Effervescent tablets of glucosamine with ibuprofen and vitamin E.
Journal name: World Journal of Pharmaceutical Research
Original article title: Formulation and evaluation of effervescent tablets of glucosamine sulphate in combination with ibuprofen and vitamin- e for the treatment of osteoarthritis
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Senthil Kumar Krishnan, Chidananda B, Mohammed Gulzar Ahmed
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Formulation and evaluation of effervescent tablets of glucosamine sulphate in combination with ibuprofen and vitamin- e for the treatment of osteoarthritis
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Osteoarthritis (OA) is recognized as the most prevalent joint disorder globally, particularly affecting the elderly population. While oral dosage forms are typically employed for managing OA, they are often hindered by slow absorption and delayed onset of action. To enhance these parameters, researchers have turned their attention to effervescent tablets, which provide a more efficient alternative by dissolving the medication in water prior to administration. This study aimed to formulate and evaluate effervescent tablets containing glucosamine sulfate, ibuprofen, and vitamin E, targeting effective treatment options for OA.
Effervescent Tablet Formulation and Advantages
Effervescent tablets present numerous advantages in drug delivery, particularly for osteoarthritis treatment. The study focused on combining ibuprofen—a well-known non-steroidal anti-inflammatory drug—with glucosamine sulfate, a nutraceutical believed to improve joint health, and vitamin E, an antioxidant. These formulations are designed to be dissolved in water, promoting quicker absorption and easing dosage administration. The development of effervescent tablets achieves a clear solution when mixed with water, indicating effective ingredient solubility and enhancing patient compliance.
Evaluation of Effervescent Tablets
The research highlighted various evaluation tests performed on the formulated effervescent tablets, which included assessments of hardness, friability, moisture content, drug content, and solution time. All formulations demonstrated acceptable ratings in these tests, with specific values indicating good flow properties and structural integrity. The angle of repose, tapped density, and Carr’s compressibility index were measured, revealing the formulations' ability to flow well, which is crucial for effective production and storage.
Drug Interaction and Effectiveness
One significant finding from this study was that the combination of ibuprofen with glucosamine sulfate potentially enhances the therapeutic effects of the former. By reducing the dosage of ibuprofen while utilizing glucosamine sulfate—recognized for its benefits in joint function—the study suggests that effective pain relief for OA can be achieved without the complications often associated with higher doses of NSAIDs. Additionally, vitamin E's role as an antioxidant may contribute further to alleviating oxidative stress linked to OA, improving patient outcomes.
Conclusion
In conclusion, the research indicates that effervescent tablets containing a combination of ibuprofen, glucosamine sulfate, and vitamin E can be effectively formulated for improved osteoarthritis treatment. The results demonstrate satisfactory evaluations across various parameters, ensuring both the mechanical integrity and patient-friendly characteristics of the tablets. This innovative drug delivery system not only addresses the common limitations of traditional oral medications but also paves the way for future advancements in the management of osteoarthritis.
FAQ section (important questions/answers):
What is the purpose of the effervescent tablets developed in the study?
The effervescent tablets aim to provide effective treatment for osteoarthritis by combining Ibuprofen, Glucosamine Sulphate, and Vitamin E, ensuring faster absorption and enhanced therapeutic effects.
What are the advantages of effervescent drug delivery systems?
Effervescent systems offer benefits such as fast onset of action, better compliance, improved solubility of active ingredients, and an easier administration method compared to traditional oral dosage forms.
How were the effervescent tablets formulated?
The tablets were formulated using a wet granulation method that included mixing citric acid, tartaric acid, sodium bicarbonate, and sodium carbonate among other ingredients for desired effervescent properties.
What evaluation tests were performed on the formulations?
The formulations underwent various tests, including angle of repose, friability, hardness, drug content, moisture content, and solution time, to ensure they meet required standards for stability and effectiveness.
What was the result regarding the drug content of the formulations?
The drug content of all formulations ranged between 85% and 98.3%, indicating good uniformity and consistency in the active pharmaceutical ingredients across the different preparations.
What conclusions were drawn about the formulated effervescent tablets?
The study concluded that the effervescent tablets containing ibuprofen, glucosamine sulphate, and vitamin E can be effectively used for treating osteoarthritis, showcasing desirable physical and chemical properties.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Effervescent tablets of glucosamine with ibuprofen and vitamin E.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Water:
Water is a crucial solvent in pharmaceuticals, especially in formulations like effervescent tablets. It facilitates the dissolution of active ingredients, allowing for quick absorption and onset of action. In the context of this study, water serves as the medium in which the effervescent tablets are dissolved before administration, enhancing drug delivery.
2) Drug:
In this study, drug refers to ibuprofen, glucosamine sulphate, and vitamin E, which are formulated into effervescent tablets for treating osteoarthritis. Proper formulation and evaluation of these drugs are essential for ensuring therapeutic efficacy. The combination aims to improve pain relief and promote joint health, showcasing the role of drugs in medical therapy.
3) Table:
The term table here refers to the various tabulated data presented in the research findings. These tables summarize important parameters such as drug content, moisture content, and evaluation of formulations. They aid in quick comparison and analysis of results, enhancing the study's overall comprehensibility and scientific rigor.
4) Powder:
Powder refers to the granulated state of the active and inactive ingredients used in effervescent tablet formulations. The characteristics of the powder, including flow properties and compressibility, play a critical role in the tablet's manufacturability and performance. Quality of powder directly influences tablet hardness, friability, and disintegration time.
5) Study (Studying):
Study refers to the comprehensive research conducted to formulate and evaluate the effervescent tablets for osteoarthritis treatment. It encompasses various methodologies, including drug formulation, evaluation tests, and statistical analyses, contributing to a better understanding of the physical and chemical properties of the tablets and their therapeutic potential.
6) Pur:
Poor relates to the characteristics of certain formulations identified during evaluations, such as flowability and compressibility index. These metrics indicate whether a formulation can be effectively processed into stable tablets. Recognizing poor properties helps researchers optimize formulations for better manufacturability and therapeutic efficacy, ensuring higher quality products.
7) Glass:
Glass is referenced as the container in which effervescent tablets are dissolved prior to consumption. Utilizing glass ensures that the tablets can be easily observed as they effervesce, allowing for an accurate assessment of dissolution time and visual clarity, which are important for patient compliance and therapeutic effectiveness.
8) Karnataka:
Karnataka is a state in India where the SAC College of Pharmacy is located. It signifies the geographic context of the research study. The institution's location often influences available resources, collaboration opportunities, and regulatory framework, all of which are critical when conducting pharmaceutical research and development.
9) Activity:
Activity in this context refers to the pharmacological effects of the formulated drugs, aimed particularly at alleviating symptoms of osteoarthritis. This term highlights the efficacy of the drug combinations, suggesting that the introduction of glucosamine sulphate may enhance ibuprofen's actions, leading to improved pain relief and patient outcomes.
10) India:
India is the country where the research was conducted, specifically at SAC College of Pharmacy in Karnataka. The Indian pharmaceutical landscape is significant for global health, with growing investments in research and development, and the study reflects local healthcare needs, particularly concerning prevalent conditions like osteoarthritis.
11) Kumar:
Kumar is part of the name of one of the authors, Senthil Kumar Krishnan, representing both individual contribution and academic affiliation in the study. Author identification is essential for academic integrity, allowing for the attribution of research findings and methodology to qualified individuals within the scientific community.
12) Heap:
Heap refers to the pile of powders formed during the preparation of the effervescent tablets, where the angle of repose is measured. This metric is critical for assessing the flow properties of the powders, influencing their uniformity and consistency during the production process, ultimately affecting tablet quality.
13) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic inflammatory disorder that can affect joints, similar to osteoarthritis. Mentioning this condition contextualizes the study within broader musculoskeletal health issues, underscoring the therapeutic importance of effective drug formulations aimed not only at pain relief but also at treating joint disorders generally.
14) Discussion:
Discussion refers to the section of the research where results are interpreted and contextualized against existing literature. This part of the study is crucial for analyzing the implications of the findings, drawing conclusions regarding the effectiveness and practicality of the formulated effervescent tablets for osteoarthritis treatment.
15) Container:
Container in pharmaceutical contexts typically refers to packaging that holds drug formulations. The study emphasizes the importance of using airtight containers for effervescent tablets to preserve their stability, prevent moisture ingress, and maintain efficacy, highlighting best practices for storage in pharmaceutical distribution.
16) Medicine:
Medicine encompasses the therapeutic agents, including ibuprofen, glucosamine, and vitamin E, used in treating osteoarthritis. These medications play vital roles in pain management and improving joint function, demonstrating the critical interplay between pharmaceutical formulations and successful health outcomes in patients with chronic conditions.
17) Disease:
Disease, specifically osteoarthritis in this context, highlights a significant area of focus for the research. Understanding the pathology of osteoarthritis guides the formulation of effective drug therapies, emphasizing the necessity for innovative approaches in managing common joint disorders through optimized pharmaceutical products.
18) Filling (Filled):
Filling may refer to the process of incorporating active and excipient powders into tablet molds during manufacturing. This step is critical as it affects tablet uniformity, content accuracy, and overall quality. Proper filling techniques ensure each tablet contains the correct dosage, adhering to pharmacopeial standards.
19) Diet:
Diet refers to the nutritional considerations that are often advocated alongside medication for managing conditions like osteoarthritis. Adequate dietary management can improve patient outcomes, highlighting the importance of holistic care approaches that include both pharmacological and lifestyle interventions for chronic health issues.
20) Sign:
Sign relates to the indication of specific symptoms or characteristics of osteoarthritis that the study aims to address with its formulated tablets. Identifying these signs helps in understanding the condition's progression and in tailoring effective therapeutic responses that target the underlying pathology and enhance patient wellbeing.
21) Pain:
Pain is a primary symptom of osteoarthritis that the formulated effervescent tablets aim to alleviate. Addressing pain effectively is crucial for improving the quality of life for patients. The study focuses on combining ibuprofen with nutraceuticals to enhance pain relief, reflecting a targeted approach in managing chronic pain conditions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Effervescent tablets of glucosamine with ibuprofen and vitamin E.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Therapeutic effect, Clinical study, Summary of results, Drug delivery system, Moisture content, Active ingredient, Air tight container, Weight variation, Hausner's ratio, Nutraceutical, Calibration curve, Osteoarthritis treatment, Wet granulation method, Tablet hardness, Absorbance measurement, Angle of repose, Drug content, Tapped density, Phosphate buffer, Carr's compressibility index, Content uniformity, Friability, Oral dosage form, Tablet thickness, Vitamin E, Treatment compliance, Glucosamine sulphate, Mechanical integrity, Roche friabilator, Effervescent tablet, Treatment of osteoarthritis.