Ethanolic extract of Scoparia dulcis L. reduces hyperglycemia dose-dependently
Journal name: World Journal of Pharmaceutical Research
Original article title: Reduction of hyperglycaemia with ethanolic extract of scoparia dulcis l. in dose dependent manner
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Aparna Talukder, Manabendra Dutta Choudhury, Biplob De
World Journal of Pharmaceutical Research:
(An ISO 9001:2015 Certified International Journal)
Full text available for: Reduction of hyperglycaemia with ethanolic extract of scoparia dulcis l. in dose dependent manner
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
The research article explores the antidiabetic effects of the ethanolic extract of Scoparia dulcis L. (Sweet Broomweed) in addressing hyperglycemia in Swiss Albino Mice. The study investigates the efficacy of two different doses of the plant extract (25 mg/kg and 50 mg/kg body weight) in comparison to Metformin, a widely used antidiabetic medication. Scoparia dulcis is noted for its historical use in various cultures for treating ailments such as diabetes and hypertension, leading to a growing interest in its potential as a natural remedy for diabetes management.
Efficacy of Scoparia Dulcis Extract
The central findings of the study indicate that the ethanolic extract of Scoparia dulcis L. demonstrates significant hypoglycemic activity. The statistical analysis shows statistically meaningful reductions in blood glucose levels for both doses of the extract when compared to diabetic controls. Notably, a p-value less than 0.05 in various comparisons suggests that the plant extract effectively restores blood glucose levels in diabetic mice, particularly at the 50 mg/kg dosing level. This underscores the potential of Scoparia dulcis as a viable natural alternative to conventional antidiabetic drugs.
Comparison with Metformin
The study also highlights the comparative effectiveness of Scoparia dulcis with Metformin, a standard antidiabetic medication. While both treatments resulted in notable decreases in blood glucose levels, the extract delivered at a dose of 50 mg/kg showed superior efficacy compared to Metformin in some measures. This aspect of the findings points to the potential of harnessing herbal remedies alongside or in place of synthetic drugs, providing alternatives that may be more acceptable to patients seeking natural products with fewer side effects.
Statistical Significance in Treatment Outcomes
Statistical analyses throughout the research demonstrate consistent results indicating significant differences between treated groups (normal, diabetic, Metformin, and various doses of plant extract). The rigor of the analysis, including ANOVA results, lends credence to the claim that Scoparia dulcis has therapeutic effects. The studies included various comparisons across multiple time points, consistently revealing significant p-values that reinforce the effectiveness of both doses of the plant extract, particularly the higher dosage.
Conclusion
In conclusion, the research supports the traditional claims regarding the medicinal properties of Scoparia dulcis, particularly its antidiabetic potential. The significant reduction in blood glucose levels observed with ethanolic extract treatment indicates that this plant could be harnessed for developing effective diabetes management strategies. Given the escalating prevalence of diabetes, further exploration into the medicinal compounds within Scoparia dulcis may yield valuable insights leading to new therapeutic options that are both effective and accessible to the public.
FAQ section (important questions/answers):
What is the aim of the study on Scoparia dulcis L.?
The study aims to investigate the blood glucose reduction effects of ethanolic extract of Scoparia dulcis L. at different concentrations (25mg/kg and 50mg/kg body weight) in diabetic animals, particularly Swiss Albino mice.
What were the key findings regarding Scoparia dulcis extract?
The ethanolic extract of Scoparia dulcis L. exhibited significant hypoglycaemic activity compared to Metformin, restoring blood glucose levels in treated diabetic mice in a dose-dependent manner.
How was diabetes induced in the experimental mice?
Diabetes was induced in Swiss Albino mice using Streptozotocin (STZ) at a dose of 150mg/kg body weight, followed by confirmation of elevated blood glucose levels after seven days.
What were the doses of Scoparia dulcis used in the study?
The study used two doses of ethanolic extract of Scoparia dulcis L.: 25mg/kg body weight and 50mg/kg body weight, both administered intraperitoneally to the diabetic mice.
What statistical methods were used to analyze the data?
The statistical analysis was performed using ANOVA, comparing blood glucose levels over time between control, diabetic, plant extract (25mg and 50mg), and Metformin-treated groups.
What is the potential significance of Scoparia dulcis in diabetes treatment?
Scoparia dulcis shows promise as a natural antidiabetic agent, with higher efficacy at certain doses than the commercial drug Metformin, suggesting its potential for managing diabetes effectively.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Ethanolic extract of Scoparia dulcis L. reduces hyperglycemia dose-dependently”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
Table refers to organized data representing the results of the study, showcasing statistical analyses between different groups concerning the effects of Scoparia dulcis on glucose levels. These tables present findings systematically, making it easier to interpret results, compare treatments, and ensure transparency in the research methodology.
2) Animal:
Animal refers to the Swiss Albino Mice used as experimental models in this research. They are pivotal for studying biological effects and testing the efficacy of the ethanolic extract, ensuring that results are scientifically valid and can be extrapolated for potential human applications. Ethical treatment of animals was emphasized.
3) Activity:
Activity in this context denotes the biological effects exhibited by Scoparia dulcis, particularly its hypoglycaemic (glucose-lowering) properties. The study measured activity through statistical significance in blood glucose levels, demonstrating that the plant extract can positively influence metabolic health in diabetic mice.
4) Drug:
Drug refers to Metformin, a standard pharmaceutical treatment for diabetes, used as a control in the study. Comparisons were made between the effects of the traditional plant extract and this widely recognized medication, assessing relative efficacy in managing blood glucose levels in diabetic subjects.
5) Science (Scientific):
Science encompasses the systematic study of the natural world through observation and experiments. This research represents a scientific inquiry into the medicinal properties of Scoparia dulcis, contributing to the broader understanding of antidiabetic treatments and highlighting the importance of evidence-based approaches in medicine.
6) India:
India is the geographical context where Scoparia dulcis is traditionally used for medicinal purposes. The study highlights local practices and ethnobotanical knowledge while investigating the plant's potential as a contemporary therapeutic option against diabetes within the Indian healthcare setting.
7) Blood:
Blood signifies the vital physiological fluid monitored in the study to evaluate the antidiabetic effects of Scoparia dulcis. Measurements of blood glucose levels were essential for assessing both the baseline diabetic condition and the effectiveness of the treatment over time.
8) Study (Studying):
Study refers to the research conducted to investigate the hypoglycaemic effects of Scoparia dulcis. It includes the methodologies, results, and interpretations, contributing to scientific knowledge regarding herbal remedies for diabetes, with implications for future research and therapeutic applications.
9) Disease:
Disease indicates diabetes mellitus, a chronic condition targeted in this research. Understanding the physiological effects of Scoparia dulcis on this disease is crucial for developing alternative treatments, particularly as diabetes prevalence continues to rise globally, necessitating effective management strategies.
10) Life:
Life refers to the broader biological context within which diabetes affects individuals. The study's findings can contribute to improving the quality of life for those suffering from diabetes by providing potential natural therapeutic options that may mitigate symptoms and complications.
11) Botany:
Botany signifies the scientific study of plants, including their properties, medicinal uses, and ecological importance. The research focuses on Scoparia dulcis as a selected botanically significant species, emphasizing its ethnopharmacological values and promoting further investigation into plant-derived treatments for health concerns.
12) Water:
Water is essential for life and represents the base medium in which experimental substances dissolve during extraction processes. In the context of the study, it is also related to the hydration of test subjects and the overall maintenance of physiological homeostasis in the experimented animals.
13) Diet:
Diet refers to the nutritional intake of the Swiss Albino Mice throughout the study. Proper dietary management is important to ensure controlled variables during the experimentation, allowing for more reliable results concerning the effects of Scoparia dulcis on blood glucose levels.
14) Pharmacotherapy:
Pharmacotherapy encompasses the treatment of diseases through the use of medications. The study compares the ethanolic extract's efficacy against traditional drugs like Metformin, highlighting the importance of natural alternatives in pharmacotherapy and potential contributions to integrative medicine approaches.
15) Inflammation:
Inflammation is a biological response that can be associated with diabetic complications. The study investigates the potential antioxidant and anti-inflammatory properties of Scoparia dulcis, suggesting that its use may not only lower blood glucose but also address underlying inflammation linked to diabetes.
16) Discussion:
Discussion refers to the section of the study where findings are interpreted, implications are drawn, and comparisons are made with existing literature. It is essential for contextualizing results, addressing limitations, and proposing future research directions, thus contributing to scholarly dialogue.
17) Knowledge:
Knowledge represents the cumulative understanding derived from the research about Scoparia dulcis and its effects on diabetes. Generating such knowledge is vital for both scientific advancement and practical applications in clinical settings, fostering informed decisions in healthcare.
18) Agartala (Āgartalā):
Agartala, mentioned in the study, is the location of the Regional Institute of Pharmaceutical Sciences and Technology, where part of the research was conducted. It emphasizes the geographical anchoring of the study, potentially influencing local insights into ethno-medicinal practices.
19) Medicine:
Medicine encompasses the broader field of health and treatment practices aimed at disease management. The study contributes to medicinal knowledge by exploring herbal remedies, thus offering insights into the integration of alternative medicine practices into conventional healthcare strategies.
20) Family:
Family refers to the biological classification of Scoparia dulcis, which belongs to the Scrophulariaceae family. Understanding taxonomic relationships is vital for identifying related species that may have similar or different medicinal properties, thus enhancing research on herbal medicine.
21) Powder:
Powder relates to the form of the plant material after extraction processes. In this study, the powdered extract of Scoparia dulcis is utilized for experimental treatment on diabetic mice, showcasing the transformation of raw plant material into a usable form for research.
22) Campu (Campū, Cāmpu):
Campu may refer to the campus at Assam University, where the plant materials were collected and the research was conducted. It underlines the importance of local biodiversity in supporting scientific research, facilitating studies on indigenous plants with medicinal properties.
23) Field:
Field pertains to the area where the plant specimens are collected for research. Extensive fieldwork ensures that the plant material represents its natural variability and ecological context, contributing to the authenticity and relevance of the research findings.
24) Cage (Cāge):
Cage refers to the housing provided for the Swiss Albino Mice during the experimental trials. Ensuring proper environmental conditions is paramount for ethical animal research, influencing the behavior and biological responses of the subjects during the study.
25) Post:
Post signifies the time points after treatment when blood glucose levels were monitored in the study. Identifying changes over time provides insights into the efficacy and duration of the effects of Scoparia dulcis, highlighting the importance of longitudinal data in pharmacological research.