Antibacterial and antifungal properties of Soymida febrifuga leaves.
Journal name: World Journal of Pharmaceutical Research
Original article title: Antibacterial and antifungal activity of leaves extract of soymida febrifuga a.juss.
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:
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Shubhangi Sharad Bhide, Suvarna Prabhakar Gajare, Kirti Sahu, ACP, Wardha.
World Journal of Pharmaceutical Research:
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Full text available for: Antibacterial and antifungal activity of leaves extract of soymida febrifuga a.juss.
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The study investigates the antibacterial and antifungal activities of the leaves of Soymida febrifuga, a tree belonging to the Meliaceae family, commonly known as Indian redwood or bastrol cedar. Traditionally utilized in ethnomedicine for treating various ailments, including diarrhea, dysentery, and rheumatic inflammation, this research aims to scientifically validate its antimicrobial properties. The study employs techniques such as well diffusion and minimum inhibitory concentration (MIC) to evaluate antimicrobial activities against specific strains of bacteria and fungi.
Antibacterial Activity of Extracts
The research highlights the antibacterial activity of different extracts of Soymida febrifuga, evaluated using the well diffusion method. Extracts prepared from petroleum ether, chloroform, methanol, water, and total aqueous solutions were tested against various strains of Gram-positive and Gram-negative bacteria, including Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Proteus vulgaris. Among the extracts, methanol and water showed significant inhibition, with water extract yielding the highest zone of inhibition for S. aureus (23.33 mm), demonstrating its effectiveness compared to the standard antibiotic tetracycline.
Minimum Inhibitory Concentration (MIC) Results
The study reveals the Minimum Inhibitory Concentration (MIC) of the extracts, emphasizing their potency at low concentrations. The methanol extract exhibited strong effectiveness against Pseudomonas aeruginosa and Candida albicans, with MIC values of 1.25 mg/ml and 0.625 mg/ml, respectively. This suggests that even in dilute concentrations, the extracts are capable of preventing microbial growth, supporting their potential as effective natural antimicrobial agents.
Antifungal Activity Findings
In addition to antibacterial properties, the antifungal activity of Soymida febrifuga was assessed using similar extraction methods and conditions. The study reported significant zones of inhibition against fungal strains such as Aspergillus niger, Aspergillus flavus, and Candida albicans. The water extract demonstrated particularly high efficacy, especially against C. albicans, with the highest zone of inhibition recorded at 24.66 mm. This further elucidates the antimicrobial spectrum of the plant, reinforcing its traditional uses.
Conclusion
The research confirms the antimicrobial potential of Soymida febrifuga, highlighting its traditional applications in modern scientific contexts. Both the antibacterial and antifungal activities showcase the plant's ability to inhibit the growth of various pathogens, with specific extracts standing out for their efficacy at lower concentrations. These findings open avenues for further exploration of Soymida febrifuga as a natural source for developing new antimicrobial agents, thus integrating traditional knowledge with contemporary science. The authors acknowledge the contributions of their respective mentors and facilities that supported the research endeavors.
FAQ section (important questions/answers):
What is the focus of the study on Soymida febrifuga?
The study investigates the antibacterial and antifungal activities of Soymida febrifuga leaves. It utilizes methods like well diffusion and minimum inhibitory concentration to assess effectiveness against various bacteria and fungi.
What methods were used for antimicrobial screening in the study?
The methods included diffusion (well diffusion method), dilution (minimum inhibitory concentration), and bioautographic techniques, which allowed the researchers to assess the antimicrobial efficacy of different plant extracts.
Which organisms were tested for antibacterial activity?
The antibacterial activity was tested on various Gram-positive and gram-negative bacteria, including Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Proteus vulgaris.
What were the main findings regarding the extracts' effectiveness?
The study found that methanol, water, and total aqueous extracts exhibited strong antimicrobial activity against all tested microorganisms, showing significant zones of inhibition in the well diffusion assays.
What were the minimum inhibitory concentration results for the extracts?
The methanol extract showed significant activity against Pseudomonas aeruginosa and Candida albicans with MIC values of 0.625mg/ml, while water extract had an MIC of 2.5 mg/ml against Proteus vulgaris.
Who contributed to the research and provided essential guidance?
The authors thanked Dr. Prabha Y. Bhogaonkar and Dr. S.S. Khadabadi for their guidance and support, which was crucial in facilitating the research process and outcomes.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antibacterial and antifungal properties of Soymida febrifuga leaves.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In the context of the study, 'activity' refers to the efficacy of the extracts of Soymida febrifuga against various microorganisms. This includes the measurement of both antibacterial and antifungal properties, which are observed through techniques like well diffusion and minimum inhibitory concentration (MIC) determination.
2) Water:
Water is one of the solvents used to extract active compounds from the leaves of Soymida febrifuga. In the study, the water extract displayed significant antimicrobial activity, being tested against various bacterial and fungal strains, highlighting its potential as a natural antibacterial and antifungal agent.
3) Table:
The term 'table' refers to the structured presentation of data derived from the experiments conducted in the study. Tables summarize findings such as zones of inhibition and minimum inhibitory concentrations for the various extracts. They provide a clear and concise way to compare results across different microbial strains.
4) Medium:
In microbial studies, 'medium' refers to the nutrient solutions or agar used to grow bacteria and fungi. The choice of medium impacts the growth of the microorganisms, which is crucial for assessing the antimicrobial activity of the plant extracts in the established experiments, including nutrient agar and Sabouraud's dextrose agar.
5) Study (Studying):
'Study' signifies the systematic investigation conducted to evaluate the antimicrobial effects of Soymida febrifuga's leaf extracts. This involves defining methodologies, conducting experiments, recording observations, and analyzing results to validate traditional medicinal claims regarding the plant's efficacy against specific pathogens.
6) Antibiotic (Antibacterial):
Antibacterial focuses on the capability of a substance to inhibit or kill bacterial growth. The study emphasizes the antibacterial activity of Soymida febrifuga's extracts against various gram-positive and gram-negative bacteria, thus underlining its potential application in treating bacterial infections.
7) Aureus:
Staphylococcus aureus is a gram-positive bacterium included in the study, tested against extracts of Soymida febrifuga. It is of clinical significance as it is responsible for numerous infections. The effects of different extracts on this organism were evaluated to determine their potential antimicrobial properties.
8) Amravati:
Amravati is a city in Maharashtra, India, where the plant samples were collected for the study. The geographical context is relevant as it pertains to the local availability of the Soymida febrifuga plant, which is integral to understanding its ethnomedicinal uses and potential for broader applications.
9) Drug:
'Drug' refers to a chemical substance used for diagnosis, cure, or prevention of disease. In this study, the extracted compounds from Soymida febrifuga are explored for their potential as therapeutic drugs, particularly for combating bacterial and fungal infections, reflecting the importance of natural drugs in medicine.
10) Medicine:
Medicine encompasses the field of health and healing practices, including the use of plant extracts studied here. The research aims to validate the medicinal claims associated with Soymida febrifuga, advocating its role in holistic and alternative treatment options for prevalent ailments.
11) Sharad (Sarad):
Sharad is part of the name of one of the authors, Shubhangi Sharad Bhide, indicating her contribution to the research. The name represents the collaboration of various researchers in the study, each contributing their expertise in pharmacology and botany to the findings presented.
12) Family:
In botanical terms, 'family' refers to the classification rank. Soymida febrifuga belongs to the Meliaceae family, which is crucial for understanding its phylogenetic relationships and potential shared properties with other species in the same family, especially concerning medicinal uses.
13) Botany:
Botany is the scientific study of plants, relevant here as the research involves the examination of a specific plant species, Soymida febrifuga. Understanding botany helps in the identification of active compounds and their potential therapeutic effects, essential for ensuring accurate ethnobotanical applications.
14) India:
India's significance in this study lies in its rich biodiversity, including various medicinal plants such as Soymida febrifuga. The country's traditional medicine practices and growing interest in plant-based therapies highlight the importance of researching indigenous flora for pharmaceutical development.
15) Fever:
Fever is mentioned in the context of traditional medicinal claims for Soymida febrifuga, indicating its historical use in treating symptoms of illness. Researching the plant's effects on pathogenic organisms contributing to fever underscores its promise in modern herbal medicine.
16) Pharmacological:
Pharmacological pertains to the study of how drugs interact with biological systems. The research investigates the pharmacological properties of Soymida febrifuga's extracts, aiming to establish their effectiveness against specific pathogens, which can lead to new therapeutic discoveries.
17) Observation:
Observation involves the systematic recording of experimental results. In this study, it pertains to documenting the effectiveness of various extracts against microbial strains, providing critical data that informs the subsequent analysis and interpretation of antimicrobial activity.
18) Discussion:
Discussion refers to the section where the implications of the study's findings are analyzed. This encompasses comparing results with existing literature, exploring the significance of the extracts' antibacterial and antifungal activities, and suggesting future research directions regarding Soymida febrifuga.
19) Swelling:
Swelling, as used in traditional medicine contexts, relates to conditions that may be treated with extracts from Soymida febrifuga. It reflects the plant's potential applications in treating inflammation-related ailments, linking ethnomedicine with contemporary treatment strategies.
20) Debility:
Debility denotes a state of weakness or lack of strength. In traditional use, Soymida febrifuga has been applied for general debility, suggesting the extracts could support overall health, an area explored within the context of the plant's pharmacological benefits.
21) Suvarna:
Suvarna is part of the collaborative authorship of the study, signifying the contributions of various researchers in the project. Personal names in scientific literature embody the collaborative effort required in conducting comprehensive research on botanical properties and ethnomedicinal claims.
22) Disease:
Disease refers to any abnormal condition of an organism caused by infection or health dysfunction. The study aims to evaluate the efficacy of Soymida febrifuga against diseases caused by specific bacteria and fungi, validating its traditional use in treating various ailments.
23) Species:
In the biological classification, 'species' identifies specific groups of organisms. The study revolves around the species Soymida febrifuga, which is critically examined for its antimicrobial properties. Understanding its classification helps assess its relevance in biodiversity and medicinal research.
24) Surface:
Surface pertains to the area of contact between the extract and the agar medium in diffusion methods. The significance lies in how well the extracts diffuse into the medium, directly affecting the observed zones of inhibition in antimicrobial susceptibility tests.
25) Prabha:
Prabha is part of the name of an author in the research, Dr. Prabha Y. Bhogaonkar. Her role in guiding the research reflects the collaborative effort in validating the ethnomedicinal significance of the studied plant and contributing to the academic rigor of the project.
26) Wardha:
Wardha is a district in Maharashtra, India, indicating a geographical relevance in the research context. Its mention underscores the local ecosystems where Soymida febrifuga may thrive and highlights the importance of regional biodiversity in pharmaceutical development.
27) Bitter:
Bitter describes one of the tasting properties of some extracts from the plant, which may be significant in traditional medicine practices. Bitter compounds often correlate with certain medicinal effects, reinforcing a key aspect of how traditional practitioners use herbal remedies.
28) Indian:
'Indian' refers to the geographical and cultural context of the study and the plant's traditional uses in Indian medicine. It emphasizes the rich heritage of ethnobotanical practices and the need to research indigenous plants for therapeutic applications.
29) Glass:
Glass is mentioned concerning the laboratory equipment used in experiments, specifically for the spread plate method and dilution techniques. It highlights the importance of using sterile glassware in microbiological studies for accurate and reliable results.
30) Kirti (Kirtti):
Kirti is part of the author's name, Kirti Sahu, contributing to the research work. The collaborative nature of authorship indicates a multidisciplinary approach in the study, combining different expertise in the investigation of the plant's antimicrobial properties.
31) Pune:
Pune is a city in Maharashtra, India, associated with the National Chemical Laboratory, where microbial strains were likely sourced for the study. Its mention highlights the institutional collaboration necessary for conducting scientific research and ensuring proper species identification for the study.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antibacterial and antifungal properties of Soymida febrifuga leaves.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Natural product, Antibacterial activity, Anti-inflammatory activity, Phytochemistry, Pharmacological activities, Antimicrobial activity, Zone of inhibition, Minimum inhibitory concentration, Antifungal activity, Botanical Description, Candida albicans, Chloroform extract, Dilution method, Water extract, Aspergillus niger, Methanol extract, Well diffusion method, Petroleum ether extract, Gram negative strain, Gram positive strain, Anti fungal activity, Vaginal infection, Plant Extract, Nutrient agar medium, Tetracycline, Fatty acid methyl ester, DPPH free radical scavenging activity, Gram positive organism, Gram negative organism, Dimethyl sulphoxide, Various extracts, New Drug, Bacterial organisms, Mean standard deviation, Council of Scientific and Industrial Research, Indian medicinal plant, Pseudomonas aeurginosa, Two-fold serial dilution method, Phytochemical constituent.
Concepts being referred in other categories, contexts and sources.