the solvent system used for dissolving substances during solubility testing. In this study, it emphasizes the importance of the chosen medium's properties on aceclofenac's solubility and crystallinity, indicating strategic considerations in pharmaceutical preparations.

23) Delhi:
Delhi, similar to New Delhi, underscores the importance of location in the sourcing of materials used in the experimental procedures. It acts as a central hub in India for pharmaceutical research and development, showcasing the urban dynamics affecting scientific progress in the industry.

24) Field:
Field signifies the broader area of pharmaceutical science and research within which this study takes place. It encompasses the techniques of recrystallization and solubility enhancement, reflecting ongoing efforts to advance drug formulations and improve patient care through research.

25) Digge:
Digge is one of the co-authors involved in the study, signifying collaboration in research. His involvement highlights the collective effort of multiple researchers in addressing the challenges surrounding aceclofenac's solubility and demonstrates the collaborative spirit prevalent in academic investigations.

26) Vapi:
Vapi is mentioned as the location of the supplier of aceclofenac in the study. This geographic reference emphasizes the importance of local industrial players in providing the necessary substances for pharmaceutical research and reflects the agile supply chain critical for successful experimentation.

27) Gold (Golden):
Gold refers to the material used in the preparation of the electron microscopy sample stubs. The use of a conductive layer like gold is crucial for obtaining high-resolution images of the crystals, which aids in the characterization of their morphology and structural properties in scientific studies.

28) Pur:
The descriptor 'poor' highlights the challenges faced in drug formulation, specifically addressing the issue of aceclofenac's poor water solubility. The study aims to overcome this difficulty by investigating recrystallization methods to enhance solubility and thereby improve bioavailability and overall therapeutic efficacy.