Profiling secondary metabolites of Melia composita leaves via ethanol.
Journal name: World Journal of Pharmaceutical Research
Original article title: Profiling the secondary chemical class of in vivo melia composita willd. leaf using ethanolic fraction
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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G. Jahirhussain, K. Kala, P. Ayyappan, V. Muniappan, V. Tamilselvan, P. Rajkumar
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Full text available for: Profiling the secondary chemical class of in vivo melia composita willd. leaf using ethanolic fraction
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Melia composita Willd., also known as Persian lilac, is a significant medicinal plant predominantly found in the Eastern Ghats of Peninsular India. As a member of the Meliaceae family, it is believed to hold various medicinal properties. The study conducted by Jahirhussain et al. aimed to analyze the phytochemical composition of the in vivo leaf extract of Melia composita using Gas Chromatography-Mass Spectrometry (GC-MS). The research identified a total of 33 phytochemicals, focusing on the active components responsible for the plant's medicinal qualities, which provide insights into its potential use in herbal medicine.
Phytochemical Analysis of Melia composita
The primary outcome of the study was the identification of significant phytochemicals within the leaf extract of Melia composita. The chromatogram analysis revealed that Vitamin E emerged as the most abundant compound, accounting for 35.46% of the total peak area. Other notable constituents included 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (18.13%), Phytol (11.28%), and 1-Monolinoleoylglycerol trimethylsilyl ether (8.88%). The presence of these compounds indicates the therapeutic potential of Melia composita, thereby contributing to its relevance as a source of natural medicinal agents.
Medicinal Properties of the Plant
In addition to the phytochemical profiling, the study also discussed the medicinal uses of Melia composita. Traditional folk medicine employs various parts of this plant for multiple health benefits, such as anthelmintic, astringent, and treatment for colic. The leaf paste is used to address scabies and maggot-infested sores, while the root bark has traditionally been utilized to eliminate intestinal parasites. Recent studies have also highlighted its antimicrobial and antidiabetic activities. These findings underscore the plant's versatility and its role in increasing knowledge about potential herbal remedies in modern medicine.
Importance of GC-MS in Phytochemical Studies
The study highlighted the utilitarian value of the GC-MS technique in identifying individual components within complex mixtures of phytochemicals. By employing GC-MS, the research successfully discerned specific natural compounds in the Melia composita extracts, providing crucial data on their relative retention times, mass spectra, and biological significance. The advanced methodologies in phytochemistry and pharmacology allowed a systematic identification and characterization of the phytochemical composition, which has far-reaching implications for drug discovery and development from plant-based resources.
Conclusion
Overall, this research serves as a foundational study in understanding the phytochemical composition and medicinal uses of Melia composita. The identification of key active components via GC-MS not only contributes to the burgeoning field of phytomedicine but also validates traditional uses of this plant within contemporary health frameworks. As scientific interest in herbal remedies continues to grow, such investigations will play a crucial role in validating folklore medicinal claims and enhancing the therapeutic potentials of plants like Melia composita in modern healthcare.
FAQ section (important questions/answers):
What was the aim of the study on Melia composita?
The study aimed to investigate the phytochemical components of the in vivo leaf extract of Melia composita using GC-MS analysis.
What were the major compounds identified in the study?
The major compounds identified included Vitamin E (35.46%), 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (18.13%), Phytol (11.28%), and Caryophyllene (4.50%).
How many phytochemicals were identified in the Melia composita extract?
A total of 33 phytochemicals were identified in the ethanolic leaf extract of Melia composita.
Which method was used for analyzing the phytochemical composition?
Gas chromatography-mass spectrometry (GC-MS) was employed for analyzing the phytochemical composition of the leaf extract.
What is the significance of studying medicinal plants like Melia composita?
Studying medicinal plants is crucial for discovering new drugs and understanding their chemical constituents that may have therapeutic effects.
What are some medicinal uses of Melia composita?
Melia composita is used in folk medicine for its anthelmintic properties, treating scabies, and intestinal parasites.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Profiling secondary metabolites of Melia composita leaves via ethanol.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Phytochemical:
Phytochemical refers to the bioactive compounds extracted from plants that have health benefits in human use. They include vitamins, flavonoids, alkaloids, and more, contributing to the plant's medicinal properties. Understanding phytochemicals is crucial for drug discovery and validating the therapeutic uses of various plants, such as Melia composita.
2) Drug:
A drug is a chemical substance used to prevent, diagnose, treat, or cure diseases. It acts on the human body to produce desired therapeutic effects. Herbal drugs, derived from plants like Melia composita, are gaining attention for their efficacy and safety, as they often contain multiple active phytochemical ingredients.
3) Relative:
In botanical terms, relative denotes a close connection or similarity among species or plants. For instance, Melia composita is related to the Azadirachta indica, sharing medicinal properties but differing in morphology and its specific chemical constituents. Understanding these relationships is essential for classification and pharmacological studies.
4) India:
India is a country rich in biodiversity and traditional medicine, including herbal remedies. The study of plants like Melia composita is significant in India, where traditional medicine practices often utilize local flora. The country’s cultural heritage embraces the use of medicinal plants, contributing to modern phytochemical research.
5) Tree:
A tree is a perennial plant with an elongated stem or trunk that supports branches and leaves. The significance of trees like Melia composita lies in their ecological roles and medicinal applications. They serve as sources of phytochemicals and contribute to biodiversity and environmental health.
6) Species:
Species is the basic unit of biological classification, referring to a group of organisms that can interbreed. The identification of species such as Melia composita is vital for phytochemical research, allowing scientists to explore their unique constituents and potential medicinal properties effectively.
7) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing diseases. Traditional and modern medicines often incorporate plant-derived substances. Understanding medicinal plants like Melia composita can lead to the discovery of new therapeutic agents and inform holistic healing practices.
8) Study (Studying):
Studying involves engaging in learning and researching to gain knowledge and insights. In the context of phytochemistry, studying plants like Melia composita is fundamental to uncovering their active compounds, validating traditional uses, and exploring their potential contributions to modern medicine and drug development.
9) Tamilnadu (Tamil-nadu, Tamilnāḍu):
Tamilnadu is a state in southern India known for its rich flora and traditional medicine. It hosts various medicinal plants, including Melia composita, which are used in local healing practices. Researching regional plants contributes to understanding their phytochemical properties and applications in healthcare.
10) Botany:
Botany is the scientific study of plants, including their structure, properties, and biochemical processes. The field is crucial for understanding the medicinal applications of species like Melia composita. Knowledge of botany facilitates phytochemical exploration and supports the sustainable use of plant resources.
11) Karur:
Karur is a city in Tamilnadu, India, known for its educational institutions. The Government Arts College, where research on plants like Melia composita occurs, emphasizes botanical studies and seeks to improve understanding of local flora. The city serves as a hub for botanical and pharmacological research.
12) Science (Scientific):
Scientific relates to the systematic approach to knowledge based on experimentation and observation. Research on plants like Melia composita employs scientific methods, including GC-MS analysis, to explore phytochemical constituents and their potential health benefits, ensuring informed conclusions about their medicinal uses.
13) Substance:
Substance refers to a particular matter that has physical properties. In phytochemistry, substances extracted from plants, such as the various phytochemicals in Melia composita, play significant roles in traditional and modern medicine. Understanding these substances is essential for drug development and therapeutic applications.
14) Education:
Education is the process of acquiring knowledge and skills through instruction. In the context of botany and phytomedicine, education plays a critical role in training researchers to study plants like Melia composita and understand their medicinal properties, leading to the development of new treatments and therapies.
15) Quality:
Quality refers to the standard or degree of excellence of a product or substance. In pharmacognosy, the quality of herbal medicines, such as those derived from Melia composita, is crucial for ensuring safety, efficacy, and consistency in therapeutic applications. Quality control measures are essential in herbal product formulation.
16) Disease:
Disease is a pathological condition of a bodily part resulting from various causes. Understanding plant-derived remedies, such as those from Melia composita, highlights the potential benefits of phytochemicals in treating diseases. Research into these relationships supports the development of novel therapeutic agents.
17) Trichy:
Trichy, or Tiruchirappalli, is a city in Tamilnadu known for its educational institutions and research initiatives. It is a significant center for botanical and pharmacological studies, including the exploration of medicinal plants like Melia composita, contributing to the body of knowledge in phytomedicine.
18) Table:
In scientific research, a table is a systematic arrangement of data in rows and columns, simplifying information presentation. In studies of Melia composita, tables typically summarize key phytochemical findings, allowing for clearer interpretation and comparison of results regarding various bioactive compounds.
19) Bevu:
Bevu is a Kannada term meaning 'tree.' It emphasizes the cultural significance of trees in local traditions. Plants like Melia composita, referred to in various regional languages, highlight the importance of understanding plant life and their uses in traditional medicine within Indian societal contexts.
20) Kala (Kālā, Kalā, Kāla):
Kala refers to the regional name of a respected academic or influential individual. In this context, Dr. K. Kala's role emphasizes the guidance and mentorship in academic research like exploring Melia composita, facilitating the development of future scholars in botany and phytomedicine.
21) Azadirachta indica:
Azadirachta indica, commonly known as neem, is a tree with notable medicinal properties. It holds a taxonomic relationship with Melia composita, showcasing the importance of studying related species in understanding their respective phytochemicals and potential therapeutic applications in traditional and modern medicine.
22) Human body:
The human body refers to the physical structure of a person, which interacts with various substances, including pharmaceuticals derived from plants. Understanding how phytochemicals from plants like Melia composita affect the human body is vital for developing effective medicinal therapies and safety assessments.
23) Pharmacology:
Pharmacology is the branch of medicine concerned with the study of drugs and their effects on biological systems. Research into the phytochemicals of plants like Melia composita informs pharmacological studies that evaluate their potential therapeutic benefits and contributions to modern medicine.
24) Accumulation (Accumulating, Accumulate):
Accumulated refers to the gradual gathering of substances over time. In the context of phytochemical research, various bioactive compounds from plants accumulate through ecological and biological processes. Exploring accumulated phytochemicals in Melia composita allows researchers to discover new therapeutic properties for medicinal purposes.
25) Discussion:
Discussion in scientific research involves the interpretation and analysis of findings. In studies on Melia composita, the discussion section reviews the implications of identified phytochemicals and their potential health benefits, encouraging further research to explore therapeutic avenues and validate traditional medicinal uses.
26) Antibiotic (Antibacterial):
Antibiotics are substances that inhibit the growth of or destroy bacteria. The exploration of phytochemicals from plants like Melia composita may yield antibiotic properties, contributing to the ongoing search for effective natural alternatives to combat antibiotic-resistant infections and improve public health outcomes.
27) Mahanimba (Mahānimba, Maha-nimba):
Mahanimba is a Sanskrit name for plants in the Melia genus, highlighting the historical and cultural context of these species in traditional medicine. Understanding local terminology fosters appreciation for plants like Melia composita and their medicinal applications within indigenous healing practices.
28) Flavonoid:
Flavonoids are a class of phytonutrients with antioxidant properties found in various plants. They play significant roles in human health by combating oxidative stress and inflammation. Research on flavonoid content in Melia composita aids in understanding its potential health benefits and therapeutic applications.
29) Ayyappan:
Ayyappan likely refers to a researcher or academic involved in the study of medicinal plants. The contribution of individuals like Ayyappan is essential in expanding the understanding of plants like Melia composita, fostering research initiatives that document their phytochemical profiles and health benefits.
30) Sanskrit:
Sanskrit is an ancient language of India often used in historical texts, including those related to medicine and herbal remedies. The use of Sanskrit names for plants like Melia composita highlights the cultural significance and traditional medicinal knowledge associated with these species.
31) Kannada (Kannaḍa):
Kannada is a language spoken predominantly in the southern Indian state of Karnataka. The local nomenclature for plants like Melia composita in Kannada reflects cultural ties to traditional medicines and emphasizes the importance of regional languages in disseminating botanical knowledge and preserving folk healing practices.
32) Bengali:
Bengali is a language spoken primarily in the Indian state of West Bengal and Bangladesh. Regional names for plants like Melia composita in Bengali showcase the cultural significance of these species and emphasize the importance of local knowledge in understanding herbal medicine and traditional practices.
33) Madurai:
Madurai is a historical city in Tamilnadu known for its rich culture and heritage, including traditional medicinal practices. Research on plants such as Melia composita in Madurai can contribute to the preservation and enhancement of local herbal knowledge, informing future herbal therapies.
34) Camphor:
Camphor is a terpenoid with various medicinal properties, including anti-inflammatory and analgesic effects. Found in plants like Melia composita, camphor's therapeutic applications symbolize the potential of phytochemicals and their importance in traditional and alternative medicine practices.
35) Family:
Family in botanical taxonomy refers to a higher classification grouping related species that share certain characteristics. Melia composita belongs to the Meliaceae family, which underscores its potential medicinal uses and the need for studies that explore the phytochemical diversity within this group.
36) Bitter:
Bitter describes a basic taste often associated with certain plants and compounds. Many medicinal plants, including Melia composita, may exhibit bitterness, indicative of active compounds that can influence health. Understanding bitter properties informs both traditional uses and modern applications in herbal therapies.
37) Medium:
Medium, in botanical context, can refer to size or the environment in which a species grows. Melia composita is identified as a medium-sized tree, which has implications for its ecological interactions and its utilitarian functions in local ecosystems and various cultural practices.
38) Insect:
Insects often interact with plants, sometimes as pests and sometimes as pollinators. Melia composita and its compounds may possess insect-repellent properties, highlighting ecological and agricultural relevance and providing potential natural insecticides to manage pests sustainably.
39) Powder:
Powder refers to a finely ground form of a material, commonly used in herbal formulations. The powdered form of leaves from plants like Melia composita facilitates extraction processes for bioactive compounds, making it easier for scientific investigations into its phytochemical constituents.
40) Mallan (Mallaṉ, Maḷḷaṉ, Maḷḷāṉ):
Mallan likely refers to a regional term connected to a specific plant or traditional name for Melia composita. Such localized nomenclature emphasizes the cultural and historical context surrounding the understanding and utilization of medicinal plants in different communities.
41) Ghora (Ghorā, Ghoradarshana):
Ghora is likely a regional reference to Melia composita in local languages. The term indicates an awareness and understanding of the plant's uses within cultural practices, highlighting how local terminologies can reflect the significance of medicinal flora in folk medicine.
42) Malai (Malaī, Maḻai, Māḻai, Māḷai):
Malai is likely a regional name for Melia composita in Tamil or related languages. It signifies the cultural relevance and ecological significance of the species within traditional herbal practices, showcasing the need for studying such local names in herbal medicine contexts.
43) Melur:
Melur is a town in Tamilnadu known for its agricultural and ecological significance. Researching plants like Melia composita in areas like Melur can enhance local knowledge of medicinal flora and promote sustainable practices linked to biodiversity and health.
44) Hindi (Hiṇḍī, Hiṃdī, Himdi, Hindī):
Hindi is one of the most widely spoken languages in India. Regional names for plants like Melia composita in Hindi reflect the cultural significance and the traditional uses of these medicinal species, emphasizing the importance of language in botanical knowledge and herbal medicine.
45) Trade:
Trade refers to the exchange of goods and services. In the context of medicinal plants like Melia composita, trade can involve the sale of herbal remedies or extracts and highlights the economic aspects of utilizing local flora for health and wellness.
46) Pride:
Pride refers to a sense of dignity and satisfaction from connections to cultural heritage, embodied in the use of native plants like Melia composita. Recognizing such plants contributes to preserving local customs and promoting sustainable practices in herbal medicine.
47) Tamil (Tamiḻ):
Tamil is a language spoken predominantly in the state of Tamilnadu, India. The various names for Melia composita in Tamil illustrate the cultural importance of this plant and the traditions surrounding its use in local herbal medicine practices.
48) Cina (Cīna, Cīnā, Ciṉa, Ciṉā, Cīṉā, Cinā):
China is known for its rich tradition of using herbal remedies and medicinal plants. Similarities and shared knowledge between traditional Chinese medicine and Indian medicinal practices involving plants like Melia composita underscore the global significance of herbal research.
49) Beta (Bēṭa, Beṭa):
Beta often refers to a specific type of chemical compound or property in scientific studies. In botanical research, understanding the role of beta compounds in phytochemistry is crucial for grasping the full spectrum of bioactive substances present in medicinal plants like Melia composita.
50) Pari:
Pari, likely referring to Dr. R. Pari, is involved in botanical research pertaining to medicinal plants. The expertise of scholars like Pari contributes significantly to advancing knowledge on phytochemicals in plants like Melia composita, fostering further studies and potential therapeutic applications.
51) Line:
Line, in the context of scientific research, may refer to a series of connected arguments or topics discussed in research studies. The clarity and structure of such lines enhance reader understanding and assist in communicating findings related to phytochemical investigations like those on Melia composita.
52) Gold (Golden):
Gold may represent a standard of excellence or value in various contexts. In research, the 'gold standard' often refers to the most reliable benchmark for measurement or effectiveness. This concept is relevant in evaluating the efficacy of herbal treatments derived from plants like Melia composita.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Profiling secondary metabolites of Melia composita leaves via ethanol.’. Further sources in the context of Science might help you critically compare this page with similair documents:
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