Artemisia annua tea as rejuvenative therapy for HIV non-ART patients
Journal name: World Journal of Pharmaceutical Research
Original article title: Artemisia annua tea as a rejuvenative therapy for hiv infected non art aids patients
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Dr. Aruna Devaraj and Dr.Med Felicitas Roelofson
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Artemisia annua tea as a rejuvenative therapy for hiv infected non art aids patients
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The study conducted by Dr. Aruna Devaraj and Dr. Med Felicitas Roelofson focuses on the potential benefits of Artemisia annua tea as a rejuvenative therapy for HIV-infected patients who are not undergoing antiretroviral therapy (non-ART). With over a million individuals suffering from immune deficiencies and life-threatening opportunistic infections related to HIV/AIDS, this investigation aims to evaluate the supplementary effect of herbal remedies in improving the quality of life and immune health of these patients. The research took place at the Jeevan Jyothi Hospice in Theni District, Tamil Nadu, over a two-year period involving ten non-ART respondents under careful observation.
The Efficacy of Artemisia annua
The key finding of the study is that the administration of Artemisia annua tea, formulated as a daily dose of five grams for two years, resulted in significant health improvements among the participants. Blood tests conducted every six months showed remarkable increases in CD4 counts and body weight. From an initial CD4 count of below 400, patients ended the study with counts exceeding 1000, indicating a revitalization of immune function. This herbal therapy not only improved immune parameters but also led to an average weight gain of 2 to 3.5 kilograms, thereby enhancing the overall quality of life for the patients.
Safety and Toxicity Analysis
The study also incorporated rigorous safety assessments of Artemisia annua, including acute, chronic, and sub-chronic toxicity studies on animals. These evaluations reported no significant adverse effects, confirming the herb’s safety for human consumption. The research substantiated that Artemisia annua does not contain toxic heavy metals above detectable limits and suggested low chronic toxicity potential. The findings prompt consideration of this herbal remedy as a safe adjunct to conventional treatment protocols for immunocompromised individuals, particularly for children and women infected with HIV.
Improvement in General Health and Lifestyle
Beyond biological markers, the patients reported lifestyle enhancements attributable to the herbal therapy. The functional capacity of participants improved, allowing them to engage in physical activities, pursue education, and operate small businesses. Notably, none experienced severe adverse events like fever, digestive problems, or significant weight loss during the trial, indicating the herb's tolerability. This highlights not only the clinical efficacy of Artemisia annua but also its potential to foster a better quality of life in patients grappling with the ramifications of HIV/AIDS.
Conclusion
In conclusion, the study presents compelling evidence for the effectiveness and safety of Artemisia annua tea as a rejuvenative therapy for non-ART HIV patients. The herbal infusion led to notable improvements in CD4 counts and general health, demonstrating its role as a supportive treatment alongside conventional meds. Given the alarming rise of opportunistic infections and the limitations of allopathic treatments, integrating Artemisia annua into care regimens can provide vital complementary relief to those affected by HIV/AIDS. Further research and clinical trials are warranted to evaluate its broader application in medical practice and to bolster traditional medicine’s role in public health.
FAQ section (important questions/answers):
What is the purpose of the study on Artemisia annua?
The study aimed to evaluate the rejuvenative effects of Artemisia annua tea on improving weight, hemoglobin levels, and CD4 count in HIV-infected non-ART patients.
How long was the study conducted, and who participated?
The study lasted two years and involved ten non-ART HIV-infected patients below the age of 40, who were receiving allopathic medication.
What improvements were observed in the patients after the study?
Patients showed significant improvement in CD4 counts (above 1000), weight gain, and hemoglobin levels, leading to better overall health and activity.
What dosages of Artemisia annua were administered to patients?
Patients were given 5 grams of herbal leaf powder daily, prepared as tea from 1 liter of boiled water.
Were there any side effects reported during the study?
Two patients experienced minor skin itching and intermittent headaches, but no severe side effects or major health issues were reported.
What are the future implications of this research on herbal medicine?
The study suggests that further human clinical trials on Artemisia annua could enhance confidence in traditional medicine and promote conservation of valuable plants.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Artemisia annua tea as rejuvenative therapy for HIV non-ART patients”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The term 'Study' refers to the structured research conducted to assess the effects of Artemisia annua tea on HIV-infected patients. It plays a critical role in understanding how the herbal remedy influences health outcomes like weight, hemoglobin levels, and CD4 counts, thereby contributing to evidence-based complementary therapies.
2) Drug:
In the context of this research, 'Drug' signifies both the traditional herbal remedy, Artemisia annua, and allopathic medications used by the HIV/AIDS patients. It underlines the integration of herbal and conventional treatments in the management of immune deficiencies and the search for effective alternatives for patients.
3) Aruna:
Dr. Aruna Devaraj, a key author of the study, represents the research team that explored the viability of Artemisia annua as a rejuvenative therapy for HIV/AIDS patients. Her involvement highlights the academic effort and commitment towards finding accessible treatments for marginalized populations affected by this disease.
4) Medicine:
The word 'Medicine' encompasses both traditional herbal remedies and conventional therapeutic approaches used in the treatment and management of HIV/AIDS. It indicates a holistic viewpoint that acknowledges the importance of integrating various treatment modalities to enhance patients' quality of life and immune function.
5) Toxicity:
Toxicity refers to the potential dangers associated with herbal remedies or drugs. The study includes assessments for acute, chronic, and subchronic toxicity of Artemisia annua, ensuring the safety and efficacy of the herbal treatment, which is crucial for patient welfare and public health recommendations.
6) Theni:
Theni is the district in Tamil Nadu, India, where the study was conducted at Jeevan Jyothi Hospice. This geographical location is significant for the research as it impacts the socio-cultural context of the participants, highlighting the local reliance on herbal medicines and the need for tailored health interventions.
7) Blood:
The term 'Blood' is essential in the context of the study as it relates to health indicators such as CD4 counts and hemoglobin levels which are monitored in the patients. Changes in these blood parameters serve as crucial metrics for assessing the impact of the treatment on immune health.
8) Life:
'Life' in this context signifies the overall quality and well-being of HIV/AIDS patients. The study aims to improve the life quality of non-ART patients through the introduction of herbal supplements, reflecting a broader goal of enhancing longevity and daily functioning despite their medical condition.
9) Disease:
The term 'Disease' refers to the HIV/AIDS condition affecting the study participants. It establishes the focus of the research, which is aimed at understanding how complementary treatments can alleviate the complications associated with the disease and provide supportive care to improve patient health outcomes.
10) Fever:
Fever is a common symptom often associated with HIV/AIDS and its opportunistic infections. The study mentions traditional herbal remedies, such as Artemisia annua, which were used historically to treat fever, showcasing the cultural significance of herbal medicine in managing symptoms linked to this chronic illness.
11) Activity:
'Activity' denotes the engagement and improved functionality of the patients following treatment. The study aims to assess not just physiological parameters, but also improvements in daily activities, such as work and education, signifying a holistic approach to health enhancement for those living with HIV/AIDS.
12) Shastra (Sastra):
Sastra University is referenced in the context of ethical approval for the animal toxicity studies conducted for the research. The university's involvement underscores the importance of ensuring that the research is conducted responsibly, adhering to ethical standards in both human and animal studies.
13) Animal:
The term 'Animal' pertains to the subjects used in the toxicity studies assessing the safety of Artemisia annua. Animal studies are crucial in the research process to evaluate potential adverse effects before proceeding to human trials, ensuring the integrity and safety of the research findings.
14) Powder:
The term 'Powder' refers to the form in which Artemisia annua is administered to the patients in the study. The use of a powdered herbal extract indicates an easy and practical approach to delivering the beneficial components of the herb, emphasizing its application in daily nutritional regimens.
15) Indian:
The term 'Indian' contextualizes the geographical and cultural setting of the study. It points to the traditional knowledge systems and herbal practices prevalent in India, which were vital in motivating the research towards exploring regional plants like Artemisia annua for medicinal use.
16) India:
India is the country where the study was conducted. This indicates the cultural and ecological backdrop that influences the use of traditional medicine and the prevalence of HIV/AIDS, necessitating research into local herbal alternatives that can serve the population's health needs.
17) Table:
'Table' features in the study as a format for presenting empirical data collected from patients regarding weight and hemoglobin levels. It lends clarity to the results, facilitating a straightforward comparison that underscores the effects of the herbal treatment over the study period.
18) Fight:
The term 'Fight' metaphorically refers to the struggle against diseases like HIV/AIDS. It embodies the patient's journey towards managing their health, emphasizing the role of supportive therapies in empowering individuals to resist opportunistic infections and improve their overall well-being.
19) Diet:
'Diet' encompasses the nutritional regimen that includes Artemisia annua and any other dietary practices adopted by the patients. It highlights the significance of a balanced intake of nutrients in conjunction with herbal remedies to support immune function and overall health.
20) Mangifera indica:
'Mangifera indica', commonly known as mango, is mentioned as one of the plant species traditionally used in treating ailments. Its inclusion in the study reflects the broader interest in exploring various herbs and their roles in health management, especially in contexts with limited access to Western medicine.
21) Pharmacognostical:
The term 'Pharmacognostical' pertains to the field of pharmacognosy, which studies the medicinal properties of plant materials. This focus serves to validate the traditional use of Artemisia annua, ensuring that its healing properties are scientifically examined and documented for effective therapeutic application.
22) Antibiotic (Antibacterial):
'Antibacterial' describes one of the beneficial properties attributed to Artemisia annua. This characteristic is essential in evaluating the herb's potential not only for managing HIV-related complications but also for addressing secondary infections commonly faced by immunocompromised individuals.
23) Discussion:
The 'Discussion' section of the study reflects on the implications of the findings. It reviews the results in context, interpreting how the rejuvenative effects of Artemisia annua may contribute to improving the health and quality of life of HIV/AIDS patients within the study population.
24) Tamilnadu (Tamil-nadu):
Tamilnadu is an alternate spelling of Tamil Nadu, denoting the regional and cultural context in which the research occurs. It emphasizes the geographical significance of the study and the lifestyles of individuals affected by health issues like HIV/AIDS in this particular area.
25) Depression:
Depression is a common mental health issue that affects individuals with chronic illnesses such as HIV/AIDS. The mention of depression signifies the need for holistic treatment approaches that address not only physical health but mental well-being, emphasizing a comprehensive view of patient care.
26) Education:
'Education' refers to the opportunities for learning and growth that patients were able to pursue during the study. This underscores the importance of improving patients' overall abilities and quality of life, demonstrating that effective treatment can lead to reintegration into society and personal development.
27) Fixation:
Fixation pertains to the establishment and determination of the appropriate dosage for administering Artemisia annua. It is a crucial step in research to ensure that the herbal remedy is prescribed safely and effectively to support health outcomes without adverse effects.
28) Quality:
Quality measures the effectiveness of Artemisia annua in improving patients' health indicators such as CD4 counts and hemoglobin levels. In this study, it signifies the overall improvement in patients' lives, reflecting the impact of herbal treatments on their holistic well-being.
29) Species:
Species refers to the classification of plants studied, specifically Artemisia annua in this research. It is significant for identifying the specific properties, benefits, and uses of this herbal species in therapeutic contexts, promoting biodiversity in treatment modalities for HIV/AIDS.
30) Itching:
Itching is mentioned as a minor side effect experienced by a couple of patients during the study. It serves as an indicator of how individuals may respond to treatment, emphasizing the importance of monitoring for any adverse reactions even when using herbal remedies.
31) Anxiety:
Anxiety is a psychological condition that may affect individuals facing chronic illnesses like HIV/AIDS. The mention of anxiety in relation to the study highlights the necessity for a comprehensive approach to treatment that addresses both mental and physical health challenges.
32) Family:
Family represents the social support system surrounding the individuals participating in the study. It underscores the importance of a supportive network which can influence health outcomes, contribute to the patients’ well-being, and assist in navigating the challenges associated with living with HIV/AIDS.
33) Cancer:
Cancer is mentioned as a potential area for further research with Artemisia annua. This indicates that beyond HIV/AIDS, the properties of the herbal extract may have implications for treating various diseases, opening avenues for broader therapeutic applications of traditional medicinal plants.
34) Nature:
Nature in this context refers to the inherent qualities and characteristics of Artemisia annua. It emphasizes the importance of understanding the natural substances and their potential health benefits, reflecting a broader trend towards leveraging herbal and natural remedies in modern medicine.
35) Medium:
'Medium' refers to the dosage level administered in the study, specifically regarding the administration of the herbal powder. It highlights the importance of controlling and measuring the amount to ensure safety and efficacy in treatment plans for the patients.
36) Water:
'Water' is significant as it is the solvent used to prepare the Artemisia annua tea. It underscores the method of administration of the herbal supplement, indicating a common and accessible way for patients to consume the remedy safely.
37) Visit:
'Visit' refers to the follow-up appointments and check-ins conducted during the research study. Regular visits are pivotal for assessing patient progress, monitoring health indicators, and ensuring adherence to treatment protocols, thereby enhancing the overall efficacy of the study.
38) Tamil:
Tamil denotes the language and cultural identity of the region where the study was conducted, indicating the local heritage and traditional practices that may influence health care approaches, including the use of herbal remedies among Tamil-speaking populations.
39) Cina:
China is referenced in the study to highlight the historical use of herbal remedies like Artemisia annua in treating various ailments, including fevers. Mentioning this context broadens the understanding of the plant's significance and efficacy in traditional medicine systems across different cultures.
40) Nadu:
Nadu is part of the name Tamil Nadu, emphasizing the regional specificity of the research setting. This contextual detail contributes to understanding how local traditions and resources influence health management and the potential role of herbal medicine in traditional care.
41) Ghat (Gham):
Ghat refers to the Western Ghats, a mountain range in India where various traditional healing plants have been utilized. The mention of this geographical feature connects the research to a rich history of herbal medicine and biodiversity, critical for studies on folk remedies.
42) Gula:
Gulu is one of the districts mentioned where traditional herbal medicines were utilized for HIV/AIDS treatment. Its inclusion illustrates the regional diversity in health practices across different areas and highlights the relevance of traditional medicinal resources in managing various health conditions.
Other Science Concepts:
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