Laser photostimulation for wound healing and hair growth in mice.
Journal name: World Journal of Pharmaceutical Research
Original article title: Photostimulation of wound healing and hair growth of swiss albino mice utilizing low power laser
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Mohemid M Al-Jebouri and Balsam Y Al-Shakarji
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Photostimulation of wound healing and hair growth of swiss albino mice utilizing low power laser
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
1) Introduction
The study conducted by Mohemid M Al-Jebouri and Balsam Y Al-Shakarji explores the effects of low power laser irradiation on wound healing and hair growth in Swiss albino mice. It builds upon previous research indicating the bactericidal properties of lasers against opportunistic bacteria, leveraging low-power diode lasers in conjunction with photochemical agents and antibiotics. The primary focus of this research is to evaluate the effectiveness of such treatments in promoting wound recovery and enhancing hair regrowth, particularly in wounds infected with Pseudomonas aeruginosa.
2) Efficacy of Povidone-Iodine as a Photosensitizer
One significant finding of the study is the effectiveness of povidone-iodine at a concentration of 256 μg/ml in acting as a photosensitizer. The research demonstrates that when Pseudomonas aeruginosa isolates are exposed to low-power diode laser light alongside this photosensitizer, there is a notable increase in bacterial cell death. Statistical analyses confirmed significant differences in wound healing rates among groups exposed to various treatment combinations, indicating that the synergy between the laser and povidone-iodine greatly enhanced the effectiveness of the treatment compared to using either modality alone.
3) Impact of Laser Irradiation on Wound Healing
The study found that laser exposition significantly accelerated wound healing processes in the experimental groups treated with combinations of laser irradiation, povidone-iodine, and cefotaxime. Specifically, animals receiving these treatments showed a marked reduction in wound size and shorter healing times compared to control groups that received no laser treatment. In stark contrast, groups infected with Pseudomonas aeruginosa but not subjected to laser exposure experienced delayed healing due to the bacterium's production of exotoxins. These findings positioned laser irradiation as a critical factor in enhancing tissue recovery and reducing healing time.
4) Accelerated Hair Regrowth Observed
Another intriguing outcome from the research indicated that the application of laser treatments along with the chosen photosensitizer and antibiotic not only sped up wound healing but also halved the time required for hair regrowth in the treated animals. Specifically, while the control group required 14 days for complete hair regrowth, the group treated with laser, povidone-iodine, and cefotaxime exhibited full regrowth in just 7 days. This aspect of the research highlights the potential therapeutic benefits of laser-assisted treatments beyond simple wound management, extending into areas like hair restoration.
5) Conclusion
In conclusion, the study underscores the efficacy of combining low power diode laser treatments with povidone-iodine and cefotaxime in managing infected wounds and promoting hair regrowth. The synergistic effects observed between the laser and photosensitizer suggest that this combined approach could provide valuable clinical applications in wound care. The research not only advances our understanding of photodynamic therapy but also lays the groundwork for future studies aimed at optimizing wound healing and hair restoration treatments using similar modalities, potentially improving patient outcomes in clinical settings.
FAQ section (important questions/answers):
What was the primary purpose of the study involving Swiss albino mice?
The study aimed to investigate the effects of low-power laser, photosensitizers, and antibiotics on wound healing and hair growth in Swiss albino mice infected with Pseudomonas aeruginosa.
What methodology was used to treat the infected mice?
Swiss albino mice were divided into groups and treated with combinations of low-power laser, povidone-iodine as a photosensitizer, and cefotaxime, with varying exposure times to assess treatment efficacy.
What were the main findings regarding wound healing with laser exposure?
The study concluded that laser exposure, combined with photosensitizers and antibiotics, significantly enhanced wound healing times in infected mice compared to control groups.
How effective was povidone-iodine as a photosensitizer in the study?
Povidone-iodine at a concentration of 256 μg/ml was found to be a highly effective photosensitizer, aiding in the microbial killing of Pseudomonas aeruginosa when combined with low-power diode laser light.
What impact did the treatments have on hair regrowth in mice?
The treatments significantly accelerated hair regrowth in the treated mice, reducing the time for regrowth to seven days compared to fourteen days without using laser or photosensitizers.
What were the safety findings related to the laser treatments?
Histological examinations revealed no adverse effects or injuries to the treated tissues from the laser exposure, indicating its safety when used appropriately.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Laser photostimulation for wound healing and hair growth in mice.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Animal:
In the context of this study, 'animal' refers to the Swiss albino mice used as experimental subjects to investigate the effects of low-power laser therapy on wound healing and hair regrowth. Animal models are crucial for preclinical research, providing insights into biological mechanisms and potential therapeutic outcomes before human trials.
2) Hair:
Within this research, 'hair' pertains to the regrowth observed in the Swiss albino mice post-wounding. The study evaluates how the application of low-power laser therapy affects the speed and quality of hair regrowth, indicating its broader implications for recovery processes in living organisms following injury.
3) Study (Studying):
The term 'study' encapsulates the systematic investigation conducted by the researchers to explore the combined effects of laser therapy, photodynamic agents, and antibiotics on wound healing and hair regrowth in infected mice. It signifies the structured approach taken to derive conclusions based on empirical evidence.
4) Antibiotic (Antibacterial):
'Antibiotic' denotes the substances, specifically cefotaxime in this study, used to treat infections caused by bacteria such as Pseudomonas aeruginosa. The research investigates how antibiotics, when combined with laser therapy, enhance wound healing, providing insights into infection management in clinical settings.
5) Medicine:
'Medicine' refers to the field encompassing various practices aimed at diagnosing, treating, and preventing diseases. This study contributes to medical knowledge by exploring innovative treatments like low-power laser therapy, enhancing wound care strategies in both veterinary and human medical practices.
6) Killing (Killed):
'Killed' indicates the outcome of exposing Pseudomonas aeruginosa to combinations of laser therapy and photosensitizers. Determining the effectiveness of such treatments in eliminating bacteria is fundamental to the study’s goal of enhancing wound healing while minimizing infection risks.
7) Table:
'Table' refers to the organized presentation of data and results within the research. It summarizes findings on wound size, healing times, and responses to treatments, making complex data easily interpretable and aiding in the communication of the study's results to the scientific community.
8) Wounded:
The term 'wounded' describes the state of the mice after incisions were made for the experiment. Understanding the healing of wounded tissues under various treatments provides valuable insights into the biological processes of recovery and the effectiveness of therapeutic interventions in reducing healing times.
9) Surface:
'Surface' relates to the external area of the wounds created on the mice's bodies. This study measured changes in wound surface area as a critical factor in assessing the effectiveness of healing therapies, thus underscoring the importance of monitoring physical changes during recovery.
10) Repair:
'Repair' signifies the biological processes involved in healing the wounds inflicted on the mice. The study addresses how treatments impact tissue repair, which is essential for understanding recovery mechanisms and improving clinical outcomes for wounds in both animals and humans.
11) Observation:
'Observation' refers to the systematic monitoring of the experimental animals throughout the study. Documenting changes and responses to treatment is crucial for drawing valid conclusions from the experiment, ensuring data is accurately captured and analyzed for potential therapeutic implications.
12) Discussion:
'Discussion' is the section of the study where researchers interpret their findings in the context of existing literature. This reflective analysis helps to place results within the broader framework of medical research, analyzing implications and potential future directions for study and clinical applications.
13) Incision:
'Incision' refers to the surgical cut made on the dorsum of the mice to create wounds for the experiment. Understanding the healing of these incisions is essential for evaluating the effects of various treatments on post-surgical recovery and development of infection.
14) Water:
'Water' describes an essential resource provided to the animals during the experiment. Adequate hydration is crucial for maintaining the health of experimental animals, ensuring valid and reliable research outputs, and supporting overall physiological functions integral to the healing processes.
15) Field:
'Field' encompasses the broader areas of biology and medicine that the study contributes to. Understanding the results has implications for various fields, including microbiology, surgical sciences, and dermatology, highlighting the interdisciplinary nature of modern medical research.
16) House:
'House' refers to the environment in which the experimental animals were kept. Proper housing controls are important for minimizing stress and ensuring the well-being of the animals, which is fundamental for obtaining valid scientific results in experimental research.
17) Blood:
'Blood' is implicated as a critical component for healing in the context of the study, as it transports nutrients and immune cells necessary for tissue repair. Understanding wound healing mechanisms involves studying how blood interacts with different treatments in infection and recovery scenarios.
18) Food:
'Food' refers to the nourishment provided to the mice during the study, ensuring they receive the necessary nutrients for health and recovery. Proper diet is vital to maintain physiological functions in experimental settings, as it can affect outcomes related to healing and overall animal welfare.
19) Cage:
'Cage' denotes the enclosures used to house the mice during the study. Appropriate cages are essential for the ethical treatment of research animals, allowing for monitoring while providing a controlled environment for conducting experiments designed to yield valid scientific data.
20) Pain:
'Pain' is a potential outcome for the animals during the wound healing process, as the study seeks to explore therapeutic options that minimize discomfort. Understanding pain mechanisms is crucial for developing effective pain management strategies in both veterinary and human medicine.
21) Burning (Burn, Burned, Burnt):
'Burn' relates to a potential injury type that can affect healing and warrant experimental study. In the context of laser therapy, understanding how burns might occur during treatment is vital for ensuring safety and efficacy while applying innovative medical technologies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Laser photostimulation for wound healing and hair growth in mice.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Wound healing, Statistical analysis, Control group, Treatment group, Experimental study, Hair growth, Histological examination, In vivo study, Clinical observation, Pseudomonas aeruginosa, Synergistic effect, Bactericidal effect, Photodynamic therapy, Nutrient broth, Healing time, Laser therapy, Photodynamic effects, Animal groups, Povidone Iodine, Experimental animal, Low power laser, Diode Laser, Virulence factor, Therapeutic laser application, Combination of treatments.