A review on pharmacological activity of hydnocarpus wightiana
Journal name: World Journal of Pharmaceutical Research
Original article title: A review on pharmacological activity of hydnocarpus wightiana
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Lija Johny, Bhat AR, Sandhya S, Kavitha MP, Krishnakumar K
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Full text available for: A review on pharmacological activity of hydnocarpus wightiana
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The World Journal of Pharmaceutical Research published a review on the pharmacological activity of Hydnocarpus wightiana, a plant recognized for its diverse medicinal properties. Traditional medicine, encompassing practices that utilize plant, animal, and mineral-based remedies, has been a crucial part of healthcare in many cultures, particularly in India, where a wealth of medicinal herbs remains under studied. The primary aim of this research is to uncover bioactive natural products that may lead to the development of new pharmaceuticals addressing health challenges.
Antibacterial and Antioxidant Activities
Hydnocarpus wightiana has shown significant antibacterial and antioxidant properties. The antibacterial activity was assessed using the disc diffusion method, demonstrating that the extracts exhibited substantial inhibition of bacterial growth, which correlates with increasing concentrations of the extract. Moreover, its antioxidant capacity was evaluated through the DPPH free radical scavenging method, wherein the leaf extract showcased potent antioxidant activity, suggesting potential benefits in combating oxidative stress-related ailments.
Anti-diabetic and Wound Healing Properties
The plant’s oil is identified for its anti-diabetic properties, displaying strong antioxidant and α-glucosidase inhibitory activities. In studies involving diabetes-induced rats, the ethanolic extract of the seed hulls significantly lowered glucose levels over 28 days, illustrating its effectiveness as a therapeutic agent. Additionally, anecdotal evidence suggests that Hydnocarpus wightiana's oil aids in wound healing, particularly among leprosy patients, providing promising insight into its utility in accelerating recovery and tissue repair.
Hypolipidemic, Anti-Inflammatory, and Anti-Neoplastic Activities
Further pharmacological studies highlighted the hypolipidemic activity of flavanolignans isolated from the seeds of Hydnocarpus wightiana, which effectively lowered serum cholesterol and triglycerides in experimental models. In addition to this, hydnocarpin exhibited anti-inflammatory and anti-neoplastic activities, suggesting the potential to inhibit cancer cell growth in both murine and human tissue cultures. These findings position Hydnocarpus wightiana as a plant with multifaceted therapeutic benefits.
Conclusion
The review underscores the therapeutic potential of Hydnocarpus wightiana, which has been traditionally utilized for various ailments. Its broad spectrum of biological activities—including antioxidant, antidiabetic, antibacterial, anti-inflammatory, and wound healing effects—highlights its value in herbal medicine. Future research focusing on the standardization of extracts, pharmacological characterization, and clinical validations is essential to further establish its efficacy and safety in therapeutic applications, ultimately contributing to a growing interest in medicinal plants in the global health care landscape.
FAQ section (important questions/answers):
What is the focus of the review on Hydnocarpus wightiana?
The review highlights the pharmacological activities of Hydnocarpus wightiana, including its antibacterial, antidiabetic, wound healing, antioxidant, hypolipidemic, anti-inflammatory, and antineoplastic properties.
What historical significance do natural products have in medicine?
Natural products have been critical sources of medicinal agents for thousands of years, leading to the development of many modern drugs derived from these sources.
Where does Hydnocarpus wightiana predominantly grow?
Hydnocarpus wightiana primarily grows in the tropical forests of the Western Ghats in India and is also found in Nigeria, Uganda, Sri Lanka, and other Southeast Asian countries.
What are the main therapeutic uses of Hydnocarpus wightiana?
Hydnocarpus wightiana is utilized for treating various conditions, including leprosy, skin diseases, abdominal issues, and metabolic disorders, exhibiting a range of medicinal effects.
How does Hydnocarpus wightiana contribute to wound healing?
The oil of Hydnocarpus has been shown to promote wound healing in leprosy patients, enhancing the strength of scar tissue and aiding in recovery.
What pharmacological activities have been studied for this plant?
Studies on Hydnocarpus wightiana demonstrate its antioxidant, antibacterial, anti-diabetic, anti-inflammatory, and anti-neoplastic activities, along with its potential in wound healing.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A review on pharmacological activity of hydnocarpus wightiana”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity in this context refers to the various pharmacological effects exhibited by Hydnocarpus wightiana, such as antibacterial, antidiabetic, wound healing, antioxidant, and anti-inflammatory properties. Understanding the activities of this plant is crucial for assessing its potential therapeutic applications and developing herbal medicines that could benefit human health.
2) Species:
Species denotes the classification of Hydnocarpus wightiana within the genus Hydnocarpus, which comprises around 40 species. The identification of specific species is relevant for medicinal research, as different species may possess varying chemical properties and biological activities that can be useful for drug development.
3) Medicine:
Medicine refers to the field focused on the study, diagnosis, treatment, and prevention of diseases. Hydnocarpus wightiana serves as a traditional medicine in various cultures, highlighting the importance of herbal sources in providing therapeutic agents that could complement or offer alternatives to modern pharmaceuticals.
4) Krishna (Krsna):
Krishna is the name of the lead author of the review article on Hydnocarpus wightiana. His contribution represents the academic effort to investigate the pharmacological potential of this plant, which is critical for advancing the understanding of natural products in medical science.
5) Antibiotic (Antibacterial):
Antibacterial activity pertains to the ability of Hydnocarpus wightiana to inhibit bacterial growth. This property is significant for the development of natural antibiotics, particularly in the context of increasing antibiotic resistance. Exploring such activities in herbal plants can lead to new treatments for bacterial infections.
6) Leprosy:
Leprosy is a chronic infectious disease caused by the bacterium Mycobacterium leprae. Historically, Hydnocarpus oil was used to treat leprosy, underlining the plant's importance in traditional medicine. Understanding its effects can contribute to developing better therapies for this disease.
7) Kerala:
Kerala is a state in India known for its rich biodiversity and traditional medicinal practices. The significance of Hydnocarpus wightiana in this region emphasizes the potential for local plants to provide therapeutic agents, as well as the need for scientific research to validate traditional uses.
8) Cina:
China is one of the regions where various species of Hydnocarpus are found. The inclusion of this geographical context stresses the global importance of plant research and its contributions to understanding the medicinal potential of natural products derived from different traditions.
9) Pharmacological:
Pharmacological pertains to the study of drug action and the therapeutic effects of substances. The pharmacological activity of Hydnocarpus wightiana indicates its potential as a source for new drugs and emphasizes the importance of research in validating and understanding these activities scientifically.
10) India:
India is home to a rich heritage of traditional medicine and diverse plant species. The country's emphasis on herbal remedies and the integration of such knowledge into modern healthcare highlights the need to explore the pharmacological potential of indigenous plants like Hydnocarpus wightiana.
11) Drug:
Drug refers to a substance used for medical treatment. The review article aims to evaluate the potential of compounds derived from Hydnocarpus wightiana in drug development, illustrating the significance of natural products in the pharmaceutical industry as alternatives to synthetic drugs.
12) Lanka (Lamka, Lànkà):
Lanka, or Sri Lanka, is mentioned as part of the geographical distribution of Hydnocarpus species. This highlights the importance of regional biodiversity in providing resources for traditional medicine and the potential for collaborative research across countries to develop effective herbal treatments.
13) Study (Studying):
Study refers to the systematic investigation into the properties and activities of Hydnocarpus wightiana. It underscores the importance of empirical research in validating traditional claims about medicinal plants and advances the knowledge necessary to develop new therapeutic agents based on natural products.
14) Disease:
Disease defines any harmful conditions affecting the body or mind. The relevance of Hydnocarpus wightiana in treating various diseases, including leprosy and infections, indicates the plant's potential role in traditional medicinal practices and modern healthcare solutions aimed at disease management.
15) Nature:
Nature signifies the natural environment, encompassing biodiversity and ecosystems. The exploration of Hydnocarpus wightiana's pharmacological properties illustrates the invaluable contributions of natural resources to human health and the importance of preserving biodiversity for ongoing medicinal discoveries.
16) Ulcer:
Ulcer refers to a sore that develops on the skin or mucous membrane, often through inflammation. Hydnocarpus wightiana has been studied for its potential in wound healing, making its therapeutic use relevant for treating ulcers and improving care for patients suffering from such conditions.
17) Tree:
Tree refers to the plant form of Hydnocarpus wightiana, which is an evergreen species. Understanding its botanical characteristics is important for conservation, cultivation, and harvesting practices, which in turn support the use of tree-derived compounds in medicine.
18) Hull:
Hull refers to the outer covering of the seeds of Hydnocarpus wightiana. The hulls contain bioactive compounds that contribute to the plant's medicinal properties. Studying the hull can help isolate these compounds for research and potential therapeutic applications.
19) Western India:
Western India is significant as it encompasses the natural habitat for Hydnocarpus species, particularly in the Western Ghats. This region's rich biodiversity contributes to the discovery of medicinal plants, and understanding local species aids in conservation and utilization efforts.
20) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in Western India where various species of Hydnocarpus can be found. The presence of the species in Maharashtra highlights the regional importance of traditional herbs and their potential medicinal properties, which warrant further exploration.
21) Developing:
Developing refers to countries that are progressing towards improved economic and social welfare, where herbal medicine plays a significant role in healthcare. The relevance of traditional medicinal plants, such as Hydnocarpus wightiana, increases in developing regions due to limited access to conventional medical treatments.
22) Knowledge:
Knowledge encompasses the understanding gained from research and experience. The cumulative knowledge of plant-based medicines, particularly from studies on Hydnocarpus wightiana, fosters the advancement of pharmacognosy and aids in the integration of traditional practices with contemporary scientific methods.
23) Sandhya (Shandhya, Samdhya):
Sandhya is one of the co-authors of the review article, reflecting collaborative efforts in scientific research. The involvement of multiple authors indicates a broader perspective and expertise in evaluating the pharmacological properties of Hydnocarpus wightiana for potential medicinal applications.
24) Quality:
Quality refers to the standard that ensures safety, efficacy, and reproducibility of herbal products. The study of Hydnocarpus wightiana emphasizes the need for quality control in herbal medicine to maintain therapeutic reliability and foster trust in natural remedies as health solutions.
25) Falling:
Falling in this context refers to the process of leaves detaching from the branches of the Hydnocarpus wightiana tree. Understanding the seasonal behaviors of the tree can contribute to insights regarding its life cycle and cultivation, impacting its utilization in herbal medicine.
26) Mineral:
Mineral denotes natural substances that can be used for medicinal or therapeutic purposes. The inclusion of minerals in traditional healing practices often complements herbal treatments; thus, understanding their roles alongside herbal sources like Hydnocarpus wightiana is vital for holistic health approaches.
27) Itching:
Itching is a sensation that often accompanies skin disorders. The efficacy of Hydnocarpus wightiana in treating conditions like itching underlines its therapeutic potential and provides additional rationale for the exploration of its constituents in developing topical treatments for skin-related issues.
28) Science (Scientific):
Science signifies the systematic study of the structure and behavior of the physical and natural world. The investigation into Hydnocarpus wightiana's pharmacological properties reflects an intersection of science and traditional medicine, indicating a growing interest in validating and harnessing natural remedies through scientific inquiry.
29) Siddha:
Siddha represents one of the ancient systems of traditional medicine practiced predominantly in South India. The relevance of Siddha medicine highlights the significance of plants like Hydnocarpus wightiana within various traditional health practices and the potential for complementary integration with modern medical treatments.
30) Forest:
Forest indicates the natural environment where Hydnocarpus wightiana grows extensively. Protecting and preserving forests is crucial for biodiversity and the sustainable use of medicinal plants, ensuring continuous access to natural resources for future generations and effective disease management.
31) Family:
Family refers to the taxonomic classification in biology. Hydnocarpus wightiana belongs to the Achariaceae family, and understanding plant family relationships facilitates research by linking chemical properties and potential uses across related species, enhancing discoveries in pharmacognosy.
32) Medium:
Medium refers to the nutrient substance used to culture bacteria in laboratory tests to assess antibacterial properties. The use of a controlled medium for experiments underscores the importance of methodical approaches in determining the efficacy of natural products like Hydnocarpus wightiana against pathogens.
33) Animal:
Animal pertains to the subjects used in pharmacological studies to evaluate the effects of plant extracts. Research involving animal models helps ascertain the safety and efficacy of Hydnocarpus wightiana's healing properties, providing critical data for future clinical applications.
34) Indian:
Indian refers to the cultural and geographical context where Hydnocarpus wightiana is found. The assessment of traditional uses of this plant reflects India's rich heritage of herbal medicine, emphasizing the need for validation through scientific research to bridge ancient practices and modern healthcare.
35) Kumar:
Kumar is another author listed in the article, showcasing collaborative research efforts. The contributions of multiple researchers in studying Hydnocarpus wightiana emphasize the value of teamwork in advancing knowledge and understanding of phytochemical properties and their potential therapeutic applications.
36) Edema (Oedema):
Edema refers to swelling caused by excess fluid trapped in the body's tissues. The historical usage of Hydnocarpus wightiana for treating edema highlights the relevance of exploring traditional remedies that could lead to novel treatments for such conditions.
37) Fever:
Fever is a common response to infection and signifies the body's attempt to fight illness. The potential use of Hydnocarpus wightiana in alleviating fever emphasizes its therapeutic relevance within traditional medicine, warranting further investigation into its effectiveness and mechanism of action.
38) Blood:
Blood is a critical component of the human body involved in numerous physiological processes. The mention of blood in relation to diseases treated with Hydnocarpus wightiana emphasizes the need to explore its impacts on various blood-related conditions for potential therapeutic benefits.
39) Java:
Java signifies one of the regions where species of Hydnocarpus are distributed. This geographical reference stresses the importance of diverse habitats in providing resources for herbal medicine and the necessity for global research collaborations to identify and utilize medicinal properties from various regions.
40) Genu:
Genu refers to a genus in biological classification. The identification of Hydnocarpus within its genus allows researchers to study related species, assessing their similarities and differences in phytochemical constituents, which is essential for uncovering potential medicinal uses.
41) Ghat (Gham):
Ghat refers to the mountain ranges, specifically the Western Ghats, where Hydnocarpus wightiana thrives. The ecological significance of these regions emphasizes the need for conservation and research to maintain biodiversity and support the utilization of medicinal plants in healthcare.
42) Rich (Rch):
Rich denotes the abundance of medicinal herbs and biodiversity in India, particularly in the context of traditional medicine. Acknowledging the richness of natural resources highlights the importance of preserving such knowledge and investigating local plants like Hydnocarpus wightiana for potential therapeutic applications.
43) Male:
Male refers to the gender of the Wistar rats used in the pilot study of Hydnocarpus oil's wound healing properties. The controlled selection of male rats in research ensures standardized conditions, facilitating accurate comparisons of efficacy related to treatments.
Other Science Concepts:
Discover the significance of concepts within the article: ‘A review on pharmacological activity of hydnocarpus wightiana’. Further sources in the context of Science might help you critically compare this page with similair documents:
Tropical forest, Flowering plant, Natural product, Traditional medicine, Ayurvedic medicine, Ayurvedic pharmacopoeia, Wound healing, Clinical trial, Antibacterial activity, Anti-inflammatory activity, Antioxidant activity, Pharmacological activity, Seed oil, Wound healing activity, Hypolipidemic activity, Antidiabetic activity, Biological Activity, Botanical Description, Anti-diabetic activity, Cytotoxicity, Botanical survey, Fatty Acid Composition, Natural source, Geographic distribution, Ethnomedicinal use, Standardization of extract, Medicinal agent.