Fast dissolving flupiritin tablets using cassava starch binder.

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Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and evaluation of fast mouth dissolving tablets of flupiritin by using cassava starch as binding agent
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

S.Mounika Reddy, K. Pooja sritanya, B.Mallesh, V. Sai Kumar, L.Krishnam Raju, Ch.Srinivas Reddy and R.Suthakaran.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Formulation and evaluation of fast mouth dissolving tablets of flupiritin by using cassava starch as binding agent

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research


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Summary of article contents:

Introduction

The article discusses the formulation and evaluation of fast mouth-dissolving tablets (FDTs) of Flupiritin, an amino pyridine used for its analgesic and anti-inflammatory properties. The study is motivated by the growing interest in oral dosage forms that provide rapid disintegration and dissolution without the need for water, making them convenient for patients. Flupiritin is noted for its unique profile as a non-opioid, non-steroidal analgesic, initially available in Europe in 1984 and marketed in India under the brand name Pruf by Intas Pharma. The paper outlines the methodology of formulating these tablets using cassava starch as a natural binding agent and explores various properties of the formulations, including in vitro dissolution and stability studies.

Fast Dissolving Tablet Technology

Fast dissolving tablets utilize different delivery systems, including terms such as "oro-dispersible" and "quick melt." The U.S. FDA defines fast dissolving tablets as those disintegrating within seconds of being placed on the tongue. This innovation in drug delivery can enhance patient compliance under various circumstances, especially for individuals who have difficulty swallowing conventional tablets. The study highlights the preparation method known as direct compression, which involves incorporating disintegrants and water-soluble excipients to facilitate rapid drug release. Additionally, this technology can use sugar-based excipients to improve taste, mouthfeel, and dissolution rates.

Role of Natural and Synthetic Excipients

The formulation of FDTs in this study employs both natural and synthetic excipients. Cassava starch is utilized as a natural binding agent, while synthetic superdisintegrants, such as Crospovidone and Sodium starch glycolate, are integrated to enhance disintegration and dissolution rates. The study examines the effectiveness of these excipients, revealing that Crospovidone demonstrates superior performance in rapid disintegration and dissolution compared to other widely used synthetic options. The use of cassava starch not only serves functional purposes in tablet formation but also presents a cost-effective approach in pharmaceutical development.

Evaluation of Formulations

The article presents a comprehensive evaluation of the formulated FDTs, emphasizing key parameters such as drug content, disintegration time, and in vitro dissolution profiles. The formulations were tested for physical properties, including hardness, friability, and weight variation. Results showed that formulation F12, prepared with Crospovidone, achieved a significant drug release of 99.47% within six minutes, indicating a high level of efficacy. Additionally, stability studies demonstrated that the tablets maintained their integrity and performance characteristics over time, signifying their potential for clinical use.

Conclusion

The study concludes that the incorporation of Crospovidone as a superdisintegrant in the formulation of Flupiritin FDTs significantly improves disintegration properties and in vitro dissolution profiles. Furthermore, the use of cassava starch as a natural binder contributes to the cost-effectiveness and sustainability of the formulations. The successful formulation and positive evaluation of these fast mouth-dissolving tablets suggest their viability as an alternative delivery system for Flupiritin, enhancing patient adherence and therapeutic outcomes. The findings underscore the potential benefits of combining natural and synthetic components in developing effective pharmaceutical dosage forms.

FAQ section (important questions/answers):

What is Flupiritin and its uses in therapy?

Flupiritin is an amino pyridine used as a centrally acting analgesic and anti-inflammatory. It is primarily utilized in Polycare therapy for both acute and chronic pain, muscle relaxation, migraines, oncology, post-operative care, and gynecology.

What are fast dissolving tablets and their benefits?

Fast dissolving tablets dissolve or disintegrate in the mouth within 15 seconds to 3 minutes. They provide a convenient drug delivery method without the need for water, making them beneficial for patients with difficulty swallowing.

How are fast dissolving tablets prepared?

Fast dissolving tablets are commonly manufactured using direct compression techniques. This involves adding superdisintegrants and water-soluble excipients to create a formulation that rapidly disintegrates upon contact with saliva.

What materials are used in the formulation of fast dissolving tablets?

The formulation may include Flupiritin, various superdisintegrants (like Croscopovidone), cassava starch, and excipients such as sodium starch glycolate, lactose, and magnesium stearate to enhance tablet properties.

What methods are used to evaluate the tablets' effectiveness?

Evaluation methods include measuring drug content, disintegration time, wetting time, and in-vitro dissolution studies to ascertain the release rate and effectiveness of the formulated fast dissolving tablets.

What were the results of the dissolution study for Flupiritin tablets?

The study revealed that Crospovidone showed superior disintegration properties, resulting in a 99.47% drug release from the optimized formulation (F12) within 6 minutes, indicating a rapid release profile.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Fast dissolving flupiritin tablets using cassava starch binder.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Drug:
The term 'Drug' refers to a chemical substance used for the treatment, prevention, or diagnosis of diseases. In the context of the study, Flupiritin is the drug formulated into fast dissolving tablets for its analgesic and anti-inflammatory properties, highlighting the importance of effective drug delivery systems.

2) Water:
Water plays a crucial role as a solvent in pharmaceutical formulations. It is used in the drug dissolution process and is essential in the preparation of fast dissolving tablets. Water solubility is integral for the bioavailability of the drug, ensuring it can be absorbed effectively by the body.

3) Sugar:
Sugar is utilized in the formulation of fast dissolving tablets as a bulking agent and sweetener. Sugar-based excipients enhance the palatability and mouthfeel of the tablet, thereby improving patient adherence. Additionally, they contribute to the rapid disintegration of the tablet in the oral cavity.

4) Study (Studying):
The term 'Study' refers to the systematic investigation of a particular subject. In this context, it pertains to the research conducted to formulate and evaluate fast dissolving tablets of Flupiritin. The study highlights the methodologies used, results obtained, and implications for drug delivery.

5) Substance:
A 'Substance' refers to a particular kind of matter with uniform properties. In pharmaceutical contexts, substances include active pharmaceutical ingredients (drugs) and excipients. The study focuses on how different substances, like Flupiritin and natural binding agents, interact to create effective drug formulations.

6) Medium:
The term 'Medium' typically refers to a substance through which another substance is distributed or dissolved. In the context of this study, the dissolution medium used for in vitro testing is essential for determining how well the drug is released from the tablet for absorption.

7) Powder:
Powder refers to the reduced form of a substance that is finely ground or homogenized, often used in tablet formulations. In this study, Flupiritin is converted into a powder for blending with excipients to create fast dissolving tablets, enabling uniform drug distribution.

8) Pain:
Pain refers to an unpleasant sensory experience often signaling injury or illness. Flupiritin, the drug formulated in the study, is utilized primarily for its analgesic properties to treat acute and chronic pain, showcasing the therapeutic goals of the research.

9) Post:
The term 'Post' denotes an event occurring after something else, often referred to in studies as post-operative care. In this research, Flupiritin is indicated for pain management in post-operative settings, emphasizing the drug's versatility and clinical relevance.

10) Purification:
Purification is a process that removes impurities from a substance to obtain a uniform sample. In the context of this study, the purification of cassava starch is essential for maintaining a consistent quality in the fast dissolving tablet formulations, impacting both efficacy and safety.

11) Swallowing:
Swallowing is the act of ingesting food or medication. Fast dissolving tablets are specifically designed to disintegrate without the need for water, thus providing an alternative for individuals who have difficulty swallowing traditional tablets, indicating their therapeutic accessibility.

12) Science (Scientific):
The term 'Scientific' relates to methods that are systematic, empirical, and based on observation and experimentation. This study's findings are derived from scientific methods, emphasizing their reliability and the rigorous testing needed in drug formulation and evaluation.

13) Crushing:
Crushing refers to the mechanical process of reducing particle size. In the preparation of pharmaceuticals, crushing is often utilized to create fine powders for uniformity in tablet formulations, as seen in the study during the processing of cassava starch and the drug.

14) Camphor:
Camphor is an example of a volatile agent used in effervescent techniques for drug formulation. Its role in creating porous structures in fast dissolving tablets enhances disintegration and absorption, showcasing the importance of various substances in the optimization of drug delivery systems.

15) Muslin:
Muslin is a type of fabric used for filtering in the purification process of cassava starch. Its role in the study signifies the necessity of proper techniques in isolating excipients for formulation, ensuring that impurities do not compromise the final product's quality.

16) Nature:
Nature refers to the inherent characteristics or properties of substances. In the context of this study, the natural binding properties of cassava starch are leveraged to create effective formulations, highlighting the trend toward utilizing natural materials in pharmacological applications.

17) Filling (Filled):
The term 'Filled' denotes the action of putting contents into a container or structure. In the context of tablets, this refers to the filling of powders into molds during compression. Proper filling is crucial for achieving uniformity and consistency in tablet dosage forms.

18) India:
India is relevant as the study mentions the formulation of Flupiritin, which is sold under the brand name Pruf by Intas Pharma in India. This indicates the geographical context of the research and its implications for drug availability and healthcare practices within the region.

19) Kumar:
Kumar refers to one of the authors of the study, indicating collaborative research efforts. The involvement of multiple authors, such as Kumar and his colleagues, emphasizes the importance of teamwork in developing and evaluating pharmaceutical products.

20) Glass:
Glass is commonly used in laboratory settings, particularly for containers and instruments, such as capillary tubes used in melting point determination. Its application in the study reflects the importance of appropriate materials in ensuring accurate and reliable experimental results.

21) Pooja:
Pooja is another author of the study, indicating collaboration among researchers. The diversity in authorship underscores the collective effort in investigating the formulation of fast dissolving tablets and contributes to the credibility of the findings presented in the research.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Fast dissolving flupiritin tablets using cassava starch binder.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Neuroprotective properties, Disintegration time, Compatibility studies, Stability Studies, Melting point determination.

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