Enzyme activities of akp, cpk, sgot and ldh in blood serum of malaria patients
Journal name: World Journal of Pharmaceutical Research
Original article title: Enzyme activities of akp, cpk, sgot & ldh in blood serum of malaria patients
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Purohit Chitra, Jain Suman
World Journal of Pharmaceutical Research:
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Full text available for: Enzyme activities of akp, cpk, sgot & ldh in blood serum of malaria patients
Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research
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Summary of article contents:
##IntroductionMalaria is a significant public health concern in India and plays a substantial role in the overall disease burden in Southeast Asia. In 2009, the National Vector Borne Disease Control Programme reported approximately 1.6 million malaria cases and around 1,100 related deaths, with estimates suggesting that the actual incidence may be much higher. Caused by the Plasmodium parasite, particularly the P.falciparum species, malaria is transmitted primarily through female Anopheles mosquitoes, affecting major organs including the liver, kidney, and brain. The liver is particularly impacted during the disease's hepatic stage, leading to a significant perturbation in the hepatocyte structure and the leakage of liver enzymes into the bloodstream.
### Enzyme Activity as Indicators in Malaria
The present study assessed serum levels of four enzymes—SGOT, AKP, LDH, and CPK—in a group of 30 malaria patients compared to a control group of healthy individuals. The findings indicated significantly elevated levels of SGOT, AKP, and LDH in malaria patients, suggesting hepatic compromise due to malaria's impact on liver functions. The increased SGOT level indicates acute liver damage, while elevated LDH levels imply tissue damage and possibly the release of the enzyme from lysed red blood cells. These changes underscore the importance of enzyme activity in indicating the severity of malaria and the extent of liver involvement.
### Decreased CPK Activity in Malarial Patients
In contrast, the study revealed a significant decrease in Creatine Phosphokinase (CPK) activity among malaria patients. Although CPK is typically associated with muscle and tissue integrity, its decreased levels in this context could suggest a reduction in the body's ATP content, potentially leading to diminished energy levels and overall immunity. This finding points to a complex metabolic disturbance in malarial infections, where an energy-deficient state might complicate patient recovery.
### Implications for Diagnosis and Treatment
The study reinforces the notion that liver enzyme levels can serve as indirect indicators of malaria infection, especially in cases where parasites are not detectable in blood smears. This highlights the potential for utilizing serum enzyme activities as a means to justify or initiate antimalarial treatment, particularly when recognizing malaria-related complications in patients without observable parasites.
In conclusion, while the definitive diagnosis of malaria relies on identifying the parasite in stained blood samples, measuring serum enzyme levels offers valuable insights into the disease's severity and metabolic impact. This study underscores the relevance of SGOT, AKP, LDH, and CPK as potential biomarkers for evaluating clinical conditions in malaria patients, contributing to better management and treatment strategies.
FAQ section (important questions/answers):
What enzymes were evaluated in malaria patients in the study?
The study evaluated serum activities of Creatine Phosphokinase (CPK), Lactate Dehydrogenase (LDH), Alkaline Phosphatase (AKP), and Glutamate Oxalo-transaminase (SGOT) in 30 malaria patients compared to healthy controls.
How does malaria affect enzyme levels in the blood serum?
In malaria patients, the activities of SGOT, AKP, and LDH significantly increased, while CPK levels decreased, indicating hepatic compromise and altered metabolic pathways.
What is the significance of elevated SGOT and LDH in malaria?
Elevated SGOT and LDH levels in malaria suggest liver damage and red blood cell destruction, linked to the malaria infection's effects on metabolic processes.
What methods were used for patient selection and diagnosis?
Patients were selected through random sampling and diagnosed based on clinical symptoms and confirmed malaria infection via microscopic examination of blood smears.
Why were certain patients excluded from the study?
Patients with conditions like AIDS, chronic anemia, kidney disorders, liver cirrhosis, and those on anti-malarial drugs were excluded to avoid confounding variables.
What conclusions can be drawn regarding enzyme activity and malaria severity?
The variation in serum enzyme activity reflects malaria severity, indicating these enzymes may serve as potential biomarkers for monitoring and diagnosing malaria.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Enzyme activities of akp, cpk, sgot and ldh in blood serum of malaria patients”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Activity:
Activity refers to the level of enzyme function measured in biological samples. In this study, increased enzyme activity in malaria patients indicates liver damage and metabolic disturbance due to the infection. Understanding enzyme activity is vital for diagnosing and monitoring the impact of malaria on organ functions.
2) Blood:
Blood is the bodily fluid that circulates in the cardiovascular system, delivering nutrients and oxygen to cells and removing waste products. In malaria, blood is critically involved as the parasite resides and multiplies within red blood cells, causing significant pathology and measurable changes in blood serum enzyme levels.
3) Disease:
Disease signifies any pathological condition that disrupts normal bodily functions. Malaria is a serious tropical disease caused by the Plasmodium parasite. The study investigates how malaria alters enzyme activity, reflecting its impact on health and highlighting the need for effective treatment and prevention measures in affected populations.
4) Table:
Table serves as an organized way to present data clearly for comparison. In this research, tables summarize enzyme activity findings for malaria patients and control subjects, facilitating easy visual interpretation of significant differences. Such structured presentations are crucial for efficiently communicating scientific results to the readers.
5) India:
India is the country where this study was conducted, representing a region severely affected by malaria. The country’s diverse climatic and socio-economic conditions contribute to malaria endemicity. The findings can inform public health strategies and resource allocation in India to combat malaria and reduce its impact.
6) Study (Studying):
Study refers to a systematic investigation aimed at discovering new knowledge or verifying existing information. This research examines enzyme activity in malaria patients, contributing to the understanding of the disease's pathology and the status of public health in malaria-endemic regions, with implications for treatment strategies.
7) Udaipur (Udaypur):
Udaipur is a city in Rajasthan, India, where the research took place. Its geographical context is important, as seasonal climatic factors influence malaria transmission rates. Local health facilities play a crucial role in diagnosing and managing malaria, providing a setting to explore disease effects on biochemical markers.
8) Transmission:
Transmission encompasses how the malaria parasite spreads, primarily through female Anopheles mosquitoes. Understanding transmission dynamics is essential for developing interventions to control malaria spread, as environmental and socio-economic factors can influence transmission rates and malaria incidence in different regions, including those analyzed in the study.
9) Rajasthan (Rājasthān):
Rajasthan is a state in India, notable for its climatic diversity and reported malaria cases. The state provides a unique context for studying malaria due to varying altitudes and humidity levels which influence both vector availability and disease prevalence, informing targeted strategies for malaria control.
10) Relative:
Relative pertains to comparative measurements that assess changes against a standard or control group. In this study, enzyme activities in malaria patients are compared to healthy controls to determine the impact of malaria on biological functions. This comparative analysis enhances understanding of the disease's severity.
11) Death:
Death signifies the cessation of biological functions. In the context of malaria, understanding mortality rates linked to the disease underscores its severity and motivates public health interventions. The study references malaria-related deaths to highlight the need for effective treatment and preventive strategies in malarial areas.
12) Life:
Life pertains to the existence of living organisms and their biological processes. In examining malaria, the research discusses how the disease disrupts vital processes in infected individuals. The life cycle of the malaria parasite within human hosts significantly affects health and necessitates effective medical responses.
13) Malnutrition:
Malnutrition refers to deficiencies, excesses or imbalances in a person's intake of energy and nutrients. It exacerbates malaria’s impact in populations with lower immunity, increasing susceptibility and severity of infection. The study emphasizes that malnutrition is a contributing factor to poor health outcomes in malarial cases.
14) Inflammation:
Inflammation is the body’s response to infection or injury, involving immune system activity. This response can lead to tissue damage and is relevant in malaria infection, as it indicates organ stress and the potential for serious complications. The study examines the relationship between malaria and inflammatory responses.
15) Discussion:
Discussion encompasses the interpretation of study findings, contextualizing results within broader research and implications. In this study, the authors analyze enzyme activity changes in malaria patients and explore possible underlying mechanisms, seeking to enhance understanding of malaria's impact on health and providing avenues for further research.
16) Reflecting:
Reflecting involves demonstrating or showing evidence of a condition. In this context, reflecting on enzyme levels indicates the physiological changes occurring due to malaria. Increased SGOT, AKP, and LDH levels reflect liver and cellular involvement in the disease's pathology, serving as markers for clinical assessment.
17) Alcoholism:
Alcoholism relates to chronic alcohol dependency, impacting various bodily functions including liver enzyme activity. The study excludes individuals with alcoholism, recognizing that its presence could confound findings on enzyme levels in malaria. This exclusion ensures that observed enzyme changes are attributable mainly to malaria infections.
18) Attending:
Attending refers to individuals seeking medical care or consultations. In this study, patients attending the medical outpatient department for clinical evaluation were included, providing a definitive cohort for assessing enzyme activity influenced by malaria. This emphasizes the relevance of healthcare access in disease management.
19) Toxicity:
Toxicity refers to the degree to which a substance can cause harm to an organism. In malaria, altered enzyme levels can reflect potential toxic effects related to liver dysfunction and metabolic imbalances. Monitoring enzyme activity provides insights into the overall health of malarial patients, influencing treatment decisions.
20) Medicine:
Medicine denotes both the science of healing and the field of medical practice. In the context of this research, it represents the discipline concerned with the diagnosis and treatment of malaria. Understanding enzyme activities helps healthcare providers in crafting effective treatment strategies against infection and associated complications.
21) Hygiene (Hygienic):
Hygienic pertains to practices that promote health and prevent disease. Poor hygienic conditions are identified as a contributing factor to malaria transmission in India. The study highlights the importance of public health measures to improve hygienic conditions that could reduce malaria incidence and associated health impacts.
22) Species:
Species denotes a group of organisms capable of interbreeding. In malaria, the Plasmodium species are crucial since different types cause variable disease manifestations. Understanding which species are prevalent helps direct targeted treatment and control strategies, reinforcing the importance of accurate diagnosis in endemic regions.
23) Reason:
Reason signifies a cause or justification for an action. In the context of malaria, identifying the reasons behind increased enzyme levels helps elucidate the disease's effects on organ function. Understanding these causes aids in determining treatment protocols and preventive measures within public health frameworks.
24) Fever:
Fever is a common symptom of malaria, representing the body’s response to infection. It is indicative of ongoing pathogenic activity and serves as a clinical sign for diagnosis. Accurate monitoring of fever patterns assists healthcare providers in assessing the severity of malaria and guiding treatment decisions.
25) Male (Mālē):
Male refers to the gender of patients in the study. Including both males and females in the research highlights the need to assess the effects of malaria across different demographics, ensuring a comprehensive understanding of disease impact and any potential gender-related differences in response to infection.
26) Bile:
Bile is a digestive fluid produced by the liver, essential for emulsifying fats. The study addresses liver function through enzyme assessment, given bile duct involvement in malaria. Liver enzyme disturbances can affect bile production, impacting digestion and nutrient absorption, reinforcing the importance of liver health in malaria.
27) Genu (Geṇu):
Genu refers to a characteristic peculiar to individuals or groups. While 'genu' is not explicitly discussed in the study, its inclusion implies attention to unique patient characteristics influencing health outcomes. Understanding these distinctions helps refine research conclusions and tailor healthcare interventions for malarial patients, ensuring personalized care.
28) Sign:
Sign indicates evidence or indication of a condition. In this research, elevated enzyme activities are examined as signs of liver damage in malaria patients. Recognizing such signs is critical for timely diagnosis and effective treatment, facilitating the management of malarial cases and their complications.
29) Rich (Ṛch):
Rich signifies an abundance or high concentration of something, such as enzymes in specific tissues. The study emphasizes that certain enzymes like LDH are rich in liver and red blood cells. This characteristic enhances the diagnostic value when assessing enzyme levels in the context of malaria infection.
30) Drug:
Drug refers to substances used for medical treatment. Antimalarial drugs are pivotal for combating malaria, and understanding their impact on biological markers, including enzyme activity, is crucial. The research underscores the importance of exploring drug interactions and their effects on liver function and overall patient outcomes.
31) Pur (Pūr):
Poor denotes a lack or deficiency, commonly relating to health or living conditions. The study highlights that poor hygienic conditions and malnutrition exacerbate malaria's impact, affecting disease susceptibility and severity. Addressing these deficiencies is vital for effective malaria prevention and treatment strategies in affected populations.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Enzyme activities of akp, cpk, sgot and ldh in blood serum of malaria patients’. Further sources in the context of Science might help you critically compare this page with similair documents:
Public Health Problem, Temperature and humidity, Liver function test, Alkaline phosphatase, Lactate dehydrogenase, Creatine phosphokinase, Enzyme activities, Blood serum, Malaria patients, Metabolic pathway.