Antimicrobial and antioxidant activity of Gymnosporia montana.
Journal name: World Journal of Pharmaceutical Research
Original article title: Antimicrobial and radical scavenging activity of gymnosporia montana (roth.) benth
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Anjana N. Raikar, Nagashree P.S, Sinchana C.V, Swathi B.B, Prashith Kekuda T.R, Raghavendra H.L
World Journal of Pharmaceutical Research:
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Full text available for: Antimicrobial and radical scavenging activity of gymnosporia montana (roth.) benth
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The study focuses on the antimicrobial and radical scavenging activities of Gymnosporia montana (Roth.) Benth., a plant belonging to the family Celastraceae and thriving in arid regions of India. Researchers investigated the leaf, flower, and fruit extracts of G. montana for their potential therapeutic properties. Recognizing the importance of natural compounds in traditional medicine, the study underscores the plant's significance in treating various ailments, including infections and oxidative stress.
Antimicrobial Activity of Gymnosporia montana
The investigation into the antimicrobial properties of G. montana utilized the agar well diffusion method to assess its effectiveness against several bacterial strains, including both Gram-positive (e.g., Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (e.g., Escherichia coli, Pseudomonas aeruginosa). The results indicated that fruit extracts exhibited the most significant antibacterial activity, particularly against E. coli, S. aureus, B. coagulans, and S. typhi. Comparatively, the leaf extract showed marked inhibition against B. subtilis. These findings show that the antimicrobial efficacy varies among different plant parts, emphasizing the potential of G. montana as a natural alternative for combating bacterial infections.
Antifungal Activity of Gymnosporia montana
The antifungal aspect of the study employed the poisoned food technique against several relevant fungi. The extracts revealed varying degrees of antifungal activity across different fungi species, with fruit extracts again outperforming the others in efficacy. Specifically, the fruit extract significantly inhibited the growth of Bipolaris sorokiniana, Fusarium oxysporum, Colletotrichum capsici, and Curvularia sp. These findings suggest that G. montana could serve as an effective bioagent in managing fungal pathogens, providing an eco-friendly alternative to synthetic chemical agents that can cause environmental damage and health concerns.
Radical Scavenging Activity of Gymnosporia montana
The radical scavenging activity of G. montana was evaluated using the DPPH assay, which measures the plant extracts' ability to neutralize free radicals. The study noted that leaf extracts displayed a stronger scavenging potential (IC₅₀ value of 10.42 µg/ml) compared to flower and fruit extracts, with the latter showing weak activity. Despite not matching the efficacy of ascorbic acid, which served as a reference standard, the significant scavenging activity of the extracts indicates that G. montana may possess antioxidant properties. This characteristic is crucial in combating oxidative stress linked to various diseases such as cardiovascular and neurodegenerative disorders.
Conclusion
The findings of this study highlight the promising antimicrobial and radical scavenging properties of Gymnosporia montana extracts. The plant demonstrates potential as a natural remedy for treating microbial infections and counteracting oxidative stress. These bioactivities are likely attributed to the presence of bioactive compounds in the plant extracts. Future research should focus on isolating these active components and exploring their specific bioactivities, which could further substantiate the medicinal value of G. montana in traditional and modern medicine.
FAQ section (important questions/answers):
What is the scientific study conducted on Gymnosporia montana about?
The study investigates the antimicrobial and radical scavenging activity of the leaf, flower, and fruit extracts of Gymnosporia montana, focusing on their potential medicinal benefits.
What methods were used to determine antimicrobial activity in the study?
Antimicrobial activity was assessed using Agar well diffusion for antibacterial properties and the Poisoned food technique for antifungal activity.
How was radical scavenging efficacy evaluated in the research?
The DPPH free radical scavenging assay was used to evaluate the radical scavenging efficacy of extracts, measuring their ability to neutralize free radicals.
Which extract showed the highest antibacterial activity against tested bacteria?
The fruit extract displayed significant antibacterial activity against Staphylococcus aureus, E. coli, and Salmonella typhi compared to leaf and flower extracts.
What fruit extract exhibited the least radical scavenging potential?
Among the extracts, the fruit extract showed the least radical scavenging potential, with an IC50 value of 593.78µg/ml, indicating lower antioxidant activity.
What traditional medicinal uses does Gymnosporia montana have?
Traditionally, Gymnosporia montana has been used to treat various ailments like jaundice, ulcers, snake bites, and skin allergies, showcasing its importance in indigenous medicine.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antimicrobial and antioxidant activity of Gymnosporia montana.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
The term 'Activity' refers to the biological efficacy of compounds extracted from the plant, specifically their ability to exhibit antimicrobial and radical scavenging properties. Understanding the activity of these plant extracts is essential for their potential application in treating infections and oxidative stress-related diseases, highlighting their therapeutic significance.
2) Study (Studying):
'Study' indicates a systematic investigation undertaken to assess the pharmacological properties of 'Gymnosporia montana.' This research aims to collect data on its antimicrobial and radical scavenging activities, contributing to the scientific understanding and potential practical applications of this plant in medicine.
3) Antibiotic (Antibacterial):
'Antibiotic' refers to substances that kill or inhibit the growth of microorganisms, particularly bacteria. The study compares the antibacterial activity of plant extracts to that of synthetic antibiotics, underlining the importance of natural alternatives in the fight against antibiotic-resistant pathogens in contemporary medicine.
4) Science (Scientific):
'Science' encompasses the systematic study of the natural world through observation and experimentation. In this context, it represents the methodologies used to explore the antimicrobial properties of extracts, contributing to the body of knowledge regarding medicinal plants and their applications in health care.
5) Medicine:
'Medicine' refers to the science and practice of diagnosing, treating, and preventing disease. The research on 'Gymnosporia montana' addresses its potential therapeutic applications, particularly in traditional and modern medicine, showcasing how natural products can supplement conventional treatments.
6) Aureus:
'Aureus' refers to 'Staphylococcus aureus,' a common bacterium responsible for a range of infections. Its presence in the study highlights the targeted evaluation of plant extracts against significant human pathogens, emphasizing the relevance of the research in contributing to future antibiotic development.
7) India:
'India' is the geographical location where 'Gymnosporia montana' is found and studied. The indigenous flora represents a rich source of potential medicinal plants, and understanding their properties can lead to the development of region-specific treatments for various ailments prevalent in the country.
8) Table:
'Table' refers to a structured representation of data, usually used to summarize results from the study. In this context, it displays the antibacterial activity of various extracts, aiding in the easy comparison of results and reinforcing the findings of the research.
9) Karnataka:
'Karnataka' is a state in India where the plant was collected for the study. The local climate and ecosystem contribute to the unique properties of 'Gymnosporia montana,' making this location significant for understanding the ethnobotanical uses and environmental adaptations of the plant.
10) Disease:
'Disease' indicates a disorder of structure or function in a living organism. The study's relevance lies in identifying plants like 'Gymnosporia montana' as potential treatment options for various diseases, particularly those caused by bacteria and oxidative stress, thereby expanding therapeutic strategies.
11) Water:
'Water' serves as a basic requirement for all living organisms. In the context of this study, it is crucial for the extraction processes of plant materials, influencing the solubility and activity of the bioactive compounds studied, which are essential for their potential medicinal properties.
12) Food:
'Food' relates to nutrients consumed by living organisms. In the study, it is significant due to the link between dietary sources of phytochemicals and health. Understanding plant-derived compounds can lead to the development of natural preservatives or treatments for foodborne pathogens.
13) Developing:
'Developing' refers to nations or regions that are in a process of growth and improvement. The study highlights the importance of traditional medicine in these areas, where accessible natural remedies can serve as alternatives to expensive pharmaceuticals, making healthcare more feasible for populations.
14) Campu:
'Campu' refers to 'Campus,' likely indicating the academic institution where the research was conducted. This context emphasizes the role of educational institutions in advancing scientific research and promoting the study of local biodiversity for potential medicinal benefits.
15) Road:
'Road' may symbolically imply the journey or path of research leading to discoveries regarding the medicinal properties of plants. In practical terms, it could relate to access routes for plant collection and field studies, indirectly highlighting the connection between ecology and research.
16) Drug:
'Drug' refers to a chemical substance used for medical treatment, which is pertinent in this study focusing on the identification of natural compounds with pharmacological effects. The potential for plants like 'Gymnosporia montana' to contribute to drug development is a core theme.
17) Pharmacological:
'Pharmacological' pertains to the study of drugs and their effects on biological systems. This term underscores the research's focus on understanding the bioactive compounds present in 'Gymnosporia montana' and their mechanisms of action, critical for assessing their therapeutic potential.
18) Raghavendra:
'Raghavendra' might refer to one of the authors of the study, emphasizing the collaborative nature of scientific research. Individual contributions highlight team efforts in conducting research and validating findings, showcasing the importance of expertise in advancing scientific knowledge.
19) Discussion:
'Discussion' refers to the section of the research where results are interpreted and contextualized. It is essential for understanding the implications of the findings related to antimicrobial properties and radical scavenging activity, offering insights for future research directions and potential applications.
20) Snake-bite:
'Snake-bite' indicates a specific ailment for which 'Gymnosporia montana' is traditionally used. The study connects ethnobotanical uses with scientific inquiry, emphasizing the importance of understanding local medicinal practices and exploring the efficacy of plants in treating dangerous conditions.
21) Ayurveda (Ayus-veda):
'Ayurveda' is an ancient system of medicine originating from India. Its relevance is significant as it underscores the traditional uses of plants like 'Gymnosporia montana' for healing, guiding research into validating these practices through scientific scrutiny and exploring their modern applications.
22) Bhavita:
'Bhavita' may refer to an author cited in the study, contributing to prior findings on the antioxidant effects of plant extracts. This indicates the collaborative basis of scientific knowledge, where new research builds upon previous studies to advance understanding in the field.
23) Allergy:
'Allergy' refers to a hypersensitive response of the immune system to substances. Understanding the antimicrobial and antioxidant properties of 'Gymnosporia montana' may link to its potential use in managing allergic reactions, further emphasizing the plant's therapeutic versatility.
24) Surface:
'Surface' relates to the outer boundary where the experiments, such as the agar diffusion tests, were conducted. It highlights the importance of the physical interaction between the extracts and microbial populations, critical for assessing antibacterial properties accurately.
25) Anjana (Amjana):
'Anjana' is likely another author of the research, indicating collaborative authorship in scientific publications. By acknowledging contributions from various researchers, it emphasizes teamwork and collective effort in advancing scientific inquiry about traditional medicinal plants.
26) Forest:
'Forest' refers to a natural ecosystem where plants like 'Gymnosporia montana' thrive. The ecological context is essential for understanding the plant's growth conditions, biodiversity, and its role in traditional medicine, emphasizing the importance of conservation for research purposes.
27) Family:
'Family' refers to the taxonomic grouping of organisms, in this case, 'Celastraceae.' Understanding the family classification is crucial for recognizing related species, their characteristics, and the possible interactions among plant metabolites that contribute to their pharmacological activity.
28) Summer:
'Summer' relates to the climatic conditions necessary for 'Gymnosporia montana' to flourish. Knowledge of seasonal growth patterns is essential for proper cultivation and harvesting of the plant, affecting the timing of research and the availability of bioactive compounds.
29) Medium:
'Medium' indicates the substance used for growing microorganisms (like agar) in which plant extracts were tested. The selection of growth medium is vital for accurately assessing antibacterial and antifungal activities, ensuring reliable and reproducible results in scientific research.
30) Animal:
'Animal' refers to living organisms that may be subjects of study, particularly concerning the mechanisms of disease or the effects of medicinal plants. This term connects the research to broader implications in veterinary medicine and the health of non-human organisms.
31) Cotton:
'Cotton' refers to the material used for swabbing and transferring bacteria in the experimental procedures. Its role highlights the importance of sterile techniques in microbiological research, ensuring that results derived from the experiments are valid and uncontaminated.
32) Botany:
'Botany' is the study of plants, essential for understanding the various aspects of plant biology and classification. It serves as the foundational knowledge base for research involving the extraction and application of medicinal properties from plants like 'Gymnosporia montana.'
33) Cilli:
'Chilli' relates to specific plant pathogens studied in the context of antimicrobial activity. Highlighting the relevance of agricultural plants helps demonstrate the potential for using 'Gymnosporia montana' extracts in crop protection against diseases, linking human health and agricultural sustainability.
34) Ulcer:
'Ulcer' denotes a painful sore on the skin or in the lining of the digestive tract, significating one of the ailments traditionally treated using 'Gymnosporia montana.' This connection illustrates the therapeutic potential of the plant in addressing common health issues.
35) Tree:
'Tree' denotes the growth form of 'Gymnosporia montana,' a woody plant that plays a crucial role in its ecosystem. Understanding its structure and function is essential for recognizing its ecological importance, uses in traditional medicine, and potential as a source of bioactive compounds.
36) Shand (Sand):
'Sand' refers to the type of soil where 'Gymnosporia montana' thrives, influencing its growth and bioactivity. Knowledge of the plant’s preferred conditions aids in conservation efforts and suggests optimal agricultural practices for cultivating medicinal species.
37) Post:
'Post' may refer to the physical layout or documentation process involved in the research, emphasizing modes of communication in scientific discourse. It may also suggest distribution methods of findings, highlighting the importance of sharing knowledge within the scientific community.
38) Soil:
'Soil' represents the medium in which plants grow, affecting their nutrient acquisition and health. Understanding soil conditions is paramount in studying 'Gymnosporia montana' as it informs its growth, ecological interactions, and the bioactivity of its extracts.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antimicrobial and antioxidant activity of Gymnosporia montana.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Moral support, Traditional medicine, Comparative evaluation, Antibacterial activity, Antioxidant activity, Antimicrobial activity, Natural origin, Antifungal activity, Radical Scavenging Activity, Total phenolic content, DPPH scavenging assay, Antioxidant, Antibiotic resistance, Gram-positive and Gram-negative bacteria, In vitro antioxidant activity, DPPH free radical scavenging assay, Antioxidant potential, Indigenous medicine, Leaf and stem extracts, Neurodegenerative disease, Antibacterial potential, Synthetic chemicals, Microbial infection, Metabolite, Free Radical, Agar well diffusion, Biological control, Bioactivities, Cytotoxic potential, Human peripheral blood mononuclear cells, Primary healthcare needs, Active component, Bioactive principle, Antioxidant agent, Chemo therapeutic agents.