Phytochemical and analgesic study of Mangifera indica flower extract.
Journal name: World Journal of Pharmaceutical Research
Original article title: Phytochemical and invivo analgesic activity study of ethanolic extract of the flower of mangifera indica l.
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Deep Kotal, Saptarshi Panigrahi, Somnath Surai, Kamalika Mazumder, N. N. Bala
World Journal of Pharmaceutical Research:
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Full text available for: Phytochemical and invivo analgesic activity study of ethanolic extract of the flower of mangifera indica l.
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The study conducted by Kotal et al. focuses on the phytochemical composition and analgesic properties of the ethanol extract of the flowers of Mangifera indica L., a plant acknowledged for its medicinal significance. It aims to identify bioactive principles within the flower extract and evaluate its efficacy against pain using animal models. The research underscores the importance of traditional medicine and the ongoing search for novel therapeutic agents derived from natural products.
Phytochemical Composition
The phytochemical analysis of Mangifera indica flowers revealed a rich presence of various bioactive compounds, including alkaloids, carbohydrates, tannins, fixed oils and fats, resins, phenols, and flavonoids. Notably, glycosides were absent in the extracts. The study employed standard qualitative screening methods to assess these compounds, indicating that the flowers possess significant potential for therapeutic use. The identification of these phytonutrients paves the way for further research into their specific medicinal applications.
Analgesic Activity Evaluation
The analgesic activity of the ethanol extract was tested using the acetic acid-induced writhing response model in Swiss albino mice. The administration of the extract at dosages of 150 mg/kg and 250 mg/kg produced a noticeable inhibitory effect on writhing responses, suggesting its potential analgesic effects. The study compared these results with the control group that received Diclofenac Sodium, demonstrating a significant reduction in pain, thereby confirming the extract's pharmacological potential.
Comparative Analysis with Diclofenac Sodium
In comparison to the standard analgesic Diclofenac Sodium, the ethanol extract of Mangifera indica flowers exhibited comparable analgesic effects at both tested dosages. The experiment recorded a percentage of inhibition of writhing that corroborated the analgesic properties of the extract. This comparative analysis highlights the potential use of the extract as a natural alternative or supplement to synthetic analgesics, thereby promoting natural product utilization in healthcare.
Conclusion
The findings of this study present compelling evidence of the analgesic potential and phytochemical richness of the Mangifera indica flower extract. As traditional medicine gains traction globally, the results emphasize the need for further research to explore additional therapeutic benefits and standardize bioactive extracts. The ongoing examination of medicinal plants plays a crucial role in the discovery of novel natural products that could contribute significantly to modern medicine and holistic healthcare approaches.
FAQ section (important questions/answers):
What is the purpose of the study on Mangifera indica flowers?
The study aimed to investigate the phytochemical content and in vivo analgesic activity of the ethanol extract of Mangifera indica flower, comparing its effects to the standard analgesic drug Diclofenac Sodium.
Which phytochemicals were found in the flowers of Mangifera indica?
Phytochemical screening revealed the presence of alkaloids, carbohydrates, tannins, fixed oils, fats, resins, phenols, and flavonoids, while glycosides were absent.
What method was used for assessing analgesic activity?
The analgesic activity was evaluated using the acetic acid-induced writhing response model in Swiss albino mice, counting the stretching movements after administering the extracts.
What were the results regarding the analgesic activity of the extract?
The ethanol extract of Mangifera indica demonstrated significant analgesic activity in a dose-dependent manner, with the higher dose showing effects comparable to Diclofenac Sodium.
What role do flavonoids play in the studied extract?
Flavonoids are known for their anti-inflammatory and analgesic properties, which potentially contribute to the observed analgesic effect of the Mangifera indica flower extract in the study.
Why is phytochemical screening important for medicinal plants?
Phytochemical screening is crucial for identifying bioactive compounds in medicinal plants, which can lead to drug discovery and the development of new therapeutic agents for healthcare.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Phytochemical and analgesic study of Mangifera indica flower extract.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
In the context of the study, 'Activity' refers to the pharmacological effects exhibited by the ethanol extract of Mangifera indica flowers, particularly its analgesic activity as measured through the acetic acid-induced writhing test in mice. Understanding this helps in assessing the potential therapeutic applications of the extract in pain relief.
2) Mangifera indica:
'Mangifera indica' is the botanical name for the mango tree, whose flowers were studied for their medicinal properties. This species is recognized for its potential therapeutic benefits including anti-inflammatory and analgesic effects, making it a significant focus in ethnobotanical research and pharmacology.
3) Phytochemical:
Phytochemicals are bioactive compounds found in plants that have health-promoting properties. In this study, the presence of various phytochemicals such as alkaloids, flavonoids, and tannins in Mangifera indica flowers indicates their potential role in therapeutic applications, including the alleviation of pain.
4) Water:
Water serves as a universal solvent and is crucial for the extraction process of phytochemicals from plant materials. Its role in the study includes the preparation of extracts and the hydration of experimental animals, impacting the overall validity of the pharmacological assessments conducted.
5) Flavonoid:
Flavonoids are a class of phytochemicals that are known for their antioxidant, anti-inflammatory, and analgesic properties. In the context of this study, the presence of flavonoids in Mangifera indica flowers may contribute to its observed analgesic effects and warrants further exploration.
6) Animal:
Animals, specifically Swiss albino mice, were used in this study to evaluate the analgesic activity of the ethanol extract of Mangifera indica flowers. Using animal models is standard in pharmacological research to understand the efficacy and safety of herbal extracts before human applications.
7) Drug:
In this study, 'drug' refers to the standard analgesic, Diclofenac sodium, used as a comparison to evaluate the analgesic effectiveness of the Mangifera indica flower extract. The drug helps establish a baseline for assessing the therapeutic potential of the plant extract.
8) Table:
Tables in the study present summarized data on the effects of the plant extract and the results of various tests, making it easier to compare and interpret the findings. They serve as vital tools for clarity and organization of complex data.
9) Study (Studying):
The term 'study' encapsulates the research process undertaken to evaluate the phytochemical properties and analgesic effect of Mangifera indica flowers. This systematic investigation contributes to the body of knowledge on traditional medicine and herbal pharmacology.
10) Pharmacological:
Pharmacological refers to the study of drugs and their effects on biological systems. In this research, it relates to understanding the medicinal properties of Mangifera indica flower extracts and their potential use in developing new therapeutic agents.
11) Medicine:
Medicine encompasses the science and practice of diagnosing and treating diseases. The study of Mangifera indica highlights its importance in traditional medicine systems and indicates the potential for developing new medications based on natural products.
12) Bengal (Bemgal):
Bengal refers to a geographic region in India where the plant specimens were collected. The regional significance adds context to the study, as it highlights the local use of Mangifera indica in traditional healthcare practices.
13) India:
India is a country with rich biodiversity and a long history of traditional medicine, including Ayurveda and Siddha. The study of Mangifera indica fits within this context by exploring the medicinal use of native plants in contemporary healthcare.
14) Disease:
Disease refers to any impairment of normal physiological function in an organism. The study aims to investigate the potential of Mangifera indica to treat conditions such as pain, thereby contributing to the broader field of disease management.
15) Gelatin:
Gelatin is mentioned in the context of detecting tannins in the phytochemical analysis process. Its chemical reactions in tests serve as indicators of the presence of specific compounds in extracts, contributing to the understanding of the plant's properties.
16) Sugar:
Sugar, specifically in the context of carbohydrates, was examined to assess its presence in the extract of Mangifera indica flowers. Understanding carbohydrate composition is important in evaluating the nutritional and therapeutic properties of plant extracts.
17) Jessore:
Jessore refers to a locality in West Bengal known for its significant biological diversity. The significance of the study conducted in this region emphasizes the importance of local flora in traditional medicine practices and the conservation of medicinal plants.
18) Species:
Species indicates the specific classification of living organisms. In this study, Mangifera indica is a species of interest for its medicinal properties, which contribute to understanding its phytochemical composition and potential therapeutic applications.
19) Powder:
Powder in this context refers to the fine form of the collected plant material after processing. It is essential for extraction and analysis of phytochemicals, impacting the efficacy of subsequent pharmacological testing and potential applications.
20) Bala (Bāla, Balā, Bālā):
Bala refers to Dr. Nripendranath Bala, the Principal of BCDA College of Pharmacy and Technology, whose support was acknowledged in the study. Institutional backing is crucial for research development and emphasizes the collaborative nature of scientific inquiry.
21) Diet:
Diet refers to the specific food and water provided to the experimental animals during the study. Maintaining a standard diet is important for ensuring consistent conditions in pharmacological experiments, impacting the validity of the observed results.
22) Road:
Road indicates the location specificity of the research institution in Barasat, Kolkata, West Bengal. The road address denotes the geographical context where the research was conducted, contributing to its regional significance.
23) Human body:
The human body is the ultimate target for the therapeutic applications explored in this study. Understanding how compounds affect biological functions in animal models provides insight into their potential effects on human health and medicine.
24) Antibiotic (Antibacterial):
Antibacterial activity is mentioned in the context of the potential benefits of Mangifera indica. This underscores the plant's broader medicinal properties beyond analgesia, indicating its relevance in treating infections and promoting health.
25) Discussion:
Discussion refers to the section of the research where results are interpreted and contextualized within existing literature. It is key for understanding the implications of findings and for drawing conclusions about the efficacy of the plant extracts studied.
26) Substance:
Substance refers to the specific chemical components in the plant extracts being studied. Analyzing these substances is critical for understanding the biological activity and therapeutic potential of Mangifera indica as a medicinal plant.
27) Container:
Container refers to the airtight storage used for the powdered plant material. Proper storage is crucial in preserving the integrity of the extracts, preventing degradation, and ensuring accurate results during phytochemical analysis.
28) Pesticide:
Pesticide denotes the potential uses of phytochemicals such as saponins in controlling pests. This connects traditional medicine's role with agricultural practices, highlighting the multifunctionality of plant compounds in various fields.
29) Ayurveda (Āyurveda, Ayus-veda):
Ayurveda is a traditional Indian system of medicine that promotes the use of natural products for health and well-being. The study's findings align with Ayurvedic principles, reflecting the broader cultural significance of using local flora for medicinal purposes.
30) Relative:
Relative refers to the context of the animals' living conditions, including temperature and humidity. Maintaining appropriate relative conditions is essential for the wellbeing of the experimental subjects and the validity of the research outcomes.
31) Surface:
Surface relates to the physical characteristics of the extracts that may affect their absorption and bioavailability in the human body. Understanding surface properties is important in evaluating the efficacy of herbal medicines.
32) Mineral:
Minerals are essential nutrients present in the fruits of Mangifera indica. Their presence highlights the nutritional value of the plant, supporting its use in herbal medicine for overall health and dietary supplementation.
33) Siddha (Siddhā):
Siddha represents another traditional Indian medicine system, similar to Ayurveda. The relevance of Siddha in the study underscores the integration of rich traditional knowledge in exploring the therapeutic potential of local flora.
34) Cotton:
Cotton is referred to in the context of filtration during the extraction of plant material. The use of cotton plugs in filtering is a standard laboratory practice, ensuring that extracts are free from solid impurities for accurate analysis.
35) Indian:
Indian denotes the geographical and cultural origin of the study. The significance lies in the rich biodiversity of India, which serves as a fertile ground for research into herbal medicines and traditional therapeutic practices.
36) House:
House refers to the animal house where Swiss albino mice were kept for the study. Proper housing conditions are vital for the ethical treatment and welfare of laboratory animals, impacting the reliability of experimental results.
37) Dish (Diś):
Dish refers to the Petri dish used for the final collection of concentrated extracts. Using appropriate laboratory equipment is essential for ensuring that the extracts are handled and stored correctly during analysis.
38) Food:
Food in this study pertains to standard diet provided to the mice, influencing their health and biological responses. Proper nutrition is necessary for maintaining the physiological condition necessary for valid experimental outcomes.
39) Tree:
Tree refers to Mangifera indica, the mango tree, whose parts were studied. Understanding the characteristics of the tree, including its growing conditions, can enhance the knowledge of its medicinal properties and applications.
40) Hind (Hiṇḍ):
Hind refers to the hind limbs of mice, used in the acetic acid writhing test measuring analgesic effects. This anatomical focus is significant for understanding pain response and testing the efficacy of analgesics in animal models.
41) Cage (Cāge):
Cage refers to the living conditions for the experimental mice. The use of standardized cages enhances animal welfare, ensuring that external factors do not influence the study's outcomes.
42) Rich (Ṛch):
Rich refers to the abundant presence of phytochemicals in Mangifera indica flowers, which are essential for medicinal properties. This richness highlights the potential of the plant for therapeutic applications and its value in traditional medicine.
43) Mud:
Mood in the context of the study refers to the behavioral state in which the analgesic activity was assessed through specific responses observed in the animal model. Understanding mood responses is key in evaluating pain and discomfort in pharmacological studies.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Phytochemical and analgesic study of Mangifera indica flower extract.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Mangifera indica, Active principle, Traditional medicine, Statistical analysis, Pharmacological activity, Phytochemical screening, Analgesic activity, Dyslipidemia, Immunomodulatory activity, Active ingredient, Secondary metabolite, Institutional Animal Ethical committee, Swiss albino mice, Acetic acid-induced writhing response, Positive control group, Acetic acid induced writhing test, Ethanol extract, Therapeutic activities, Sample collection, Table 2, Plant material extraction, Analgesic drug, Negative control group, Phytopharmaceutical, Gelatin test, Phytochemical activity, Ferric chloride test, Experimental animal, Percent inhibition, Qualitative Estimation, Fixed oils and fats, Fixed oil, Bioactive principle, Dose rate, Phytochemical parameter, Anti-diarrhoeal activity, Phytochemists and pharmacologists, Detection method, Analgesic screening, In vivo analgesic activity, Analgesic and anti-inflammatory drug, Preliminary qualitative test.