Synthesis and characterization of azo-4,6-dipropionylresorcinol derivatives.
Journal name: World Journal of Pharmaceutical Research
Original article title: Synthesis and characterisation of 2-(substituted phenyl)azo-4,6-dipropionylresorcinol derivatives
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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K. Loganathan, K. Sithick Ali, M. Purushothaman, S. Silambarasan, A. Jamal Abdul Nasser
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Synthesis and characterisation of 2-(substituted phenyl)azo-4,6-dipropionylresorcinol derivatives
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Azo compounds are a class of organic molecules characterized by one or more azo groups, where the nitrogen atoms are sp^2 hybridized. Known for their ability to form diverse colors, azo compounds have significant applications in multiple fields, including dyes for fiber and food coloring, due to their stability against light, heat, and solvents. The study conducted by Loganathan et al. synthesizes a series of 2-(substituted phenyl)azo-4,6-dipropionylresorcinol derivatives (I-VI) with an emphasis on eco-friendliness, cost-effectiveness, and high yield, providing important insights into the structural characteristics and potential applications of these compounds.
Synthesis and Characterization of Azo Compounds
The synthesis of the 2-(substituted phenyl)azo-4,6-dipropionylresorcinol derivatives followed a methodical approach involving the diazotization of substituted aniline, followed by coupling with 4,6-dipropionylresorcinol. The authors employed inexpensive raw materials and carried out reactions at low temperatures, predominantly in water, which contributes to reducing environmental impact. The synthesized compounds were characterized using elemental analysis, infrared spectroscopy (IR), nuclear magnetic resonance (NMR), and mass spectral analysis. This multifaceted characterization indicates the simplicity and efficiency of azo compound synthesis while confirming the structural integrity of the synthesized derivatives.
Spectroscopic Analysis
Spectroscopic techniques played a vital role in confirming the structure and stability of the synthesized azo derivatives. The IR spectra revealed key absorption peaks indicative of functional groups present in the compounds, including O–H, C=O, and N=N bonds. In particular, the absorption peak at 1590 cm^-1 confirmed the presence of the azo group, while the absence of certain peaks in the corresponding spectra confirmed that the compounds exist predominantly in the azo form rather than undergoing hydrazone tautomerism. Moreover, the 1H NMR and 13C NMR spectra provided additional insights into the molecular structure, aiding in the identification of specific hydrogen and carbon environments within the compounds.
Biological Significance and Applications
The azo compounds synthesized in this study have demonstrated biological importance and potential applications in various domains. Azo compounds are recognized for their roles as anti-inflammatory, antibacterial, antifungal, and even anticancer agents. The study outlines their advantages over natural dyes, including enhanced stability across a variety of conditions, lower toxicity levels, and minimal allergic reactions, making them suitable for food industry applications. The versatility of azo compounds extends beyond just coloration, positioning them as valuable resources in pharmaceutical and biological fields, thus highlighting the relevance of this study.
Conclusion
In summary, the research conducted by Loganathan et al. successfully synthesizes and characterizes a series of novel 2-(substituted phenyl)azo-4,6-dipropionylresorcinol derivatives, showcasing their structural integrity and potential applications. The findings underscore the compatibility of azo compounds with sustainable practices while maintaining their functional efficacy. The results contribute significantly to the understanding and utilization of azo compounds, encouraging further exploration into their biological properties and practical implementations in various industries. As the authors suggest, continued research may pave the way for enhanced applications of azo dyes and derivatives in both biological and commercial contexts.
FAQ section (important questions/answers):
What are 2-(substituted phenyl)azo-4,6-dipropionylresorcinol derivatives?
They are organic compounds synthesized through diazotization and coupling of substituted aniline with 4,6-dipropionylresorcinol, characterized by their azo structure.
What methods were used to characterize the synthesized compounds?
The compounds were characterized using elemental analysis, IR spectroscopy, 1H NMR, 13C NMR, and mass spectral analysis.
What is the significance of azo compounds in applications?
Azo compounds are valued for their stability, low toxicity, and effectiveness in applications such as dyes in textiles and food products.
How were the purity and melting points of the compounds verified?
Purity was checked via TLC on silica gel-G plates, and melting points were recorded using open capillary tubes.
What temperatures were utilized in the synthesis of azo compounds?
The synthesis was generally carried out at low temperatures, particularly during azo coupling, maintained at 0-5˚C.
What environmental benefits are associated with the synthesis of azo dyes?
The synthesis process involves low-cost and readily available materials, often using water as a solvent, minimizing environmental impact.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Synthesis and characterization of azo-4,6-dipropionylresorcinol derivatives.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Water:
Water is crucial as it is the primary solvent used in the synthesis of azo compounds, contributing to lower environmental impact due to its availability and non-toxic nature. In this study, reactions are conducted in aqueous solutions, which also facilitate easier product separation and enhance the eco-friendliness of the synthesis process.
2) India:
India is significant in this context as the research is conducted at Jamal Mohamed College, Tiruchirappalli, India. The geographical and cultural aspects of India may influence the development and application of the synthesized compounds, particularly in local industries like textiles and pharmaceuticals, highlighting regional advancements in chemical research.
3) Study (Studying):
The study aims to analyze the synthesis and characterization of 2-(substituted phenyl)azo-4,6-dipropionylresorcinol derivatives. It explores the effects of various substituents on azo compound properties, providing valuable insights into creating effective dyes and pharmaceuticals, thereby enhancing scientific knowledge and applications in organic chemistry and material science.
4) Food:
Food is relevant as azo dyes are utilized in food products due to their stability, low toxicity, and vibrant colors. The research highlights the safe application of these dyes in food industries, which is vital for consumer safety and regulatory compliance while ensuring aesthetic appeal in food presentations.
5) Antibiotic (Antibacterial):
Antibacterial properties of azo compounds are highlighted as these compounds are known for their effectiveness against various bacteria. This aspect is critical since developing antibacterial agents is essential in addressing microbial resistance and enhancing public health, showcasing the therapeutic potential of azo derivatives in medicinal chemistry.
6) Purification:
Purification is an essential step in the synthesis process, ensuring that the final products exhibit high quality and the desired chemical structure. Techniques like crystallization are employed to separate and purify the azo compounds, which is crucial for achieving accurate characterization and effective performance in practical applications.
7) Discussion:
The discussion section of research papers is pivotal for interpreting the findings, comparing them with existing literature, and exploring implications. It provides context for the synthesized compounds, supporting scientists in understanding the significance of their results and guiding future research directions in chemical synthesis and application.
8) Toxicity:
Toxicity is a crucial consideration when developing azo compounds, especially for applications in food and pharmaceuticals. The study emphasizes the lower toxicity of azo dyes compared to natural alternatives, which is significant for ensuring safety in consumer products and minimizing health risks associated with dye exposure.
9) Colouring (Coloring):
Coloring is an essential attribute of azo compounds due to their vibrant hues and stability. The study investigates the potential applications of these dyes in various industries, including textiles and food, where coloring properties play a vital role in aesthetics and product appeal, impacting marketability and consumer preferences.
10) Trichy:
Trichy, short for Tiruchirappalli, is the location in India where the research takes place. This city's educational institutions, like Jamal Mohamed College, contribute to scientific advancement and practical applications in the field of chemistry, emphasizing the local context of research and its integration into national development goals.
11) Purity:
Purity of synthesized compounds is essential in chemical research, determining the compounds' effectiveness and usability. The study employs Thin Layer Chromatography (TLC) to assess the purity of azo derivatives. High purity levels ensure reliable data and enhance the compounds' performance in various applications, from dyes to pharmaceuticals.
12) Table:
Tables in research papers are utilized to present data succinctly and clearly, allowing for easy comparison and analysis of results. The table within the study provides concise analytical data of the synthesized compounds, including their physical properties and spectral information, making it a valuable reference for readers.
13) Line:
Line may refer to line spectra, which are spectral lines utilized for the identification of compounds. In the context of this research, line patterns in infrared or NMR spectroscopy may help elucidate structural information about the synthesized azo compounds, aiding in confirming their identity and characteristics.
14) Salt (Salty):
Salt, particularly sodium nitrite, is involved in the diazotization process in the synthesis of azo compounds. This step is vital for constructing the azo linkage, signifying salt's importance in facilitating chemical reactions and influencing the overall success and efficiency of the azo synthesis procedure.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Synthesis and characterization of azo-4,6-dipropionylresorcinol derivatives.’. Further sources in the context of Science might help you critically compare this page with similair documents:
TLC analysis, Melting point, Elemental analysis, Environmental Impact, Spectral data, Melting point determination, Antimicrobial evaluation, Low toxicity, Hydrogen bonding interaction.