Antipyretic and antiepileptic study of Hemidesmus indicus roots
Journal name: World Journal of Pharmaceutical Research
Original article title: Antipyretic and antiepileptic activity studies on the roots of hemidesmus indicus (l.) r. br. var. pubescens (wt. & arn.) hook. f.
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Sandeep Darbari, V. Madhavan1, E. Maheswari, S. N. yoganarasimhan
World Journal of Pharmaceutical Research:
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Full text available for: Antipyretic and antiepileptic activity studies on the roots of hemidesmus indicus (l.) r. br. var. pubescens (wt. & arn.) hook. f.
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The study aimed to investigate the antipyretic and antiepileptic activities of Hemidesmus indicus (L.) R. Br. var. pubescens (Wight. & Arn.) Hook. f., a plant traditionally used for treating fever and epilepsy in various medicinal systems. Recognizing the ongoing erosion of traditional knowledge related to plant medicine, the researchers sought to explore the pharmacological benefits of this plant through rigorous testing on animal models. This investigation reflects a growing interest in the potential therapeutic properties of natural products amidst the challenges posed by synthetic medications.
Antipyretic Activity of Hemidesmus indicus
The antipyretic potential of Hemidesmus indicus was evaluated using a yeast-induced pyrexia model in albino rats. The study demonstrated that both aqueous and alcoholic extracts of the roots displayed significant reductions in body temperature, especially at a dose of 400 mg/kg. These reductions were statistically comparable to the effects of paracetamol, a standard antipyretic drug. This finding affirms the plant’s traditional use for treating fever, highlighting its relevance in modern pharmacotherapy.
Antiepileptic Effects of the Extracts
The antiepileptic effects were assessed using the maximal electroshock (MES) and pentylenetetrazole (PTZ) models of convulsion in mice. Both aqueous and alcoholic extracts significantly reduced the duration of seizures and recovery time in a dose-dependent manner, with 600 mg/kg extracts showing particularly potent results comparable to the standard drugs phenytoin and diazepam. These findings indicate that Hemidesmus indicus possesses notable anticonvulsant properties, supporting its historical usage for epilepsy treatment.
Phytochemical Analysis and Safety
Preliminary phytochemical analyses revealed the presence of bioactive compounds such as alkaloids, tannins, and phenolic constituents, which are likely responsible for the observed pharmacological effects. Additionally, acute toxicity studies revealed that the extracts were non-toxic at doses up to 2000 mg/kg, indicating a favorable safety profile. The safety validation further enhances the potential for therapeutic use in traditional and modern medicine alike, emphasizing the need for further exploration into these compounds.
Conclusion
The research findings establish Hemidesmus indicus (L.) R. Br. var. pubescens as a promising candidate for both antipyretic and antiepileptic pharmacological applications. Given its safety, effectiveness, and the historical significance of this plant in traditional medicine, it can be considered a viable alternative to existing treatments for fever and epilepsy. The results warrant further studies to elucidate the mechanisms underlying these effects and to potentially integrate this natural remedy into contemporary therapeutic practices, thus bridging traditional knowledge with modern medicine.
FAQ section (important questions/answers):
What was the objective of the study on Hemidesmus indicus?
The study aimed to investigate and evaluate the antipyretic and antiepileptic activities of aqueous and alcoholic extracts from the roots of Hemidesmus indicus, which could provide insights into its medicinal benefits.
How were the extracts of Hemidesmus indicus prepared?
The dried roots were extracted using 95% ethanol in a Soxhlet apparatus and also macerated with chloroform water for 24 hours, then concentrated for analysis.
What methods were used to test antipyretic activity?
Antipyretic activity was assessed using the yeast-induced pyrexia model in albino rats, with body temperatures measured post-treatment after administering the extracts.
What were the results concerning antiepileptic activity?
The study found that both aqueous and alcoholic extracts significantly reduced seizures in mice during MES and PTZ induced convulsions, showing effects comparable to standard antiepileptic drugs.
What preliminary phytochemical constituents were found in the extracts?
Phytochemical analysis revealed the presence of alkaloids, carbohydrates, phytosterols, phenolic compounds, tannins, and volatile oils, which may contribute to the observed biological activities.
What conclusion was drawn from the study's findings?
The findings suggest that Hemidesmus indicus var. pubescens exhibits significant antipyretic and antiepileptic effects, indicating its potential as an alternative medication equivalent to the known variant.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antipyretic and antiepileptic study of Hemidesmus indicus roots”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the physiological effects produced by a substance, particularly in pharmacological research. In this context, it pertains to the antipyretic and antiepileptic activities of Hemidesmus indicus extracts, demonstrating their potential as therapeutic agents in treating conditions like fever and epilepsy.
2) Drug:
Drug signifies a chemical substance that alters physiological functions in the body. In the study, the extracts of Hemidesmus indicus are investigated for their potential as drugs in traditional medicine. This highlights the importance of exploring natural products for therapeutic applications, particularly when synthetic options have adverse effects.
3) Animal:
Animal denotes the living subjects utilized in research to assess the biological effects of substances. In the study, albino rats and Swiss albino mice are used to evaluate the antipyretic and antiepileptic activities of extracts, providing a biological model to understand the extracts' effects before human trials.
4) Epilepsy:
Epilepsy is a neurological disorder characterized by recurrent seizures caused by excessive neuronal activity. The study investigates the antiepileptic properties of Hemidesmus indicus, which is significant due to epilepsy's prevalence and the need for effective treatments with fewer side effects than conventional medications.
5) Study (Studying):
Study refers to a systematic investigation into a subject to establish facts or principles. This study focuses on the pharmacological evaluation of Hemidesmus indicus, contributing to knowledge in herbal medicine. It aims to validate traditional claims and encourage further research on this plant's therapeutic efficacy.
6) Toxicity:
Toxicity is the degree to which a substance can cause harm to organisms. In pharmacological research, assessing toxicity, such as through acute toxicity studies, is crucial to ensure safety before human use. The study emphasizes the need for examining the safety profile of Hemidesmus indicus extracts.
7) Water:
Water is the solvent used in various extraction methods to obtain the bioactive compounds from plants. In this study, aqueous extracts of Hemidesmus indicus are prepared and tested, underlining the significance of water as a universal solvent for extracting medicinal properties from herbal sources.
8) India:
India is the geographical context within which Hemidesmus indicus is traditionally used in herbal medicine, particularly Ayurveda. The study highlights the indigenous knowledge related to the therapeutic uses of plants in India, posing Hemidesmus indicus as a potential modern alternative to traditional treatments.
9) Fever:
Fever is a symptom characterized by an elevated body temperature, often indicative of infections or illnesses. The study's focus on antipyretic activity underscores the importance of addressing fever in clinical settings. Understanding how Hemidesmus indicus can lower body temperature offers significant clinical implications.
10) Phytochemical:
Phytochemical refers to bioactive compounds derived from plants that exhibit various health benefits, including antipyretic and antiepileptic properties. Analyzing the phytochemicals present in Hemidesmus indicus is essential for understanding the mechanisms behind its physiological effects and therapeutic potential.
11) Death:
Death in this context refers to the potential fatality resulting from toxic effects or severe reactions during toxicity testing in animals. Ensuring that the extracts of Hemidesmus indicus are non-lethal is vital for establishing their safety for further therapeutic exploration.
12) Medicine:
Medicine signifies the science of diagnosing, treating, and preventing illness, often utilizing drugs, including those derived from plants. This study contributes to the field of medicine by investigating the efficacy of Hemidesmus indicus, emphasizing the role of traditional remedies in modern therapeutic approaches.
13) Disease:
Disease is a pathological condition affecting the body and represents a fundamental aspect of medical research. The study's focus on antipyretic and antiepileptic activities connects to broader efforts to find effective treatments for diseases associated with fever and seizures, enhancing public health.
14) Pharmacological:
Pharmacological pertains to the study of drug action and the interactions between living organisms and drugs. This research evaluates the pharmacological properties of Hemidesmus indicus, emphasizing the relevance of traditional medicinal plants in pharmacology and potential drug development.
15) Table:
Table refers to the organized presentation of data and results within the study, aiding in the comparison of the extracts' effects on antipyretic and antiepileptic activities. Tables help clearly convey findings to readers, facilitating better understanding and interpretation of the results.
16) Fight:
Fight in this context refers to the biological endeavor to overcome diseases or health issues. The study aims to explore how extracts of Hemidesmus indicus can help 'fight' fever and seizures, contributing to the search for effective natural treatment options based on traditional medicine.
17) House:
House in this research context refers to the controlled environment where the animals are kept for experiments. Proper animal housing ensures the integrity of the study, maintaining optimal conditions for health and hygiene, thereby supporting reliable and valid research findings.
18) Cage:
Cage denotes the physical containment used for housing animals in research settings. Cages must provide adequate space and comfort for the animals' welfare, allowing researchers to study the physiological effects of treatments while ensuring ethical standards are upheld during experimentation.
19) Glycyrrhiza glabra:
Glycyrrhiza glabra, commonly known as licorice, is a plant known for its medicinal properties. Although not the main focus of this study, its mention emphasizes the broader context of research into various plants with significant therapeutic potential, showcasing the rich diversity of herbal medicine.
20) Southern India:
Southern India represents the specific geographical region where Hemidesmus indicus is found and traditionally utilized. The regional study emphasizes the importance of indigenous plants in local cultures, underlining the significance of bioprospecting in areas rich in biodiversity for potential therapeutic agents.
21) Pharmacology:
Pharmacology is the branch of medicine that studies drugs' interactions with biological systems. This study contributes to pharmacology by evaluating the effects of Hemidesmus indicus extracts, potentially identifying new sources of therapeutic agents that align with both modern and traditional medical practices.
22) Inflammation:
Inflammation is the body's response to tissue damage or infection, often associated with increased fever. The study indirectly connects to inflammation through its focus on antipyretic activity, exploring how Hemidesmus indicus extracts can reduce fever resulting from inflammatory processes.
23) Discussion:
Discussion refers to the section of research where results are interpreted and contextualized within existing literature. This part of the study provides insights into the implications of Hemidesmus indicus findings, highlighting its significance in traditional and modern medicinal practices.
24) Leucoderma:
Leucoderma is a skin condition characterized by loss of pigmentation. The mention of this condition reflects the traditional uses of Hemidesmus indicus in treating various ailments, showcasing the plant's diverse applications in folk medicine and the continuing relevance of ethnopharmacology.
25) Developing:
Developing refers to emerging nations or regions where traditional medicine thrives due to limited access to modern healthcare. The study’s focus on Hemidesmus indicus emphasizes the potential of traditional herbal remedies as accessible treatment alternatives in developing countries facing health challenges.
26) Tamilnadu (Tamil-nadu):
Tamil Nadu is the Indian state where Hemidesmus indicus is found and used in traditional medicine. Its regional specificity highlights the cultural and historical significance of local flora in addressing health issues, emphasizing the importance of ethnobotanical studies in understanding traditional practices.
27) Knowledge:
Knowledge signifies the understanding gained through research and experience. In the context of this study, it underscores the importance of integrating traditional wisdom and scientific inquiry, enhancing collective understanding regarding the medicinal properties of plants and their therapeutic potential.
28) Education:
Education refers to the systematic process of acquiring knowledge, particularly about health and medicinal practices. The study of Hemidesmus indicus contributes to educational efforts in pharmacology and ethnobotany, promoting awareness of potential herbal treatments and their roles in contemporary health strategies.
29) Ayurveda (Ayus-veda):
Ayurveda is a traditional Indian system of medicine focusing on holistic treatment and natural healing. The research on Hemidesmus indicus connects with Ayurvedic principles; exploring its medicinal applications aligns with ongoing efforts to validate and integrate traditional practices into modern healthcare systems.
30) Matavan:
Madhavan appears to reference one of the researchers involved in the study, denoting the collaborative nature of scientific research. This inclusion highlights the importance of teamwork in advancing knowledge and integrating diverse expertise in pharmacological investigations.
31) Hygiene (Hygienic):
Hygienic refers to conditions that promote health and prevent disease, particularly in laboratory settings. Maintaining hygienic conditions in animal houses ensures the well-being of research subjects and contributes to the reliability of experimental results, emphasizing ethical scientific practices.
32) Leprosy:
Leprosy, also known as Hansen's disease, is an infectious disease that can cause severe skin lesions and nerve damage. Its mention reflects traditional medicinal practices where Hemidesmus indicus may play a role in addressing various skin ailments, promoting further investigation into its therapeutic properties.
33) Species:
Species denotes a group of living organisms possessing similar characteristics. Identifying and studying various plant species, such as Hemidesmus indicus, enhances our understanding of biodiversity and the potential medicinal uses of plants, vital for drug discovery and conservation efforts.
34) Surface:
Surface refers to the external part of the body where physiological measurements, like body temperature, can be taken. Alterations in surface temperature, often related to fever, are crucial in clinical evaluations, guiding approaches to treatment and understanding physiological responses.
35) Gokula (Go-kula):
Gokula may refer to an institution or organization that supported the study. Recognizing the affiliated institutions is significant for acknowledging the contributions of various stakeholders in promoting research, facilitating knowledge transfer, and enhancing collaboration within the scientific community.
36) Sariva (Shariva):
Sariva, derived from Hemidesmus indicus, is recognized in Ayurveda for its therapeutic properties. This study’s exploration of the plant’s medicinal qualities emphasizes its relevance, potentially establishing it as an alternative or complementary treatment option in modern medicinal approaches.
37) Family:
Family, in the botanical context, refers to a higher taxonomic rank categorizing related plants. Hemidesmus indicus belongs to the family Periplocaceae. Understanding familial relationships in plants aids in predicting medicinal properties and guiding the search for new therapeutic agents.
38) Pitta:
Pitta is one of the three doshas in Ayurveda, representing metabolic and thermogenic functions. The study's relevance to Ayurvedic concepts underscores the integration of traditional beliefs about plant properties relating to human health and herbal remedies enhancing balance among bodily systems.
39) Paddy:
Paddy refers to rice that is harvested and serves as a staple food in many cultures, including India. Mentioning paddy in the study signifies the context of local agriculture, pairing with traditional medicine, unveiling insights into cultural practices associated with food and health.
40) Tamil:
Tamil denotes the language and culture present in Tamil Nadu, where Hemidesmus indicus is recognized. Cultural elements are pivotal in medicinal practices, reflecting how language and traditional knowledge influence health behavior and the usage of indigenous plant remedies.
41) Vata:
Vata, another dosha in Ayurveda, is associated with movement and bodily functions. The study’s emphasis on vata reflects the holistic approach in traditional systems of medicine, where specific plants are linked to balancing doshas, guiding the therapeutic use of Hemidesmus indicus.
42) Nadu:
Nadu denotes 'land' or 'country' in Tamil, specifically referring to regions within Tamil Nadu. Its mention highlights the geographical and cultural context where Hemidesmus indicus is used traditionally, emphasizing the importance of regional knowledge in understanding plant-based medicines.
43) Food:
Food refers to the substance consumed for nutritional support. Within the study context, it highlights the intertwined relationship between diet and health, emphasizing how traditional practices may incorporate plants like Hemidesmus indicus not just as medicine, but also as food sources influencing health.
44) Hind:
Hind denotes a reference to the Indian subcontinent where diverse cultures and traditions exist. This relevance highlights the multi-faceted approach to health practiced in this region, recognizing the importance of both cultural heritage and evolving practices in the field of medicine.
45) Pain:
Pain signifies a critical symptom necessitating treatment. The study's exploration of Hemidesmus indicus addresses its potential in alleviating pain associated with conditions like fever and seizures, broadening the understanding of herbal remedies in pain management.
46) Post:
Post refers to the time frame following a particular event, such as post-treatment observations. In the context of the study, it highlights the importance of monitoring physiological changes after administration of treatments to gauge efficacy and derive meaningful conclusions from the research.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antipyretic and antiepileptic study of Hemidesmus indicus roots’. Further sources in the context of Science might help you critically compare this page with similair documents:
Gaba, Statistical analysis, Control group, Significant reduction, Acute Toxicity Studies, Phytochemical analysis, Chronic toxicity, Antiepileptic activity, Traditional System of Medicine, Aqueous extract, Anti-epileptic activity, Acute toxicity study, Rectal temperature, Swiss albino mice, Yeast induced pyrexia, Vehicle control, Body weight, Anticonvulsant activity, Standard drug diazepam, Standard drug, Antipyretic activity, Alcoholic extract, Maximal electroshock, Glutamic acid, Experimental Pharmacology, Treatment Administration, Hyperpyrexia, Maximal Electroshock (MES), Albino Wistar rats, Aqueous and alcoholic extract, Pentylenetetrazole (PTZ), Alcohol extract, Pentylenetetrazole-induced convulsion, Phytoconstituent, OECD Guideline, Albino rat, Minimum lethal dose, Febrile rats, Dose-dependent fashion.