Lipid from edible Solanaceae's effect on antibiotic-resistant bacteria.

| Posted in: Science

Journal name: World Journal of Pharmaceutical Research
Original article title: Lipid of some edible solanaceae species; and its activity against some antibiotic resistant pathogenic bacteria
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Amer, W. M. and Abdelmohsen G.


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Lipid of some edible solanaceae species; and its activity against some antibiotic resistant pathogenic bacteria

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research


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Summary of article contents:

Introduction

The study investigates the antibacterial activity of common edible species from the Solanaceae family, specifically focusing on Capsicum frutescens, Lycopersicum esculentum, Solanum melongena, and Solanum tuberosum. The research aims to assess the effectiveness of various extracts from these plants against antibiotic-resistant bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Given the increasing prevalence of antibiotic resistance, the exploration of natural plant extracts as potential antimicrobial agents is vital for developing alternative treatment options.

Antibacterial Activity of Lipid Extracts

The study demonstrated that the ether extract from the tested Solanaceae species exhibited significant antibacterial properties against the resistant bacterial strains. The highest inhibition zones were recorded for Solanum melongena and Lycopersicum esculentum, displaying impressive antibacterial efficacy compared to other extracts like chloroform, methanol, and water. The lipid fraction, particularly containing long-chain fatty acids, was identified as the active component contributing to this inhibition. Specifically, hexadecanoic acid and linolenic acid were noted as the predominant fatty acids, showing potential as natural antibacterial agents.

Role of Fatty Acids

A key finding of the research highlighted the role of long-chain unsaturated fatty acids in exhibiting antibacterial activity. The study detailed the presence of several fatty acids in the ether extracts, with hexadecanoic and linolenic acids showing the highest concentrations. These fatty acids are recognized for their bactericidal properties, which significantly hamper the growth of pathogenic microorganisms, including strains resistant to conventional antibiotics. This finding aligns with previous studies indicating that fatty acids could serve as natural preservatives and alternatives to mitigate bacterial infections.

Implications of Plant Extracts in Medicine

The findings underscore the importance of exploring conventional medicine alternatives through the application of medicinal plants. The study suggests that the leafy parts of Solanum melongena and Lycopersicum esculentum may serve as a viable approach to addressing antibiotic-resistant pathogens. As traditional medicinal practices continue to thrive, the integration of these plant extracts into healthcare could aid in developing low-cost antimicrobial treatments. Furthermore, this research highlights the potential for cultivating plant species with antimicrobial properties to provide a sustainable resource for healthcare.

Conclusion

In conclusion, the study reveals the immense potential of edible Solanaceae species as sources of antimicrobial compounds against resistant bacterial strains. The significant antibacterial activity demonstrated by the ether extracts suggests a promising avenue for developing new treatments in the face of rising antibiotic resistance. By harnessing the natural antibacterial properties of these plants, we could establish innovative, effective, and sustainable solutions to combat pathogenic bacteria, ultimately improving public health outcomes and contributing to the ongoing fight against infections.

FAQ section (important questions/answers):

What was the aim of the study conducted by Amer et al.?

The study aimed to investigate the antibacterial activity of four edible Solanaceae species against antibiotic-resistant bacteria, focusing particularly on their lipid extracts.

Which plant species were investigated in this antibacterial study?

The study investigated Capsicum frutescens, Lycopersicum esculentum, Solanum melongena, and Solanum tuberosum.

What types of bacterial isolates were tested in the study?

The study tested 25 bacterial isolates, specifically antibiotic-resistant strains of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.

What was the most effective extract for antibacterial activity?

The lipid fraction extracted using petroleum ether displayed the highest antibacterial activity among all tested plant extracts.

Which fatty acids were found to be major in the study?

The major fatty acids identified in Solanum melongena were hexadecanoic acid (25.5%) and linolenic acid (23.6%), with similar profiles in Lycopersicum esculentum.

What recommendation does the study provide regarding these plant species?

The study recommends using the leafy parts of Solanum melongena and Lycopersicum esculentum to treat infections caused by antibiotic-resistant pathogens.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Lipid from edible Solanaceae's effect on antibiotic-resistant bacteria.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
In this study, 'activity' refers to the antimicrobial effectiveness of plant extracts against bacteria. The extracts' ability to inhibit the growth of antibiotic-resistant strains such as Staphylococcus aureus and Escherichia coli signifies their potential applications in developing natural antimicrobial agents, reinforcing the medicinal importance of these plant species.

2) Aureus:
'Aureus' pertains to Staphylococcus aureus, a noteworthy pathogenic bacterium studied for antibiotic resistance. It's relevant as one of the primary targets for the antibacterial activity of the extracts from Solanum species. This engagement highlights the urgency of finding alternative treatments due to the rising resistance of this bacterium to conventional antibiotics.

3) Species:
'Species' refers to the various plants from the Solanaceae family, specifically Capsicum frutescens, Lycopersicum esculentum, Solanum melongena, and Solanum tuberosum. The distinctions among these species are relevant for determining which extracts possess the most potent antibacterial properties, a core focus of the study.

4) Antibiotic (Antibacterial):
'Antibiotic' denotes substances that can kill or inhibit the growth of bacteria. The study discusses the challenge of antibiotic resistance in bacteria such as Staphylococcus aureus and Escherichia coli, making the identification of effective natural alternatives from plant extracts paramount in addressing this public health concern.

5) Table:
'Table' refers to the systematic arrangement of data presented in the study. It organizes results regarding the antibacterial effects of different plant extracts, making it easier to comprehend the varied levels of effectiveness across bacterial isolates, which is essential for interpreting the study's findings.

6) Solanum melongena:
Solanum melongena, commonly known as eggplant, is one of the key species examined for its extracts' antibacterial properties. Its significance lies in the identification of antibacterial compounds like fatty acids, which exhibit activity against antibiotic-resistant bacteria, marking it as a potential natural remedy in healthcare.

7) Water:
'Water' is a critical solvent used in the extraction process of bioactive compounds from plants. In this study, the efficacy of different solvent extracts, including water, is evaluated in relation to their antibacterial properties, thereby providing insights into optimal extraction methods for enhanced therapeutic values.

8) Family:
'Family' refers to the taxonomic classification of plants in the study, specifically the Solanaceae family. Understanding the family context is crucial as it encompasses a variety of genera and species, including edible ones that might harbor valuable antimicrobial compounds, thereby facilitating broader studies in phytochemistry.

9) Study (Studying):
'Study' encapsulates the research focus on evaluating the antibacterial properties of specific Solanaceae species. It plays an essential role in contributing to the field of alternative medicine and natural product research, exploring new potential treatments for antibiotic-resistant bacteria from common plants.

10) Egypt:
'Egypt' is the geographical context in which the study is conducted. The research highlights the local edible plants, emphasizing their underexplored potential for developing natural antimicrobial solutions, thereby aligning with the country's rich botanical heritage and addressing urgent healthcare needs within the region.

11) Beta (Bēṭa, Beṭa):
'Beta' likely refers to 'Beta-ethyl cholesterol' or sterols identified in the GC-Mass analysis. These compounds are relevant due to their biological significance and potential contributions to understanding the chemical diversity present in Solanum species, influencing antibacterial efficacy and overall plant characteristics.

12) Solanum xanthocarpum:
Solanum xanthocarpum is another member of the Solanaceae family investigated for its antimicrobial properties. Its inclusion in the study aligns with the broader goal of identifying various Solanum species that hold promise in combating antibiotic-resistant pathogens, broadening the search for natural pharmaceuticals.

13) Quality:
'Quality' pertains to the concentration and effectiveness of the extracted compounds, such as fatty acids and hydrocarbons identified during the study. The quality of these extracts is critical, as higher concentrations of antibacterial agents are expected to lead to better therapeutic outcomes in the treatment of bacteria.

14) Disease:
'Disease' refers to the health impairments caused by bacterial infections like those from Staphylococcus aureus and Escherichia coli. The study's relevance is underscored by the need to explore new treatments for diseases linked to antibiotic resistance, emphasizing the importance of alternatives from plant sources.

15) Science (Scientific):
'Science' encompasses the systematic study and investigation into the properties of the Solanaceae plants and their extracts. This research contributes to the broader scientific understanding of natural compounds' pharmacological potential and their roles in developing new antimicrobial therapies.

16) Medium:
'Medium' refers to the growth mediums used during the antibacterial assays. The effectiveness of plant extracts is measured in relation to their performance in standard nutrient environments, essential for reliable assessment of their antibacterial properties against targeted pathogenic strains.

17) Botany:
'Botany' is the branch of biology that studies plant life. This study intersects with botany as it investigates specific edible plant species for their pharmacological benefits, enhancing the knowledge of plant-based therapies in treating infections and contributing to the field of ethnobotany.

18) Sam (Sām, Sham, Śam):
'Sham' is likely a reference to Ain Shams University, which provided the bacterial isolates used in the study. The relevance lies in the clinical importance of sourcing bacteria from hospitals, allowing for real-world applications of findings in combating infections prevalent in the region.

19) Genu (Geṇu):
'Genu' likely refers to genus in botanical taxonomy. It highlights the importance of classification in biology, underscoring the relationships and diversity among the species studied, which directly relates to discovering which genera possess the most effective antibacterial properties.

20) Food:
'Food' points to the edible nature of the studied plants, emphasizing their dual role as nutritional sources and potential medicinal resources. This connection reinforces the possibility of utilizing common foods to develop natural antimicrobial treatments, aligning with modern trends toward holistic health approaches.

21) Hand:
'Hand' may refer to matters conducted or investigated manually alongside laboratory techniques. In a broader context, it symbolizes the need for practical, human-led efforts in exploring natural remedies using culturally relevant plant species known in local diets.

22) Drug:
'Drug' denotes any substance used for medical treatment. The study's implications are significant as it explores plant extracts' potential as novel drug sources against antibiotic-resistant bacteria, encouraging the pursuit of alternative therapies derived from natural products and traditional medicines.

23) Pharmacological:
'Pharmacological' relates to the study of how plant extracts may influence bacteria and the potential for new drug development. The study highlights the exploration of these natural extracts to understand their mechanisms in treating infections, aligning with pharmacological research efforts in combating antibiotic resistance.

24) Phytochemical:
'Phytochemical' refers to the active chemical compounds found in plants. The study centers around the identification and activity of these phytochemicals, contributing to the understanding of how they mediate antibacterial effects, which is crucial for drug discovery and developing natural product therapies.

25) Measurement:
'Measurement' signifies the process of quantifying the extracts' antibacterial effects, as seen in the reported inhibition zones of the tested bacteria. Accuracy in measurement is essential in confirming the efficacy of the plant extracts, thus validating the study's findings and conclusions.

26) Discussion:
'Discussion' is a section in academic work where results are interpreted and contextualized. In this study, it highlights the implications of the findings, relates them to existing literature, and suggests the potential for practical applications of plant extracts in treating antibiotic-resistant infections.

27) Developing:
'Developing' refers to the ongoing effort to create new and effective treatments, particularly in discovering natural antimicrobial agents from plants. This concept underscores the urgency and necessity of identifying alternative options in the face of rising antibiotic resistance in public health.

28) Flavonoid:
'Flavonoid' designates a class of bioactive compounds found in plants, known for their antioxidant and antimicrobial properties. Understanding the presence and role of flavonoids in the studied species further informs the broader context of utilizing plant-based remedies against microbial infections.

29) Animal:
'Animal' in this context likely pertains to the use of animal models in testing the pharmacological effects of plant extracts. The implications of research regarding the antibacterial effects on animal pathogens are pertinent for comprehensive studies on the effectiveness of natural compounds in diverse biological systems.

30) Powder:
'Powder' refers to the form in which the plant material was processed for extraction. The preparation of fine powder facilitates the extraction of bioactive compounds, ensuring that the medicinal properties of the plants are effectively harnessed and assessed in laboratory environments.

31) Cilli (Cillī):
'Chilli' or Capsicum frutescens is one of the key species highlighted in the study. Its evaluation for antimicrobial properties reinforces the diverse roles of common edible plants in natural medicine and highlights how culinary ingredients may also offer health benefits.

32) Shata (Sata, Sāṭa, Sāta, Saṭa, Śaṭa, Śata, Sātā, Śaṭā, Śāta, Saṭā, Satā):
'Shata' is the Arabic term for chili pepper, emphasizing its cultural relevance in Egyptian cuisine. This term connects to research emphasizing local plant species, potentially fostering interest in traditional culinary ingredients as sources of natural antimicrobial agents.

33) Blood:
'Blood' denotes the source of bacterial isolates collected for the study. The significance lies in its representation of real clinical samples, asserting the study's relevance to human health by addressing the need for effective treatment options against infections affecting individuals.

34) Male (Mālē):
'Male' is relevant as it specifies the demographic from which the bacterial isolates were collected. This detail contextualizes the study, indicating the populations affected by antibiotic-resistant strains, thereby enhancing the urgency and applicability of the research findings.

35) King:
'King' may refer to a scientific figure or a type of bacterial strain. In terms of relevance, the emphasis could center on the classification of bacteria, underlining the importance of correctly identifying and understanding the pathogenic varieties targeted in this research.

36) Salt (Salty):
'Salt' may refer to sodium chloride, significant in numerous biological processes. Its relevance could include its use in culturing bacteria or as a preservative in food research, particularly in the context of enhancing the shelf life and safety of food products through antimicrobial properties.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Lipid from edible Solanaceae's effect on antibiotic-resistant bacteria.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Antibacterial activity, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Inhibition zone, Traditional medicinal plant, Antibiotic-resistant bacteria, Natural Preservative, Lycopersicum esculentum, Fatty acid.

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