Analytical methods for the determination of leflunomide - a short review

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Analytical methods for the determination of leflunomide - a short review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In the context of scientific research, a table presents data in a structured format, allowing for easy comparison and analysis of results. In the text, tables are used to summarize validation parameters, method comparisons, and other key findings related to Leflunomide and its analytical determination, enhancing clarity and understanding.

2) Drug:
A drug is a chemical substance used for medical purposes, primarily to diagnose, cure, treat, or prevent diseases. In this paper, Leflunomide is highlighted as a disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid arthritis, showcasing its pharmacological importance in modern medicine.

3) Sah:
Shah refers to the lead author, Shah Kruti V., of the review article. Authors' names are essential in academic publications as they attribute credit for the research and findings. Shah's work contributes to the understanding of analytical methods for Leflunomide determination in pharmaceutical sciences.

4) Measurement:
Measurement refers to the quantitative evaluation of substances or properties, crucial in scientific research. In the context of analytical methods for Leflunomide, measurement techniques like HPLC and spectrophotometry are discussed for their roles in determining drug concentrations in pharmaceutical preparations and biological samples.

5) Water:
Water serves as a solvent and is often used in analytical chemistry methods, including chromatography and preparation of buffers. In the analysis of Leflunomide, water is mentioned in the context of mobile phases and buffers, critical for sample preparation and maintaining reaction conditions during measurements.

6) Rheumatoid arthritis:
Rheumatoid arthritis is an autoimmune disorder characterized by chronic inflammation of joints. Leflunomide is specifically mentioned as a treatment for this condition, emphasizing the drug's relevance in managing symptoms and preventing joint damage, which outlines its therapeutic importance in rheumatology.

7) Study (Studying):
A study involves systematic investigation to discover or validate facts and theories. This article presents various studies that analyze Leflunomide's stability, analytical methods, and pharmacological effects. These studies underscore the importance of research in enhancing drug safety and efficacy in treatment regimens.

8) Performance:
Performance pertains to the functioning or effectiveness of analytical methods in measuring drug concentrations. The text evaluates the performance of various analytical techniques used for Leflunomide, discussing precision, accuracy, recovery rates, and sensitivity, which are critical in ensuring reliable results in pharmaceutical analyses.

9) Gujarat:
Gujarat is a state in India where the research institution, Dharamsinh Desai University, is located. The geographical context is essential in academic publications as it often reflects the research environment, available resources, and cultural perspectives, influencing studies in pharmaceutical sciences like Leflunomide evaluation.

10) Disease:
A disease refers to a pathological condition of a bodily part or system resulting from various causes, manifesting through characteristic symptoms. The article focuses on Leflunomide's application in treating rheumatoid arthritis, identifying it as a significant intervention in managing chronic diseases and improving patient quality of life.

11) Pharmacological:
Pharmacological relates to the study of drug action on biological systems. In the text, the pharmacological properties of Leflunomide are examined, particularly its mechanisms of action as an immunosuppressive agent, highlighting the compound's roles in treatment strategies for autoimmune conditions.

12) Pharmacology:
Pharmacology is the branch of medicine concerned with the uses, effects, and mechanisms of drugs. The article provides insights into pharmacological aspects of Leflunomide, discussing how its metabolites and mechanisms contribute to therapeutic effects, pivotal for understanding drug development and clinical applications.

13) Toxicology:
Toxicology is the study of the adverse effects of substances on living organisms. Although the primary focus of the article is on analytical methods, toxicological studies are essential in evaluating the safety of drugs like Leflunomide, ensuring that their therapeutic benefits outweigh potential risks in patients.

14) Substance:
A substance generally refers to a particular kind of matter with uniform properties. In the context of this research, 'substance' refers to Leflunomide and its metabolites, which are studied for their pharmaceutical relevance, stability, and analytical determination using various methods discussed in the article.

15) Activity:
Activity describes the functional effect of a drug within biological systems. In this case, the pharmacological activity of Leflunomide, particularly its metabolite Teriflunomide, is assessed regarding its immunosuppressive properties, crucial for effectively managing autoimmune diseases such as rheumatoid arthritis.

16) Chauhan (Chauhān):
Chauhan references another author, Sanjay P. Chauhan, contributing to the collective expertise and credibility of the research team. The collaboration among authors enriches the study's findings on Leflunomide, demonstrating a multidisciplinary approach to pharmaceutical research and development.

17) Quality:
Quality refers to the standard of a product or method in terms of performance and reliability. The article discusses the importance of method validation in ensuring the quality of pharmaceutical products containing Leflunomide, highlighting analytical techniques that guarantee consistency and safety in medicinal formulations.

18) Company:
Company refers to the pharmaceutical firms involved in the marketing and production of drugs like Leflunomide. Specifically, Sanofi-Aventis is mentioned, emphasizing the role of companies in the drug development process, including the importance of quality control and analytical methods in ensuring efficacy and safety.

19) Medium:
Medium often refers to the solvent used in chemical reactions or the physical environment in which experiments are conducted. In this article, the choice of medium, such as buffers and solvents in chromatographic methods, is critical for achieving accurate measurements and maintaining the stability of compounds being analyzed.

20) Joshi (Jōśī, Jośī):
Joshi is another author involved in the study, contributing to the research on Leflunomide's analytical methods. The inclusion of multiple authors showcases a collaborative effort in the scientific community, enriching the insights and findings presented regarding the stability and validation of Leflunomide analysis.

21) Food:
Food typically pertains to substances consumed for nutritional purposes, but in this context, it represents the regulatory aspect of drug safety governed by organizations like the FDA. The mention of the FDA highlights the importance of food and drug safety standards in the approval and use of pharmaceuticals, including Leflunomide.

22) Post:
Post can refer to a stage following an event or action, often used in research to denote procedures that occur after data collection. In this article, it might refer to post-analysis considerations, including the implications of study results for drug efficacy and the need for further research or validation.