A multifactorial approach to management of ckd due to struvite stones
Journal name: World Journal of Pharmaceutical Research
Original article title: A multifactorial approach to management of ckd due to struvite stones
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Aruna Devaraj R., Devaraj P., Raveena Judie Dolly D. and Dinesh Peter J.
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: A multifactorial approach to management of ckd due to struvite stones
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
Copyright (license): WJPR: All rights reserved
Download the PDF file of the original publication
Summary of article contents:
Introduction
The research paper "A Multifactorial Approach to Management of CKD Due to Struvite Stones" by Aruna Devaraj R. et al. explores the complexities and treatment dynamics of chronic kidney disease (CKD) stemming from struvite stones. Struvite stones, consisting of magnesium, ammonium phosphate, and calcium carbonate, predominantly occur due to urinary tract infections caused by urea-splitting bacteria, leading to alkaline urine and subsequent stone formation. Through a comprehensive analysis of case studies and a four-year observational study involving 322 patients, the authors delve into symptoms, causes, treatment plans, and preventative measures associated with CKD related to struvite stones.
The Role of Urea-Splitting Organisms
One crucial concept presented in the study is the significant role played by urea-splitting organisms in the formation of struvite stones. The bacteria responsible for this condition include Proteus, Klebsiella, Pseudomonas, and Staphylococcus, which hydrolyze urea to ammonia. This biochemical process raises urine pH levels, creating an environment conducive to crystal formation. The study highlights that these organisms are primarily associated with urinary tract infections, which can complicate managing chronic kidney disease, as they contribute to both stone formation and recurrent infection rates.
Multifactorial Treatment Approaches
The research also emphasizes a multifactorial treatment methodology for managing CKD related to struvite stones. The authors recommend an integrated treatment plan that combines herbal formulations, dietary control, and lifestyle modifications. This approach includes the use of the Rajendra Kidney formula for pain management, control of blood sugar levels, and specific treatments for fatty liver, among other strategies. The study suggests that personalized herbal treatments can effectively address recurring kidney stones and manage related chronic conditions, indicating a shift toward more holistic healthcare practices in managing CKD.
Impact of Seasonal Factors on CKD Occurrence
Another key aspect discussed in the paper is the correlation between seasonal changes and the prevalence of struvite stones. Statistical analysis of patient data collected over five years revealed variable occurrence rates of CKD linked to seasonal activity patterns, with certain times of year showing higher incidences of struvite stones. For example, the months with increased recreational activities such as April to June were found to correlate with a rise in cases, suggesting lifestyle factors influenced by seasons significantly impact kidney health outcomes.
Conclusion
In summary, the study provides essential insights into managing chronic kidney disease due to struvite stones through a multifaceted approach that transcends traditional medical practices. By analyzing the effects of urea-splitting bacteria, advocating for a comprehensive treatment plan, and considering the impact of seasonal behavior on health, the research advocates for a collaborative effort involving various stakeholders to enhance public health strategies. The authors call for increased research and integrated health approaches that leverage herbal remedies in conjunction with modern medical practices to improve outcomes for patients suffering from CKD related to struvite stones.
FAQ section (important questions/answers):
What are struvite stones and what causes them?
Struvite stones are made of magnesium, ammonium phosphate, and calcium carbonate, primarily caused by bacterial infections that hydrolyze urea to ammonium, raising urine pH to alkaline levels.
What are the common symptoms of struvite kidney stones?
Common symptoms include severe pain, hematuria (blood in urine), changes in urine color, chills, fever, and nausea, often occurring suddenly or in cycles.
What is the multifactorial approach mentioned for CKD management?
The approach includes herbal treatments like Rajendra Kidney Formula for pain relief, managing diabetes, magneto herbal treatments, and dietary adjustments to support kidney function and overall health.
How are urinary infections related to struvite stones?
Struvite stones often form due to urinary tract infections caused by urease-producing bacteria like Klebsiella and Proteus, which increase ammonia concentrations and elevate urine pH.
What statistical methods were used to analyze CKD data?
Analysis included correlation coefficients, linear regression, one-way and two-way ANOVA tests to assess the relationship between seasonal occurrences of struvite stones and total calculi throughout the years.
What are the preventive measures for kidney infections?
Preventive measures include drinking plenty of fluids, practicing good hygiene, avoiding contact with contaminated water, and addressing lifestyle factors that promote urinary infections.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A multifactorial approach to management of ckd due to struvite stones”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Pain:
Pain is a central symptom associated with many medical conditions, including CKD and struvite stones. The study discusses various case studies where patients experience severe pain as a result of kidney stones, underscoring the necessity of effective pain management in the overall treatment protocol for renal diseases.
2) Aruna:
Aruna refers to the leading author of the research article, who is affiliated with the Rajendra Herbal Research Foundation. The involvement of Aruna in this study highlights her contributions to herbal medicine, particularly in the management and treatment of chronic kidney disease.
3) Study (Studying):
The term study refers to the comprehensive analysis conducted over several years to investigate the symptoms, causes, treatment, and prevention of struvite stones. This multifactorial approach essential for understanding the complexities of CKD provides valuable insights into effective management practices.
4) Disease:
Disease signifies the health complications faced by patients, particularly chronic kidney disease and its association with struvite stones. The document emphasizes the need for early detection, treatment, and management strategies to combat the escalating prevalence of such kidney-related diseases.
5) Blood:
Blood plays a critical role in diagnosing various health conditions. Parameters like hemoglobin levels, platelet count, and blood urea levels are investigated in patients with CKD, as blood tests provide vital information for assessing kidney function and the effectiveness of treatment.
6) Male:
The term Male appears frequently, denoting the gender of several study participants. The study notes that certain conditions like prostate enlargement are more prevalent among older males, elucidating gender-specific risk factors in the development of struvite stones.
7) Vomiting:
Vomiting is mentioned among the symptoms experienced by some patients with kidney stones or urinary infections. It's crucial for clinicians to consider such symptoms when diagnosing renal conditions to provide appropriate and timely interventions.
8) Theni:
Theni is a district in Tamil Nadu, India, mentioned as the location of some respondents in the study. This geographical context is important because it helps identify prevalent regional health issues related to CKD and facilitates targeted healthcare initiatives.
9) Water:
Water is essential for kidney health and the prevention of kidney stones. The study emphasizes the importance of adequate hydration to prevent struvite stone formation and manage existing kidney conditions effectively.
10) Diet:
Diet is a key factor influencing kidney health. Different dietary interventions, including herbal treatments, are explored in the study, illustrating the role of nutrition in preventing and managing CKD and struvite stones.
11) Line:
In this context, Line refers to the linear correlation and regression analysis performed on the data collected. Such statistical methods are crucial for understanding relationships between seasonal occurrences of CKD and the total cases of calculi.
12) Civakankai:
Sivagangai is another district in Tamil Nadu, India, mentioned in the study as a region where herbal respondents were analyzed. It provides further geographical context when considering health trends associated with CKD.
13) Madurai:
Madurai is yet another district in Tamil Nadu involved in the study. Its mention indicates the regional breadth of data collection, emphasizing the importance of local demographics in understanding kidney stone disease prevalence.
14) Nausea:
Nausea is listed as one of the symptoms experienced by patients suffering from CKD. It highlights the gastric disturbances that accompany renal issues, which can complicate treatment and recovery.
15) Sugar:
Sugar intake is highlighted in the study as an important consideration, especially in diabetic patients. Managing sugar levels is critical in CKD management to prevent complications caused by uncontrolled diabetes.
16) Post:
The word Post signifies postoperative conditions or complications mentioned in the text. It indicates the relevance of ongoing treatment and monitoring after surgical procedures related to kidney stones.
17) Table:
Table refers to the various tabulated data presented in the study outlining patient demographics, treatment outcomes, and statistical analyses, enabling easy interpretation of findings related to CKD and struvite stones.
18) Fever:
Fever is a symptom that may accompany infections related to CKD or struvite stones. The study mentions fever as one of the indicators of underlying infections that complicate kidney disease management.
19) Antibiotic (Antibacterial):
Antibacterial is an important therapeutic approach discussed in the context of managing urinary tract infections that contribute to struvite stone formation, emphasizing the need for effective infection control.
20) Substance:
Substance refers to various materials mentioned in the context of kidney stones, including components of struvite stones like magnesium, ammonium phosphate, and calcium carbonate, highlighting their role in stone formation.
21) Suffering:
Suffering encapsulates the physical and emotional distress faced by individuals dealing with chronic kidney disease. The article emphasizes the importance of addressing this aspect in treatment to improve patients' quality of life.
22) Splitting:
Splitting refers to urea-splitting organisms responsible for raising urine pH, contributing to struvite stone formation. Understanding this mechanism is vital in developing effective treatment strategies for CKD associated with infections.
23) Species:
Species is relevant in identifying specific bacterial pathogens, such as Proteus and Klebsiella, which contribute to urinary infections and struvite stone formation. This knowledge helps tailor effective anti-bacterial treatments.
24) Burning (Burn, Burned, Burnt):
Burning refers to burning micturition, a common and distressing symptom associated with urinary infections in CKD patients. Effective management of this symptom is crucial for improving patient comfort.
25) Surana (Shurana):
Surana refers to a specific anti-bacterial agent used in the study for treating infections in CKD patients. Its mention highlights the importance of integrating targeted drugs into treatment plans.
26) Sign:
Sign refers to clinical signs observed in patients that indicate the presence of kidney disease or infection. Accurate identification of these signs is essential for timely intervention and management.
27) Raising:
Raising refers to the elevation of urine pH due to urea-splitting bacteria, a crucial aspect in the chemistry of struvite stone formation. Understanding this process is vital for prevention measures.
28) Aureus:
Aureus, as in Staphylococcus aureus, is mentioned in the context of bacteria involved in urinary infections. Its presence signifies the need for specific antibacterial treatment in CKD management.
29) Milk:
Milk is mentioned in the article as a dietary component. The potential implications of consuming unboiled milk in association with bacterial infections highlight dietary considerations in CKD management.
30) Pole:
Pole is used to describe anatomical locations in terms of kidney stones, indicating the specific locations of stones within the urinary tract, which aids in planning treatment interventions.
31) Bronchial asthma:
Bronchial asthma is a condition introduced as a potential complication in individuals with CKD. It highlights the need for careful management of coexisting health issues to ensure effective treatments.
32) Water pond:
Water pond refers to standing water where bacteria may thrive, possibly leading to infections in individuals who swim or bathe in such environments. The study emphasizes hygiene precautions.
33) Chemotherapy:
Chemotherapy is mentioned as a potential cause of uric acid stones, indicating the diverse underlying conditions that can contribute to kidney stone formation and the need for careful medical management.
34) Tuberculosis:
Tuberculosis is referenced to highlight other significant health issues that individuals may face alongside CKD. Addressing multiple health conditions is critical in comprehensive patient management.
35) Calculation:
Calculation pertains to the statistical analyses performed on patient data, which are essential for deriving conclusions about treatment effectiveness and the impact of various factors on kidney health.
36) Observation:
Observation is critical in the clinical understanding of patient symptoms and treatment outcomes. Systematic observation of changes in health can inform better management strategies.
37) Discussion:
Discussion refers to the analysis of findings within the study pertaining to CKD management. Engaging in discourse around results is essential for refining treatment approaches and understanding disease progression.
38) Dindugal:
Dindugal is another district in Tamil Nadu referenced in the study to provide geographical context for the involved patient population, highlighting regional health disparities in CKD prevalence.
39) Medicine:
Medicine encompasses all treatment modalities discussed in the study, including herbal and conventional approaches. The interplay of different medical practices is essential for the holistic management of CKD.
40) Activity:
Activity refers to daily living and lifestyle variations that can influence kidney health. It emphasizes the need for a balanced lifestyle while managing chronic conditions like CKD.
41) Chennai:
Chennai is mentioned as a significant urban area in Tamil Nadu where patients may seek treatment. Its urban context provides insights into population health trends related to CKD.
42) Channel:
Channel may refer to water bodies or pathways related to potential sources of bacteria that contribute to urinary tract infections. This highlights the significance of environmental hygiene in health.
43) Account:
Account relates to the detailed record of case histories and patient experiences chronicled in the study, important for understanding the multifactorial nature of CKD.
44) Hygiene (Hygienic):
Hygiene is emphasized throughout the study as a critical factor in preventing urinary tract infections, thereby mitigating the risk of developing struvite stones and CKD.
45) Indian:
Indian refers to the cultural and contextual background of the study's respondents, indicating the relevance of local practices and health beliefs in the management of CKD.
46) Ramya:
Ramya is mentioned as part of the academic reference framework in the study, indicating collaboration and research efforts in understanding herbal treatments for urinary infections.
47) Sweating (Sweat):
Sweat is involved when discussing symptoms and general patient well-being; it signifies the body's response to various health conditions, including CKD, highlighting its importance in monitoring health.
48) Lemon:
Lemon is noted in the context of dietary interventions and potential benefits for kidney health, particularly in neutralizing acidic conditions associated with kidney stones.
49) Food:
Food is crucial as various dietary components can either exacerbate or ameliorate kidney conditions. The study discusses the importance of healthy dietary choices for kidney disease management.
50) Meat:
Meat consumption is highlighted as a dietary factor that can affect kidney health. Certain types of meat may contribute to the development of kidney stones, necessitating careful dietary restrictions.
51) Drug:
Drug refers to both conventional medications and herbal treatments discussed in the context of their efficacy in managing CKD and associated complications, emphasizing their role in patient care.
52) Life:
Life encapsulates the overall quality of living impacted by chronic health conditions like CKD. The study emphasizes the goal of improving patients' lives through effective treatment strategies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘A multifactorial approach to management of ckd due to struvite stones’. Further sources in the context of Science might help you critically compare this page with similair documents:
Excruciating pain, Loss of appetite, Pain relief, Public health, Anemia, Protective measures, Herbal treatment, Pain management, Urine characteristics, Fluid intake, Statistical analysis, Controlled diet, Young mother, Urolithiasis, Public Health Problem, Study group, Body mass index (BMI), Research article, Age range, Cost-effective treatment, Health care system, Chronic Kidney Disease, Hematuria, Calcium oxalate, Renal replacement therapy, Urinary tract infection, Burning micturition, Weight loss, Correlation coefficient, Acute bacterial infection, One-way analysis of variance, Urinary infection, Immunity booster, Normal delivery, Prevention measures, E. coli, Health problem, Chronic kidney disease (CKD), Kidney Stone, Asymptomatic bacteriuria, Hydronephrosis, Diagnosis and management, Diabetic Kidney Disease, Cystine stones, Hydro nephrosis, Pseudomonas, Cohort studies, Two-way ANOVA, Diabetic patient, Renal stone, Klebsiella, Flank Pain, Ureter, Herbal respondents, Severe infection, Uric Acid Stone, Herbalists, Clinical challenge, Hydroureteronephrosis, Elderly patient, Klebsiella infection.
Concepts being referred in other categories, contexts and sources.