A pilot study on effect of metformin in polycystic ovary syndrome
Journal name: World Journal of Pharmaceutical Research
Original article title: A pilot study on effect of metformin in polycystic ovary syndrome
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Lakshmi KS, Jayasutha J, Anjalakshi Chandrasekar3, Muthulakshmi M
World Journal of Pharmaceutical Research:
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Full text available for: A pilot study on effect of metformin in polycystic ovary syndrome
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
Introduction
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting approximately 6.5–6.7% of premenopausal women. Initially described as a cystic disease of the ovaries, PCOS is now associated with various endocrine and metabolic disruptions, such as insulin resistance, hypertension, and increased risks for type 2 diabetes and other serious health conditions. The diagnosis of PCOS requires the presence of at least two of three features: oligo/anovulation, hyperandrogenism, and polycystic ovarian morphology observed via ultrasound. Insulin resistance plays a considerable role in the pathophysiology of PCOS, leading researchers to explore the effectiveness of insulin-sensitizing agents like Metformin.
Efficacy of Metformin in Menstrual Regularity
A pilot study was conducted to evaluate the efficacy of Metformin on women diagnosed with PCOS, with 42 overweight patients included after careful selection based on inclusion and exclusion criteria. The results indicated that Metformin significantly improved menstrual regularity: out of 24 patients experiencing oligomenorrhea, 18 returned to having regular cycles post-treatment. Similarly, from the 8 patients with amenorrhea, 4 experienced a return to regular menstruation. The study underscores Metformin's role in normalizing menstrual cycles in women suffering from hormonal imbalances associated with PCOS.
Impact on Biochemical Parameters
The study also focused on biochemical parameters before and after Metformin treatment. Initial measurements included fasting glucose, fasting insulin, and the glucose/insulin ratio, with values recorded as 96.6 mg/dl, 24.1 mIU/ml, and 3.8, respectively. After three months of treatment, significant reductions were observed: fasting glucose decreased to 90.6 mg/dl, fasting insulin to 18.7 mIU/ml, and the glucose/insulin ratio increased to 5.5. The results exhibited statistically significant changes, indicating Metformin's effectiveness in improving metabolic markers associated with insulin resistance in PCOS patients.
Changes in Hormonal Levels
Moreover, the hormonal parameters, including luteinizing hormone (LH), follicle-stimulating hormone (FSH), the LH/FSH ratio, and serum testosterone, were evaluated to assess the overall impact of Metformin treatment. Initial values for these hormones were significantly higher and decreased post-treatment, showcasing marked improvement. Specifically, LH reduced from 13.4 mIU/ml to 10.3 mIU/ml, and testosterone levels saw a significant decrease from 2.6 nmol/l to 1.1 nmol/l. This hormonal modulation reaffirms Metformin’s role in not only enhancing ovulatory function but also mitigating the hyperandrogenic features commonly present in PCOS.
Conclusion
In conclusion, the pilot study demonstrates that Metformin is an effective treatment option for women suffering from PCOS, as evidenced by improvements in menstrual regularity, reductions in insulin and glucose levels, and favorable changes in hormonal parameters. By addressing both the metabolic and hormonal aspects of PCOS, Metformin serves as a valuable therapeutic choice in managing this complex disorder.
FAQ section (important questions/answers):
What was the purpose of the study on Metformin and PCOS?
The study aimed to evaluate the efficacy of Metformin in treating women with polycystic ovary syndrome (PCOS), particularly focusing on menstrual regularity and hormonal balance.
How many patients were included in the Metformin study?
A total of 50 patients were initially recruited, but 8 were excluded due to insufficient data, leaving 42 overweight women with PCOS for the study.
What dosage of Metformin was administered to the patients?
Patients received Metformin at a dosage of 500 mg three times daily over a treatment period of three months.
What improvements were observed after Metformin treatment?
After treatment, many patients experienced regular menstrual cycles, decreased BMI, reduced fasting insulin levels, and improved hormonal parameters, including LH, FSH, and testosterone.
What were the main findings related to hormonal parameters?
Significant decreases were noted in hormonal levels, particularly for LH, FSH, and serum testosterone, indicating a positive response to Metformin treatment in managing PCOS.
What conclusions were drawn from the study on Metformin's effectiveness?
The study concluded that Metformin is a simple and effective treatment for PCOS, capable of restoring spontaneous ovulation in most patients.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “A pilot study on effect of metformin in polycystic ovary syndrome”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The 'Study' refers to the prospective research conducted to evaluate the efficacy of Metformin, an insulin-sensitizing drug, in treating women with polycystic ovary syndrome (PCOS). This study aimed to investigate the effects of Metformin on hormonal levels, menstrual regularity, and associated metabolic parameters, providing valuable insights into treatment options for PCOS.
2) Lakshmi (Lakṣmī):
'Lakshmi' is the name of the primary author of the study on the effects of Metformin in women with PCOS. As a researcher affiliated with SRM College of Pharmacy, her contributions are instrumental in the academic community, particularly for understanding and treating endocrine disorders in female patients.
3) Kancipura (Kāñcīpura, Kancipuram, Kāñcipura, Kanchipuram, Kāṃcīpura, Kanci-pura, Kamci-pura):
'Kancheepuram' is the location of SRM University, where the study was conducted. This region in Tamil Nadu, India, serves as a hub for medical and pharmaceutical research, highlighting the significance of local institutions in addressing women's health issues like polycystic ovary syndrome.
4) Tamilnadu (Tamil-nadu, Tamilnāḍu):
'Tamilnadu' is a state in India where the research took place. The state is noted for its educational institutions and healthcare facilities, contributing to significant studies in various medical fields, including the management and treatment of polycystic ovary syndrome among women.
5) Disease:
'Disease' refers to polycystic ovary syndrome (PCOS) in the context of the study. PCOS is a common endocrine disorder affecting reproductive-age women, characterized by hormonal imbalances, insulin resistance, and various metabolic complications that can impact fertility and overall health.
6) India:
'India' is the country where the study was performed, emphasizing its diverse population and varying prevalence of health conditions like PCOS. Understanding the effectiveness of treatments in different populations is crucial for developing tailored healthcare approaches and public health strategies.
7) Table:
'Table' refers to the organized format used to present data and results in the study. Tables are vital for summarizing demographic details, laboratory results, and treatment outcomes, making it easier for readers to interpret significant findings and quantitative comparisons.
8) Young women (Young woman):
'Young women' denotes the target demographic for the study, specifically those aged 18 to 35 years suffering from PCOS. This focus is essential as it helps researchers understand the specific impacts of PCOS and treatments like Metformin in a reproductive-age cohort.
9) Discussion:
'Discussion' in the context of the study refers to the section where findings are interpreted, compared to previous research, and implications for treatment are explored. This part is crucial for placing the study's results within the broader context of PCOS management and future research needs.
10) Medicine:
'Medicine' relates to the field of practice that includes the study and application of medical interventions, like Metformin. This encompasses the investigation of various therapies for managing conditions like PCOS, linking pharmaceutical research to clinical practice and improving patient care.
11) Family:
'Family' is relevant as PCOS often has genetic components, and the study observed family history among some participants. Understanding familial links to health conditions can aid in recognizing at-risk individuals and promoting preventive healthcare measures within families.
12) Cancer:
'Cancer' is mentioned in the study concerning health risks associated with PCOS, such as an increased risk of endometrial and breast cancer. This connection emphasizes the importance of effective management and treatment of PCOS to mitigate long-term health risks.
13) Blood:
'Blood' pertains to the various laboratory tests performed in the study that monitored hormonal levels and metabolic parameters, including fasting glucose and insulin levels. These tests are critical for assessing the physiological impacts of Metformin treatment in participants with PCOS.
14) Drug:
'Drug' refers specifically to Metformin, the medication evaluated in the study. As an insulin sensitizer, its role in treating PCOS is explored, focusing on its effects on insulin resistance, hormonal balance, and metabolic health in women suffering from this syndrome.
Other Science Concepts:
Discover the significance of concepts within the article: ‘A pilot study on effect of metformin in polycystic ovary syndrome’. Further sources in the context of Science might help you critically compare this page with similair documents:
Amenorrhea, Significant change, Inclusion and exclusion criteria, Body mass index, Insulin resistance, Menstrual history, Oligomenorrhea, Systolic blood pressure, Ovulation induction, Hyperinsulinemia, Fasting blood glucose, Student's t test, Polycystic Ovary Syndrome, Endocrine disorder, Fasting insulin levels, Hyperandrogenemia, Metformin treatment, Metformin therapy, Fasting insulin, Insulin growth factor.
Concepts being referred in other categories, contexts and sources.