Drugs for chronic alcoholism and their quantitative estimation
Journal name: World Journal of Pharmaceutical Research
Original article title: Drugs for chronic alcoholism and their quantitative estimation
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Rupinder Kaur and Dr. Manish Sinha
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Drugs for chronic alcoholism and their quantitative estimation
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
1) Introduction
Chronic alcoholism poses significant health risks and affects various aspects of life, leading to severe ailments such as liver cirrhosis, psychological disturbances, and an array of socio-economic challenges. Alcohol is metabolized in the body into acetaldehyde through enzymes like alcohol dehydrogenase and catalase, which contributes to intoxication and a host of related health issues. Addressing this condition necessitates a multifaceted approach that includes both psychological support and pharmacological treatment to reduce cravings and improve overall patient welfare. A selection of drugs, including acamprosate, fluoxetine, disulfiram, ondansetron, and naltrexone, are explored for their effectiveness in treating chronic alcoholism.
2) Pharmacological Treatments and their Mechanisms
One of the most noteworthy medications for treating alcohol dependence is Naltrexone, an opioid receptor antagonist. This drug has demonstrated efficacy in reducing relapse rates and heavy drinking among people with a history of alcohol abuse. Naltrexone operates by blocking the μ-opioid receptors, thus diminishing the reinforcing effects of alcohol consumption and reducing the desire for intoxication. It is marketed under various names like Revia and Vivitrol but comes with potential side effects including nausea, headache, and liver damage. For optimal outcomes, it is recommended to administer the drug under carefully monitored conditions to prevent complications like liver failure.
3) Disulfiram and its Role in Deterrence
Disulfiram serves a different function in the treatment of chronic alcoholism. Unlike Naltrexone, Disulfiram does not directly suppress cravings but creates adverse reactions upon alcohol consumption, inducing discomfort and discouraging drinking behavior. By inhibiting acetaldehyde dehydrogenase, Disulfiram causes toxic levels of acetaldehyde to accumulate, leading to unpleasant symptoms. It is marketed as Antabuse and is contraindicated in patients with certain health issues, such as liver disease, making it crucial to tailor treatment plans to individual patient needs.
4) Acamprosate: A Neuroprotective Approach
Another essential medication is Acamprosate, which demonstrates a neuroprotective effect by stabilizing neurotransmission disrupted by chronic alcohol use. This drug is believed to impact the N-methyl-D-aspartate (NMDA) receptors while maximizing the inhibitory effects of GABA, thereby aiding in the management of withdrawal symptoms. Given its mechanism, Acamprosate can help prevent relapse and support abstinence by reducing withdrawal symptoms and cravings. Despite its benefits, the prescription of Acamprosate is carefully considered for patients with renal disease due to its renal clearance.
5) Conclusion
The treatment of chronic alcoholism requires a comprehensive understanding of the various pharmacological options available, each with unique mechanisms of action and potential side effects. Medications like Naltrexone, Disulfiram, and Acamprosate provide essential tools in combating alcohol dependence, but individual therapeutic responses may vary. An effective treatment strategy should integrate these medications with psychological support, tailored approaches, and continuous monitoring to optimize patient care and enhance the effectiveness of interventions against chronic alcoholism. This holistic approach serves not only to improve individual health outcomes but also to address the broader social implications of alcohol addiction.
FAQ section (important questions/answers):
What is chronic alcoholism and its main symptoms?
Chronic alcoholism is excessive alcohol use causing health issues like liver cirrhosis, psychiatric disturbances, anorexia, and weight loss.
What medications are used to treat chronic alcoholism?
Medications include acamprosate, fluoxetine, disulfiram, ondansetron, and naltrexone, which help reduce cravings and withdrawal symptoms.
How does Naltrexone work in treating alcoholism?
Naltrexone reduces cravings and relapse rates by blocking opioid receptors, diminishing the effects of alcohol.
What mechanism does Disulfiram use against alcoholism?
Disulfiram inhibits acetaldehyde dehydrogenase, causing unpleasant reactions to alcohol consumption, thus discouraging drinking.
What are the side effects of Acamprosate?
Common side effects of Acamprosate include headache, nausea, diarrhea, and flatulence, requiring caution in patients with kidney impairment.
What role does psychological therapy play in alcohol addiction treatment?
Psychological and motivational therapies empower patients with knowledge and skills to effect change in drinking behavior, improving treatment outcomes.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Drugs for chronic alcoholism and their quantitative estimation”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Drug:
A drug is a substance used to treat, prevent, or diagnose diseases and medical conditions. In the context of alcoholism, drugs aim to reduce cravings and withdrawal symptoms, thereby aiding in recovery. Various classes of drugs target different neurotransmitter systems to help manage alcohol dependence effectively.
2) Alcoholism:
Alcoholism is a chronic disease characterized by an inability to control or stop drinking despite adverse consequences. It leads to significant social, psychological, and physical problems. Understanding alcoholism is essential for developing effective treatment strategies, as it affects not only the individual but also their family and community.
3) Water:
Water is essential for life, acting as a solvent for biochemical reactions and maintaining physiological balance within the body. In alcoholic patients, dehydration can exacerbate health issues, including liver disease. Understanding hydration's role is vital in managing overall health in individuals recovering from alcoholism.
4) Disease:
A disease is a pathological condition of a bodily part or system resulting from various causes, often characterized by identifiable signs and symptoms. Chronic alcoholism leads to multiple diseases, including liver cirrhosis and mental health disorders, necessitating comprehensive treatment approaches encompassing both pharmacological and psychological interventions.
5) Performance:
Performance in this context refers to the ability of individuals to function in daily life, which can be severely impaired by chronic alcoholism. Alcohol undermines cognitive and physical performance, impacting work, relationships, and self-care. Understanding these impacts is crucial for developing effective recovery strategies.
6) Craving (Crave, Craved):
Craving is an intense desire for a substance, such as alcohol, and is a significant challenge in addiction recovery. Effective treatments often target craving reduction to facilitate abstinence and long-term recovery. Medications like naltrexone and acamprosate are designed to manage cravings effectively.
7) Death:
Death linked to chronic alcoholism can result from various complications, such as liver failure, accidents, or alcohol poisoning. Understanding the mortality risks associated with alcoholism emphasizes the urgent need for effective intervention and treatment options to prevent premature death in affected individuals.
8) Relative:
In the context of health, 'relative' often pertains to the comparative nature of health risks and outcomes. It helps in understanding the proportion of disease burden attributable to alcohol use, enabling health professionals to prioritize interventions and allocate resources effectively in treatment plans.
9) Nausea:
Nausea is a common side effect associated with alcohol withdrawal and certain medications used in treatment. It can complicate recovery efforts by discouraging patients from adhering to their treatment protocols. Understanding and managing nausea is crucial for improving patient compliance and overall well-being.
10) Pharmacological:
Pharmacological refers to the effects and actions of drugs on biological systems. In alcoholism treatment, pharmacological approaches involve the use of medications to alter brain chemistry, reduce cravings, and manage withdrawal symptoms, thus assisting in the recovery process for individuals with alcohol dependence.
11) Chemotherapy:
In this context, chemotherapy refers to the use of pharmacological agents to treat alcoholism by modifying the body's response to alcohol. Various drugs work through different mechanisms to help reduce cravings, manage withdrawal symptoms, or create aversive reactions to alcohol consumption.
12) Depression:
Depression is frequently associated with chronic alcoholism, complicating recovery by affecting mood and motivation. It can lead to increased alcohol consumption as a form of self-medication. Addressing both depression and alcohol dependence is crucial for effective treatment and improved patient outcomes.
13) Suffering:
Suffering encompasses the physical, emotional, and psychological pain experienced by individuals with alcoholism. It is essential for healthcare providers to recognize and address this suffering, as it impairs quality of life and hinders recovery. Comprehensive treatment approaches must consider the whole person.
14) Activity:
Activity in this context refers to both physical and mental engagement. Chronic alcoholism can significantly hinder an individual's ability to participate in daily activities, resulting in a sedentary lifestyle and social isolation. Encouraging re-engagement in healthy activities is vital during recovery.
15) Cancer:
Cancer is one of the many health risks associated with chronic alcohol use. Alcohol consumption significantly increases the risk of various cancers, including liver and esophageal cancer. Understanding this association emphasizes the importance of preventive strategies and cancer screenings for individuals struggling with alcoholism.
16) Life:
Life reflects the overall quality of existence for individuals, which is often severely affected by alcoholism. Recovery efforts aim to restore a fulfilling life through improved health, stable relationships, and re-engagement in social activities, highlighting the holistic nature of effective treatment.
17) Quality:
Quality of life relates to individuals’ overall well-being, including physical, emotional, and social health. Chronic alcoholism often degrades quality of life, necessitating comprehensive interventions that address not just abstinence, but also the restoration of physical health and social connections.
18) Anxiety:
Anxiety often coexists with alcoholism, contributing to a cyclic pattern of substance use and emotional distress. Effective treatment must address both anxiety and alcohol dependence, utilizing therapies and medications that target these interconnected issues for improved recovery outcomes.
19) Ropar:
Ropar is a location in India associated with the research conducted in the study on alcoholism. Geographic context is essential in understanding local patterns of alcohol use, availability of treatment options, and cultural attitudes towards alcoholism, which can influence recovery strategies.
20) India:
India is the country where the referenced research was conducted, reflecting the broader societal and healthcare context regarding alcohol dependence. Recognizing cultural, socioeconomic, and healthcare challenges in India is crucial for framing effective treatment and prevention strategies for alcoholism.
21) Blood:
Blood plays a key role in the pharmacokinetics of drugs used in treating alcoholism, including their distribution and effects on various organs. Understanding how drugs interact with blood components is essential for determining dosing, efficacy, and safety profiles in individuals undergoing alcohol treatment.
22) Bela:
Bela is a specific town in Ropar, India, noted in the research. Local factors such as community health resources and social support systems in Bela may impact the efficacy of treatment programs for alcoholism and the populations' visibility of alcohol-related issues.
23) Salt (Salty):
Salt, or sodium, can be relevant in discussions around hydration and health, especially in the context of liver functionality impaired by chronic alcohol misuse. Managing dietary intake, including salt, may play a role in recovery and overall well-being for alcohol-dependent individuals.
24) Transformation (Transform, Transforming):
Transforming refers to the process of significant change, which is often necessary for individuals recovering from alcoholism. Effective programs focus on transforming behaviors, mindsets, and life circumstances to foster sustainable changes and long-term recovery.
25) Transmission:
Transmission in the context of health refers to the ways diseases or conditions are spread. Understanding the transmission of alcohol-related complications emphasizes the importance of education and intervention strategies aimed at preventing the spread of harmful drinking behaviors within communities.
26) Accumulation (Accumulating, Accumulate):
Accumulation relates to the buildup of substances in the body, such as toxins resulting from excessive alcohol consumption. Chronic accumulation of alcohol-related damage can lead to serious health complications, emphasizing the need for effective detoxification strategies as part of recovery.
27) Developing:
Developing refers to the process of creating or enhancing treatment programs for alcoholism. Continuous development of research, practices, and policies is crucial to effectively address the ever-evolving challenges posed by alcohol dependence in society.
28) Knowledge:
Knowledge encompasses the understanding and information about alcoholism, its effects, treatment options, and recovery processes. Enhancing knowledge among patients, healthcare providers, and communities is vital for creating effective prevention and intervention strategies for alcohol-related issues.
29) Vomiting:
Vomiting is a common symptom of alcohol withdrawal and a significant side effect of certain medications. Managing nausea and vomiting is important to ensure that patients adhere to treatment regimens and maintain positivity during their recovery journey.
30) Teaching:
Teaching refers to the process of imparting knowledge and skills, particularly in the context of educating patients and families about alcoholism. Effective teaching strategies can empower individuals to make informed decisions about treatment, lifestyle changes, and relapse prevention.
31) Pregnant:
Pregnant refers to women who are expecting a child, emphasizing the significant risks that alcohol consumption poses during pregnancy. Understanding these risks is vital for prevention, as chronic alcohol use can lead to fetal alcohol syndrome and other developmental issues.
32) Sweating (Sweat):
Sweating can occur as a withdrawal symptom for individuals dependent on alcohol, representing a physical manifestation of their body’s adjustment to abstinence. Recognizing sweating as a symptom highlights the importance of supportive care during detoxification and adjustment periods.
33) Channel:
Channel refers to pathways or mechanisms through which substances exert effects in the body. In the context of pharmacology for alcoholism, understanding the channels involved in neurotransmitter activity is crucial for developing effective therapeutic interventions.
34) Family:
Family plays a crucial role in the recovery process from alcoholism, providing emotional support and stability. Engaging the family in treatment can enhance outcomes and facilitate healthier relationships, addressing the interconnectedness of individual recovery and family dynamics.
35) Nature:
Nature refers to the inherent qualities or characteristics of a condition or individual, shaping how they experience alcoholism and recovery. Understanding the nature of addiction can aid in creating personalized treatment strategies that cater to individual needs and strengths.
36) Firing:
Firing pertains to the activity of neurons in the brain, particularly in relation to neurotransmitter release and signaling. During alcohol use and withdrawal, changes in neuronal firing patterns significantly influence cravings, mood, and overall brain function.
37) Desire:
Desire signifies the intense urge or longing for alcohol, a central component of addiction. Understanding the complexities of desire helps in creating targeted treatments that address the emotional and psychological triggers associated with alcohol dependence.
38) Simha:
Sinha, referenced in the study, signifies the academic contribution of the co-author, Dr. Manish Sinha. Acknowledging contributors is essential for recognizing the collaborative effort in advancing research and treatments for chronic alcoholism and related health issues.
39) Birth:
Birth refers to the beginning of life, highlighting the importance of prenatal care in preventing fetal alcohol syndrome. Understanding the effects of alcohol on pregnancy underscores the necessity of education and resources for expectant mothers to reduce risks associated with alcohol consumption.
40) Mud:
Mood reflects the emotional state of an individual and is often significantly impacted by chronic alcoholism. Effective treatment approaches should target mood stabilization, considering the interplay between mood disorders and alcohol use to foster comprehensive recovery.
41) Male:
Male references the demography most often studied in relation to alcohol consumption patterns. Understanding gender differences in alcoholism can guide tailored treatment strategies, resources, and public health initiatives aimed at addressing male-specific drinking behaviors and resulting health complications.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Drugs for chronic alcoholism and their quantitative estimation’. Further sources in the context of Science might help you critically compare this page with similair documents:
Alcohol consumption, Pharmaceutical preparation, Analytical method, Psychological treatment, Quality Control, High performance liquid chromatography, Oxidative stress, Heavy alcohol consumption, Liver Cirrhosis, Pharmacological action, Controlled Study, Retention time, Mechanism of action, Clinical pharmacology, Mobile phase, Quantitative estimation, CNS depressant, Neuroprotective effect, Method development, Calibration curve, Chronic Alcoholism, Alcohol Addiction, Cirrhosis, Method validation, Spectrophotometric method, Linear Relationship, Limits of detection and quantification, Relative standard deviation, Cytochrome P450, Alcohol dehydrogenase, Fluoxetine, CNS Effects, Renal System, Acetaldehyde, Reverse Phase C18 Column, Selective serotonin reuptake inhibitor, Alcohol dependence, Combined efficacy, Ethanol consumption, Serotonin Reuptake Inhibitor, Future research directions, Recent findings, Glutamatergic neurotransmission, Neurotransmitter Glutamate.
Concepts being referred in other categories, contexts and sources.