Synthesis and antimicrobial activity of novel pyrazoline and flavone derivatives.
Journal name: World Journal of Pharmaceutical Research
Original article title: Synthesis and antimicrobial activity of some novel pyrazoline and flavone derivatives derived from furan chalcones
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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R. A. Shastri
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Synthesis and antimicrobial activity of some novel pyrazoline and flavone derivatives derived from furan chalcones
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
1. Introduction
This study focuses on the synthesis and antimicrobial activity evaluation of novel pyrazoline and flavone derivatives derived from furan chalcones. The research highlights the significance of heterocyclic compounds containing nitrogen or oxygen, particularly pyrazolines and flavones, due to their diverse pharmacological activities, including antibacterial, antifungal, anti-inflammatory, and anticancer properties. A series of new compounds were synthesized by reacting substituted o-hydroxyacetophenones with furan-2-aldehyde, followed by further reactions to create the desired derivatives. All synthesized compounds were characterized using IR and NMR spectroscopic techniques.
2. The Importance of Pyrazoline Derivatives
Pyrazolinoids are recognized for their extensive biological activities, including antibacterial, antifungal, anti-inflammatory, and antitumor effects. The study emphasizes the compelling need to explore new pyrazoline derivatives to combat various diseases, particularly infections caused by bacteria and fungi. The synthesized pyrazoline compounds exhibit significant antimicrobial activity, suggesting their potential use in medicinal chemistry. This characteristic makes pyrazoline derivatives a focal point of interest for researchers seeking to develop effective antimicrobial agents.
3. Flavones and Their Pharmacological Effects
Flavones represent another class of heterocyclic compounds being investigated for their notable pharmacological effects. The research emphasizes that flavones exhibit antioxidant, anxiolytic, anticancer, and antimicrobial activities. The synthesis of flavone derivatives from furan chalcones aligns with ongoing efforts to discover compounds that can enhance biological activity while being beneficial for disease treatment. The incorporation of the furan moiety into the flavone structure is shown to increase biological efficacy, making these derivatives valuable for therapeutic applications.
4. Antimicrobial Activity Evaluation
The synthesized compounds were rigorously screened for their antimicrobial activity against various bacterial and fungal strains, specifically using techniques such as agar cup method for antibacterial assessment and poison plate method for antifungal evaluation. The results showed promising antibacterial activity for compounds 4a-g against pathogens like E. coli, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis, with several derivatives displaying significant antifungal activity against Aspergillus and Penicillium species. These findings suggest the potential of the synthesized derivatives as effective antimicrobial agents.
5. Conclusion
In conclusion, the study successfully synthesized a series of novel pyrazoline and flavone derivatives derived from furan chalcones and characterized them through spectral analysis. The evaluation of antimicrobial activities showed that these compounds possess promising antibacterial and antifungal properties. Given the increasing resistance to conventional antimicrobial agents, the derivatives synthesized in this work could represent a vital addition to the arsenal of available treatments, paving the way for future research in drug development using these novel compounds.
FAQ section (important questions/answers):
What compounds were synthesized in this research study?
The study synthesized novel 1-(3-(2-hydroxyphenyl substituted)-5-(furan-2-yl-4,5-dihydropyrazol-1-yl)ethanone and 2-(furan-2-yl)-4H-chromen-4-one derivatives.
What methods were used for compound characterization?
The synthesized compounds were characterized using IR and 1H NMR spectroscopy, as well as thin layer chromatography.
What types of biological activity were evaluated?
The synthesized compounds were evaluated for their antibacterial and antifungal activities against various pathogens.
Which microorganisms were tested for antibacterial activity?
Antibacterial activity was tested against E. coli, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis.
What were the findings of the antimicrobial activity results?
All synthesized compounds demonstrated significant antibacterial and antifungal activities, showcasing their potential therapeutic uses.
Who acknowledged support for this research?
The author acknowledged support from SAIF, CIL Chandigarh, and local educational institutions for research facilities and help.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Synthesis and antimicrobial activity of novel pyrazoline and flavone derivatives.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the biological effects that compounds exhibit against microorganisms. In the context of this research, antimicrobial activity is evaluated to determine how effectively the synthesized pyrazoline and flavone derivatives inhibit or kill bacterial and fungal strains. This aspect is significant in the development of new pharmaceuticals.
2) Antibiotic (Antibacterial):
Antibacterial designates the property of a substance to fight against bacteria. The study focuses on testing the new compounds for their antibacterial properties against various bacterial strains, such as E. coli and Staphylococcus aureus, highlighting their potential application in treating bacterial infections in medicine.
3) Water:
Water serves as a crucial solvent in the synthesis and purification processes outlined in the research. It is employed in various stages, including the precipitation of synthesized compounds and subsequent washing steps, which are essential for removing impurities and isolating the desired products in their pure form.
4) Table:
In scientific literature, a table is used to present data systematically. This includes physical constants, yields, and antimicrobial screening results for the synthesized compounds. Tables provide a clear and concise overview of experimental results, facilitating easier comparison and analysis of the data gathered in research studies.
5) Science (Scientific):
Science is the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. This paper emphasizes the application of chemical synthesis and microbiology to explore novel therapeutic agents, thus contributing to advancements in pharmaceutical science and medicinal chemistry.
6) Aureus:
Aureus refers to Staphylococcus aureus, a common bacterium that can cause various infections in humans. The research evaluates the synthesized compounds against this particular strain to determine their effectiveness, which is relevant given the bacterium’s role in clinical settings and the need for effective treatments.
7) Pharmacological:
Pharmacological pertains to the study of how drugs interact with biological systems. The compounds synthesized in this research possess various pharmacological activities, such as antibacterial and antifungal effects, indicating their potential as therapeutic agents in treating infections and enhancing drug development in pharmaceutical applications.
8) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in India where the research was conducted. The geographical and institutional context is important as it highlights the regional advancements in chemistry and pharmaceutical research, linking local academic efforts to global scientific inquiry and the dissemination of knowledge.
9) India:
India is the country where the research originates. It symbolizes the growing importance of Indian institutions in the global scientific community, especially in fields like chemistry and pharmacology. The findings contribute to the country's contribution to medical research and the development of new treatments.
10) Biodegradable:
Biodegradable refers to substances that can be broken down by microorganisms. The research suggests that some synthesized pyrazolines exhibit biodegradable properties, making them environmentally friendly options in drug development and agrochemicals, thus highlighting the significance of sustainability in modern scientific research.
11) Discussion:
Discussion refers to the section in scientific papers where authors interpret the results and implications of their findings. It allows researchers to connect experimental data to broader scientific questions, analyze the effects of new compounds, and suggest potential applications or further research needed.
12) Raising:
Raising in this context pertains to the enhancement of certain biological activities by the compounds studied. The mention of raising cyclic adenosine 3', 5'-monophosphate (cAMP) suggests a mechanism of action for some compounds, indicating a direction for future investigations in pharmacology.
13) Disease:
Disease refers to any condition that impairs normal functioning and can be caused by various pathogens. This research is significant as it aims to develop new compounds that can potentially treat infectious diseases, addressing a critical area in healthcare and pharmacotherapy.
14) Purity:
Purity indicates the extent to which a substance is free from contaminants or undesired components. The study emphasizes the importance of ensuring the synthesized compounds are pure through methods like TLC, IR, and NMR, as the efficacy of potential drugs heavily relies on their purity.
15) Ulcer:
Ulcer refers to a sore that develops on the lining of the stomach or intestine. The mention of Ranitidine as a chemotherapeutic agent indicates a focus on developing drugs that can treat such conditions, underscoring the potential therapeutic applications of the synthesized compounds in gastrointestinal disorders.
16) Study (Studying):
Study refers to the systematic investigation to understand or test hypotheses. In this context, it highlights the comprehensive research undertaken to synthesize new compounds, evaluate their antimicrobial activity, and explore their pharmacological potential, contributing valuable data to scientific discourse.
17) Shri (Sri, Sr):
Shri is a respectful title used in India that denotes honor and reverence. Its inclusion in the acknowledgment section reflects the author's appreciation for contributions made by individuals, emphasizing the collaborative nature of scientific research and the respect for academic guidance.
18) Drug:
Drug refers to a substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease. The research aims to develop new drugs through the synthesis of pyrazoline and flavone derivatives, showcasing their potential to become effective therapeutic agents against infectious pathogens.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Synthesis and antimicrobial activity of novel pyrazoline and flavone derivatives.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Camp, Treatment of disease, Penicillin, Anti-inflammatory activity, Antioxidant activity, Thin Layer Chromatography, Antimicrobial activity, Aspergillus niger, Acetic acid, Biological activities, Elemental analysis, DMSO, Spectral analysis, Spectroscopic data, Aspergillus flavus, Antifungal screening, Dimethyl sulphoxide.