Oxidative stress status in obesity algerians population

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Journal name: World Journal of Pharmaceutical Research
Original article title: Oxidative stress status in obesity algerians population
The WJPR includes peer-reviewed publications such as scientific research papers, reports, review articles, company news, thesis reports and case studies in areas of Biology, Pharmaceutical industries and Chemical technology while incorporating ancient fields of knowledge such combining Ayurveda with scientific data.
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Original source:

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Author:

Karouche Saida, Rouabah Leila, Ameddah Souad, Benlatreche Moufida, Bellil Ines, Hamma Sihem Amina, Rouabah Abdelkader


World Journal of Pharmaceutical Research:

(An ISO 9001:2015 Certified International Journal)

Full text available for: Oxidative stress status in obesity algerians population

Source type: An International Peer Reviewed Journal for Pharmaceutical and Medical and Scientific Research


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Summary of article contents:

Obesity is a significant global public health issue, with rates having more than doubled since 1980, affecting over 1.5 billion adults. It is a risk factor for many non-communicable diseases like diabetes, heart conditions, and certain cancers, contributing to approximately three million deaths annually. Factors associated with oxidative stress in obesity include increased body fat, insulin resistance, chronic inflammation, and hypertension. This study aimed to evaluate oxidative stress in overweight and obese individuals in eastern Algeria.

One critical finding is the relationship between obesity and antioxidant status. The study observed that overweight individuals exhibit higher serum levels of antioxidants, such as vitamins E and A, compared to those who are obese. This suggests that as body mass index increases, the antioxidant levels decline, indicating a degradation in the body’s ability to neutralize oxidative stress.

Another important aspect is the variability between genders in antioxidant levels and oxidative stress parameters. Women show reduced antioxidant status associated with increased physical inactivity, while men present a more pronounced decrease in antioxidant enzyme activity as obesity persists. This discrepancy indicates that women may be in earlier stages of obesity compared to men, who tend to experience longer-term obesity effects on their antioxidant systems.

Additionally, the research highlights how obesity correlates with adverse metabolic changes. The levels of total cholesterol, triglycerides, and fasting glucose are significantly elevated in obese subjects, confirming that obesity is associated with increased oxidative stress. The study underlines that proper physical activity may help in mitigating these oxidative stress effects, although the majority of participants demonstrated high levels of physical inactivity.

In conclusion, the study reveals that obesity negatively impacts serum antioxidant levels and increases oxidative stress indicators. It emphasizes the significance of maintaining a healthy lifestyle, including physical activity, to mitigate oxidative stress and its related health risks, particularly among women and individuals as they age. This research supports the need for community strategies to address obesity and enhance antioxidant defenses.

FAQ section (important questions/answers):

What was the aim of the study on obesity in Algerian population?

The study aimed to evaluate oxidative stress status in patients with obesity, particularly focusing on the relationship between anthropometric measurements, biochemical markers, and antioxidant levels.

How many subjects were included in the study and what were their BMI criteria?

The study included 61 subjects aged 20 to 67 with a BMI ≥ 25, indicating they were either overweight or obese.

What antioxidant vitamins were measured in the study?

The study measured serum levels of vitamins E and A, along with antioxidant status indicators like glutathione (GSH) and catalase activity.

What were the significant findings regarding antioxidant levels in obesity?

Results showed that antioxidant serum levels of vitamins E and A, GSH, and catalase activity were significantly lower in obese subjects compared to overweight individuals.

What relationship was observed between obesity and lipid profile?

The study found significantly higher plasma levels of total cholesterol, triglycerides, and fasting glucose in obese subjects, indicating disrupted lipid metabolism.

How did physical inactivity relate to the antioxidant status in women?

Reduced antioxidant status in women was associated with a higher percentage of physical inactivity, suggesting that exercise can help reduce oxidative stress.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Oxidative stress status in obesity algerians population”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the degree of physical exertion individuals engage in, which has been highlighted in the study as a factor related to oxidative stress and its antioxidant status. The research indicates that increased physical inactivity, especially among women, correlates with reduced antioxidant levels, emphasizing the importance of exercise in mitigating health risks associated with obesity.

2) Blood:
Blood is a vital fluid analyzed in this study to evaluate various biochemical markers, including glucose levels, lipid profiles, and antioxidant statuses. Blood assays are instrumental in assessing the health implications of obesity, determining oxidative stress levels, and understanding how different parameters correlate with obesity prevalence and health outcomes.

3) Study (Studying):
The study aims to evaluate oxidative stress status related to obesity within an Algerian population. It involves anthropometric measurements and biochemical assays to understand the relationship between body mass index (BMI), oxidative stress indicators, and associated health risks, contributing essential data to obesity research.

4) Disease:
Disease in this context refers to metabolic and non-communicable diseases linked with obesity, such as diabetes, hypertension, and heart disease. Understanding the interplay between obesity and disease is crucial, as the research highlights how oxidative stress and lifestyle factors exacerbate health conditions prevalent in the studied population.

5) Table:
Tables in the study present detailed data on anthropometric measurements, lipid profiles, antioxidant levels, and statistical results. They serve as clear visual aids summarizing the research findings, comparing different groups (overweight vs. obese) and emphasizing significant differences in biochemical markers which help in interpreting the results.

6) Diet:
Diet is a critical aspect of the study, indicating how nutritional intake, particularly antioxidants from vitamins E and A, affects oxidative stress and health. The research suggests that a diet rich in fruits and vegetables can bolster antioxidant levels and combat the oxidative burdens prevalent in obese individuals.

7) Life:
Life pertains to the quality of health and longevity in relation to obesity and oxidative stress factors. The study addresses how obesity diminishes life expectancy and increases the risk of serious conditions, thereby highlighting the urgency of interventions aimed at improving lifestyle choices to enhance overall well-being.

8) Measurement:
Measurement involves quantifying various physiological and biochemical parameters such as BMI, antioxidant levels, and blood glucose. Accurate measurement is fundamental in the study to assess the health impacts of obesity, determine associations with oxidative stress, and draw meaningful conclusions regarding interventions and health risk management.

9) Science (Scientific):
Science refers to the systematic study of phenomena, in this case, the biological and biochemical aspects of obesity and oxidative stress. The study is rooted in scientific methodologies, utilizing biochemical assays and statistical analysis to reveal insights into health issues affecting the Algerian population and contributing to broader obesity research.

10) Family:
Family history is considered in evaluating risk factors for obesity-related health conditions. The prevalence of obesity in individuals with a family history emphasizes the genetic and environmental components of health, suggesting that familial tendencies may play a role in the metabolic health outcomes observed in the study.

11) Inflammation:
Inflammation is a biological response linked to obesity that contributes to oxidative stress, impacting metabolic syndrome and related diseases. The correlation between obesity and chronic inflammation is essential, as inflammation may exacerbate oxidative damage, influencing antioxidant defenses and overall health in the studied population.

12) Death:
Death is highlighted as a critical outcome related to obesity, with statistics indicating that millions die annually from obesity-related conditions. This aspect underscores the urgency of tackling obesity as a public health crisis, supporting the study's aim to understand oxidative stress and improve health interventions.

13) Fight:
Fight refers to the efforts required to combat obesity and associated oxidative stress through lifestyle changes, diet, and physical activity. The study suggests that understanding these relationships is paramount in developing strategies to reduce obesity prevalence and its myriad health consequences.

14) Rich (Ṛch):
Rich is used to describe a diet abundant in antioxidants, which is important for combating oxidative stress. The study emphasizes the health benefits of consuming a rich variety of fruits and vegetables to bolster antioxidant levels, thereby mitigating the adverse health effects associated with obesity.

15) Calculation:
Calculation refers to the statistical analysis performed to assess the significance of the differences in biochemical markers across different BMI categories. The rigorous calculation process ensures that the findings are robust, providing credible insights into the health impact of obesity in the study population.

16) Performance:
Performance in the context of this study may relate to how the body's antioxidant defenses respond to oxidative stress as influenced by obesity and physical activity. Examining performance metrics helps in understanding the interplay between lifestyle choices and health outcomes across different demographic groups.

17) Discussion:
Discussion encompasses the interpretation and analysis of results obtained from the study. This section provides a platform for examining similarities and discrepancies with existing literature, unpacking the implications of findings on oxidative stress, obesity, and public health strategies.

18) Suffering:
Suffering reflects the health burdens experienced by individuals facing obesity and its associated health risks. The emotional and physical suffering stemming from obesity-related diseases underscores the critical need for effective interventions and education to promote healthier lifestyle choices within communities.

19) Medicine:
Medicine represents the clinical aspects of managing and treating conditions arising from obesity and oxidative stress. The study informs medical practice by providing evidence for the need for targeted interventions, preventive measures, and health education in combating obesity and improving metabolic health.

20) Species:
Species may refer to the biological variations among populations and how genetic predispositions influence obesity and antioxidant status. The study's population specifics contribute to a broader understanding of how different species, including humans, respond to oxidative stress and health management practices.

21) Cancer:
Cancer is mentioned as one of the diseases significantly linked to obesity. Understanding the mechanisms by which obesity and oxidative stress may facilitate cancer development is crucial for creating tailored public health initiatives aimed at reducing incidence rates through lifestyle modifications and screening.

22) Repair:
Repair signifies the body's ability to heal oxidative damage, often reliant on sufficient antioxidant levels. This study indicates that the diminished antioxidant status in obese individuals hampers the natural repair processes, stressing the importance of antioxidant intake for maintaining cellular integrity in the context of obesity.

23) Medium:
Medium refers to the environment in which biochemical assays are conducted, influencing the results of antioxidant analysis in the study. The medium in which interactions occur plays a pivotal role in determining the effectiveness of antioxidants and the overall assessment of oxidative stress levels.

24) Animal:
Animal studies provide foundational knowledge that informs human obesity research. Research findings often extrapolate observations from animal models to understand human physiology in obesity, oxidative stress, and metabolic syndromes, bridging basic science and clinical applications.

25) Water:
Water is an essential component of biological systems and may indirectly influence obesity and overall health. While not a primary focus of the study, hydration status could play a role in maintaining physiological balance, impacting metabolism and the effectiveness of antioxidants in combating oxidative stress.

26) Male (Mālē):
Male refers to the male participants in the study whose data was used to compare oxidative stress and antioxidant status with females. The distinction between male and female participants helps highlight potential gender differences in the impact of obesity and resultant health interventions.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Oxidative stress status in obesity algerians population’. Further sources in the context of Science might help you critically compare this page with similair documents:

Health consequences, Body mass index, Oxidative stress, Lipid profile, Physical Inactivity, Fasting blood glucose, Waist circumference, Antioxidant status, Catalase activity, Overweight individuals, Superoxide dismutase activity, Oxidative stress parameters, Malondialdehyde Level.

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