Importance of screening of prl andtsh in primary infertile women
Journal name: World Journal of Pharmaceutical Research
Original article title: Importance of screening of prl &tsh in primary infertile women
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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S.A.Meenakshi, S.Kalavathy and S.Kavitha
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Importance of screening of prl &tsh in primary infertile women
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Infertility, defined as the inability to conceive after one year of unprotected intercourse, affects a significant number of couples worldwide, with estimates ranging from 60 to 80 million. Among various causes of primary infertility, hormonal imbalances, particularly related to prolactin (PRL) and thyroid-stimulating hormone (TSH), have been highlighted as significant factors. This study aimed to investigate the correlation between hyperprolactinemia and hypothyroidism in women suffering from primary infertility. It involved a sample of 54 women, including both infertile and fertile control groups, aged between 20 and 40 years.
Hyperprolactinemia and Its Impact on Fertility
Hyperprolactinemia is characterized by elevated levels of prolactin in the blood, which can disrupt the normal functioning of the hypothalamic-pituitary-ovarian axis. This disruption may lead to anovulation and subsequent reproductive dysfunction. In the present study, 75% of the infertile women exhibited hyperprolactinemia, which is noteworthy considering that such hormonal abnormalities can severely compromise fertility. The study’s findings emphasize that measurement of PRL levels is crucial in identifying and addressing potential obstacles to conception in women experiencing menstrual irregularities.
The Role of Hypothyroidism in Infertility
Hypothyroidism, marked by insufficient production of thyroid hormones, has also been shown to affect reproductive health. In this study, about 25% of the women diagnosed with primary infertility were found to have elevated TSH levels indicative of hypothyroidism. Thyroid dysfunction can influence the secretion of various hormones that regulate the menstrual cycle and ovulation. Specifically, the study suggests that increased TSH can indirectly contribute to hyperprolactinemia, highlighting the interconnectedness of these hormonal pathways and their contribution to obstacles in achieving pregnancy.
Correlation Between PRL and TSH Levels
The study identifies a positive correlation between hyperprolactinemia and elevated TSH levels. The mechanism involves the role of thyrotropin-releasing hormone (TRH), which stimulates both prolactin and TSH secretion. In cases of hypothyroidism, increased TRH production results in the simultaneous rise of prolactin levels, further complicating fertility issues. This relationship underscores the necessity of screening for both hormones in women with unexplained infertility, as addressing one hormonal imbalance may help alleviate the other, thus improving reproductive outcomes.
Conclusion
In conclusion, the study demonstrates a significant prevalence of hyperprolactinemia in women experiencing infertility, with 75% of the infertile group affected. The results suggest that routine screening for PRL and TSH levels is essential for women with fertility challenges, especially those presenting with menstrual irregularities or anovulation. By comprehensively evaluating these hormonal levels, healthcare providers can better understand and manage the complex interplay of factors contributing to infertility. Future research involving larger populations is warranted to further validate these findings and enhance infertility treatment strategies.
FAQ section (important questions/answers):
What was the aim of the study on PRL and TSH?
The study aimed to investigate the correlation of hyperprolactinemia and hypothyroidism in primary infertile women, examining the hormonal levels in both infertile and fertile groups.
What were the age ranges of the study participants?
Participants included 54 women aged 20-40 years old, with 32 being infertile and 22 being fertile as controls, ensuring a comparable age distribution.
What were the findings regarding prolactin and TSH levels?
The study found significantly elevated levels of serum prolactin and TSH in infertile women compared to the control group, indicating a possible hormonal imbalance.
What percentage of infertile women showed hyperprolactinemia?
The results indicated that 75% of the infertile women had hyperprolactinemia, highlighting its prevalence among those experiencing infertility.
Why is screening for PRL and TSH important?
Screening for serum prolactin and TSH levels is crucial as they play significant roles in reproductive health and may help identify underlying causes of infertility.
What recommendations were made based on the study findings?
The study recommends measuring serum prolactin and TSH levels in infertile women, particularly those with menstrual irregularities, to facilitate appropriate clinical evaluations.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Importance of screening of prl andtsh in primary infertile women”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The term 'Study' refers to the systematic investigation outlined in the text, focusing on the correlation between hyperprolactinemia and hypothyroidism in primary infertile women. It encompasses the methodology, objectives, results, and conclusions drawn from the research conducted at an infertility center, emphasizing the need for hormone screening in infertility cases.
2) Meenakshi:
Meenakshi is the first author of the study, representing a key contributor to the research. In an academic context, the author's identity is crucial for citing the work and recognizing the individual behind the analysis and findings, which aimed to identify the hormonal imbalances affecting fertility in women.
3) Table:
The term 'Table' signifies the organized presentation of data, summarizing key findings from the study such as serum prolactin and TSH levels in different groups. Tables are essential in research for conveying complex information clearly, allowing easier comparison and understanding of the results obtained from the study.
4) Measurement:
Measurement refers to the process of quantifying serum levels of prolactin and TSH, which are central to the study's investigation. Accurate measurements are critical in hormonal studies as they facilitate the assessment of hormonal imbalances and their potential link to infertility, thus guiding clinical diagnosis and treatment.
5) Trichy:
Trichy refers to the geographical location of the Pankajam Sitharam Nursing Home where the study was conducted. The relevance of this location lies in its provision of a specific context for the research, highlighting how regional factors might influence the prevalence of hormonal abnormalities in the studied population.
6) Pregnant:
The term 'Pregnant' is relevant in the context of infertility, as the research explores the inability to conceive and factors contributing to this condition. Understanding the hormonal imbalances outlined in the study can potentially lead to solutions for women struggling with pregnancies, making this term central to the topic.
7) Male:
In the study, 'Male' represents a point of exclusion, as the focus is solely on female primary infertility. Male factors of infertility were not considered, signifying the study's emphasis on female hormone levels and their impact on fertility, thus highlighting a gender-specific approach to reproductive health.
8) Discussion:
The term 'Discussion' pertains to the section that interprets the results, relates them to existing research, and considers their implications for clinical practice. In scientific literature, this section is crucial for contextualizing findings and exploring their significance in relation to the broader field of infertility research.
9) Bleeding:
In this context, 'Bleeding' refers to potential ovarian dysfunctions related to hormonal imbalances such as amenorrhea or irregular periods, which are symptoms of infertility. Recognizing bleeding patterns is essential for diagnosing reproductive issues in women, thereby linking it to the study's exploration of hormonal status.
10) Disease:
The word 'Disease' highlights the underlying medical conditions, such as hyperprolactinemia and hypothyroidism, that can lead to infertility. It stresses the need for medical intervention and the relevance of understanding how these diseases affect the reproductive system, which is the primary concern of the study.
11) Filling (Filled):
The term 'Filled' relates to the description of ovarian follicles containing immature eggs within a female's reproductive system. This biological aspect is important in understanding fertility and ovulation, and it underscores the complexity of the female reproductive cycle, which is impacted by hormonal regulation.
12) Botany:
Botany refers to the field of study associated with one of the co-authors, S. Kalavathy, who is linked to the Department of Botany. Although not directly related to the study of infertility, the mention of various academic disciplines reflects interdisciplinary approaches to health, emphasizing the complex nature of reproductive issues.
13) Blood:
The term 'Blood' is significant in the context of the study as it mentions the collection of blood samples for hormonal analysis. Blood tests are a cornerstone in diagnosing hormonal disorders and assessing the health status of individuals, making it a vital aspect of the research methodology.
14) Drug:
The word 'Drug' references potential medications that may affect hormonal levels and fertility. While not a direct focus in the study, understanding how certain drugs might interact with hormonal balance is pertinent in infertility research, as some treatments can significantly impact reproductive health outcomes.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Importance of screening of prl andtsh in primary infertile women’. Further sources in the context of Science might help you critically compare this page with similair documents:
Amenorrhea, Primary infertility, Menstrual irregularities, Oligomenorrhea, Anovulatory cycle, Thyroid stimulating hormone, Hypothyroidism, Ovulatory disorders, Hyperprolactinemia, Reproductive physiology, Serum prolactin.